ATE159521T1 - Thioacylierungsmittel und zwischenprodukte, thiopeptide, und verfahren zu deren herstellung und anwendung - Google Patents

Thioacylierungsmittel und zwischenprodukte, thiopeptide, und verfahren zu deren herstellung und anwendung

Info

Publication number
ATE159521T1
ATE159521T1 AT90911857T AT90911857T ATE159521T1 AT E159521 T1 ATE159521 T1 AT E159521T1 AT 90911857 T AT90911857 T AT 90911857T AT 90911857 T AT90911857 T AT 90911857T AT E159521 T1 ATE159521 T1 AT E159521T1
Authority
AT
Austria
Prior art keywords
compounds
thiopeptides
relates
thioacylating
production
Prior art date
Application number
AT90911857T
Other languages
English (en)
Inventor
Denis Brillon
Gilles Sauve
Boulos Zacharie
Bernard Belleau
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Application granted granted Critical
Publication of ATE159521T1 publication Critical patent/ATE159521T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/66—Thymopoietins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AT90911857T 1989-08-04 1990-08-03 Thioacylierungsmittel und zwischenprodukte, thiopeptide, und verfahren zu deren herstellung und anwendung ATE159521T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/389,852 US5138061A (en) 1989-08-04 1989-08-04 Thioacylating reagents

Publications (1)

Publication Number Publication Date
ATE159521T1 true ATE159521T1 (de) 1997-11-15

Family

ID=23540015

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90911857T ATE159521T1 (de) 1989-08-04 1990-08-03 Thioacylierungsmittel und zwischenprodukte, thiopeptide, und verfahren zu deren herstellung und anwendung

Country Status (11)

Country Link
US (2) US5138061A (de)
EP (1) EP0485458B1 (de)
JP (1) JP3165698B2 (de)
AT (1) ATE159521T1 (de)
CA (1) CA2059647C (de)
DE (1) DE69031623T2 (de)
DK (1) DK0485458T3 (de)
ES (1) ES2109236T3 (de)
HU (1) HU220756B1 (de)
OA (1) OA09561A (de)
WO (1) WO1991001976A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138061A (en) * 1989-08-04 1992-08-11 Biochem Pharma Inc. Thioacylating reagents
EP0655055B1 (de) * 1992-08-13 2000-11-29 Warner-Lambert Company Tachykinin antagonistes
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
AU7937298A (en) 1997-07-08 1999-02-08 Ono Pharmaceutical Co. Ltd. Amino acid derivatives
KR100281826B1 (ko) * 1998-04-21 2001-02-15 박호군 N,n-디아실이미다졸론 유도체를 이용한 아민의 아실화 방법
TWI245035B (en) 1998-06-26 2005-12-11 Ono Pharmaceutical Co Amino acid derivatives and a pharmaceutical composition comprising the derivatives
KR100633349B1 (ko) 1998-07-14 2006-10-16 오노 야꾸힝 고교 가부시키가이샤 아미노산 유도체 및 이들을 유효 성분으로서 함유하는 약제
GB0401008D0 (en) * 2004-01-17 2004-02-18 Univ Manchester Drug delivery system
AU2022238571A1 (en) 2021-03-18 2023-09-14 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2927116A (en) * 1960-03-01 Chlorobenzimidazolone compounds
DE1542886A1 (de) * 1966-10-04 1970-05-14 Bayer Ag Fungizide Mittel
US3901909A (en) * 1972-12-04 1975-08-26 Squibb & Sons Inc Mercaptobenzimidazolyl ureas and thioureas
DE3540495A1 (de) * 1985-11-15 1987-05-21 Merck Patent Gmbh Aminosaeurederivate
JPS62255485A (ja) * 1986-04-25 1987-11-07 Kissei Pharmaceut Co Ltd ベンズイミダゾリン誘導体
US4835166A (en) * 1986-06-09 1989-05-30 Pfizer Inc. Antiallergy and antiinflammatory agents
US5138061A (en) * 1989-08-04 1992-08-11 Biochem Pharma Inc. Thioacylating reagents

Also Published As

Publication number Publication date
DE69031623T2 (de) 1998-02-19
AU6064290A (en) 1991-03-11
OA09561A (en) 1993-01-31
HU220756B1 (hu) 2002-05-28
US5138061A (en) 1992-08-11
ES2109236T3 (es) 1998-01-16
JPH05501865A (ja) 1993-04-08
EP0485458B1 (de) 1997-10-22
DK0485458T3 (da) 1998-04-20
AU651557B2 (en) 1994-07-28
DE69031623D1 (de) 1997-11-27
CA2059647A1 (en) 1991-02-05
HUT63395A (en) 1993-08-30
CA2059647C (en) 2001-06-05
JP3165698B2 (ja) 2001-05-14
WO1991001976A1 (en) 1991-02-21
HU9200338D0 (en) 1992-04-28
US5371185A (en) 1994-12-06
EP0485458A1 (de) 1992-05-20

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee