ATE161534T1 - Diphenylylchinuclidine als squalen-synthetase- inhibitoren - Google Patents

Diphenylylchinuclidine als squalen-synthetase- inhibitoren

Info

Publication number: ATE161534T1
Authority: AT; Austria
Prior art keywords: alkyl; compounds; carbamoyl; pct; halogeno
Prior art date: 1991-10-30

Application number

AT92921983T

Other languages

English (en)

Inventor

George Robert Brown

Keith Blakeney Mallion

Peter John Harrison

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-30

Filing date

1992-10-27

Publication date

1998-01-15

1992-10-27 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1998-01-15 Application granted granted Critical

1998-01-15 Publication of ATE161534T1 publication Critical patent/ATE161534T1/de

Links

239000004059 squalene synthase inhibitor Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 4
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
-1 hydroxy, amino Chemical group 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
108010022535 Farnesyl-Diphosphate Farnesyltransferase Proteins 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
208000031888 Mycoses Diseases 0.000 abstract 1
102100037997 Squalene synthase Human genes 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Separation Using Semi-Permeable Membranes (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Detergent Compositions (AREA)

AT92921983T 1991-10-30 1992-10-27 Diphenylylchinuclidine als squalen-synthetase- inhibitoren ATE161534T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB919122988A GB9122988D0 (en)	1991-10-30	1991-10-30	Heterocyclic compounds

Publications (1)

Publication Number	Publication Date
ATE161534T1 true ATE161534T1 (de)	1998-01-15

Family

ID=10703745

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92921983T ATE161534T1 (de)	1991-10-30	1992-10-27	Diphenylylchinuclidine als squalen-synthetase- inhibitoren

Country Status (16)

Country	Link
US (1)	US5792777A (de)
EP (1)	EP0569564B1 (de)
JP (1)	JPH06504069A (de)
AT (1)	ATE161534T1 (de)
AU (1)	AU658458B2 (de)
CA (1)	CA2081674A1 (de)
CZ (1)	CZ127293A3 (de)
DE (1)	DE69223769T2 (de)
FI (1)	FI932996A0 (de)
GB (1)	GB9122988D0 (de)
HU (1)	HUT64063A (de)
IL (1)	IL103587A (de)
NO (1)	NO932382L (de)
NZ (1)	NZ244962A (de)
WO (1)	WO1993009115A1 (de)
ZA (1)	ZA928428B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9211796D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Heterocyclic derivatives
DE69330069D1 (en) *	1992-12-21	2001-05-03	Syngenta Ltd	Chinuclidin derivate als squalen synthase inhibitoren
US5451596A (en) *	1992-12-29	1995-09-19	Rhone Poulenc Rorer Pharmaceuticals Inc.	Cycloalkyl amine bis-aryl squalene synthase inhibitors
US5455260A (en) *	1993-05-21	1995-10-03	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Aliphatic amino bis-aryl squalene synthase inhibitors
US5395846A (en) *	1993-06-25	1995-03-07	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Amino Bi- and tri-carbocyclic aklane bis-aryl squalene synthase inhibitors
US5556990A (en) *	1994-12-16	1996-09-17	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
US5561143A (en) *	1995-01-25	1996-10-01	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Aliphatic amino bis-aryl squalene synthase inhibitors

Family Cites Families (32)

* Cited by examiner, † Cited by third party
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US3405134A (en) *	1965-08-17	1968-10-08	Colgate Palmolive Co	Quinuclidyl esters of aromatic acids
NL6715600A (de) *	1966-12-02	1968-06-04
US3534053A (en) *	1967-05-24	1970-10-13	American Home Prod	Quinuclidine derivatives
US3763168A (en) *	1968-09-09	1973-10-02	Sterling Drug Inc	N-(3-quinuclidinyl) acylanilides
US3655675A (en) *	1968-09-09	1972-04-11	Sterling Drug Inc	N-(n-heteryl)-acylanilides
US3725410A (en) *	1970-07-15	1973-04-03	American Home Prod	3-aminomethyl-3-quinuclidinols
US3679690A (en) *	1971-03-18	1972-07-25	Sterling Drug Inc	Certain n-(pyridyl) propionanilides
FR2183565B1 (de) *	1972-05-10	1975-12-26	Cerm Cent Europ Rech Mauvernay
CA1014958A (en) *	1973-10-05	1977-08-02	Jacques Moleyre	.alpha.-QUINUCLIDYLMETHYL PHENYL KETONES
US4038402A (en) *	1974-03-05	1977-07-26	Mikhail Emmanuilovich Kaminka	Method of effecting antihistaminic, antiserotonin and antiallergic actions
SU495310A1 (ru) *	1974-03-05	1975-12-15	Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе	Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
FR2414044A1 (fr) *	1978-01-10	1979-08-03	Pharmindustrie	Nouveaux derives d'aza-1 bicyclo(2,2,2) octane, utilisables comme medicaments
US4599344A (en) *	1984-10-31	1986-07-08	Schering A.G.	Quinuclidines and quinuclidinium salts as antiarrhythmic agents
CH667657A5 (de) *	1985-01-07	1988-10-31	Sandoz Ag	Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
IL88156A (en) *	1987-11-13	1997-02-18	Novo Nordisk As	Azacyclic compounds their preparation and pharmaceutical compositions containing them
EP0322182A3 (de) *	1987-12-22	1992-01-02	Beecham Group Plc	Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
DK730588A (da) *	1988-02-03	1989-08-04	Asta Pharma Ag	Anvendelse af pyridin-2-ethere eller pyridin-2-thioethere med en nitrogenholdig cycloalifatisk ring som antidepressivt laegemiddel
NZ227841A (en) *	1988-02-12	1991-08-27	Merck Sharp & Dohme	Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
US5242914A (en) *	1988-04-01	1993-09-07	Sankyo Company, Limited	2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
EP0597821A1 (de) *	1988-04-01	1994-05-18	Sankyo Company Limited	2-(Heterocyclylthio) carbapenemderivate, deren Herstellung und Verwendung als Antibiotika
DE8817121U1 (de) *	1988-11-22	1993-02-04	Boehringer Ingelheim Kg, 55218 Ingelheim	Neue Quinuclidine
US5286864A (en) *	1988-11-22	1994-02-15	Boehringer Ingelheim Kg	Quinuclidines, their use as medicaments and processes for their preparation
GB8918061D0 (en) *	1989-08-08	1989-09-20	Merck Sharp & Dohme	Therapeutic agents
DE4116582A1 (de) *	1990-05-19	1991-11-21	Boehringer Ingelheim Kg	Bicyclische 1-aza-cycloalkane
YU84791A (sh) *	1990-05-19	1994-06-10	Boehringer Ingelheim Kg.	Biciklicni 1-aza-cikloalkalni
ZA92278B (en) *	1991-02-01	1992-10-28	Akzo Nv	3-quinuclidine derivatives
AU1752792A (en) *	1991-03-08	1992-10-06	Rhone-Poulenc Rorer International (Holdings) Inc.	Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5385912A (en) *	1991-03-08	1995-01-31	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
US5135935A (en) *	1991-05-17	1992-08-04	Merck & Co., Inc.	Squalene synthetase inhibitors
GB9201749D0 (en) *	1992-01-28	1992-03-11	Smithkline Beecham Plc	Medicaments
GB9202443D0 (en) *	1992-02-05	1992-03-18	Fujisawa Pharmaceutical Co	A novel substituted-acetamide compound and a process for the preparation thereof
GB9211796D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Heterocyclic derivatives

