ATE163937T1 - Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol - Google Patents

Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol

Info

Publication number: ATE163937T1
Authority: AT; Austria
Prior art keywords: fructopyranose; methylethylidene; methylcyclohexyl; beta; bis
Prior art date: 1991-09-19

Application number

AT92308509T

Other languages

English (en)

Inventor

Cynthia A Maryanoff

Kirk L Sorgi

Lorraine Scott

Original Assignee

Mcneilab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-19

Filing date

1992-09-18

Publication date

1998-03-15

1992-09-18 Application filed by Mcneilab Inc filed Critical Mcneilab Inc

1998-03-15 Application granted granted Critical

1998-03-15 Publication of ATE163937T1 publication Critical patent/ATE163937T1/de

Links

UUBPRIUBEQJUQL-UHFFFAOYSA-N (1-methylcyclohexyl)methanol Chemical compound OCC1(C)CCCCC1 UUBPRIUBEQJUQL-UHFFFAOYSA-N 0.000 title abstract 2
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
XTHPWXDJESJLNJ-UHFFFAOYSA-N sulfurochloridic acid Chemical compound OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 title 1
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 6
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 4
BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
PSSHGMIAIUYOJF-XBWDGYHZSA-N [(3as,5ar,8ar,8bs)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methanol Chemical compound C1O[C@@]2(CO)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 PSSHGMIAIUYOJF-XBWDGYHZSA-N 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
XTHPWXDJESJLNJ-UHFFFAOYSA-M chlorosulfate Chemical compound [O-]S(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-M 0.000 abstract 1
-1 heterocyclic amine Chemical class 0.000 abstract 1
YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92308509T 1991-09-19 1992-09-18 Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol ATE163937T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US76272091A	1991-09-19	1991-09-19
US92626992A	1992-08-05	1992-08-05

Publications (1)

Publication Number	Publication Date
ATE163937T1 true ATE163937T1 (de)	1998-03-15

Family

ID=27117178

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92308509T ATE163937T1 (de)	1991-09-19	1992-09-18	Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol

Country Status (23)

Country	Link
US (1)	US5387700A (de)
EP (1)	EP0533483B1 (de)
JP (1)	JP3174410B2 (de)
KR (1)	KR100229180B1 (de)
CN (1)	CN1035820C (de)
AT (1)	ATE163937T1 (de)
AU (1)	AU651244B2 (de)
CA (1)	CA2078519C (de)
DE (1)	DE69224691T2 (de)
DK (1)	DK0533483T3 (de)
EG (1)	EG20164A (de)
ES (1)	ES2114917T3 (de)
FI (1)	FI107731B (de)
GR (1)	GR3026618T3 (de)
HU (1)	HU212634B (de)
IL (1)	IL103172A (de)
MX (1)	MX9205305A (de)
MY (1)	MY113564A (de)
NO (1)	NO179284C (de)
NZ (1)	NZ244409A (de)
PH (1)	PH31291A (de)
TW (1)	TW217413B (de)
ZW (1)	ZW14792A1 (de)

