ES2110993T3 - Anticuerpos monoclonales especificos para la toxina b de clostridium difficile. - Google Patents

Anticuerpos monoclonales especificos para la toxina b de clostridium difficile.

Info

Publication number
ES2110993T3
ES2110993T3 ES91909906T ES91909906T ES2110993T3 ES 2110993 T3 ES2110993 T3 ES 2110993T3 ES 91909906 T ES91909906 T ES 91909906T ES 91909906 T ES91909906 T ES 91909906T ES 2110993 T3 ES2110993 T3 ES 2110993T3
Authority
ES
Spain
Prior art keywords
monoclonal antibodies
clostridium difficile
antibodies specific
difficile toxin
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91909906T
Other languages
English (en)
Inventor
Richard T Coughlin
Dante J Marciani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meridian Bioscience Inc
Original Assignee
Meridian Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meridian Diagnostics Inc filed Critical Meridian Diagnostics Inc
Application granted granted Critical
Publication of ES2110993T3 publication Critical patent/ES2110993T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE PRESENTAN ANTICUERPOS MONOCLONALES ESPECIFICOS DE LA TOXINA B DEL CLOSTRIDIUM DIFFICILE. ADEMAS SE PRESENTAN LOS METODOS PARA HACER Y UTILIZAR LOS ANTICUERPOS, EN PARTICULAR EL USO DE LOS ANTICUERPOS PARA DETECTAR EL C. DIFFICILE.
ES91909906T 1990-05-11 1991-05-06 Anticuerpos monoclonales especificos para la toxina b de clostridium difficile. Expired - Lifetime ES2110993T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/522,881 US5231003A (en) 1990-05-11 1990-05-11 Monoclonal antibodies specific for toxin b of clostridium difficile

Publications (1)

Publication Number Publication Date
ES2110993T3 true ES2110993T3 (es) 1998-03-01

Family

ID=24082747

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91909906T Expired - Lifetime ES2110993T3 (es) 1990-05-11 1991-05-06 Anticuerpos monoclonales especificos para la toxina b de clostridium difficile.

Country Status (11)

Country Link
US (1) US5231003A (es)
EP (1) EP0482176B1 (es)
JP (1) JPH05500011A (es)
AT (1) ATE160575T1 (es)
AU (1) AU655586B2 (es)
CA (1) CA2063709A1 (es)
DE (1) DE69128273T2 (es)
DK (1) DK0482176T3 (es)
ES (1) ES2110993T3 (es)
IE (1) IE911617A1 (es)
WO (1) WO1991018293A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610023A (en) * 1995-03-31 1997-03-11 Lee Laboratories, Inc. Method of purification of clostridium difficile toxin A and production of mono-specific antibodies
US7179611B2 (en) * 1997-02-10 2007-02-20 Bd Lee Laboratories Mono-specific polyclonal antibodies and methods for detecting Clostridium difficile Toxin A
US5965375A (en) * 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile
DE19739685A1 (de) 1997-09-10 1999-03-11 Eichel Streiber Christoph Von Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
US6270755B1 (en) 1999-05-13 2001-08-07 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders
US6290946B1 (en) 1999-05-13 2001-09-18 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders and antibacterial agents
CA2314494A1 (en) 2000-05-02 2001-11-02 Geltex Pharmaceuticals, Inc. Anionic polymers as species specific antibacterial agents
NZ537594A (en) * 2002-07-22 2008-05-30 Genzyme Corp Poly (potassium and sodium styrene sulfonate), its manufacture and its uses
ES2366626T3 (es) 2004-02-06 2011-10-24 University Of Massachusetts Anticuerpos contra toxinas de clostridium difficile y usos de los mismos.
US20060078534A1 (en) * 2004-10-13 2006-04-13 Dominique Charmot Toxin binding compositions
WO2006044577A1 (en) * 2004-10-13 2006-04-27 Ilypsa, Inc. Pharmaceutical compositions comprising a toxin-binding oligosaccharide and a polymeric particle
CA2680741A1 (en) 2007-03-22 2009-01-15 The Regents Of The University Of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
EP2271366A4 (en) 2008-02-28 2012-06-20 3M Innovative Properties Co ANTIBODIES DIFFICULT CLOSTRIDIUM SPORES AND USES THEREOF
US9000131B2 (en) * 2008-07-31 2015-04-07 The Regents Of The University Of California Antibodies that neutralize botulinum neurotoxins
CA2768528C (en) * 2009-07-27 2017-05-23 Christoph Von Eichel-Streiber Method for detecting and identifying a variant c. difficile strain in a sample
AU2011239470B2 (en) * 2010-04-15 2015-09-10 Progenics Pharmaceuticals, Inc. Antibodies for the treatment of Clostridium difficile-associated infection and disease
US9243057B2 (en) 2010-08-31 2016-01-26 The Regents Of The University Of California Antibodies for botulinum neurotoxins
AR086199A1 (es) 2011-04-22 2013-11-27 Wyeth Llc Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos
US9505847B2 (en) 2011-08-22 2016-11-29 Cnj Holdings Inc Clostridium difficile antibodies
US8790880B2 (en) * 2011-09-26 2014-07-29 Techlab, Inc. Cysteine protease Cwp84 (CD2787) as a diagnostic marker for Clostridium difficile
MX2014010527A (es) 2012-03-02 2014-10-14 Regeneron Pharma Anticuerpos humanos para toxinas de clostridium difficile.
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
WO2021255690A2 (en) 2020-06-19 2021-12-23 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
CN114853895B (zh) * 2020-11-30 2023-05-09 四川大学华西医院 一种抗糖基转移酶a亚单位的纳米抗体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4533630A (en) * 1982-09-13 1985-08-06 Wilkins Tracy D Toxins and antibodies of C. difficile
US4879218A (en) * 1982-09-13 1989-11-07 Virginia Tech Intellectual Properties, Inc. Antibody for C.difficile
EP0154064A1 (en) * 1984-03-02 1985-09-11 Tracy Dale Wilkins Toxins and antibodies of C. difficile

Also Published As

Publication number Publication date
DE69128273D1 (de) 1998-01-08
DK0482176T3 (da) 1998-05-18
DE69128273T2 (de) 1998-06-25
ATE160575T1 (de) 1997-12-15
EP0482176A1 (en) 1992-04-29
IE911617A1 (en) 1991-11-20
US5231003A (en) 1993-07-27
AU7883091A (en) 1991-12-10
CA2063709A1 (en) 1991-11-12
EP0482176A4 (en) 1992-08-05
AU655586B2 (en) 1995-01-05
JPH05500011A (ja) 1993-01-14
EP0482176B1 (en) 1997-11-26
WO1991018293A1 (en) 1991-11-28

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