ATE161890T1 - Verfahren zur herstellung von s-(+)-2-(- 3benzoylphenyl)propionsäure durch enzym katalysierte enanthioselektieve umesterung in einem organischen lösungsmittel. - Google Patents

Verfahren zur herstellung von s-(+)-2-(- 3benzoylphenyl)propionsäure durch enzym katalysierte enanthioselektieve umesterung in einem organischen lösungsmittel.

Info

Publication number: ATE161890T1
Authority: AT; Austria
Prior art keywords: organic solvent; propionic acid; enzyme; branched; straight
Prior art date: 1992-06-08

Application number

AT93912796T

Other languages

English (en)

Inventor

Germano Carganico

Casellas David Mauleon

Benet Albert Palomer

Original Assignee

Menarini Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-08

Filing date

1993-05-26

Publication date

1998-01-15

1992-06-08 Priority claimed from ES9201191A external-priority patent/ES2050067B1/es

1992-06-08 Priority claimed from ES9201190A external-priority patent/ES2048653B1/es

1993-05-26 Application filed by Menarini Lab filed Critical Menarini Lab

1998-01-15 Application granted granted Critical

1998-01-15 Publication of ATE161890T1 publication Critical patent/ATE161890T1/de

Links

239000003960 organic solvent Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
125000006165 cyclic alkyl group Chemical group 0.000 abstract 3
150000002148 esters Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000005809 transesterification reaction Methods 0.000 abstract 2
102000013392 Carboxylesterase Human genes 0.000 abstract 1
108010051152 Carboxylesterase Proteins 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000006575 electron-withdrawing group Chemical group 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
230000000813 microbial effect Effects 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
230000000707 stereoselective effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT93912796T 1992-06-08 1993-05-26 Verfahren zur herstellung von s-(+)-2-(- 3benzoylphenyl)propionsäure durch enzym katalysierte enanthioselektieve umesterung in einem organischen lösungsmittel. ATE161890T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES9201191A ES2050067B1 (es)	1992-06-08	1992-06-08	Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva con un alcohol bifuncional catalizada enzimaticamente en medio organico.
ES9201190A ES2048653B1 (es)	1992-06-08	1992-06-08	Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva catalizada enzimaticamente en un disolvente organico.

Publications (1)

Publication Number	Publication Date
ATE161890T1 true ATE161890T1 (de)	1998-01-15

Family

ID=26154631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93912796T ATE161890T1 (de)	1992-06-08	1993-05-26	Verfahren zur herstellung von s-(+)-2-(- 3benzoylphenyl)propionsäure durch enzym katalysierte enanthioselektieve umesterung in einem organischen lösungsmittel.

Country Status (5)

Country	Link
EP (1)	EP0672165B1 (de)
AT (1)	ATE161890T1 (de)
AU (1)	AU4318293A (de)
DE (1)	DE69316238D1 (de)
WO (1)	WO1993025704A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9304256D0 (en) *	1993-03-03	1993-04-21	Chiros Ltd	Arylalkanoic acid resolution
US5912164A (en) *	1993-03-03	1999-06-15	Laboratorios Menarini S.A.	Stereoselective hydrolysis of chiral carboxylic acid esters using esterase from ophiostoma or ceratocystis
US6620600B2 (en) *	2000-09-15	2003-09-16	Bristol-Myers Squibb Co.	Enzymatic resolution of aryl and thio-substituted acids
AU2006200618B2 (en) *	2000-09-15	2007-08-09	Bristol-Myers Squibb Company	Enzymatic resolution of aryl and thio-substituted acids
US7589233B2 (en)	2003-07-29	2009-09-15	Signature R&D Holdings, Llc	L-Threonine derivatives of high therapeutic index
US8173840B2 (en)	2003-07-29	2012-05-08	Signature R&D Holdings, Llc	Compounds with high therapeutic index
HU231033B1 (hu) *	2016-03-22	2019-12-30	CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt.	Eljárás 3-as kötést tartalmazó optikailag aktív karbonsavak, karbonsav sók és karbonsav származékok előállítására

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1982003873A1 (en) *	1981-05-07	1982-11-11	Halling Peter James	Fat processing
DK620486A (da) *	1985-12-20	1987-06-21	Wisconsin Alumni Res Found	Fremgangsmaade til fremstilling af eddikesyrederivater
EP0461043A3 (en) *	1990-06-08	1992-11-04	Sepracor, Inc.	Enantiomer separation by transesterification
FR2672600B1 (fr) *	1991-02-08	1994-10-14	Synthelabo	Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle.

1993
- 1993-05-26 AT AT93912796T patent/ATE161890T1/de active
- 1993-05-26 AU AU43182/93A patent/AU4318293A/en not_active Abandoned
- 1993-05-26 DE DE69316238T patent/DE69316238D1/de not_active Expired - Lifetime
- 1993-05-26 EP EP93912796A patent/EP0672165B1/de not_active Expired - Lifetime
- 1993-05-26 WO PCT/EP1993/001322 patent/WO1993025704A1/en not_active Ceased

Also Published As

Publication number	Publication date
WO1993025704A1 (en)	1993-12-23
DE69316238D1 (de)	1998-02-12
EP0672165B1 (de)	1998-01-07
AU4318293A (en)	1994-01-04
EP0672165A1 (de)	1995-09-20

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