ATE159186T1 - Verfahren zur erhöhung der stabilität von nanokapseln während deren lagerung - Google Patents

Verfahren zur erhöhung der stabilität von nanokapseln während deren lagerung

Info

Publication number
ATE159186T1
ATE159186T1 AT94200884T AT94200884T ATE159186T1 AT E159186 T1 ATE159186 T1 AT E159186T1 AT 94200884 T AT94200884 T AT 94200884T AT 94200884 T AT94200884 T AT 94200884T AT E159186 T1 ATE159186 T1 AT E159186T1
Authority
AT
Austria
Prior art keywords
nanocapsules
stability
storage
increase
temperature
Prior art date
Application number
AT94200884T
Other languages
English (en)
Inventor
Valdivia Francisco Javie Galan
Dachs Anna Coll
Perdiguer Nuria Carreras
Original Assignee
Cusi Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cusi Lab filed Critical Cusi Lab
Application granted granted Critical
Publication of ATE159186T1 publication Critical patent/ATE159186T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/20After-treatment of capsule walls, e.g. hardening
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/20After-treatment of capsule walls, e.g. hardening
    • B01J13/203Exchange of core-forming material by diffusion through the capsule wall
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/701Integrated with dissimilar structures on a common substrate
    • Y10S977/715On an organic substrate
    • Y10S977/717Lipid substrate
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
AT94200884T 1993-04-20 1994-03-30 Verfahren zur erhöhung der stabilität von nanokapseln während deren lagerung ATE159186T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09300827A ES2070076B1 (es) 1993-04-20 1993-04-20 Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.

Publications (1)

Publication Number Publication Date
ATE159186T1 true ATE159186T1 (de) 1997-11-15

Family

ID=8281529

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94200884T ATE159186T1 (de) 1993-04-20 1994-03-30 Verfahren zur erhöhung der stabilität von nanokapseln während deren lagerung

Country Status (8)

Country Link
US (1) US5885491A (de)
EP (1) EP0621073B1 (de)
JP (1) JPH0815550B2 (de)
AT (1) ATE159186T1 (de)
DE (1) DE69406178T2 (de)
DK (1) DK0621073T3 (de)
ES (1) ES2070076B1 (de)
GR (1) GR3025888T3 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10008305A1 (de) * 2000-02-23 2001-09-06 Henkel Kgaa Mittel zur Reinigung und Pflege von Haut und/oder Haaren
FR2805761B1 (fr) * 2000-03-02 2002-08-30 Mainelab Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US20060286064A1 (en) * 2000-08-30 2006-12-21 Medivas, Llc Therapeutic polymers and methods
BR0212833A (pt) * 2001-09-26 2004-10-13 Baxter Int Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
JP2007522085A (ja) * 2003-06-27 2007-08-09 スミスクライン・ビーチャム・コーポレイション 安定化されたトポテカンリポソーム組成物および方法
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
JP5178520B2 (ja) * 2005-09-22 2013-04-10 メディバス エルエルシー 固体ポリマー送達組成物およびその使用法
WO2007067744A2 (en) * 2005-12-07 2007-06-14 Medivas, Llc Method for assembling a polymer-biologic delivery composition
CA2649672C (en) * 2006-05-02 2015-07-07 Medivas, Llc Delivery of ophthalmologic agents to the exterior or interior of the eye
WO2007133616A2 (en) * 2006-05-09 2007-11-22 Medivas, Llc Biodegradable water soluble polymers
WO2008082721A2 (en) * 2006-09-05 2008-07-10 Medivas, Llc Polymer-stabilized liposomal compositions and methods of use
CA2709412A1 (en) * 2007-07-24 2009-01-29 Medivas, Llc Biodegradable cationic polymer gene transfer compositions and methods of use
WO2010019716A1 (en) * 2008-08-13 2010-02-18 Medivas, Llc Aabb-poly(depsipeptide) biodegradable polymers and methods of use
JP2011241147A (ja) * 2008-08-29 2011-12-01 Nano Egg:Kk インドメタシン含有ナノカプセルおよびその製造方法
US8666685B2 (en) 2011-04-19 2014-03-04 Schneider Electronic IT Corporation System of intelligent sensors in an electrical panelboard
US8660810B2 (en) 2011-04-19 2014-02-25 Schneider Electric It Corporation System and method to calculate RMS current and true power in a multidrop sensor network
ES2992024T3 (es) 2011-06-23 2024-12-05 Dsm Ip Assets Bv Nuevos copolímeros de poliesteramida biodegradables para la administración de fármacos
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
US10434071B2 (en) 2014-12-18 2019-10-08 Dsm Ip Assets, B.V. Drug delivery system for delivery of acid sensitivity drugs
US11147811B2 (en) * 2016-03-10 2021-10-19 Sumitomo Dainippon Pharma Co., Ltd. Composition comprising fine particle and process thereof
CA3160955A1 (en) 2019-11-12 2021-05-20 Dsm Ip Assets B.V. Polyesteramide copolymers possessing high glass transition temperatures

