DK358384A - Farmaceutiske midler til bekaempelse af diabetes mellitus - Google Patents

Farmaceutiske midler til bekaempelse af diabetes mellitus Download PDF

Info

Publication number: DK358384A
Authority: DK; Denmark
Prior art keywords: diabetes mellitus; denotes; pharmaceutical agents; phe; formula
Prior art date: 1983-07-22

Application number

DK358384A

Other languages

English (en)

Other versions

DK172456B1 (da

DK358384D0 (da

Inventor

Ulrich Grau

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-07-22

Filing date

1984-07-20

Publication date

1985-01-23

1984-07-20 Application filed by Hoechst Ag filed Critical Hoechst Ag

1984-07-20 Publication of DK358384D0 publication Critical patent/DK358384D0/da

1985-01-23 Publication of DK358384A publication Critical patent/DK358384A/da

1998-08-24 Application granted granted Critical

1998-08-24 Publication of DK172456B1 publication Critical patent/DK172456B1/da

Links

206010012601 diabetes mellitus Diseases 0.000 title abstract 2
239000008177 pharmaceutical agent Substances 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 3
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
239000004026 insulin derivative Substances 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
125000000962 organic group Chemical group 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicinal Preparation (AREA)
Prostheses (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK198403583A 1983-07-22 1984-07-20 Lægemidler indeholdende insulinderivater til behandling af diabetes mellitus DK172456B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3326473		1983-07-22
DE19833326473 DE3326473A1 (de)	1983-07-22	1983-07-22	Pharmazeutisches mittel zur behandlung des diabetes mellitus

Publications (3)

Publication Number	Publication Date
DK358384D0 DK358384D0 (da)	1984-07-20
DK358384A true DK358384A (da)	1985-01-23
DK172456B1 DK172456B1 (da)	1998-08-24

Family

ID=6204661

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198403583A DK172456B1 (da)	1983-07-22	1984-07-20	Lægemidler indeholdende insulinderivater til behandling af diabetes mellitus

Country Status (19)

