ATE161184T1 - Glukagon-analoge mit austauschungen oder deletionen in asp-9 - Google Patents

Glukagon-analoge mit austauschungen oder deletionen in asp-9

Info

Publication number: ATE161184T1
Authority: AT; Austria
Prior art keywords: deletions; asp; exchanges; glucagon analogues; acid residue
Prior art date: 1990-08-31

Application number

AT91915449T

Other languages

English (en)

Inventor

Robert Bruce Merrifield

Cecilia G Unson

Original Assignee

Univ Rockefeller

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-31

Filing date

1991-08-08

Publication date

1998-01-15

1991-08-08 Application filed by Univ Rockefeller filed Critical Univ Rockefeller

1998-01-15 Application granted granted Critical

1998-01-15 Publication of ATE161184T1 publication Critical patent/ATE161184T1/de

Links

MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT91915449T 1990-08-31 1991-08-08 Glukagon-analoge mit austauschungen oder deletionen in asp-9 ATE161184T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57597090A	1990-08-31	1990-08-31

Publications (1)

Publication Number	Publication Date
ATE161184T1 true ATE161184T1 (de)	1998-01-15

Family

ID=24302433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91915449T ATE161184T1 (de)	1990-08-31	1991-08-08	Glukagon-analoge mit austauschungen oder deletionen in asp-9

Country Status (5)

Country	Link
EP (1)	EP0546013B1 (de)
AT (1)	ATE161184T1 (de)
AU (1)	AU8497391A (de)
DE (1)	DE69128479T2 (de)
WO (1)	WO1992004042A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5480867A (en) *	1993-12-29	1996-01-02	The Rockefeller University	Glucagon analogs with serine replacements
US9944687B2 (en)	2011-07-04	2018-04-17	Imperial Innovations Limited	Compounds and their effects on feeding behaviour

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4879273A (en) *	1987-05-22	1989-11-07	The Rockefeller University	Glucagon homologs and therapeutic use thereof
ATE135372T1 (de) *	1991-01-17	1996-03-15	Zymogenetics Inc	Verfahren zum nachweis von glucagon-antagonisten

1991
- 1991-08-08 AU AU84973/91A patent/AU8497391A/en not_active Abandoned
- 1991-08-08 DE DE69128479T patent/DE69128479T2/de not_active Expired - Fee Related
- 1991-08-08 AT AT91915449T patent/ATE161184T1/de not_active IP Right Cessation
- 1991-08-08 WO PCT/US1991/005643 patent/WO1992004042A1/en not_active Ceased
- 1991-08-08 EP EP91915449A patent/EP0546013B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0546013A1 (de)	1993-06-16
WO1992004042A1 (en)	1992-03-19
DE69128479D1 (de)	1998-01-29
AU8497391A (en)	1992-03-30
DE69128479T2 (de)	1998-06-04
EP0546013B1 (de)	1997-12-17
EP0546013A4 (en)	1993-09-15

Legal Events

Date	Code	Title	Description
1998-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DK358384A (da)	1985-01-23	Farmaceutiske midler til bekaempelse af diabetes mellitus
YU46023B (sh)	1992-12-21	Postupak za dobijanje novih analoga insulina
NO884596D0 (no)	1988-10-14	Stabile interferonkomplekser.
PT77512A (en)	1983-11-01	Process for preparing cysteine-depleted muteins of biologically active proteins
ES8505646A1 (es)	1985-06-01	Procedimiento para la preparacion de un derivado de insulina
EP0122798A3 (en)	1986-09-03	Rcrf and analogs
DE68922405D1 (de)	1995-06-01	Deletionsanaloga von magaininpeptiden.
HUT55801A (en)	1991-06-28	Process for producing anti-coagulative peptides marked with radioactivity
DE69029377D1 (de)	1997-01-23	Substituierungsanaloge von magaininpeptiden
FI98731B (fi)	1997-04-30	Menetelmä superaktiivisten insuliinianalogien valmistamiseksi
ATE161184T1 (de)	1998-01-15	Glukagon-analoge mit austauschungen oder deletionen in asp-9
ATE98963T1 (de)	1994-01-15	Somatotropinanaloge.
DE3468031D1 (en)	1988-01-21	Cyclic peptides with somatostatin activity
ES435990A1 (es)	1976-12-16	Un metodo para producir nuevos polipeptidos.
ES2058290T3 (es)	1994-11-01	Analogos de somatostatina terapeuticos.
GR74351B (de)	1984-06-26
SE7909653L (sv)	1981-05-23	Tyrosylerade proinsulin c-peptidderivat
ATE186570T1 (de)	1999-11-15	Wachstumshormon-releasingfaktor-analoge
KR890010288U (ko)	1989-07-08	당구용 초크(Chalk) 케이스
IT1048579B (it)	1980-12-20	Braccio agli attacchi dentali per collegarli con vite alle protesi dentarie