ATE163937T1 - Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol - Google Patents

Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol

Info

Publication number: ATE163937T1
Authority: AT; Austria
Prior art keywords: fructopyranose; methylethylidene; methylcyclohexyl; beta; bis
Prior art date: 1991-09-19

Application number

AT92308509T

Other languages

English (en)

Inventor

Cynthia A Maryanoff

Kirk L Sorgi

Lorraine Scott

Original Assignee

Mcneilab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-19

Filing date

1992-09-18

Publication date

1998-03-15

1992-09-18 Application filed by Mcneilab Inc filed Critical Mcneilab Inc

1998-03-15 Application granted granted Critical

1998-03-15 Publication of ATE163937T1 publication Critical patent/ATE163937T1/de

Links

UUBPRIUBEQJUQL-UHFFFAOYSA-N (1-methylcyclohexyl)methanol Chemical compound OCC1(C)CCCCC1 UUBPRIUBEQJUQL-UHFFFAOYSA-N 0.000 title abstract 2
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
XTHPWXDJESJLNJ-UHFFFAOYSA-N sulfurochloridic acid Chemical compound OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 title 1
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 6
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 4
BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
PSSHGMIAIUYOJF-XBWDGYHZSA-N [(3as,5ar,8ar,8bs)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methanol Chemical compound C1O[C@@]2(CO)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 PSSHGMIAIUYOJF-XBWDGYHZSA-N 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
XTHPWXDJESJLNJ-UHFFFAOYSA-M chlorosulfate Chemical compound [O-]S(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-M 0.000 abstract 1
-1 heterocyclic amine Chemical class 0.000 abstract 1
YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92308509T 1991-09-19 1992-09-18 Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol ATE163937T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US76272091A	1991-09-19	1991-09-19
US92626992A	1992-08-05	1992-08-05

Publications (1)

Publication Number	Publication Date
ATE163937T1 true ATE163937T1 (de)	1998-03-15

Family

ID=27117178

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92308509T ATE163937T1 (de)	1991-09-19	1992-09-18	Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol

Country Status (23)

Country	Link
US (1)	US5387700A (de)
EP (1)	EP0533483B1 (de)
JP (1)	JP3174410B2 (de)
KR (1)	KR100229180B1 (de)
CN (1)	CN1035820C (de)
AT (1)	ATE163937T1 (de)
AU (1)	AU651244B2 (de)
CA (1)	CA2078519C (de)
DE (1)	DE69224691T2 (de)
DK (1)	DK0533483T3 (de)
EG (1)	EG20164A (de)
ES (1)	ES2114917T3 (de)
FI (1)	FI107731B (de)
GR (1)	GR3026618T3 (de)
HU (1)	HU212634B (de)
IL (1)	IL103172A (de)
MX (1)	MX9205305A (de)
MY (1)	MY113564A (de)
NO (1)	NO179284C (de)
NZ (1)	NZ244409A (de)
PH (1)	PH31291A (de)
TW (1)	TW217413B (de)
ZW (1)	ZW14792A1 (de)

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CA2415093A1 (en) *	2000-07-07	2002-01-17	Carlos Plata-Salaman	Anticonvulsant derivatives useful for preventing the development of type ii diabetes mellitus and syndrome x
CA2417304A1 (en)	2000-08-02	2002-02-07	Ortho-Mcneil Pharmaceutical, Inc.	Anticonvulsant derivatives useful for the treatment of depression
DE60121988T2 (de) *	2000-10-30	2007-02-15	Ortho-Mcneil Pharmaceutical, Inc.	Kombinationstherapie mit antidiabetischen und antikonvulsiven mitteln
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HRP20040846A2 (en) *	2002-02-26	2005-06-30	Ortho-Mcneil Pharmaceutical	Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents
IL163846A0 (en)	2002-03-01	2005-12-18	Univ South Florida	Multiple-component solid phases containing at least one active pharmaceutical ingredient
US7060725B2 (en) *	2002-05-13	2006-06-13	Janssen Pharmaceutica N.V.	Substituted sulfamate anticonvulsant derivatives
AR039744A1 (es) *	2002-06-26	2005-03-09	Alza Corp	Metodos y formas de dosificacion para aumentar la solubilidad de las composiciones de farmacos para la administracion controlada
EP1534238A1 (de) *	2002-07-29	2005-06-01	ALZA Corporation	Formulierungen und dosierformen fuer die kontrollierte abgabe von topiramat
US7196209B2 (en) *	2002-10-31	2007-03-27	Ortho-Mcneil Pharmaceutical, Inc.	Continuous process for the preparation of fructopyranose sulfamate derivatives
CN100430408C (zh) *	2002-10-31	2008-11-05	奥索-麦克尼尔药品公司	制备吡喃果糖氨基磺酸酯衍生物的连续法
UA81657C2 (ru) *	2003-03-04	2008-01-25	Орто-Макнейл Фармасьютикел, Инк.	Способ получения противосудорожных производных топирамата
WO2004108732A1 (en) *	2003-05-12	2004-12-16	Sun Pharmaceutical Industries Limited	PROCESS FOR THE PREPARATION OF 2,3:4,5-BIS-O(1-METHYLETHYLIDENE)-ß-D-FRUCTOPYRANOSE SULFAMATE
JP2007501248A (ja) *	2003-08-06	2007-01-25	アルザ・コーポレーシヨン	増進した分散調合物による長時間にわたるトピラメートの均一送達
MXPA06002067A (es) *	2003-08-22	2006-08-11	Johnson & Johnson	Suministro gradual de topiramato durante periodo prolongado.
WO2005020959A2 (en) *	2003-09-02	2005-03-10	Alza Corporation	Novel drug compositions and dosage forms of topiramate
EP1684713A1 (de) *	2003-11-14	2006-08-02	ALZA Corporation	Kontrollierte freisetzung von topirimat in flüssigen dosierformen
KR20050062976A (ko) *	2003-12-19	2005-06-28	일동제약주식회사	2,3:4,5-비스-오-(1-메틸에틸리덴)-베타-디-프럭토피라노즈설파메이트의 새로운 개량된 제조방법
AU2004312082A1 (en) *	2003-12-29	2005-07-21	Alza Corporation, Inc.	Novel drug compositions and dosage forms
WO2005065648A2 (en) *	2003-12-29	2005-07-21	Alza Corporation, Inc.,	Novel drug compositions and dosage forms of topiramate
US20050175696A1 (en) *	2003-12-29	2005-08-11	David Edgren	Drug granule coatings that impart smear resistance during mechanical compression
US20050203287A1 (en) *	2004-03-11	2005-09-15	Chandrasekhar Batchu	Process for the preparation of sulfamate derivatives
AR049646A1 (es) *	2004-06-16	2006-08-23	Janssen Pharmaceutica Nv	Derivados de sulfamato y sulfamida utiles para el tratamiento de la epilepsia y trastornos relacionados
MY147767A (en) *	2004-06-16	2013-01-31	Janssen Pharmaceutica Nv	Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
JP4912312B2 (ja) *	2004-08-24	2012-04-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	抗痙攣薬として有用な新規なベンゾ−縮合ヘテロアリールスルファミド誘導体
BRPI0516562A (pt) *	2004-10-05	2008-10-28	Fallbrook Technologies Inc	transmissão continuamente variável
