ES2072837T1 - Procedimiento para la preparacion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada por una enzima. - Google Patents

Procedimiento para la preparacion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada por una enzima.

Info

Publication number
ES2072837T1
ES2072837T1 ES93912795T ES93912795T ES2072837T1 ES 2072837 T1 ES2072837 T1 ES 2072837T1 ES 93912795 T ES93912795 T ES 93912795T ES 93912795 T ES93912795 T ES 93912795T ES 2072837 T1 ES2072837 T1 ES 2072837T1
Authority
ES
Spain
Prior art keywords
benzoylphenyl
ester
preparation
enzyme
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES93912795T
Other languages
English (en)
Inventor
Germano Carganico
Casellas David Mauleon
Benet Albert Palomer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Publication of ES2072837T1 publication Critical patent/ES2072837T1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DEL ACIDO (3BENZOILFENILO)PROPIONICO-2-(+)-S (Y), POR LA RESOLUCION DEL RACEMATO A TRAVES DE LA HIDROLISIS ENANTIOSELECTIVA DE UN ESTER REACTIVO (II) EN UN MEDIO ORGANICO, CUYA HIDROLISIS ES CATALIZADA POR UNA LIPASA EXTRACELULAR DE ORIGEN MICROBIAL. LA SEPARACION DEL ACIDO LIBRE RESULTANTE DEL ESTER RESTANTE ES REALIZADA POR LA EXTRACCION EN UN MEDIO BASICO, PARA DEJAR EL ESTER-S EN LA FASE ORGANICA Y EL ACIDO-R EN UNO ACUOSO. FINALMENTE, EL ISOMERO S DESEADO ES OBTENIDO POR LA HIDROLISIS ACUOSA DEL ESTER-S REACTIVO REMANENTE, A PH CONSTANTE, O ENZIMATICAMENTE.
ES93912795T 1992-06-08 1993-05-26 Procedimiento para la preparacion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada por una enzima. Pending ES2072837T1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09201189A ES2046950B1 (es) 1992-06-08 1992-06-08 Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente.

Publications (1)

Publication Number Publication Date
ES2072837T1 true ES2072837T1 (es) 1995-08-01

Family

ID=8277264

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09201189A Expired - Fee Related ES2046950B1 (es) 1992-06-08 1992-06-08 Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente.
ES93912795T Pending ES2072837T1 (es) 1992-06-08 1993-05-26 Procedimiento para la preparacion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada por una enzima.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES09201189A Expired - Fee Related ES2046950B1 (es) 1992-06-08 1992-06-08 Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente.

Country Status (6)

Country Link
EP (1) EP0644949B1 (es)
AT (1) ATE160820T1 (es)
AU (1) AU4318193A (es)
DE (2) DE644949T1 (es)
ES (2) ES2046950B1 (es)
WO (1) WO1993025703A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9304256D0 (en) * 1993-03-03 1993-04-21 Chiros Ltd Arylalkanoic acid resolution
US5912164A (en) * 1993-03-03 1999-06-15 Laboratorios Menarini S.A. Stereoselective hydrolysis of chiral carboxylic acid esters using esterase from ophiostoma or ceratocystis
DE10004926A1 (de) 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten
US7589233B2 (en) 2003-07-29 2009-09-15 Signature R&D Holdings, Llc L-Threonine derivatives of high therapeutic index
US8173840B2 (en) 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
WO2008012605A1 (en) * 2006-07-27 2008-01-31 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate
KR20150058566A (ko) 2007-06-04 2015-05-28 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 ｎｓａｉａ 약물전구체 및 이들의 새로운 의약적 용도
BR122021011394B1 (pt) 2008-12-04 2021-09-28 Chongxi Yu Composição de alta penetração de um fármaco principal, e uso de uma hpc

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK620486A (da) * 1985-12-20 1987-06-21 Wisconsin Alumni Res Found Fremgangsmaade til fremstilling af eddikesyrederivater
FR2596415B1 (fr) * 1986-03-26 1988-07-01 Elf Aquitaine Procede pour l'execution de reactions enzymatiques au sein d'un solvant organique
US5108916A (en) * 1989-06-05 1992-04-28 Rhone-Poulenc Rorer, S.A. Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa
EP0517798B1 (en) * 1990-02-26 1997-04-16 Rhone-Poulenc Inc. Stereospecific resolution by hydrolysis of esters of 2-arylpropionic acids by liver enzymes

Also Published As

Publication number Publication date
WO1993025703A1 (en) 1993-12-23
AU4318193A (en) 1994-01-04
DE644949T1 (de) 1996-09-12
ATE160820T1 (de) 1997-12-15
EP0644949B1 (en) 1997-12-03
ES2046950B1 (es) 1994-10-01
ES2046950A1 (es) 1994-02-01
DE69315577D1 (de) 1998-01-15
EP0644949A1 (en) 1995-03-29

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