Country	Link
US (1)	US4608364A (da)
EP (1)	EP0132769B1 (da)
JP (1)	JPS6042334A (da)
AT (1)	ATE31625T1 (da)
AU (1)	AU564648B2 (da)
CA (1)	CA1236012A (da)
DE (2)	DE3326473A1 (da)
DK (1)	DK172456B1 (da)
ES (1)	ES8504456A1 (da)
FI (1)	FI79786C (da)
GR (1)	GR81550B (da)
HU (1)	HUT34889A (da)
IE (1)	IE57690B1 (da)
IL (1)	IL72468A (da)
NO (1)	NO167187C (da)
NZ (1)	NZ208960A (da)
PH (1)	PH21328A (da)
PT (1)	PT78941A (da)
ZA (1)	ZA845621B (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4946828A (en) *	1985-03-12	1990-08-07	Novo Nordisk A/S	Novel insulin peptides
US5008241A (en) *	1985-03-12	1991-04-16	Novo Nordisk A/S	Novel insulin peptides
DE3880346T2 (de) *	1987-02-25	1993-07-29	Novonordisk As	Insulinderivate.
US4764592A (en) *	1987-04-23	1988-08-16	Eli Lilly And Company	Crystalline human proinsulin and process for its production
DE3717370A1 (de) *	1987-05-22	1988-12-01	Hoechst Ag	Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
US4789660A (en) *	1987-09-10	1988-12-06	American Home Products Corporation	Insulin administration using methyl and propyl paraben
US6875589B1 (en)	1988-06-23	2005-04-05	Hoechst Aktiengesellschaft	Mini-proinsulin, its preparation and use
DE58906966D1 (de) *	1988-06-23	1994-03-24	Hoechst Ag	Mini-Proinsulin, seine Herstellung und Verwendung.
DE3827533A1 (de) *	1988-08-13	1990-02-15	Hoechst Ag	Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) *	1988-11-08	1990-05-10	Hoechst Ag	Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
DE3936876A1 (de) *	1989-11-06	1991-05-23	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
IL99699A (en)	1990-10-10	2002-04-21	Autoimmune Inc	Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
WO1992010284A2 (en)	1990-12-07	1992-06-25	Cnc Development, Inc.	Catalytic chemical reactor
YU66892A (sh) *	1991-08-20	1995-10-24	Hoechst Ag.	Fosfoinositolglikan - peptid sa delovanjem kao insulin
TW224471B (da) *	1991-11-26	1994-06-01	Lilly Co Eli
EP0545198B1 (de) *	1991-11-29	1999-09-15	Hoechst Aktiengesellschaft	Peptide mit insulinartiger Wirkung
CA2087087C (en) *	1992-01-22	2000-07-18	Burton H. Sage, Jr.	Molecules for iontophoretic delivery
DK72793D0 (da) *	1993-06-21	1993-06-21	Novo Nordisk As	Nyt produkt
US5461031A (en) *	1994-06-16	1995-10-24	Eli Lilly And Company	Monomeric insulin analog formulations
US5547929A (en) *	1994-09-12	1996-08-20	Eli Lilly And Company	Insulin analog formulations
US6451970B1 (en) *	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives
SE520392C2 (sv)	1996-09-27	2003-07-01	Creative Peptides Sweden Ab C	Specifika peptider för behandling av diabetes mellitus
DE19649350A1 (de) *	1996-11-28	1998-06-04	Hoechst Ag	Inositolglykane mit insulinartiger Wirkung
US6444641B1 (en)	1997-10-24	2002-09-03	Eli Lilly Company	Fatty acid-acylated insulin analogs
JP2001521004A (ja)	1997-10-24	2001-11-06	イーライ・リリー・アンド・カンパニー	脂肪酸−アシル化インスリン類似体
CO4970787A1 (es) *	1997-12-23	2000-11-07	Lilly Co Eli	Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
CA2369451C (en) *	1999-04-08	2009-09-22	Genentech, Inc.	Composition based on oppositely-charged polypeptides
AU2002248464A1 (en)	2001-02-21	2002-09-12	Medtronic Minimed, Inc.	Stabilized insulin formulations
DE10114178A1 (de)	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) *	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
GB0323979D0 (en)	2003-10-13	2003-11-19	Creative Peptides Sweden Ab	Therapeutic applications for c-peptide
GB0601950D0 (en) *	2006-01-31	2006-03-15	Creative Peptides Sweden Ab	Compositions and methods of treating diabetes
DE102006031955A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Amidiertes Insulin Glargin
EP2898900B1 (en)	2008-09-19	2017-11-15	Nektar Therapeutics	Polymer conjugates of ziconotide
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
KR101853606B1 (ko)	2009-07-06	2018-05-03	사노피-아벤티스 도이칠란트 게엠베하	메티오닌을 함유하는 수성 인슐린 제제
US8410049B2 (en)	2009-10-28	2013-04-02	Cebix	Methods and kits for preventing hypoglycemia
DK2498802T3 (da)	2009-11-13	2015-04-13	Sanofi Aventis Deutschland	Farmaceutisk præparat omfattende en glp-1-agonist, et insulin og en methionin
KR101337322B1 (ko)	2009-11-13	2013-12-06	사노피-아벤티스 도이칠란트 게엠베하	Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
ES2606554T3 (es)	2010-08-30	2017-03-24	Sanofi-Aventis Deutschland Gmbh	Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl)	2011-08-29	2015-12-31	Sanofi Aventis Deutschland	Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
AU2015359376B2 (en)	2014-12-12	2021-09-09	Sanofi-Aventis Deutschland Gmbh	Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
EP3463413A4 (en) *	2016-05-25	2020-03-04	Merck Sharp & Dohme Corp.	INSULIN RECEPTOR PART AGONISTS
WO2025068976A1 (en)	2023-09-28	2025-04-03	Biotts Inc.	Compositions comprising insulin agonists, and said compositions for use in the treatment of diabetes or obesity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH650679A5 (de) *	1981-08-27	1985-08-15	Lilly Co Eli	Gegen diabetes mellitus wirksames pharmazeutisches mittel.
CH650677A5 (de) *	1981-08-27	1985-08-15	Lilly Co Eli	Gegen diabetes mellitus wirksames pharmazeutisches mittel.
DOP1982004086A (es) *	1981-08-27	1988-03-22	Lilly Co Eli	Formula farmaceutica que comprende insulina humana y proinsulina humana
CH650680A5 (de) *	1981-08-27	1985-08-15	Lilly Co Eli	Pharmazeutisches mittel aus human-insulin, human-c-peptid und human-proinsulin.
NL8201650A (nl) *	1982-04-21	1983-11-16	Akzo Nv	Semisynthetische bereiding van humane insuline.

1983
- 1983-07-22 DE DE19833326473 patent/DE3326473A1/de not_active Withdrawn
1984
- 1984-07-16 HU HU842765A patent/HUT34889A/hu unknown
- 1984-07-18 GR GR75341A patent/GR81550B/el unknown
- 1984-07-18 DE DE8484108441T patent/DE3468323D1/de not_active Expired
- 1984-07-18 AT AT84108441T patent/ATE31625T1/de not_active IP Right Cessation
- 1984-07-18 EP EP84108441A patent/EP0132769B1/de not_active Expired
- 1984-07-19 FI FI842915A patent/FI79786C/fi not_active IP Right Cessation
- 1984-07-19 PT PT78941A patent/PT78941A/pt not_active IP Right Cessation
- 1984-07-20 ZA ZA845621A patent/ZA845621B/xx unknown
- 1984-07-20 DK DK198403583A patent/DK172456B1/da not_active IP Right Cessation
- 1984-07-20 IL IL72468A patent/IL72468A/xx not_active IP Right Cessation
- 1984-07-20 IE IE1890/84A patent/IE57690B1/en not_active IP Right Cessation
- 1984-07-20 ES ES534488A patent/ES8504456A1/es not_active Expired
- 1984-07-20 PH PH31011A patent/PH21328A/en unknown
- 1984-07-20 CA CA000459385A patent/CA1236012A/en not_active Expired
- 1984-07-20 US US06/632,859 patent/US4608364A/en not_active Expired - Lifetime
- 1984-07-20 JP JP59149785A patent/JPS6042334A/ja active Granted
- 1984-07-20 NZ NZ208960A patent/NZ208960A/xx unknown
- 1984-07-20 AU AU30917/84A patent/AU564648B2/en not_active Ceased
- 1984-07-20 NO NO842978A patent/NO167187C/no unknown