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KR100664612B1 (ko) *	1999-02-17	2007-01-04	오르토-맥네일 파마슈티칼, 인코퍼레이티드	본태성 진전의 치료에 유용한 항경련성 유도체
US6420369B1 (en)	1999-05-24	2002-07-16	Ortho-Mcneil Pharmaceutical, Inc.	Anticonvulsant derivatives useful in treating dementia
DK1309324T3 (da) *	2000-07-07	2006-06-12	Ortho Mcneil Pharm Inc	Antikonvulsive derivater egnede til behandling og forebyggelse af udvikling af type II diabetes mellitus og syndrom X
AU2001280865A1 (en)	2000-08-02	2002-02-13	Ortho-Mcneil Pharmaceutical, Inc.	Anticonvulsant derivatives useful for the treatment of depression
NZ537490A (en)	2000-10-30	2006-11-30	Ortho Mcneil Pharm Inc	Treatment of diabetes and syndrome X using a sulfamate derivate such as topiramate and metformin
UA78211C2 (en) *	2001-07-09	2007-03-15	Ortho Mcneil Pharm Inc	Salts of fructopyranose derivatives as anticonvulsant
US7041650B2 (en) *	2001-07-09	2006-05-09	Ortho-Mcneil Pharmaceutical, Inc.	Anticonvulsant derivative salts
JP2005508373A (ja) *	2001-11-06	2005-03-31	オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド	抗痙攣剤誘導体およびカリウムを用いる共同療法を含んでなる感覚異常の処置および予防
WO2003074474A2 (en)	2002-03-01	2003-09-12	University Of South Florida	Multiple-component solid phases containing at least one active pharmaceutical ingredient
IL163720A0 (en) *	2002-02-26	2005-12-18	Ortho Mcneil Pharm Inc	Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents
US7060725B2 (en)	2002-05-13	2006-06-13	Janssen Pharmaceutica N.V.	Substituted sulfamate anticonvulsant derivatives
AR039744A1 (es) *	2002-06-26	2005-03-09	Alza Corp	Metodos y formas de dosificacion para aumentar la solubilidad de las composiciones de farmacos para la administracion controlada
NZ537543A (en) *	2002-07-29	2007-08-31	Alza Corp	Formulations and high dose osmotic dosage forms for controlled delivery of topiramate
CN100430408C (zh) *	2002-10-31	2008-11-05	奥索-麦克尼尔药品公司	制备吡喃果糖氨基磺酸酯衍生物的连续法
US7196209B2 (en) *	2002-10-31	2007-03-27	Ortho-Mcneil Pharmaceutical, Inc.	Continuous process for the preparation of fructopyranose sulfamate derivatives
UA81657C2 (ru) *	2003-03-04	2008-01-25	Орто-Макнейл Фармасьютикел, Инк.	Способ получения противосудорожных производных топирамата
WO2004108732A1 (en) *	2003-05-12	2004-12-16	Sun Pharmaceutical Industries Limited	PROCESS FOR THE PREPARATION OF 2,3:4,5-BIS-O(1-METHYLETHYLIDENE)-ß-D-FRUCTOPYRANOSE SULFAMATE
JP2007501248A (ja) *	2003-08-06	2007-01-25	アルザ・コーポレーシヨン	増進した分散調合物による長時間にわたるトピラメートの均一送達
US20050136108A1 (en) *	2003-08-22	2005-06-23	Yam Noymi V.	Stepwise delivery of topiramate over prolonged period of time
WO2005020959A2 (en) *	2003-09-02	2005-03-10	Alza Corporation	Novel drug compositions and dosage forms of topiramate
JP2007511519A (ja) *	2003-11-14	2007-05-10	アルザ・コーポレーシヨン	液状投薬形態物におけるトピラメートの制御放出
KR20050062976A (ko) *	2003-12-19	2005-06-28	일동제약주식회사	2,3:4,5-비스-오-(1-메틸에틸리덴)-베타-디-프럭토피라노즈설파메이트의 새로운 개량된 제조방법
MXPA06007510A (es) *	2003-12-29	2009-06-10	Johnson & Johnson	Composiciones de farmaco y formas de dosis novedosas de topiramato.
US20050175696A1 (en) *	2003-12-29	2005-08-11	David Edgren	Drug granule coatings that impart smear resistance during mechanical compression
CA2551815A1 (en) *	2003-12-29	2005-07-21	Alza Corporation	Novel drug compositions and dosage forms
US20050203287A1 (en) *	2004-03-11	2005-09-15	Chandrasekhar Batchu	Process for the preparation of sulfamate derivatives
MY147767A (en) *	2004-06-16	2013-01-31	Janssen Pharmaceutica Nv	Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
TW200612905A (en) *	2004-06-16	2006-05-01	Janssen Pharmaceutica Nv	Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
