ATE160820T1 - Verfahren zur herstellung von s-(1)-2-(3- benzoylphenyl)propionsäure durch enzymkatalinierte enantioselektive hydrolyse. - Google Patents
Verfahren zur herstellung von s-(1)-2-(3- benzoylphenyl)propionsäure durch enzymkatalinierte enantioselektive hydrolyse.Info
- Publication number
- ATE160820T1 ATE160820T1 AT93912795T AT93912795T ATE160820T1 AT E160820 T1 ATE160820 T1 AT E160820T1 AT 93912795 T AT93912795 T AT 93912795T AT 93912795 T AT93912795 T AT 93912795T AT E160820 T1 ATE160820 T1 AT E160820T1
- Authority
- AT
- Austria
- Prior art keywords
- ester
- benzoylphenyl
- hydrolysis
- propionic acid
- catalinated
- Prior art date
Links
- 230000007062 hydrolysis Effects 0.000 title abstract 4
- 238000006460 hydrolysis reaction Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 2
- USWINTIHFQKJTR-UHFFFAOYSA-N 3-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=C2C=C(S(O)(=O)=O)C(O)=CC2=C1 USWINTIHFQKJTR-UHFFFAOYSA-N 0.000 abstract 1
- 101710158368 Extracellular lipase Proteins 0.000 abstract 1
- 101710128940 Triacylglycerol lipase Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09201189A ES2046950B1 (es) | 1992-06-08 | 1992-06-08 | Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE160820T1 true ATE160820T1 (de) | 1997-12-15 |
Family
ID=8277264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93912795T ATE160820T1 (de) | 1992-06-08 | 1993-05-26 | Verfahren zur herstellung von s-(1)-2-(3- benzoylphenyl)propionsäure durch enzymkatalinierte enantioselektive hydrolyse. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0644949B1 (de) |
| AT (1) | ATE160820T1 (de) |
| AU (1) | AU4318193A (de) |
| DE (2) | DE644949T1 (de) |
| ES (2) | ES2046950B1 (de) |
| WO (1) | WO1993025703A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9304256D0 (en) * | 1993-03-03 | 1993-04-21 | Chiros Ltd | Arylalkanoic acid resolution |
| US5912164A (en) * | 1993-03-03 | 1999-06-15 | Laboratorios Menarini S.A. | Stereoselective hydrolysis of chiral carboxylic acid esters using esterase from ophiostoma or ceratocystis |
| DE10004926A1 (de) | 2000-02-04 | 2001-08-09 | Gruenenthal Gmbh | Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten |
| US8173840B2 (en) | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
| US7589233B2 (en) | 2003-07-29 | 2009-09-15 | Signature R&D Holdings, Llc | L-Threonine derivatives of high therapeutic index |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| WO2008012605A1 (en) * | 2006-07-27 | 2008-01-31 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| KR20210103586A (ko) | 2007-06-04 | 2021-08-23 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도 |
| RU2630577C2 (ru) | 2008-12-04 | 2017-09-11 | Чунси ЮЙ | Композиции интенсивного проникновения и их применение |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0227078A1 (de) * | 1985-12-20 | 1987-07-01 | Wisconsin Alumni Research Foundation | Verfahren zur Herstellung von S-alpha-methylarylessigsäuren |
| FR2596415B1 (fr) * | 1986-03-26 | 1988-07-01 | Elf Aquitaine | Procede pour l'execution de reactions enzymatiques au sein d'un solvant organique |
| US5108916A (en) * | 1989-06-05 | 1992-04-28 | Rhone-Poulenc Rorer, S.A. | Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa |
| EP0517798B1 (de) * | 1990-02-26 | 1997-04-16 | Rhone-Poulenc Inc. | Stereospezifische trennung durch hydrolyse von 2-arylpropionsäureestern mit leberenzymen |
-
1992
- 1992-06-08 ES ES09201189A patent/ES2046950B1/es not_active Expired - Fee Related
-
1993
- 1993-05-26 WO PCT/EP1993/001321 patent/WO1993025703A1/en not_active Ceased
- 1993-05-26 EP EP93912795A patent/EP0644949B1/de not_active Expired - Lifetime
- 1993-05-26 AU AU43181/93A patent/AU4318193A/en not_active Abandoned
- 1993-05-26 DE DE0644949T patent/DE644949T1/de active Pending
- 1993-05-26 AT AT93912795T patent/ATE160820T1/de not_active IP Right Cessation
- 1993-05-26 ES ES93912795T patent/ES2072837T1/es active Pending
- 1993-05-26 DE DE69315577T patent/DE69315577D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2072837T1 (es) | 1995-08-01 |
| WO1993025703A1 (en) | 1993-12-23 |
| DE644949T1 (de) | 1996-09-12 |
| ES2046950A1 (es) | 1994-02-01 |
| EP0644949B1 (de) | 1997-12-03 |
| AU4318193A (en) | 1994-01-04 |
| EP0644949A1 (de) | 1995-03-29 |
| DE69315577D1 (de) | 1998-01-15 |
| ES2046950B1 (es) | 1994-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |