ATE160575T1 - Für toxin b von clostridium difficile spezifische monoklonale antikörper - Google Patents

Für toxin b von clostridium difficile spezifische monoklonale antikörper

Info

Publication number
ATE160575T1
ATE160575T1 AT91909906T AT91909906T ATE160575T1 AT E160575 T1 ATE160575 T1 AT E160575T1 AT 91909906 T AT91909906 T AT 91909906T AT 91909906 T AT91909906 T AT 91909906T AT E160575 T1 ATE160575 T1 AT E160575T1
Authority
AT
Austria
Prior art keywords
toxin
monoclonal antibodies
antibodies specific
clostridium difficile
difficile
Prior art date
Application number
AT91909906T
Other languages
English (en)
Inventor
Richard T Coughlin
Dante J Marciani
Original Assignee
Meridian Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meridian Diagnostics Inc filed Critical Meridian Diagnostics Inc
Application granted granted Critical
Publication of ATE160575T1 publication Critical patent/ATE160575T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT91909906T 1990-05-11 1991-05-06 Für toxin b von clostridium difficile spezifische monoklonale antikörper ATE160575T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/522,881 US5231003A (en) 1990-05-11 1990-05-11 Monoclonal antibodies specific for toxin b of clostridium difficile

Publications (1)

Publication Number Publication Date
ATE160575T1 true ATE160575T1 (de) 1997-12-15

Family

ID=24082747

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91909906T ATE160575T1 (de) 1990-05-11 1991-05-06 Für toxin b von clostridium difficile spezifische monoklonale antikörper

Country Status (11)

Country Link
US (1) US5231003A (de)
EP (1) EP0482176B1 (de)
JP (1) JPH05500011A (de)
AT (1) ATE160575T1 (de)
AU (1) AU655586B2 (de)
CA (1) CA2063709A1 (de)
DE (1) DE69128273T2 (de)
DK (1) DK0482176T3 (de)
ES (1) ES2110993T3 (de)
IE (1) IE911617A1 (de)
WO (1) WO1991018293A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610023A (en) * 1995-03-31 1997-03-11 Lee Laboratories, Inc. Method of purification of clostridium difficile toxin A and production of mono-specific antibodies
US7179611B2 (en) * 1997-02-10 2007-02-20 Bd Lee Laboratories Mono-specific polyclonal antibodies and methods for detecting Clostridium difficile Toxin A
US5965375A (en) * 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile
DE19739685A1 (de) 1997-09-10 1999-03-11 Eichel Streiber Christoph Von Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
US6270755B1 (en) 1999-05-13 2001-08-07 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders
US6290946B1 (en) * 1999-05-13 2001-09-18 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders and antibacterial agents
CA2314494A1 (en) 2000-05-02 2001-11-02 Geltex Pharmaceuticals, Inc. Anionic polymers as species specific antibacterial agents
EP1542706A1 (de) * 2002-07-22 2005-06-22 Genzyme Corporation Poly (kalium- und natriumstyrolsulfonat), seine herstellung und verwendungszwecke
EP2857418B1 (de) * 2004-02-06 2017-07-26 University of Massachusetts Antikörper gegen Clostridium difficile Toxine und ihre Verwendung
EP1802349A1 (de) * 2004-10-13 2007-07-04 Ilypsa, Inc. Pharmazeutische zusammensetzungen mit einem toxin-bindenden oligosaccharid und einem polymerteilchen
US20060078534A1 (en) * 2004-10-13 2006-04-13 Dominique Charmot Toxin binding compositions
WO2009008916A2 (en) 2007-03-22 2009-01-15 The Regents Of The University Of Californina Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
AU2009219358A1 (en) 2008-02-28 2009-09-03 3M Innovative Properties Company Antibodies to Clostridium difficile spores and uses thereof
CA2732003A1 (en) 2008-07-31 2010-02-04 James D. Marks Antibodies that neutralize botulinum neurotoxins
AU2009350614B2 (en) * 2009-07-27 2013-04-04 Biodics Gmbh Method for detecting and identifying a variant C. difficile strain in a sample
BR112012026021B1 (pt) * 2010-04-15 2022-05-03 Progenics Pharmaceuticals, Inc Anticorpos, seus fragmentos de ligação ao antígeno e seus usos, composições e uso das mesmas, linhagem de células de hibridoma, kit, ácido nucleico, e vetor de expressão
US9243057B2 (en) 2010-08-31 2016-01-26 The Regents Of The University Of California Antibodies for botulinum neurotoxins
ES2969952T3 (es) 2011-04-22 2024-05-23 Wyeth Llc Composiciones relacionadas con una toxina mutante de Clostridium difficile y sus procedimientos
BR112014004162A2 (pt) 2011-08-22 2018-04-24 Cangene Corp anticorpos contra clostridium difficile
US8790880B2 (en) * 2011-09-26 2014-07-29 Techlab, Inc. Cysteine protease Cwp84 (CD2787) as a diagnostic marker for Clostridium difficile
NZ714516A (en) * 2012-03-02 2017-06-30 Regeneron Pharma Human antibodies to clostridium difficile toxins
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
WO2021255690A2 (en) 2020-06-19 2021-12-23 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
CN114853895B (zh) * 2020-11-30 2023-05-09 四川大学华西医院 一种抗糖基转移酶a亚单位的纳米抗体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879218A (en) * 1982-09-13 1989-11-07 Virginia Tech Intellectual Properties, Inc. Antibody for C.difficile
US4533630A (en) * 1982-09-13 1985-08-06 Wilkins Tracy D Toxins and antibodies of C. difficile
EP0154064A1 (de) * 1984-03-02 1985-09-11 Tracy Dale Wilkins Toxine und Antikörper von C. Difficile

Also Published As

Publication number Publication date
WO1991018293A1 (en) 1991-11-28
DK0482176T3 (da) 1998-05-18
IE911617A1 (en) 1991-11-20
DE69128273T2 (de) 1998-06-25
EP0482176A1 (de) 1992-04-29
CA2063709A1 (en) 1991-11-12
US5231003A (en) 1993-07-27
ES2110993T3 (es) 1998-03-01
JPH05500011A (ja) 1993-01-14
EP0482176B1 (de) 1997-11-26
AU7883091A (en) 1991-12-10
EP0482176A4 (en) 1992-08-05
DE69128273D1 (de) 1998-01-08
AU655586B2 (en) 1995-01-05

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