ATE146785T1 - Verfahren zur herstellung von diltiazem - Google Patents
Verfahren zur herstellung von diltiazemInfo
- Publication number
- ATE146785T1 ATE146785T1 AT93116782T AT93116782T ATE146785T1 AT E146785 T1 ATE146785 T1 AT E146785T1 AT 93116782 T AT93116782 T AT 93116782T AT 93116782 T AT93116782 T AT 93116782T AT E146785 T1 ATE146785 T1 AT E146785T1
- Authority
- AT
- Austria
- Prior art keywords
- diltiazem
- producing
- producing diltiazem
- benzothiazepine
- chem
- Prior art date
Links
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 title abstract 2
- 229960004166 diltiazem Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- FHGWEHGZBUBQKL-UHFFFAOYSA-N 1,2-benzothiazepine Chemical compound S1N=CC=CC2=CC=CC=C12 FHGWEHGZBUBQKL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI922432A IT1255545B (it) | 1992-10-23 | 1992-10-23 | Procedimento per la preparazione di diltiazem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE146785T1 true ATE146785T1 (de) | 1997-01-15 |
Family
ID=11364158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93116782T ATE146785T1 (de) | 1992-10-23 | 1993-10-18 | Verfahren zur herstellung von diltiazem |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5495013A (de) |
| EP (1) | EP0594101B1 (de) |
| JP (1) | JP3531954B2 (de) |
| AT (1) | ATE146785T1 (de) |
| CA (1) | CA2108950A1 (de) |
| DE (1) | DE69306908T2 (de) |
| IL (1) | IL107246A (de) |
| IT (1) | IT1255545B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2576690B2 (ja) * | 1993-03-11 | 1997-01-29 | 日本電気株式会社 | ディジタル携帯電話機 |
| FI97725C (fi) * | 1995-02-17 | 1997-02-10 | Orion Yhtymae Oy | Menetelmä diltiatseemin valmistamiseksi |
| TW438787B (en) | 1997-02-27 | 2001-06-07 | Tanabe Seiyaku Co | Process for preparing optically active trans-3-substituted glycidic acid ester |
| CN103305583A (zh) * | 2012-03-12 | 2013-09-18 | 江苏华荣生物科技有限公司 | 简便化提取消旋对甲氧苯基缩水甘油酸甲酯 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562257A (en) * | 1967-10-28 | 1971-02-09 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
| JPS5899471A (ja) * | 1981-12-07 | 1983-06-13 | Tanabe Seiyaku Co Ltd | ベンゾチアゼピン誘導体の新規製造法 |
| US4902684A (en) * | 1988-06-20 | 1990-02-20 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
| US5002942A (en) * | 1988-07-25 | 1991-03-26 | Sankyo Company, Limited | 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders |
| IT1244878B (it) * | 1990-12-11 | 1994-09-12 | Lusochimica Spa | Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato |
-
1992
- 1992-10-23 IT ITMI922432A patent/IT1255545B/it active IP Right Grant
-
1993
- 1993-10-11 IL IL10724693A patent/IL107246A/en not_active IP Right Cessation
- 1993-10-18 EP EP93116782A patent/EP0594101B1/de not_active Expired - Lifetime
- 1993-10-18 AT AT93116782T patent/ATE146785T1/de active
- 1993-10-18 DE DE69306908T patent/DE69306908T2/de not_active Expired - Fee Related
- 1993-10-21 CA CA002108950A patent/CA2108950A1/en not_active Abandoned
- 1993-10-21 JP JP28563593A patent/JP3531954B2/ja not_active Expired - Fee Related
-
1994
- 1994-10-20 US US08/326,312 patent/US5495013A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL107246A (en) | 1999-11-30 |
| EP0594101A1 (de) | 1994-04-27 |
| US5495013A (en) | 1996-02-27 |
| ITMI922432A0 (it) | 1992-10-23 |
| JP3531954B2 (ja) | 2004-05-31 |
| JPH06228117A (ja) | 1994-08-16 |
| DE69306908D1 (de) | 1997-02-06 |
| IT1255545B (it) | 1995-11-09 |
| CA2108950A1 (en) | 1994-04-24 |
| DE69306908T2 (de) | 1997-05-07 |
| IL107246A0 (en) | 1994-01-25 |
| ITMI922432A1 (it) | 1994-04-23 |
| EP0594101B1 (de) | 1996-12-27 |
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