ATE156828T1 - Phosphinyloxy propanaminium innersalzderivate - Google Patents

Phosphinyloxy propanaminium innersalzderivate

Info

Publication number
ATE156828T1
ATE156828T1 AT93810406T AT93810406T ATE156828T1 AT E156828 T1 ATE156828 T1 AT E156828T1 AT 93810406 T AT93810406 T AT 93810406T AT 93810406 T AT93810406 T AT 93810406T AT E156828 T1 ATE156828 T1 AT E156828T1
Authority
AT
Austria
Prior art keywords
phosphinyloxy
propanaminium
internal salt
salt derivatives
thiolysis
Prior art date
Application number
AT93810406T
Other languages
English (en)
Inventor
Robert Charles Anderson
Gregory R Bebernitz
James D Fraser
Jeffrey W Hughes
Prasad K Kapa
Mahavir Prashad
Howard C Smith
Edwin B Willhauer
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE156828T1 publication Critical patent/ATE156828T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT93810406T 1992-06-11 1993-06-07 Phosphinyloxy propanaminium innersalzderivate ATE156828T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89721092A 1992-06-11 1992-06-11

Publications (1)

Publication Number Publication Date
ATE156828T1 true ATE156828T1 (de) 1997-08-15

Family

ID=25407534

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93810406T ATE156828T1 (de) 1992-06-11 1993-06-07 Phosphinyloxy propanaminium innersalzderivate

Country Status (21)

Country Link
EP (1) EP0574355B1 (de)
JP (1) JPH0673077A (de)
KR (1) KR940005647A (de)
CN (1) CN1039326C (de)
AT (1) ATE156828T1 (de)
AU (1) AU667537B2 (de)
CA (1) CA2098133A1 (de)
CZ (1) CZ108393A3 (de)
DE (1) DE69313029T2 (de)
DK (1) DK0574355T3 (de)
ES (1) ES2105194T3 (de)
FI (1) FI932662A7 (de)
GR (1) GR3024684T3 (de)
HU (2) HUT65327A (de)
IL (1) IL105965A (de)
MY (1) MY109005A (de)
NO (1) NO932096L (de)
NZ (1) NZ247840A (de)
SG (1) SG42983A1 (de)
SK (1) SK58893A3 (de)
ZA (1) ZA934157B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1299266B1 (it) 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
EP1528063B1 (de) * 2003-02-18 2010-09-29 Tokai University Verbindung mit phoshorylcholingruppe, dessen polymer und verfahren zu dessen herstellung
US20090312286A1 (en) 2006-08-02 2009-12-17 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Derivatives of 4-trimethylammonium-3-aminobutyrate and 4-trimethylphosphonium-3-aminobutyrate as cpt-inhibitors
JP7645244B2 (ja) 2019-08-30 2025-03-13 中国科学院動物研究所 代謝性疾患と闘うために使用される組成物およびその組成物の使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0348859A1 (de) * 1988-07-01 1990-01-03 MAGIS FARMACEUTICI S.p.A. 1,2-Di-O-acyl glycero(DI)phosphat von L-carnitin und dessen Derivate, ein Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
IT1230142B (it) * 1989-05-03 1991-10-14 Fidia Spa Derivati della carnitina, processo per la loro preparazione e impiego in terapia umana
IT1230141B (it) * 1989-05-03 1991-10-14 Fidia Spa Impiego di derivati della fosfatidil carnitina per la preparazione di composizioni farmaceutiche aventi attivita' nella terapia delle patologie dell'uomo associate con un danno neuronale.

Also Published As

Publication number Publication date
GR3024684T3 (en) 1997-12-31
DK0574355T3 (da) 1998-01-26
FI932662L (fi) 1993-12-12
NO932096L (no) 1993-12-13
DE69313029T2 (de) 1998-01-29
ES2105194T3 (es) 1997-10-16
CN1039326C (zh) 1998-07-29
ZA934157B (en) 1994-09-05
IL105965A0 (en) 1993-10-20
NO932096D0 (no) 1993-06-09
JPH0673077A (ja) 1994-03-15
SG42983A1 (en) 1997-10-17
CN1086217A (zh) 1994-05-04
EP0574355B1 (de) 1997-08-13
CA2098133A1 (en) 1993-12-12
FI932662A7 (fi) 1993-12-12
AU667537B2 (en) 1996-03-28
AU4011593A (en) 1993-12-16
MY109005A (en) 1996-11-30
NZ247840A (en) 1995-04-27
DE69313029D1 (de) 1997-09-18
EP0574355A1 (de) 1993-12-15
FI932662A0 (fi) 1993-06-10
SK58893A3 (en) 1994-06-08
HU211489A9 (en) 1995-11-28
CZ108393A3 (en) 1995-02-15
HU9301587D0 (en) 1993-09-28
KR940005647A (ko) 1994-03-22
HUT65327A (en) 1994-05-02
IL105965A (en) 1997-03-18

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee