ATE183750T1 - Phosphonyldipeptide zur bekämpfung von kardiovasvakuläre erkrankungen - Google Patents

Phosphonyldipeptide zur bekämpfung von kardiovasvakuläre erkrankungen

Info

Publication number: ATE183750T1
Authority: AT; Austria
Prior art keywords: carbon atoms; alkyl; pct; groups; alkyl moiety
Prior art date: 1994-04-14

Application number

AT95916625T

Other languages

English (en)

Inventor

Gabriele Norcini

Gabriele Morazzoni

Francesco Santangelo

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-14

Filing date

1995-04-11

Publication date

1999-09-15

1995-04-11 Application filed by Zambon Spa filed Critical Zambon Spa

1999-09-15 Application granted granted Critical

1999-09-15 Publication of ATE183750T1 publication Critical patent/ATE183750T1/de

Links

208000024172 Cardiovascular disease Diseases 0.000 title abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000004846 (C1-C4) allyl group Chemical group 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000006267 biphenyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004001 thioalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT95916625T 1994-04-14 1995-04-11 Phosphonyldipeptide zur bekämpfung von kardiovasvakuläre erkrankungen ATE183750T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI940696A IT1274673B (it)	1994-04-14	1994-04-14	Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari

Publications (1)

Publication Number	Publication Date
ATE183750T1 true ATE183750T1 (de)	1999-09-15

Family

ID=11368561

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95916625T ATE183750T1 (de)	1994-04-14	1995-04-11	Phosphonyldipeptide zur bekämpfung von kardiovasvakuläre erkrankungen

Country Status (8)

Country	Link
US (1)	US5760285A (de)
EP (1)	EP0755405B1 (de)
AT (1)	ATE183750T1 (de)
AU (1)	AU2305895A (de)
DE (1)	DE69511689T2 (de)
ES (1)	ES2136848T3 (de)
IT (1)	IT1274673B (de)
WO (1)	WO1995028417A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1276161B1 (it) *	1995-11-23	1997-10-27	Zambon Spa	Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
US6166052A (en) *	1998-03-11	2000-12-26	Warner-Lambert Company	Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4379146A (en) *	1981-02-17	1983-04-05	Merck & Co., Inc.	Substituted phosphonamides as antihypertensives
US4432972A (en) *	1981-08-03	1984-02-21	E. R. Squibb & Sons, Inc.	Phosphonamidate compounds
IT1224405B (it) *	1987-12-23	1990-10-04	Simes	Composti attivi sul sistema cardiovascolare
FR2652087B1 (fr) *	1989-09-15	1993-10-15	Bioprojet Ste Civile	Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
US5155100A (en) *	1991-05-01	1992-10-13	Ciba-Geigy Corporation	Phosphono/biaryl substituted dipeptide derivatives
US5294632A (en) *	1991-05-01	1994-03-15	Ciba-Geigy Corporation	Phosphono/biaryl substituted dipetide derivatives
JPH05105698A (ja) *	1991-06-13	1993-04-27	Takeda Chem Ind Ltd	ホスホン酸誘導体、その製造法および用途
IT1254521B (it) *	1992-03-17	1995-09-25	Zambon Spa	Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare

1994
- 1994-04-14 IT ITMI940696A patent/IT1274673B/it active IP Right Grant
1995
- 1995-04-11 AT AT95916625T patent/ATE183750T1/de not_active IP Right Cessation
- 1995-04-11 WO PCT/EP1995/001322 patent/WO1995028417A1/en not_active Ceased
- 1995-04-11 EP EP95916625A patent/EP0755405B1/de not_active Expired - Lifetime
- 1995-04-11 ES ES95916625T patent/ES2136848T3/es not_active Expired - Lifetime
- 1995-04-11 AU AU23058/95A patent/AU2305895A/en not_active Abandoned
- 1995-04-11 US US08/702,701 patent/US5760285A/en not_active Expired - Fee Related
- 1995-04-11 DE DE69511689T patent/DE69511689T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2136848T3 (es)	1999-12-01
DE69511689D1 (de)	1999-09-30
ITMI940696A0 (it)	1994-04-14
ITMI940696A1 (it)	1995-10-14
EP0755405A1 (de)	1997-01-29
WO1995028417A1 (en)	1995-10-26
AU2305895A (en)	1995-11-10
DE69511689T2 (de)	2000-04-27
US5760285A (en)	1998-06-02
IT1274673B (it)	1997-07-24
EP0755405B1 (de)	1999-08-25

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Legal Events

Date	Code	Title	Description
2000-03-15	UEP	Publication of translation of european patent specification
2006-01-15	REN	Ceased due to non-payment of the annual fee