Also Published As

Publication number	Publication date
US4608364A (en)	1986-08-26
FI842915A0 (fi)	1984-07-19
IL72468A (en)	1989-08-15
IE841890L (en)	1985-01-22
FI79786B (fi)	1989-11-30
JPH0469128B2 (da)	1992-11-05
PT78941A (de)	1984-08-01
AU3091784A (en)	1985-01-24
JPS6042334A (ja)	1985-03-06
EP0132769B1 (de)	1988-01-07
NO167187C (no)	1991-10-16
EP0132769A1 (de)	1985-02-13
GR81550B (da)	1984-12-11
DK172456B1 (da)	1998-08-24
HUT34889A (en)	1985-05-28
FI79786C (fi)	1990-03-12
DE3326473A1 (de)	1985-01-31
DK358384D0 (da)	1984-07-20
CA1236012A (en)	1988-05-03
DE3468323D1 (en)	1988-02-11
ES534488A0 (es)	1985-05-01
AU564648B2 (en)	1987-08-20
IL72468A0 (en)	1984-11-30
FI842915L (fi)	1985-01-23
ES8504456A1 (es)	1985-05-01
NZ208960A (en)	1989-02-24
NO842978L (no)	1985-01-23
PH21328A (en)	1987-10-13
NO167187B (no)	1991-07-08
ATE31625T1 (de)	1988-01-15
IE57690B1 (en)	1993-03-10
ZA845621B (en)	1985-02-27

Legal Events

Date	Code	Title	Description
1998-08-24	B1	Patent granted (law 1993)
2003-03-03	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK358384D0 (da)	1984-07-20	Farmaceutiske midler til bekaempelse af diabetes mellitus
ES8505646A1 (es)	1985-06-01	Procedimiento para la preparacion de un derivado de insulina
GR1001503B (el)	1994-02-28	Μέ?οδος δια την παρασκευή φαρμακευτικών ενώσεων αι οποίαι περιέχουν ως δραστική ουσία καρβονικά οξέα τα οποία περιέχουν ?είον κα?ώς και η χρησιμοποίησις αυτών δια την καταπολέμησιν των ρετροιών.
FI98460B (fi)	1997-03-14	Menetelmä terapeuttisesti käyttökelpoisen 4H-1-bentsopyran-4-onijohdoksen tai sen suolan valmistamiseksi ja menetelmässä käyttökelpoinen välituote
DE69025336D1 (de)	1996-03-21	Antihypertensive Zubereitungen und deren Verwendung
SE8102193L (sv)	1982-10-07	Terapeutiskt aktiv organisk forening och dess anvendning
DE69111205D1 (de)	1995-08-17	Stabilisierung von Calcitonin enthaltenden pharmazeutischen Verbindungen.
HUT38950A (en)	1986-07-28	Process for producing 2-substituted-1,3-propylidene-diphosphonate derivatives and pharmaceutical compositions containing them as active agents
DK296389D0 (da)	1989-06-15	Farmaceutiske forbindelser
SE8202380L (sv)	1982-10-17	Analgetisk komposition
DK204686A (da)	1986-11-07	Quinolylglycinamidderivater og fremgangsmaade til fremstilling deraf
HUT55034A (en)	1991-04-29	Process for producing peptides with hemoregulating effect and pharmaceutical compositions comprising such compounds as active ingredient
MX9307991A (es)	1994-08-31	Analogos de insulina, procedimiento para su preparacion y formulaciones farmaceuticas que los incluyen.
SE8204873L (sv)	1983-02-28	Farmaceutiska preparat, innefattande humant insulin och human c-peptid
BG60101B2 (bg)	1993-10-29	Метод за получаване на 4-флуор-2-(((4-метокси-2- пиридинил)метил)тионил)-1н-бензимидазол
NO911119L (no)	1991-09-23	Fremgangsmaate for fremstilling av farmasoeytisk jodpreparat
JPS5344616A (en)	1978-04-21	Injections
DE3667472D1 (de)	1990-01-18	Analoge von hypokalzemischen polypeptiden, welche den kalziumgehalt des koerpers schonen, deren herstellung, deren verwendung als arznei und diese enthaltende zusammensetzungen.
GB2021581A (en)	1979-12-05	Stabilisation of PGl2 derivatives
GR77250B (da)	1984-09-11
KR940002268A (ko)	1994-02-17	21-클로로-프레그난 유도체
JPS5251362A (en)	1977-04-25	Preparation of optically active pyrrolidine derivatives