PE20060500A1 (es) *	2004-08-24	2006-07-13	Janssen Pharmaceutica Nv	Derivados de heteroaril sulfamida benzo-fusionada como anticonvulsivantes
KR101276082B1 (ko) *	2004-10-05	2013-06-18	폴브룩 테크놀로지즈 인크	연속 가변 변속기
BRPI0610864A2 (pt) *	2005-05-20	2010-08-03	Janssen Pharmaceutica Nv	processo para preparação de derivados de sulfamida
AU2006251213A1 (en) *	2005-05-25	2006-11-30	Janssen Pharmaceutica N.V.	Pediatric formulation of topiramate
US8716231B2 (en) *	2005-12-19	2014-05-06	Janssen Pharmaceutica Nv	Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US20070155823A1 (en) *	2005-12-19	2007-07-05	Smith-Swintosky Virginia L	Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents
US8937096B2 (en) *	2005-12-19	2015-01-20	Janssen Pharmaceutica Nv	Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US20070155827A1 (en) *	2005-12-19	2007-07-05	Smith-Swintosky Virginia L	Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression
AR058389A1 (es) *	2005-12-19	2008-01-30	Janssen Pharmaceutica Nv	Uso de derivados heterociclicos benzo-fusionados de sulfamida para el tratamiento de la obesidad
US8691867B2 (en) *	2005-12-19	2014-04-08	Janssen Pharmaceutica Nv	Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8497298B2 (en) *	2005-12-19	2013-07-30	Janssen Pharmaceutica Nv	Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US20070191449A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression
US20070191461A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
US20070191459A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels
US20070191453A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of benzo-heteroaryl sulfamide derivatives for the treatment of substance abuse and addiction
US20070191474A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
WO2007099388A1 (en) *	2006-03-01	2007-09-07	Glade Organics Private Limited	An improved process for the manufacture of topiramate
WO2007108009A1 (en) *	2006-03-17	2007-09-27	Alembic Limited	A process for purification of topiramate
JP2009537635A (ja) *	2006-05-19	2009-10-29	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	癲癇の処置のための共同−療法
JP5424571B2 (ja) *	2007-04-12	2014-02-26	協和発酵キリン株式会社	トピラマート含有固形製剤
CN102943855B (zh) *	2007-04-24	2016-01-27	福博科技术公司	电力牵引传动装置
CN101450951B (zh) *	2007-11-30	2012-10-10	重庆凯林制药有限公司	托吡酯的制备方法
US20090247617A1 (en) *	2008-03-26	2009-10-01	Abdel-Magid Ahmed F	Process for the preparation of benzo-fused heteroaryl sulfamates
US20090247616A1 (en) *	2008-03-26	2009-10-01	Smith-Swintosky Virginia L	Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety
PE20110060A1 (es)	2008-06-23	2011-01-31	Janssen Pharmaceutica Nv	Forma cristalina de (2s)-(-)-n-(6-cloro-2,3-dihidro-benzo[1,4]dioxin-2-ilmetil)-sulfamida
US8815939B2 (en) *	2008-07-22	2014-08-26	Janssen Pharmaceutica Nv	Substituted sulfamide derivatives
CN102725301B (zh) *	2010-02-05	2015-05-13	台湾神隆股份有限公司	用于制造和纯化托吡酯的方法
CN102936268A (zh) *	2012-11-13	2013-02-20	江苏吉贝尔药业有限公司	一种托吡酯中间体丙酮叉的制备方法
CN106397502A (zh) *	2016-08-31	2017-02-15	安徽省润生医药股份有限公司	一种托吡酯的合成工艺
CN108341844A (zh) *	2018-04-25	2018-07-31	广州小桔生物科技有限公司	一种高纯度托吡酯的制备方法
CN110655541A (zh) *	2018-06-29	2020-01-07	鲁南制药集团股份有限公司	一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯晶型
CN110655542A (zh) *	2018-06-29	2020-01-07	鲁南制药集团股份有限公司	一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯的晶型
WO2020104837A1 (en)	2018-11-21	2020-05-28	Rosemont Pharmaceuticals Limited	Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability
CN114350340B (zh) *	2022-01-13	2023-01-17	陕西科技大学	一种压裂用增渗剂及其制备方法和应用
WO2025049333A2 (en) *	2023-08-25	2025-03-06	University Of Iowa Research Foundation	Therapeutic compounds and methods

