ATE164834T1 - Amidinophenolderivate mit phospholipase a2 inhibitorischer wirkung - Google Patents
Amidinophenolderivate mit phospholipase a2 inhibitorischer wirkungInfo
- Publication number
- ATE164834T1 ATE164834T1 AT94308932T AT94308932T ATE164834T1 AT E164834 T1 ATE164834 T1 AT E164834T1 AT 94308932 T AT94308932 T AT 94308932T AT 94308932 T AT94308932 T AT 94308932T AT E164834 T1 ATE164834 T1 AT E164834T1
- Authority
- AT
- Austria
- Prior art keywords
- phospholipase
- formula
- inhibitory effect
- pancreatitis
- chem
- Prior art date
Links
- IYELGEUXPAPULN-UHFFFAOYSA-N 2-hydroxybenzenecarboximidamide Chemical class NC(=N)C1=CC=CC=C1O IYELGEUXPAPULN-UHFFFAOYSA-N 0.000 title abstract 2
- 102100037611 Lysophospholipase Human genes 0.000 title abstract 2
- 108010058864 Phospholipases A2 Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 206010033645 Pancreatitis Diseases 0.000 abstract 2
- 208000034486 Multi-organ failure Diseases 0.000 abstract 1
- 208000010718 Multiple Organ Failure Diseases 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 208000009190 disseminated intravascular coagulation Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 abstract 1
- -1 nitro, benzoyl Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30404893 | 1993-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE164834T1 true ATE164834T1 (de) | 1998-04-15 |
Family
ID=17928422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94308932T ATE164834T1 (de) | 1993-12-03 | 1994-12-01 | Amidinophenolderivate mit phospholipase a2 inhibitorischer wirkung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5514713A (de) |
| EP (1) | EP0656349B1 (de) |
| KR (1) | KR0185678B1 (de) |
| CN (1) | CN1035998C (de) |
| AT (1) | ATE164834T1 (de) |
| CA (1) | CA2137106C (de) |
| DE (1) | DE69409471T2 (de) |
| DK (1) | DK0656349T3 (de) |
| ES (1) | ES2115887T3 (de) |
| TW (1) | TW419454B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69508875T2 (de) | 1994-09-20 | 1999-09-16 | Ono Pharmaceutical Co. Ltd., Osaka | Amidinophenol-Derivate als Protease-hemmende Verbindungen |
| EP0893437A4 (de) * | 1996-04-10 | 2000-12-27 | Ono Pharmaceutical Co | Tryptase-Inhibitor und Guanidino-Derivate |
| EP0942903A1 (de) | 1996-09-26 | 1999-09-22 | Novartis AG | Arylsubstituierte acrylamine mit leukotriene b4-(ltb-4)-rezeptor antagonistischer aktivität |
| US6849605B1 (en) * | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
| AU3731400A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
| AU3864000A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| WO2000051623A2 (en) | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
| US20040220242A1 (en) * | 2003-05-02 | 2004-11-04 | Leland Shapiro | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions |
| DK2520654T3 (en) | 2003-08-26 | 2017-05-01 | Univ Colorado Regents | Inhibitors of serine protease activity and their use in methods and compositions for the treatment of bacterial infections |
| US7671057B2 (en) * | 2004-11-08 | 2010-03-02 | Ono Pharmaceutical Co., Ltd. | Therapeutic agent for type II diabetes comprising protease-inhibiting compound |
| US20100063146A1 (en) * | 2006-11-07 | 2010-03-11 | Medof M Edward | Method for treating disorders related to complement activation |
| GB2445920A (en) * | 2007-01-25 | 2008-07-30 | Mucokinetica Ltd | Amidino compounds for treatment of respiratory disease |
| BRPI1011322A2 (pt) * | 2009-04-17 | 2018-09-18 | Merz Pharma Gmbh & Co Kgaa | 1-amino-1,3,3,5,5-pentametilciclohexano mesilato, seu processo de fabricação, suas partículas e seus cristais, uso de anisol ou uma mistura de anisol e pelo menos um dos solventes, e composição farmacêutica. |
| CN102225903B (zh) * | 2011-04-21 | 2014-11-26 | 任建东 | 脒基胍基取代芳杂环类化合物的合成方法及其用途 |
| CN102491921A (zh) * | 2011-12-13 | 2012-06-13 | 苏州瑞辉生物医药研发中心有限公司 | 一种4-胍基苯甲酸（4-甲氧甲酰基）苯酯甲烷磺酸盐的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE555319A (de) * | 1956-03-21 | 1900-01-01 | ||
| US3095355A (en) * | 1961-10-12 | 1963-06-25 | Revlon | Aerosol composition |
| GB2095239B (en) * | 1981-02-27 | 1985-03-06 | Torii & Co Ltd | Novel amidine compounds |
| JP3220225B2 (ja) * | 1992-04-10 | 2001-10-22 | 小野薬品工業株式会社 | グアニジノフェノール誘導体 |
-
1994
- 1994-12-01 AT AT94308932T patent/ATE164834T1/de not_active IP Right Cessation
- 1994-12-01 DE DE69409471T patent/DE69409471T2/de not_active Expired - Fee Related
- 1994-12-01 ES ES94308932T patent/ES2115887T3/es not_active Expired - Lifetime
- 1994-12-01 DK DK94308932.6T patent/DK0656349T3/da active
- 1994-12-01 CA CA002137106A patent/CA2137106C/en not_active Expired - Fee Related
- 1994-12-01 EP EP94308932A patent/EP0656349B1/de not_active Expired - Lifetime
- 1994-12-02 KR KR1019940032540A patent/KR0185678B1/ko not_active Expired - Fee Related
- 1994-12-02 US US08/352,723 patent/US5514713A/en not_active Expired - Fee Related
- 1994-12-03 CN CN94112793A patent/CN1035998C/zh not_active Expired - Fee Related
- 1994-12-09 TW TW083111456A patent/TW419454B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0656349B1 (de) | 1998-04-08 |
| KR950017929A (ko) | 1995-07-20 |
| EP0656349A1 (de) | 1995-06-07 |
| CN1035998C (zh) | 1997-10-01 |
| KR0185678B1 (ko) | 1999-05-15 |
| DK0656349T3 (da) | 1998-06-02 |
| CA2137106C (en) | 2000-02-08 |
| US5514713A (en) | 1996-05-07 |
| DE69409471D1 (de) | 1998-05-14 |
| DE69409471T2 (de) | 1998-08-27 |
| TW419454B (en) | 2001-01-21 |
| CN1110679A (zh) | 1995-10-25 |
| CA2137106A1 (en) | 1995-06-04 |
| ES2115887T3 (es) | 1998-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |