ATE164851T1 - Polyethylenglycol (peg)-protein addukte und prozess zu ihrer auftrennung - Google Patents
Polyethylenglycol (peg)-protein addukte und prozess zu ihrer auftrennungInfo
- Publication number
- ATE164851T1 ATE164851T1 AT89912002T AT89912002T ATE164851T1 AT E164851 T1 ATE164851 T1 AT E164851T1 AT 89912002 T AT89912002 T AT 89912002T AT 89912002 T AT89912002 T AT 89912002T AT E164851 T1 ATE164851 T1 AT E164851T1
- Authority
- AT
- Austria
- Prior art keywords
- peg
- polyethylene glycol
- separation
- protein adducts
- adducts
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/42—Flow patterns using counter-current
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Jellies, Jams, And Syrups (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyethers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888824591A GB8824591D0 (en) | 1988-10-20 | 1988-10-20 | Fractionation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE164851T1 true ATE164851T1 (de) | 1998-04-15 |
Family
ID=10645511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89912002T ATE164851T1 (de) | 1988-10-20 | 1989-10-20 | Polyethylenglycol (peg)-protein addukte und prozess zu ihrer auftrennung |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6384195B1 (de) |
| EP (4) | EP0727438A3 (de) |
| JP (2) | JP3195336B2 (de) |
| AT (1) | ATE164851T1 (de) |
| DE (1) | DE68928638T2 (de) |
| GB (1) | GB8824591D0 (de) |
| WO (1) | WO1990004606A1 (de) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8824591D0 (en) | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Fractionation process |
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| US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| US5336923A (en) * | 1992-12-31 | 1994-08-09 | Honeywell, Inc. | Varactor diode having a stepped capacitance-voltage profile |
| US5449720A (en) * | 1993-05-24 | 1995-09-12 | Biotech Australia Pty Limited | Amplification of the VB12 uptake system using polymers |
| GB9317618D0 (en) * | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
| US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
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| GEP20002180B (en) * | 1994-03-31 | 2000-07-25 | Amgen Inc | Composition and Methods for Stimulating Megakaryocyte Growth and Differentiation |
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| US20030053982A1 (en) | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
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| CA2739933A1 (en) | 2000-02-11 | 2001-08-16 | Bayer Healthcare Llc | Factor vii or viia-like molecules |
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| WO2002074806A2 (en) | 2001-02-27 | 2002-09-26 | Maxygen Aps | New interferon beta-like molecules |
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| US20090221496A1 (en) * | 2006-03-01 | 2009-09-03 | Keio University | novel antithrombotic agent |
| JP5033177B2 (ja) | 2006-04-12 | 2012-09-26 | サビエント ファーマセウティカルズ インク． | 陽イオン界面活性剤によるタンパク質の精製 |
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| JP2008069073A (ja) * | 2006-09-12 | 2008-03-27 | Yokohama Tlo Co Ltd | ラクトフェリン複合体及びその製造方法 |
| CN107501407B (zh) | 2007-03-30 | 2022-03-18 | Ambrx公司 | 经修饰fgf-21多肽和其用途 |
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| EA030886B1 (ru) | 2010-08-17 | 2018-10-31 | Амбркс, Инк. | Модифицированные полипептиды релаксина, содержащие некодируемую в природе аминокислоту, связанную с полимером, и их применение |
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| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| RU2014103288A (ru) | 2011-07-01 | 2015-08-10 | Байер Интеллектчуал Проперти Гмбх | Слитые полипептиды релаксина и их применение |
| EP2859017B1 (de) | 2012-06-08 | 2019-02-20 | Sutro Biopharma, Inc. | Antikörper mit nichtnatürlichen stellenspezifischen aminosäureresten, verfahren zu deren herstellung und verfahren zu deren verwendung |
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| EP2890402B1 (de) | 2012-08-31 | 2019-04-17 | Sutro Biopharma, Inc. | Modifizierte aminosäuren mit einer azidogruppe |
| MY186423A (en) * | 2013-03-05 | 2021-07-22 | Hanmi Pharm Ind Co Ltd | Improved preparation method for high-yield production of physiologically active polypeptide conjugate |
| WO2015006555A2 (en) | 2013-07-10 | 2015-01-15 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| EP3055298B1 (de) | 2013-10-11 | 2020-04-29 | Sutro Biopharma, Inc. | Modifizierte aminosäuren mit funktionellen tetrazingruppen, verfahren zur herstellung und verfahren zu deren verwendung |
| CN114805532A (zh) | 2014-10-24 | 2022-07-29 | 百时美施贵宝公司 | 修饰的fgf-21多肽及其用途 |
| CN116637177A (zh) | 2016-11-11 | 2023-08-25 | 好利恩治疗美国公司 | 泼尼松和尿酸酶分子的组合疗法及其用途 |
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| JP2022512746A (ja) | 2018-10-19 | 2022-02-07 | アンブルックス，インコーポレイテッド | インターロイキン－１０ポリペプチド複合体、その二量体、およびそれらの使用 |
| CN109030669A (zh) * | 2018-10-31 | 2018-12-18 | 苏州赛分科技有限公司 | 一种分离peg修饰蛋白样品中游离peg的高效液相色谱方法 |
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| CN112394115A (zh) * | 2019-08-19 | 2021-02-23 | 鲁南制药集团股份有限公司 | 一种聚乙二醇化重组粒细胞刺激因子peg俢饰度的检测方法 |
| EP4117732A1 (de) | 2020-03-11 | 2023-01-18 | Ambrx, Inc. | Interleukin-2-polypeptidkonjugate und verfahren zur verwendung davon |
| JP2023538071A (ja) | 2020-08-20 | 2023-09-06 | アンブルックス，インコーポレイテッド | 抗体－ｔｌｒアゴニストコンジュゲート、その方法及び使用 |
| CA3213805A1 (en) | 2021-04-03 | 2022-10-06 | Feng Tian | Anti-her2 antibody-drug conjugates and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4415665A (en) | 1980-12-12 | 1983-11-15 | Pharmacia Fine Chemicals Ab | Method of covalently binding biologically active organic substances to polymeric substances |
| DE3380726D1 (en) * | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
| JPS58225025A (ja) * | 1982-06-24 | 1983-12-27 | Nippon Chem Res Kk | 効力持続性組成物 |
| WO1985003934A1 (fr) * | 1984-03-06 | 1985-09-12 | Takeda Chemical Industries, Ltd. | Proteine modifiee chimiquement et son procede de preparation |
| DE3572982D1 (en) * | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
| US4758512A (en) | 1984-03-06 | 1988-07-19 | President And Fellows Of Harvard College | Hosts and methods for producing recombinant products in high yields |
| US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| SE462100B (sv) * | 1985-08-08 | 1990-05-07 | Perstorp Ab | Komposition och dess anvaendning i ett tvaa- eller flerfassystem |
| US5078996A (en) * | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
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| GB8824591D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Fractionation process |
| US5349052A (en) * | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
| US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
-
1988
- 1988-10-20 GB GB888824591A patent/GB8824591D0/en active Pending
-
1989
- 1989-10-20 DE DE68928638T patent/DE68928638T2/de not_active Expired - Fee Related
- 1989-10-20 WO PCT/GB1989/001261 patent/WO1990004606A1/en not_active Ceased
- 1989-10-20 EP EP96105185A patent/EP0727438A3/de not_active Withdrawn
- 1989-10-20 JP JP51118589A patent/JP3195336B2/ja not_active Expired - Fee Related
- 1989-10-20 AT AT89912002T patent/ATE164851T1/de not_active IP Right Cessation
- 1989-10-20 EP EP89912002A patent/EP0439508B1/de not_active Expired - Lifetime
- 1989-10-20 EP EP96105184A patent/EP0727437A3/de not_active Withdrawn
- 1989-10-20 EP EP03003388A patent/EP1316562A3/de not_active Withdrawn
-
1999
- 1999-01-21 US US09/234,493 patent/US6384195B1/en not_active Expired - Fee Related
- 1999-01-25 JP JP11016055A patent/JPH11315098A/ja active Pending
-
2002
- 2002-03-12 US US10/094,995 patent/US20020127244A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0727438A3 (de) | 1997-03-05 |
| JPH11315098A (ja) | 1999-11-16 |
| JPH04501260A (ja) | 1992-03-05 |
| GB8824591D0 (en) | 1988-11-23 |
| EP0727437A2 (de) | 1996-08-21 |
| EP0439508B1 (de) | 1998-04-08 |
| EP1316562A3 (de) | 2003-12-17 |
| JP3195336B2 (ja) | 2001-08-06 |
| US20020127244A1 (en) | 2002-09-12 |
| EP0727438A2 (de) | 1996-08-21 |
| DE68928638D1 (de) | 1998-05-14 |
| WO1990004606A1 (en) | 1990-05-03 |
| EP1316562A2 (de) | 2003-06-04 |
| US6384195B1 (en) | 2002-05-07 |
| EP0727437A3 (de) | 1997-01-08 |
| DE68928638T2 (de) | 1998-08-20 |
| EP0439508A1 (de) | 1991-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |