ATE160575T1 - Für toxin b von clostridium difficile spezifische monoklonale antikörper - Google Patents

Für toxin b von clostridium difficile spezifische monoklonale antikörper

Info

Publication number
ATE160575T1
ATE160575T1 AT91909906T AT91909906T ATE160575T1 AT E160575 T1 ATE160575 T1 AT E160575T1 AT 91909906 T AT91909906 T AT 91909906T AT 91909906 T AT91909906 T AT 91909906T AT E160575 T1 ATE160575 T1 AT E160575T1
Authority
AT
Austria
Prior art keywords
toxin
monoclonal antibodies
antibodies specific
clostridium difficile
difficile
Prior art date
Application number
AT91909906T
Other languages
English (en)
Inventor
Richard T Coughlin
Dante J Marciani
Original Assignee
Meridian Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meridian Diagnostics Inc filed Critical Meridian Diagnostics Inc
Application granted granted Critical
Publication of ATE160575T1 publication Critical patent/ATE160575T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT91909906T 1990-05-11 1991-05-06 Für toxin b von clostridium difficile spezifische monoklonale antikörper ATE160575T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/522,881 US5231003A (en) 1990-05-11 1990-05-11 Monoclonal antibodies specific for toxin b of clostridium difficile

Publications (1)

Publication Number Publication Date
ATE160575T1 true ATE160575T1 (de) 1997-12-15

Family

ID=24082747

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91909906T ATE160575T1 (de) 1990-05-11 1991-05-06 Für toxin b von clostridium difficile spezifische monoklonale antikörper

Country Status (11)

Country Link
US (1) US5231003A (de)
EP (1) EP0482176B1 (de)
JP (1) JPH05500011A (de)
AT (1) ATE160575T1 (de)
AU (1) AU655586B2 (de)
CA (1) CA2063709A1 (de)
DE (1) DE69128273T2 (de)
DK (1) DK0482176T3 (de)
ES (1) ES2110993T3 (de)
IE (1) IE911617A1 (de)
WO (1) WO1991018293A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610023A (en) * 1995-03-31 1997-03-11 Lee Laboratories, Inc. Method of purification of clostridium difficile toxin A and production of mono-specific antibodies
US7179611B2 (en) * 1997-02-10 2007-02-20 Bd Lee Laboratories Mono-specific polyclonal antibodies and methods for detecting Clostridium difficile Toxin A
US5965375A (en) * 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile
DE19739685A1 (de) * 1997-09-10 1999-03-11 Eichel Streiber Christoph Von Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
US6290946B1 (en) 1999-05-13 2001-09-18 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders and antibacterial agents
US6270755B1 (en) 1999-05-13 2001-08-07 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders
CA2314494A1 (en) 2000-05-02 2001-11-02 Geltex Pharmaceuticals, Inc. Anionic polymers as species specific antibacterial agents
BR0312884A (pt) * 2002-07-22 2005-06-14 Genzyme Corp Copolìmero de sulfonato de polistireno, método de preparação e composição farmacêutica que compreende o mesmo, método para tratar, inibir o inìcio e a reincidência de diarréia, regime de tratamento, mistura e composição farmacêutica
NZ548821A (en) * 2004-02-06 2009-12-24 Univ Massachusetts Antibodies against clostridium difficile toxins and uses thereof
US20060078534A1 (en) * 2004-10-13 2006-04-13 Dominique Charmot Toxin binding compositions
WO2006044577A1 (en) * 2004-10-13 2006-04-27 Ilypsa, Inc. Pharmaceutical compositions comprising a toxin-binding oligosaccharide and a polymeric particle
WO2009008916A2 (en) 2007-03-22 2009-01-15 The Regents Of The University Of Californina Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
JP2011512817A (ja) 2008-02-28 2011-04-28 スリーエム イノベイティブ プロパティズ カンパニー クロストリジウム・ディフィシル胞子に対する抗体及びその使用
EP2313434A4 (de) 2008-07-31 2013-03-27 Univ California Antikörper zur neutralisierung von botulinneurotoxinen
EP2459588B1 (de) * 2009-07-27 2016-06-29 BioDics GmbH Verfahren zum nachweis und zur identifikation eines varianten c. difficile stammes in einer probe
MX339253B (es) * 2010-04-15 2016-05-18 Progenics Pharm Inc Anticuerpos para el tratamiento de infeccion y enfermedad asociadas con clostridium dificile.
WO2012047427A2 (en) 2010-08-31 2012-04-12 The Regents Of The University Of California Antibodies for botulinum neurotoxins
CN103619871B (zh) 2011-04-22 2016-12-14 惠氏有限责任公司 涉及突变体难辨梭菌毒素的组合物及其方法
SG11201400916XA (en) 2011-08-22 2014-06-27 Cangene Corp Clostridium difficile antibodies
US8790880B2 (en) * 2011-09-26 2014-07-29 Techlab, Inc. Cysteine protease Cwp84 (CD2787) as a diagnostic marker for Clostridium difficile
SG10201610123UA (en) * 2012-03-02 2017-01-27 Regeneron Pharma Human antibodies to clostridium difficile toxins
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
WO2021255690A2 (en) 2020-06-19 2021-12-23 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
CN114853896B (zh) * 2020-11-30 2023-05-09 四川大学华西医院 一种抗糖基转移酶a亚单位的纳米抗体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4533630A (en) * 1982-09-13 1985-08-06 Wilkins Tracy D Toxins and antibodies of C. difficile
US4879218A (en) * 1982-09-13 1989-11-07 Virginia Tech Intellectual Properties, Inc. Antibody for C.difficile
EP0154064A1 (de) * 1984-03-02 1985-09-11 Tracy Dale Wilkins Toxine und Antikörper von C. Difficile

Also Published As

Publication number Publication date
DE69128273T2 (de) 1998-06-25
WO1991018293A1 (en) 1991-11-28
DK0482176T3 (da) 1998-05-18
US5231003A (en) 1993-07-27
EP0482176A4 (en) 1992-08-05
JPH05500011A (ja) 1993-01-14
DE69128273D1 (de) 1998-01-08
EP0482176A1 (de) 1992-04-29
EP0482176B1 (de) 1997-11-26
AU7883091A (en) 1991-12-10
CA2063709A1 (en) 1991-11-12
AU655586B2 (en) 1995-01-05
ES2110993T3 (es) 1998-03-01
IE911617A1 (en) 1991-11-20

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