ATE163547T1 - Stabilisierte impfstoffzusammensetzungen - Google Patents

Stabilisierte impfstoffzusammensetzungen

Info

Publication number: ATE163547T1
Authority: AT; Austria
Prior art keywords: vaccine compositions; stabilized vaccine; polyimines; stabilized; amino
Prior art date: 1989-08-15

Application number

AT90913372T

Other languages

English (en)

Inventor

Brent Dorval

Marie Chow

Alexander Klibanov

Original Assignee

Massachusetts Inst Technology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-15

Filing date

1990-08-14

Publication date

1998-03-15

1990-08-14 Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology

1998-03-15 Application granted granted Critical

1998-03-15 Publication of ATE163547T1 publication Critical patent/ATE163547T1/de

Links

239000000203 mixture Substances 0.000 title abstract 2
229960005486 vaccine Drugs 0.000 title abstract 2
-1 poly(ethylenimine) Polymers 0.000 abstract 2
239000003381 stabilizer Substances 0.000 abstract 2
241000991587 Enterovirus C Species 0.000 abstract 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000879 imine group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/13—Poliovirus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT90913372T 1989-08-15 1990-08-14 Stabilisierte impfstoffzusammensetzungen ATE163547T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39399689A	1989-08-15	1989-08-15

Publications (1)

Publication Number	Publication Date
ATE163547T1 true ATE163547T1 (de)	1998-03-15

Family

ID=23557105

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90913372T ATE163547T1 (de)	1989-08-15	1990-08-14	Stabilisierte impfstoffzusammensetzungen

Country Status (9)

Country	Link
US (1)	US5618539A (de)
EP (1)	EP0487632B1 (de)
JP (1)	JP3064413B2 (de)
AT (1)	ATE163547T1 (de)
CA (1)	CA2065023A1 (de)
DE (1)	DE69032102T2 (de)
DK (1)	DK0487632T3 (de)
ES (1)	ES2113348T3 (de)
WO (1)	WO1991002543A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4370451B2 (ja) *	2001-09-28	2009-11-25	大塚製薬株式会社	医薬組成物
AU2003225057A1 (en) *	2002-04-19	2003-11-03	The Regents Of The University Of Michigan	Polymer compositions that stabilize and control the release of formaldehyde-treated vaccine antigens
US7262045B2 (en) *	2003-02-25	2007-08-28	Medimmune Vaccines, Inc.	Methods of producing influenza vaccine compositions
US20060110406A1 (en) *	2003-02-25	2006-05-25	Medimmune Vaccines, Inc.	Refrigerator-temperature stable influenza vaccine compositions
US20060141483A1 (en) *	2004-12-23	2006-06-29	Calton Gary J	Stabilization of viral compositions
TWI398272B (zh)	2005-03-08	2013-06-11	Intervet Int Bv	化學定義的安定劑
BRPI0800357A2 (pt) *	2008-03-10	2009-10-27	Fundacao Oswaldo Cruz	método para produção de uma vacina estabilizada
US20110212127A1 (en) *	2008-09-24	2011-09-01	Stabilitech Ltd.	Method for Preserving Polypeptides Using a Sugar and Polyethyleneimine
JP2012503637A (ja) *	2008-09-24	2012-02-09	スタビリテックリミテッド	糖およびポリエチレンイミンを使用するポリペプチドの保存方法
GB2499480A (en)	2010-03-31	2013-08-21	Stabilitech Ltd	Method for preserving alum adjuvants and alum-adjuvanted vaccines
JP5869553B2 (ja)	2010-03-31	2016-02-24	スタビリテックリミテッド	ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤
JP5960120B2 (ja)	2010-03-31	2016-08-02	スタビリテックリミテッド	ウイルス粒子の安定化
US11060068B2 (en)	2011-06-28	2021-07-13	Leukocare Ag	Stabilisation method for viruses or bacteria
GB201117233D0 (en)	2011-10-05	2011-11-16	Stabilitech Ltd	Stabilisation of polypeptides
IN2012MU00206A (de)	2012-01-20	2013-08-09
TWI690322B (zh) *	2012-10-02	2020-04-11	法商傳斯堅公司	含病毒的調配物及其使用
PT3010537T (pt) *	2013-06-17	2019-12-03	De Staat Der Nederlanden Vert Door De Mini Van Vws Miniie Van Volksgezondheid Welzijn En Sport	Métodos para a prevenção da agregação de componentes virais
GB201406569D0 (en)	2014-04-11	2014-05-28	Stabilitech Ltd	Vaccine compositions
GB2562241B (en)	2017-05-08	2022-04-06	Stabilitech Biopharma Ltd	Vaccine compositions
EP3761962A4 (de) *	2018-03-07	2021-12-15	ReForm Biologics, Inc.	Hilfsstoffverbindungen für proteinformulierungen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097142A (en) *	1960-03-30	1963-07-09	Merck & Co Inc	Benzyl alcohol stabilized polio vaccines and production thereof
US3097143A (en) *	1960-03-30	1963-07-09	Merck & Co Inc	Myristyl-gamma-picolinium chloride preserved polio vaccine and its production
US3128229A (en) *	1961-10-05	1964-04-07	Baylor Medical Foundation	Stabilization of viral vaccine and inactivation of adventitious tissue culture contaminants therein
GB1564998A (en) *	1975-03-21	1980-04-16	Connaught Lab	Vaccine and stabilizing solution therefor
US4337242A (en) *	1980-02-05	1982-06-29	Merck & Co., Inc.	Vaccine stabilizer containing L-glutamic acid and L-arginine
US4338335A (en) *	1980-02-05	1982-07-06	Merck & Co., Inc.	Vaccine stabilizer containing L-glutamic acid and L-arginine
FR2505657A1 (fr) *	1981-05-13	1982-11-19	Pasteur Institut	Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation

1990
- 1990-08-14 CA CA002065023A patent/CA2065023A1/en not_active Abandoned
- 1990-08-14 DK DK90913372.0T patent/DK0487632T3/da active
- 1990-08-14 AT AT90913372T patent/ATE163547T1/de not_active IP Right Cessation
- 1990-08-14 WO PCT/US1990/004581 patent/WO1991002543A1/en not_active Ceased
- 1990-08-14 EP EP90913372A patent/EP0487632B1/de not_active Expired - Lifetime
- 1990-08-14 DE DE69032102T patent/DE69032102T2/de not_active Expired - Fee Related
- 1990-08-14 JP JP2512507A patent/JP3064413B2/ja not_active Expired - Fee Related
- 1990-08-14 ES ES90913372T patent/ES2113348T3/es not_active Expired - Lifetime
1994
- 1994-09-29 US US08/314,571 patent/US5618539A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1991002543A1 (en)	1991-03-07
US5618539A (en)	1997-04-08
CA2065023A1 (en)	1991-02-16
JPH04506973A (ja)	1992-12-03
DE69032102T2 (de)	1998-06-25
ES2113348T3 (es)	1998-05-01
DK0487632T3 (da)	1998-05-25
JP3064413B2 (ja)	2000-07-12
DE69032102D1 (de)	1998-04-09
EP0487632B1 (de)	1998-03-04
EP0487632A1 (de)	1992-06-03

Similar Documents

Publication	Publication Date	Title
DK0487632T3 (da)	1998-05-25	Stabiliserede vaccinesammensætninger
DK0414263T3 (da)	1995-01-16	Fremgangsmåde til stabilisering af et fast farmaceutisk præparat indeholdende cycliske aminosyrer
FI931708A0 (fi)	1993-04-15	Herbicida substituerade aryl-haloalkylpyrazoler
PL336704A1 (en)	2000-07-03	Multivalent vaccine containing a mixed carrier
IL94915A0 (en)	1991-04-15	Substituted quinazolinones and pharmaceutical compositions containing them
IL83567A (en)	1992-02-16	Starburst conjugates with a carried material,such as an agricultural or pharmaceutical material
DK669088A (da)	1989-06-02	Fremgangsmaade og praeparat til forbedring af erkendelsesfunktionen
DE3876050D1 (de)	1992-12-24	Okulare hypotensivagenzien.
NL194828B (nl)	2002-12-02	Somatostatinepeptiden, alsmede dergelijke somatostatinepeptiden bevattende farmaceutische preparaten.
DE3068320D1 (en)	1984-07-26	S-triazine derivatives, processes for their preparation from halotriazinylamines and polyamines, and their use as stabilizers
ATE183747T1 (de)	1999-09-15	Halogen-freie, cyclische, phosphor enthaltende flammenhemmende verbindungen
DK0559079T3 (da)	1998-03-30	Substituerede aminophosphonatderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne
EP0176106A3 (en)	1987-08-19	N,n',n-tris((2,2,6,6-tetramethyl-4-piperidyl)triazinyl)-undecane triamines as stabilizers for synthetic polymers
NO924774D0 (no)	1992-12-10	Karboksyvinylpolymer som har newtonsk viskositet
SE8702272D0 (sv)	1987-06-01	A fibrnectin binding protein as well as its preparation
DK0487562T3 (da)	1995-05-22	Farmaceutiske sammensætninger
DE69032258D1 (de)	1998-05-28	Antikoagulierende Peptide
DK444982A (da)	1983-04-11	Substituerede hydroxymalonsyrediamider, fremgangsmaade til fremstilling deraf samt deres anvendelse som skadedyrsbekaempende midler
IT8820117A0 (it)	1988-04-07	Procedimento per la preparazione di bis(2,2,6,6_tetrametil_4_piperidil)ammina.
FR2616785B1 (fr)	1989-10-06	Composes guanidiniques comprenant un ion tetraphenylborate substitue et procede d'obtention de ces composes et utilisation des composes lors de la synthese peptidique
EP0169051A3 (de)	1986-12-10	Pyridazinylharnstoffverbindungen
IT8921360A0 (it)	1989-07-28	Stabilizzatore aminico polimerico per spandex.
ATE98478T1 (de)	1994-01-15	Calcitonin enthaltende pharmazeutische zusammensetzungen.
GR1001309B (el)	1993-08-31	Μεθοδος παρασκευης παραγωγου ενωσεως της διχλωροανιλινης.
ES8800204A1 (es)	1987-10-16	Un procedimiento para la preparacion de piridazinilimidazolidinonas

Legal Events

Date	Code	Title	Description
1999-04-15	UEP	Publication of translation of european patent specification
2004-05-15	REN	Ceased due to non-payment of the annual fee