1991
- 1991-10-30 GB GB919122988A patent/GB9122988D0/en active Pending
1992
- 1992-10-27 WO PCT/GB1992/001968 patent/WO1993009115A1/en not_active Ceased
- 1992-10-27 JP JP5508231A patent/JPH06504069A/ja active Pending
- 1992-10-27 AT AT92921983T patent/ATE161534T1/de not_active IP Right Cessation
- 1992-10-27 AU AU27833/92A patent/AU658458B2/en not_active Ceased
- 1992-10-27 CZ CS931272A patent/CZ127293A3/cs unknown
- 1992-10-27 EP EP92921983A patent/EP0569564B1/de not_active Expired - Lifetime
- 1992-10-27 DE DE69223769T patent/DE69223769T2/de not_active Expired - Fee Related
- 1992-10-27 US US08/081,367 patent/US5792777A/en not_active Expired - Fee Related
- 1992-10-27 HU HU9301846A patent/HUT64063A/hu unknown
- 1992-10-29 CA CA002081674A patent/CA2081674A1/en not_active Abandoned
- 1992-10-29 IL IL10358792A patent/IL103587A/en not_active IP Right Cessation
- 1992-10-30 ZA ZA928428A patent/ZA928428B/xx unknown
- 1992-10-30 NZ NZ244962A patent/NZ244962A/en unknown
1993
- 1993-06-29 NO NO93932382A patent/NO932382L/no unknown
- 1993-06-29 FI FI932996A patent/FI932996A0/fi unknown

Also Published As

Publication number	Publication date
WO1993009115A1 (en)	1993-05-13
HU9301846D0 (en)	1993-10-28
NO932382D0 (no)	1993-06-29
IL103587A (en)	1996-10-31
EP0569564B1 (de)	1997-12-29
JPH06504069A (ja)	1994-05-12
FI932996A7 (fi)	1993-06-29
DE69223769D1 (en)	1998-02-05
EP0569564A1 (de)	1993-11-18
GB9122988D0 (en)	1991-12-18
DE69223769T2 (de)	1998-05-07
HUT64063A (en)	1993-11-29
CA2081674A1 (en)	1993-05-01
ZA928428B (en)	1993-05-03
IL103587A0 (en)	1993-03-15
US5792777A (en)	1998-08-11
NO932382L (no)	1993-06-29
FI932996A0 (fi)	1993-06-29
CZ127293A3 (en)	1994-02-16
NZ244962A (en)	1995-04-27
AU2783392A (en)	1993-06-07
AU658458B2 (en)	1995-04-13

Legal Events

Date	Code	Title	Description
1998-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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MA30075B1 (fr)	2008-12-01	Derives de pyrimidine pour le traitement d'une croissance cellulaire anormale
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MY140653A (en)	2010-01-15	Substituted diketopiperazines and their use as oxytocyn antagonists
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ATE160348T1 (de)	1997-12-15	Chimuclidine derivate als squalen synthetase inhibitoren
ATE159255T1 (de)	1997-11-15	Chinuclidine derivate als squalen synthase inhibitoren
EP1057829A4 (de)	1999-12-10	Kondensierte Pyrimidinderivate und diese enthaltende pharmazeutische Zubereitungen
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MY103509A (en)	1993-06-30	Indole derivatives.
LTIP1450A (en)	1994-10-25	Azaspiroalkane derivatives,processes for their preparation and pharmaceutical compositions containing them