CA2609185A1 (en) *	2005-05-20	2006-11-30	Ahmed F. Abdel-Magid	Process for preparation of sulfamide derivatives
MX2007014713A (es) *	2005-05-25	2008-02-14	Janssen Pharmaceutica Nv	Formulacion pediatrica de topiramato.
US8492431B2 (en) *	2005-12-19	2013-07-23	Janssen Pharmaceutica, N.V.	Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US8937096B2 (en) *	2005-12-19	2015-01-20	Janssen Pharmaceutica Nv	Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8691867B2 (en) *	2005-12-19	2014-04-08	Janssen Pharmaceutica Nv	Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US20070155827A1 (en) *	2005-12-19	2007-07-05	Smith-Swintosky Virginia L	Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression
US8497298B2 (en) *	2005-12-19	2013-07-30	Janssen Pharmaceutica Nv	Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US20070155823A1 (en) *	2005-12-19	2007-07-05	Smith-Swintosky Virginia L	Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents
US8716231B2 (en) *	2005-12-19	2014-05-06	Janssen Pharmaceutica Nv	Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US20070191459A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels
US20070191474A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
US20070191461A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
US20070191453A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of benzo-heteroaryl sulfamide derivatives for the treatment of substance abuse and addiction
US20070191449A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression
WO2007099388A1 (en) *	2006-03-01	2007-09-07	Glade Organics Private Limited	An improved process for the manufacture of topiramate
WO2007108009A1 (en) *	2006-03-17	2007-09-27	Alembic Limited	A process for purification of topiramate
AU2007253814A1 (en) *	2006-05-19	2007-11-29	Janssen Pharmaceutica N.V.	Co-therapy for the treatment of epilepsy
JP5424571B2 (ja) *	2007-04-12	2014-02-26	協和発酵キリン株式会社	トピラマート含有固形製剤
EP2573425A3 (de) *	2007-04-24	2017-07-26	Fallbrook Intellectual Property Company LLC	Elektrische Fahrantriebe
CN101450951B (zh) *	2007-11-30	2012-10-10	重庆凯林制药有限公司	托吡酯的制备方法
US20090247617A1 (en) *	2008-03-26	2009-10-01	Abdel-Magid Ahmed F	Process for the preparation of benzo-fused heteroaryl sulfamates
US20090247616A1 (en) *	2008-03-26	2009-10-01	Smith-Swintosky Virginia L	Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety
WO2010008776A2 (en)	2008-06-23	2010-01-21	Janssen Pharmaceutica Nv	Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems
US8815939B2 (en) *	2008-07-22	2014-08-26	Janssen Pharmaceutica Nv	Substituted sulfamide derivatives
JP5643844B2 (ja) *	2010-02-05	2014-12-17	サイノファームタイワンリミテッド	トピラマート（ｔｏｐｉｒａｍａｔｅ）の製造方法
CN102936268A (zh) *	2012-11-13	2013-02-20	江苏吉贝尔药业有限公司	一种托吡酯中间体丙酮叉的制备方法
CN106397502A (zh) *	2016-08-31	2017-02-15	安徽省润生医药股份有限公司	一种托吡酯的合成工艺
CN108341844A (zh) *	2018-04-25	2018-07-31	广州小桔生物科技有限公司	一种高纯度托吡酯的制备方法
CN110655541A (zh) *	2018-06-29	2020-01-07	鲁南制药集团股份有限公司	一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯晶型
CN110655542A (zh) *	2018-06-29	2020-01-07	鲁南制药集团股份有限公司	一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯的晶型
WO2020104837A1 (en)	2018-11-21	2020-05-28	Rosemont Pharmaceuticals Limited	Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability
CN114350340B (zh) *	2022-01-13	2023-01-17	陕西科技大学	一种压裂用增渗剂及其制备方法和应用
WO2025049333A2 (en) *	2023-08-25	2025-03-06	University Of Iowa Research Foundation	Therapeutic compounds and methods

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US4513006A (en) *	1983-09-26	1985-04-23	Mcneil Lab., Inc.	Anticonvulsant sulfamate derivatives
US4582916A (en) *	1983-09-26	1986-04-15	Mcneilab, Inc.	Chlorosulfate and azidosulfate esters of tetrahydro-2H-pyran-2-yl-methanol

1992
- 1992-09-15 AU AU24518/92A patent/AU651244B2/en not_active Expired
- 1992-09-15 IL IL10317292A patent/IL103172A/xx not_active IP Right Cessation
- 1992-09-17 CA CA002078519A patent/CA2078519C/en not_active Expired - Lifetime
- 1992-09-17 MY MYPI92001667A patent/MY113564A/en unknown
- 1992-09-17 EG EG54692A patent/EG20164A/xx active
- 1992-09-18 NO NO923637A patent/NO179284C/no not_active IP Right Cessation
- 1992-09-18 EP EP92308509A patent/EP0533483B1/de not_active Expired - Lifetime
- 1992-09-18 DK DK92308509T patent/DK0533483T3/da active
- 1992-09-18 FI FI924189A patent/FI107731B/fi not_active IP Right Cessation
- 1992-09-18 JP JP27351092A patent/JP3174410B2/ja not_active Expired - Lifetime
- 1992-09-18 AT AT92308509T patent/ATE163937T1/de active
- 1992-09-18 KR KR1019920017043A patent/KR100229180B1/ko not_active Expired - Lifetime
- 1992-09-18 MX MX9205305A patent/MX9205305A/es unknown
- 1992-09-18 HU HU9202974A patent/HU212634B/hu unknown
- 1992-09-18 ES ES92308509T patent/ES2114917T3/es not_active Expired - Lifetime
- 1992-09-18 ZW ZW14792A patent/ZW14792A1/xx unknown
- 1992-09-18 PH PH44955A patent/PH31291A/en unknown
- 1992-09-18 NZ NZ244409A patent/NZ244409A/en not_active IP Right Cessation
- 1992-09-18 DE DE69224691T patent/DE69224691T2/de not_active Expired - Lifetime
- 1992-09-19 CN CN92111591A patent/CN1035820C/zh not_active Expired - Lifetime
- 1992-11-10 TW TW081108966A patent/TW217413B/zh not_active IP Right Cessation
1993
- 1993-08-12 US US08/106,470 patent/US5387700A/en not_active Expired - Lifetime
1998
- 1998-04-10 GR GR980400814T patent/GR3026618T3/el unknown

Also Published As

Publication number	Publication date
EP0533483A3 (en)	1994-11-02
MY113564A (en)	2002-04-30
ZW14792A1 (en)	1994-04-20
JP3174410B2 (ja)	2001-06-11
IL103172A0 (en)	1993-02-21
CA2078519A1 (en)	1993-03-20
HU212634B (en)	1996-09-30
MX9205305A (es)	1993-07-01
EP0533483B1 (de)	1998-03-11
CN1075317A (zh)	1993-08-18
DK0533483T3 (da)	1998-09-28
IL103172A (en)	1997-01-10
PH31291A (en)	1998-07-06
NO923637L (no)	1993-03-22
EP0533483A2 (de)	1993-03-24
KR100229180B1 (ko)	1999-11-01
DE69224691D1 (de)	1998-04-16
HU9202974D0 (en)	1992-11-30
NZ244409A (en)	1995-02-24
CN1035820C (zh)	1997-09-10
DE69224691T2 (de)	1998-08-20
HUT63612A (en)	1993-09-28
CA2078519C (en)	2003-09-16
FI924189A0 (fi)	1992-09-18
NO923637D0 (no)	1992-09-18
GR3026618T3 (en)	1998-07-31
AU2451892A (en)	1993-03-25
FI924189L (fi)	1993-03-20
JPH05230011A (ja)	1993-09-07
NO179284C (no)	1996-09-11
FI107731B (fi)	2001-09-28
US5387700A (en)	1995-02-07
KR930006029A (ko)	1993-04-20
EG20164A (en)	1997-08-31
ES2114917T3 (es)	1998-06-16
TW217413B (de)	1993-12-11
NO179284B (no)	1996-06-03
AU651244B2 (en)	1994-07-14

Legal Events

Date	Code	Title	Description
1998-09-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69224691D1 (de)	1998-04-16	Verfahren zur Herstellung von Chlorsulfat und Sulfamatderivate von 2,3:4,5-bis-0-(1-Methylethylidene)-Beta-D-Fructopyranose und (1-Methylcyclohexyl)Methanol
DE59306602D1 (de)	1997-07-03	Verfahren zur herstellung von polycarboxylaten auf polysaccharid-basis
DE59109217D1 (de)	2001-09-20	Verfahren zur Herstellung eines Olefinpolymers
ATE211724T1 (de)	2002-01-15	Verfahren zur herstellung von 4-hydroxystyrol
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