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
JPS57147430A (en) * 1981-03-06 1982-09-11 Kureha Chem Ind Co Ltd Preparation of microcapsule
FR2515960A1 (fr) * 1981-11-06 1983-05-13 Alkhouri Fallouh Nazir Nanocapsules ou nanoparticules biodegradables contenant une substance biologiquement active, leur preparation et leur application
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
DE3678308D1 (de) * 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
CA1285491C (en) * 1985-09-12 1991-07-02 Robert J. Smith Method of treating catabolic dysfunction
US4806343A (en) * 1986-03-13 1989-02-21 University Of Southwestern Louisiana Cryogenic protectant for proteins
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5093198A (en) * 1987-06-19 1992-03-03 Temple University Adjuvant-enhanced sustained release composition and method for making
JP3226300B2 (ja) * 1990-07-18 2001-11-05 エーザイ株式会社 プロナノスフィア及びその製造方法
KR930006431B1 (ko) * 1990-10-11 1993-07-16 재단법인 한국화학연구소 약물의 미세캡슐화 방법
US5250236A (en) * 1991-08-05 1993-10-05 Gasco Maria R Method for producing solid lipid microspheres having a narrow size distribution
FR2692168B1 (fr) * 1992-06-16 1995-03-24 Centre Nat Rech Scient Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles

Also Published As

Publication number Publication date
DK0621073T3 (da) 1998-06-02
JPH0815550B2 (ja) 1996-02-21
DE69406178T2 (de) 1998-06-04
EP0621073B1 (de) 1997-10-15
US5885491A (en) 1999-03-23
ES2070076B1 (es) 1996-04-16
GR3025888T3 (en) 1998-04-30
ES2070076A1 (es) 1995-05-16
EP0621073A1 (de) 1994-10-26
DE69406178D1 (de) 1997-11-20
JPH06343854A (ja) 1994-12-20
HK1011943A1 (en) 1999-07-23

Similar Documents

Publication Publication Date Title
ATE159186T1 (de) Verfahren zur erhöhung der stabilität von nanokapseln während deren lagerung
DE59109210D1 (de) Verfahren zur Herstellung von Wasseradsorptionsmaterial und dessen Verwendung in Hygieneartikeln und zur Bodenverbesserung
ATE36447T1 (de) Bindung von fluechtigen stoffen auf einem amorphen substrat und die so erhaltenen produkte.
AU8138287A (en) Aqueous gel comprising carrageenan
DE69111051D1 (de) Verbessertes verfahren zur herstellung von mikrokapseln und verbesserte produkte.
Fox et al. Abiotic production of primitive protein and formed microparticles
DE59601880D1 (de) Verfahren zur herstellung hydrophiler oder teilweise hydrophiler, anorganischer aerogele
DE69033874D1 (de) Verfahren zur Herstellung von arzneimittelenthaltenden gefriergetrockneten Formulierungen
ATE61378T1 (de) Waessrige schreibfluessigkeiten sowie ein verfahren zu deren herstellung.
ATE150642T1 (de) Verfahren zur kontinuierlichen herstellung von dispersen kolloide-systemen in form von nanokapseln oder nanopartikeln
DE68927669D1 (de) Verfahren zur herstellung von in lösungsmitteln verdünnbaren mikroträgern
DE59006474D1 (de) Substituierte (Chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln.
PT87658A (pt) Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet loesung enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin
DE3676833D1 (de) Verfahren zur herstellung von perfluorpolyaethern mit regulierter molekuelmasse aus dem produkt erhalten in der c2f4 photooxydation.
AU2673688A (en) Method of producing free flowing beads of biological materials and method for their application to the leaf surface of plants
DE3584610D1 (de) Lebende mikroorganismen enthaltendes fluessiges praeparat, verfahren zu dessen herstellung, lebende mikroorganismen enthaltendes pelletiertes produkt und verfahren zu dessen herstellung.
ATE77211T1 (de) Verfahren zur herstellung von snacks oder dergleichen produkte.
ATE3974T1 (de) Verfahren zur herstellung von 4,4'-dinitrostilben-2,2'-disulfonsaeure und deren salzen und deren verwendung.
ATE138654T1 (de) Verfahren zur herstellung von 1-carbamoyl- pyrazolen
AT315159B (de) Verfahren zur gemeinsamen Spaltung von dl-Kampfer-10-sulfonsäure und α-dl-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol in ihre entsprechenden optisch aktiven d- und 1-Isomeren
ATE209444T1 (de) Verfahren und gerät zur behandlung von flüssigeiprodukten
ATE163541T1 (de) Herstellungsverfahren von mit biologischen strukturen, biopolymeren und/oder oligomeren beladenen vesikeln
ATE156660T1 (de) Verfahren zur erleichterung der ernte von nahrungserträgen
ATE193897T1 (de) Ein verfahren zur herstellung eines nicht- faserigen porösen stoffes
Vol'kenshteĭn et al. Electronic-conformational interactions of molecular-biological systems. I. Quantum-chemical aspect of the theory of electronic-conformational interaction

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee