ATE163937T1 - Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol - Google Patents

Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol

Info

Publication number: ATE163937T1
Authority: AT; Austria
Prior art keywords: fructopyranose; methylethylidene; methylcyclohexyl; beta; bis
Prior art date: 1991-09-19

Application number

AT92308509T

Other languages

English (en)

Inventor

Cynthia A Maryanoff

Kirk L Sorgi

Lorraine Scott

Original Assignee

Mcneilab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-19

Filing date

1992-09-18

Publication date

1998-03-15

1992-09-18 Application filed by Mcneilab Inc filed Critical Mcneilab Inc

1998-03-15 Application granted granted Critical

1998-03-15 Publication of ATE163937T1 publication Critical patent/ATE163937T1/de

Links

UUBPRIUBEQJUQL-UHFFFAOYSA-N (1-methylcyclohexyl)methanol Chemical compound OCC1(C)CCCCC1 UUBPRIUBEQJUQL-UHFFFAOYSA-N 0.000 title abstract 2
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
XTHPWXDJESJLNJ-UHFFFAOYSA-N sulfurochloridic acid Chemical compound OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 title 1
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 6
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 4
BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
PSSHGMIAIUYOJF-XBWDGYHZSA-N [(3as,5ar,8ar,8bs)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methanol Chemical compound C1O[C@@]2(CO)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 PSSHGMIAIUYOJF-XBWDGYHZSA-N 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
XTHPWXDJESJLNJ-UHFFFAOYSA-M chlorosulfate Chemical compound [O-]S(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-M 0.000 abstract 1
-1 heterocyclic amine Chemical class 0.000 abstract 1
YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92308509T 1991-09-19 1992-09-18 Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol ATE163937T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US76272091A	1991-09-19	1991-09-19
US92626992A	1992-08-05	1992-08-05

Publications (1)

Publication Number	Publication Date
ATE163937T1 true ATE163937T1 (de)	1998-03-15

Family

ID=27117178

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92308509T ATE163937T1 (de)	1991-09-19	1992-09-18	Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol

Country Status (23)

Country	Link
US (1)	US5387700A (de)
EP (1)	EP0533483B1 (de)
JP (1)	JP3174410B2 (de)
KR (1)	KR100229180B1 (de)
CN (1)	CN1035820C (de)
AT (1)	ATE163937T1 (de)
AU (1)	AU651244B2 (de)
CA (1)	CA2078519C (de)
DE (1)	DE69224691T2 (de)
DK (1)	DK0533483T3 (de)
EG (1)	EG20164A (de)
ES (1)	ES2114917T3 (de)
FI (1)	FI107731B (de)
GR (1)	GR3026618T3 (de)
HU (1)	HU212634B (de)
IL (1)	IL103172A (de)
MX (1)	MX9205305A (de)
MY (1)	MY113564A (de)
NO (1)	NO179284C (de)
NZ (1)	NZ244409A (de)
PH (1)	PH31291A (de)
TW (1)	TW217413B (de)
ZW (1)	ZW14792A1 (de)

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BR0008791A (pt) *	1999-02-17	2005-04-05	Ortho Mcneil Pharm Inc	Derivados anticonvulsivos, úteis no tratamento de tremor essencial
US6420369B1 (en)	1999-05-24	2002-07-16	Ortho-Mcneil Pharmaceutical, Inc.	Anticonvulsant derivatives useful in treating dementia
NZ523531A (en) *	2000-07-07	2005-07-29	Ortho Mcneil Pharm Inc	Anticonvulsant derivatives useful for preventing the development of type II diabetes mellitus and syndrome X
EP1309325A1 (de)	2000-08-02	2003-05-14	Ortho-McNeil Pharmaceutical, Inc.	Antikonvulsive derivate zur behandlung von depression
MXPA03003870A (es) *	2000-10-30	2004-08-12	Johnson & Johnson	Terapia de combinacion que comprende agentes antidiabeticos y anticonvulsionantes.
US7041650B2 (en) *	2001-07-09	2006-05-09	Ortho-Mcneil Pharmaceutical, Inc.	Anticonvulsant derivative salts
UA78211C2 (en) *	2001-07-09	2007-03-15	Ortho Mcneil Pharm Inc	Salts of fructopyranose derivatives as anticonvulsant
WO2003039563A1 (en) *	2001-11-06	2003-05-15	Ortho-Mcneil Pharmaceutical Inc.	Treatment and prevention of paresthesia comprising co-therapy with anticonvulsant derivatives and potassium
WO2003072138A1 (en) *	2002-02-26	2003-09-04	Ortho-Mcneil Pharmaceutical Inc.	Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents
CA2477923C (en)	2002-03-01	2021-02-23	University Of South Florida	Multiple-component solid phases containing at least one active pharmaceutical ingredient
US7060725B2 (en) *	2002-05-13	2006-06-13	Janssen Pharmaceutica N.V.	Substituted sulfamate anticonvulsant derivatives
AR039744A1 (es) *	2002-06-26	2005-03-09	Alza Corp	Metodos y formas de dosificacion para aumentar la solubilidad de las composiciones de farmacos para la administracion controlada
NZ537543A (en) *	2002-07-29	2007-08-31	Alza Corp	Formulations and high dose osmotic dosage forms for controlled delivery of topiramate
US7196209B2 (en) *	2002-10-31	2007-03-27	Ortho-Mcneil Pharmaceutical, Inc.	Continuous process for the preparation of fructopyranose sulfamate derivatives
CN100430408C (zh) *	2002-10-31	2008-11-05	奥索-麦克尼尔药品公司	制备吡喃果糖氨基磺酸酯衍生物的连续法
UA81657C2 (ru) *	2003-03-04	2008-01-25	Орто-Макнейл Фармасьютикел, Инк.	Способ получения противосудорожных производных топирамата
WO2004108732A1 (en) *	2003-05-12	2004-12-16	Sun Pharmaceutical Industries Limited	PROCESS FOR THE PREPARATION OF 2,3:4,5-BIS-O(1-METHYLETHYLIDENE)-ß-D-FRUCTOPYRANOSE SULFAMATE
AU2004264316A1 (en) *	2003-08-06	2005-02-24	Alza Corporation	Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
MXPA06002067A (es) *	2003-08-22	2006-08-11	Johnson & Johnson	Suministro gradual de topiramato durante periodo prolongado.
AU2004268661A1 (en) *	2003-09-02	2005-03-10	Alza Corporation	Novel drug compositions and dosage forms of topiramate
JP2007511519A (ja) *	2003-11-14	2007-05-10	アルザ・コーポレーシヨン	液状投薬形態物におけるトピラメートの制御放出
KR20050062976A (ko) *	2003-12-19	2005-06-28	일동제약주식회사	2,3:4,5-비스-오-(1-메틸에틸리덴)-베타-디-프럭토피라노즈설파메이트의 새로운 개량된 제조방법
US20050175696A1 (en) *	2003-12-29	2005-08-11	David Edgren	Drug granule coatings that impart smear resistance during mechanical compression
JP2007517063A (ja) *	2003-12-29	2007-06-28	アルザ・コーポレーシヨン	トピラメートの新規な薬剤組成物および剤形
AU2004312082A1 (en) *	2003-12-29	2005-07-21	Alza Corporation, Inc.	Novel drug compositions and dosage forms
US20050203287A1 (en) *	2004-03-11	2005-09-15	Chandrasekhar Batchu	Process for the preparation of sulfamate derivatives
MY147767A (en) *	2004-06-16	2013-01-31	Janssen Pharmaceutica Nv	Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
AR049646A1 (es) *	2004-06-16	2006-08-23	Janssen Pharmaceutica Nv	Derivados de sulfamato y sulfamida utiles para el tratamiento de la epilepsia y trastornos relacionados
ES2310366T3 (es) *	2004-08-24	2009-01-01	Janssen Pharmaceutica Nv	Nuevos derivados de heteroaril sulfonamida benzo-condensada utiles como agentes anticonvulsivos.
JP4974896B2 (ja) *	2004-10-05	2012-07-11	フォールブルックテクノロジーズインコーポレイテッド	連続可変変速機
JP2008545650A (ja) *	2005-05-20	2008-12-18	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	スルファミド誘導体の製造方法
RU2007148444A (ru) *	2005-05-25	2009-06-27	Янссен Фармацевтика Н.В. (Be)	Педиатрическая композиция топирамата
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US8716231B2 (en) *	2005-12-19	2014-05-06	Janssen Pharmaceutica Nv	Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US20070155827A1 (en) *	2005-12-19	2007-07-05	Smith-Swintosky Virginia L	Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression
US8937096B2 (en) *	2005-12-19	2015-01-20	Janssen Pharmaceutica Nv	Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US20070155823A1 (en) *	2005-12-19	2007-07-05	Smith-Swintosky Virginia L	Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents
US8691867B2 (en) *	2005-12-19	2014-04-08	Janssen Pharmaceutica Nv	Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US20070191453A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of benzo-heteroaryl sulfamide derivatives for the treatment of substance abuse and addiction
US20070191461A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
US20070191459A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels
US20070191474A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
US20070191449A1 (en) *	2006-02-15	2007-08-16	Smith-Swintosky Virginia L	Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression
WO2007099388A1 (en) *	2006-03-01	2007-09-07	Glade Organics Private Limited	An improved process for the manufacture of topiramate
WO2007108009A1 (en) *	2006-03-17	2007-09-27	Alembic Limited	A process for purification of topiramate
EP2026790A2 (de) *	2006-05-19	2009-02-25	Janssen Pharmaceutica, N.V.	Kombinationstherapie zur behandlung von epilepsie und assoziierten erkrankungen
JP5424571B2 (ja) *	2007-04-12	2014-02-26	協和発酵キリン株式会社	トピラマート含有固形製剤
JP5591686B2 (ja) *	2007-04-24	2014-09-17	フォールブルックインテレクチュアルプロパティーカンパニーエルエルシー	電気牽引駆動装置
CN101450951B (zh) *	2007-11-30	2012-10-10	重庆凯林制药有限公司	托吡酯的制备方法
US20090247617A1 (en) *	2008-03-26	2009-10-01	Abdel-Magid Ahmed F	Process for the preparation of benzo-fused heteroaryl sulfamates
US20090247616A1 (en) *	2008-03-26	2009-10-01	Smith-Swintosky Virginia L	Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety
US8809385B2 (en)	2008-06-23	2014-08-19	Janssen Pharmaceutica Nv	Crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
US8815939B2 (en) *	2008-07-22	2014-08-26	Janssen Pharmaceutica Nv	Substituted sulfamide derivatives
CN102725301B (zh) *	2010-02-05	2015-05-13	台湾神隆股份有限公司	用于制造和纯化托吡酯的方法
CN102936268A (zh) *	2012-11-13	2013-02-20	江苏吉贝尔药业有限公司	一种托吡酯中间体丙酮叉的制备方法
CN106397502A (zh) *	2016-08-31	2017-02-15	安徽省润生医药股份有限公司	一种托吡酯的合成工艺
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CN110655542A (zh) *	2018-06-29	2020-01-07	鲁南制药集团股份有限公司	一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯的晶型
CN110655541A (zh) *	2018-06-29	2020-01-07	鲁南制药集团股份有限公司	一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯晶型
EP3883546A1 (de)	2018-11-21	2021-09-29	Rosemont Pharmaceuticals Ltd	Orale topiramat-suspensionsformulierungen mit verlängerter lagerstabilität und verbesserter bioverfügbarkeit
CN114350340B (zh) *	2022-01-13	2023-01-17	陕西科技大学	一种压裂用增渗剂及其制备方法和应用
WO2025049333A2 (en) *	2023-08-25	2025-03-06	University Of Iowa Research Foundation	Therapeutic compounds and methods

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US4582916A (en) *	1983-09-26	1986-04-15	Mcneilab, Inc.	Chlorosulfate and azidosulfate esters of tetrahydro-2H-pyran-2-yl-methanol
US4513006A (en) *	1983-09-26	1985-04-23	Mcneil Lab., Inc.	Anticonvulsant sulfamate derivatives

1992
- 1992-09-15 IL IL10317292A patent/IL103172A/xx not_active IP Right Cessation
- 1992-09-15 AU AU24518/92A patent/AU651244B2/en not_active Expired
- 1992-09-17 CA CA002078519A patent/CA2078519C/en not_active Expired - Lifetime
- 1992-09-17 MY MYPI92001667A patent/MY113564A/en unknown
- 1992-09-17 EG EG54692A patent/EG20164A/xx active
- 1992-09-18 JP JP27351092A patent/JP3174410B2/ja not_active Expired - Lifetime
- 1992-09-18 EP EP92308509A patent/EP0533483B1/de not_active Expired - Lifetime
- 1992-09-18 PH PH44955A patent/PH31291A/en unknown
- 1992-09-18 ES ES92308509T patent/ES2114917T3/es not_active Expired - Lifetime
- 1992-09-18 DE DE69224691T patent/DE69224691T2/de not_active Expired - Lifetime
- 1992-09-18 DK DK92308509T patent/DK0533483T3/da active
- 1992-09-18 HU HU9202974A patent/HU212634B/hu unknown
- 1992-09-18 ZW ZW14792A patent/ZW14792A1/xx unknown
- 1992-09-18 KR KR1019920017043A patent/KR100229180B1/ko not_active Expired - Lifetime
- 1992-09-18 FI FI924189A patent/FI107731B/fi not_active IP Right Cessation
- 1992-09-18 NO NO923637A patent/NO179284C/no not_active IP Right Cessation
- 1992-09-18 AT AT92308509T patent/ATE163937T1/de active
- 1992-09-18 NZ NZ244409A patent/NZ244409A/en not_active IP Right Cessation
- 1992-09-18 MX MX9205305A patent/MX9205305A/es unknown
- 1992-09-19 CN CN92111591A patent/CN1035820C/zh not_active Expired - Lifetime
- 1992-11-10 TW TW081108966A patent/TW217413B/zh not_active IP Right Cessation
1993
- 1993-08-12 US US08/106,470 patent/US5387700A/en not_active Expired - Lifetime
1998
- 1998-04-10 GR GR980400814T patent/GR3026618T3/el unknown

Also Published As

Publication number	Publication date
GR3026618T3 (en)	1998-07-31
CN1035820C (zh)	1997-09-10
TW217413B (de)	1993-12-11
CA2078519A1 (en)	1993-03-20
NO179284B (no)	1996-06-03
JPH05230011A (ja)	1993-09-07
MX9205305A (es)	1993-07-01
NO923637D0 (no)	1992-09-18
DE69224691D1 (de)	1998-04-16
AU2451892A (en)	1993-03-25
IL103172A (en)	1997-01-10
PH31291A (en)	1998-07-06
DK0533483T3 (da)	1998-09-28
IL103172A0 (en)	1993-02-21
FI924189A0 (fi)	1992-09-18
CN1075317A (zh)	1993-08-18
HU9202974D0 (en)	1992-11-30
EP0533483A2 (de)	1993-03-24
EP0533483B1 (de)	1998-03-11
FI107731B (fi)	2001-09-28
NO923637L (no)	1993-03-22
HUT63612A (en)	1993-09-28
ZW14792A1 (en)	1994-04-20
FI924189L (fi)	1993-03-20
NZ244409A (en)	1995-02-24
NO179284C (no)	1996-09-11
EP0533483A3 (en)	1994-11-02
AU651244B2 (en)	1994-07-14
US5387700A (en)	1995-02-07
KR100229180B1 (ko)	1999-11-01
KR930006029A (ko)	1993-04-20
CA2078519C (en)	2003-09-16
ES2114917T3 (es)	1998-06-16
DE69224691T2 (de)	1998-08-20
JP3174410B2 (ja)	2001-06-11
EG20164A (en)	1997-08-31
MY113564A (en)	2002-04-30
HU212634B (en)	1996-09-30

Legal Events

Date	Code	Title	Description
1998-09-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE163937T1 (de)	1998-03-15	Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol
DE59109217D1 (de)	2001-09-20	Verfahren zur Herstellung eines Olefinpolymers
ATE211724T1 (de)	2002-01-15	Verfahren zur herstellung von 4-hydroxystyrol
DE59010446D1 (de)	1996-09-19	Verfahren zur Herstellung eines Syndio-Isoblockpolymeren
ATE121088T1 (de)	1995-04-15	Verfahren zur herstellung von imidazo(4,5- c>chinolin-4-aminen.
ATA242687A (de)	1996-01-15	Verfahren zur herstellung eines antioxidationsmittels, insbesondere zur verwendung als arzneimittel
DE69117528D1 (de)	1996-04-04	Verfahren zur herstellung von hydroxymethyl-5-furfural durch heterogene katalyse
DE59308119D1 (de)	1998-03-12	Verfahren zur herstellung von optischen polymerelementen mit integrierten vertikalen kopplungsstrukturen
DE69105275D1 (de)	1995-01-05	Verfahren zur herstellung von tertiären perfluoraminen.
DE69401386D1 (de)	1997-02-20	Verfahren zur Herstellung eines Isopren-Butadien Kautschuks
ATE153073T1 (de)	1997-05-15	Verfahren zur herstellung von n- acetylneuraminsäure
ATE126361T1 (de)	1995-08-15	Verfahren zur herstellung einer brillenfassung.
DE69002765D1 (de)	1993-09-16	Verfahren zur herstellung eines deckenpaneels.
ATA7489A (de)	1995-07-15	Verfahren zur herstellung eines an die scheibenform eines brillengestells angepassten brillenglases
DE69626802D1 (de)	2003-04-24	Verfahren zur herstellung von einem selbstausrichtenden vertikalen bipolaren transistor auf einem soi
DE59001842D1 (de)	1993-07-29	Verfahren zur herstellung von telomeralkoholen.
DE3765611D1 (de)	1990-11-22	Verfahren zur herstellung eines feinkoernig rekristallisierten bleches.
DE3763921D1 (de)	1990-08-30	Verfahren zur herstellung eines thermoplastischen schaumes.
ATA240890A (de)	1996-03-15	Verfahren zur herstellung eines zwischenproduktes von diltiazem
DE3783690D1 (de)	1993-03-04	Verfahren zur herstellung eines kohlensaeureesters.
DE69107956D1 (de)	1995-04-13	Verfahren zur Herstellung eines Plastikschaumes.
DE3775835D1 (de)	1992-02-20	Verfahren zur herstellung eines buten-1-polymers.
ATE132535T1 (de)	1996-01-15	Verfahren zur diskontinuierlichen herstellung von l-carnitin auf mikrobiologischem weg
DE69503106D1 (de)	1998-07-30	Verfahren zur Herstellung von L-Ascorbinsäure
ATE146785T1 (de)	1997-01-15	Verfahren zur herstellung von diltiazem