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US4513006A (en) *	1983-09-26	1985-04-23	Mcneil Lab., Inc.	Anticonvulsant sulfamate derivatives
US4582916A (en) *	1983-09-26	1986-04-15	Mcneilab, Inc.	Chlorosulfate and azidosulfate esters of tetrahydro-2H-pyran-2-yl-methanol

1992
- 1992-09-15 IL IL10317292A patent/IL103172A/xx not_active IP Right Cessation
- 1992-09-15 AU AU24518/92A patent/AU651244B2/en not_active Expired
- 1992-09-17 EG EG54692A patent/EG20164A/xx active
- 1992-09-17 CA CA002078519A patent/CA2078519C/en not_active Expired - Lifetime
- 1992-09-17 MY MYPI92001667A patent/MY113564A/en unknown
- 1992-09-18 MX MX9205305A patent/MX9205305A/es unknown
- 1992-09-18 DE DE69224691T patent/DE69224691T2/de not_active Expired - Lifetime
- 1992-09-18 ZW ZW14792A patent/ZW14792A1/xx unknown
- 1992-09-18 EP EP92308509A patent/EP0533483B1/de not_active Expired - Lifetime
- 1992-09-18 PH PH44955A patent/PH31291A/en unknown
- 1992-09-18 JP JP27351092A patent/JP3174410B2/ja not_active Expired - Lifetime
- 1992-09-18 KR KR1019920017043A patent/KR100229180B1/ko not_active Expired - Lifetime
- 1992-09-18 NO NO923637A patent/NO179284C/no not_active IP Right Cessation
- 1992-09-18 NZ NZ244409A patent/NZ244409A/en not_active IP Right Cessation
- 1992-09-18 DK DK92308509T patent/DK0533483T3/da active
- 1992-09-18 ES ES92308509T patent/ES2114917T3/es not_active Expired - Lifetime
- 1992-09-18 AT AT92308509T patent/ATE163937T1/de active
- 1992-09-18 HU HU9202974A patent/HU212634B/hu unknown
- 1992-09-18 FI FI924189A patent/FI107731B/fi not_active IP Right Cessation
- 1992-09-19 CN CN92111591A patent/CN1035820C/zh not_active Expired - Lifetime
- 1992-11-10 TW TW081108966A patent/TW217413B/zh not_active IP Right Cessation
1993
- 1993-08-12 US US08/106,470 patent/US5387700A/en not_active Expired - Lifetime
1998
- 1998-04-10 GR GR980400814T patent/GR3026618T3/el unknown

Also Published As

Publication number	Publication date
FI107731B (fi)	2001-09-28
HU212634B (en)	1996-09-30
PH31291A (en)	1998-07-06
IL103172A (en)	1997-01-10
HUT63612A (en)	1993-09-28
CA2078519A1 (en)	1993-03-20
DE69224691T2 (de)	1998-08-20
EP0533483A3 (en)	1994-11-02
MY113564A (en)	2002-04-30
CA2078519C (en)	2003-09-16
US5387700A (en)	1995-02-07
NO923637L (no)	1993-03-22
KR930006029A (ko)	1993-04-20
AU651244B2 (en)	1994-07-14
DK0533483T3 (da)	1998-09-28
ZW14792A1 (en)	1994-04-20
CN1035820C (zh)	1997-09-10
JP3174410B2 (ja)	2001-06-11
MX9205305A (es)	1993-07-01
AU2451892A (en)	1993-03-25
JPH05230011A (ja)	1993-09-07
EP0533483B1 (de)	1998-03-11
NO179284B (no)	1996-06-03
ES2114917T3 (es)	1998-06-16
FI924189A0 (fi)	1992-09-18
TW217413B (de)	1993-12-11
HU9202974D0 (en)	1992-11-30
CN1075317A (zh)	1993-08-18
IL103172A0 (en)	1993-02-21
NO179284C (no)	1996-09-11
GR3026618T3 (en)	1998-07-31
KR100229180B1 (ko)	1999-11-01
NZ244409A (en)	1995-02-24
DE69224691D1 (de)	1998-04-16
NO923637D0 (no)	1992-09-18
EG20164A (en)	1997-08-31
FI924189L (fi)	1993-03-20
EP0533483A2 (de)	1993-03-24

Legal Events

Date	Code	Title	Description
1998-09-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
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