ATE165092T1 - Thiazolidinederivate, die eine quinone-gruppe enthalten, ihre herstellung und therapeutische anwendung - Google Patents

Thiazolidinederivate, die eine quinone-gruppe enthalten, ihre herstellung und therapeutische anwendung

Info

Publication number: ATE165092T1
Authority: AT; Austria
Prior art keywords: preparation; therapeutic use; derivatives containing; thiazolidine derivatives; quinone group
Prior art date: 1991-12-26

Application number

AT92311814T

Other languages

English (en)

Inventor

Takao Yoshioka

Takahide Nishi

Tsutomu Kanai

Yuichi Aizawa

Kunio Wada

Takashi Fujita

Hiroyoshi Horikoshi

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-26

Filing date

1992-12-24

Publication date

1998-05-15

1992-12-24 Application filed by Sankyo Co filed Critical Sankyo Co

1998-05-15 Application granted granted Critical

1998-05-15 Publication of ATE165092T1 publication Critical patent/ATE165092T1/de

Links

230000001225 therapeutic effect Effects 0.000 title abstract 2
OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical class C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 title 1
AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical group O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000003178 anti-diabetic effect Effects 0.000 abstract 1
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92311814T 1991-12-26 1992-12-24 Thiazolidinederivate, die eine quinone-gruppe enthalten, ihre herstellung und therapeutische anwendung ATE165092T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP34457091		1991-12-26

Publications (1)

Publication Number	Publication Date
ATE165092T1 true ATE165092T1 (de)	1998-05-15

Family

ID=18370296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92311814T ATE165092T1 (de)	1991-12-26	1992-12-24	Thiazolidinederivate, die eine quinone-gruppe enthalten, ihre herstellung und therapeutische anwendung

Country Status (23)

Country	Link
US (1)	US5338855A (de)
EP (1)	EP0549366B1 (de)
JP (1)	JP2833948B2 (de)
KR (1)	KR100198183B1 (de)
CN (1)	CN1033639C (de)
AT (1)	ATE165092T1 (de)
AU (1)	AU654222B2 (de)
CA (1)	CA2086179C (de)
CZ (1)	CZ279917B6 (de)
DE (1)	DE69225123T2 (de)
DK (1)	DK0549366T3 (de)
ES (1)	ES2115650T3 (de)
FI (1)	FI925848A7 (de)
GR (1)	GR3026656T3 (de)
HK (1)	HK1007050A1 (de)
HU (1)	HU215448B (de)
IL (1)	IL104237A (de)
MX (1)	MX9207594A (de)
NO (1)	NO302519B1 (de)
NZ (1)	NZ245611A (de)
RU (1)	RU2103265C1 (de)
TW (1)	TW211008B (de)
ZA (1)	ZA9210020B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO302471B1 (no) *	1991-12-26	1998-03-09	Sankyo Co	Tiazolidinforbindelser og farmasöytisk preparat
CZ289317B6 (cs) *	1994-04-11	2002-01-16	Sankyo Company Limited	Heterocyklická sloučenina, farmaceutický prostředek ji obsahující a její pouľití
CZ293016B6 (cs) *	1995-06-01	2004-01-14	Sankyo Company Limited	Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem
US6147101A (en) *	1995-06-02	2000-11-14	Kyorin Pharmaceutical Co., Ltd.	N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same
JP3144624B2 (ja) *	1995-06-02	2001-03-12	杏林製薬株式会社	Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
US6001862A (en) *	1995-06-02	1999-12-14	Kyorin Pharameuticals Co., Ltd.	N-benzyldioxothiazolidylbenzamide derivatives and processes for preparing the same
EP0783888A1 (de)	1995-12-26	1997-07-16	Sankyo Company Limited	Verwendung von Troglitazone und verwandten Thiazolidinedionen zur Herstellung eines Medikaments für die Behandlung und Vorbeugung der Osteoporose
JPH10338679A (ja) *	1997-04-08	1998-12-22	Mitsubishi Rayon Co Ltd	チアゾリジン誘導体の製造方法
US6414123B1 (en) *	1997-10-21	2002-07-02	Vitro Diagnostics, Inc.	Method for purifying FSH
US6077849A (en) *	1998-04-02	2000-06-20	Merck & Co., Inc.	Antidiabetic agents
US6028088A (en) *	1998-10-30	2000-02-22	The University Of Mississippi	Flavonoid derivatives
US6204288B1 (en)	1999-03-08	2001-03-20	The University Of Mississippi	1,2-dithiolane derivatives
US6127394A (en) *	1999-03-08	2000-10-03	The University Of Mississippi	1,2-Dithiolane derivatives
EP1253145B1 (de) *	2000-02-01	2006-09-20	Kyorin Pharmaceutical Co., Ltd.	Alkalimetallsalz von thiazolidin-2,4-dion-derivaten
CN1839142B (zh)	2003-08-22	2010-06-16	澳新制药公司	用作靶向线粒体的抗氧化剂的线粒体醌衍生物
US7888334B2 (en)	2003-08-22	2011-02-15	Antipodean Pharmaceuticals, Inc.	Mitoquinone derivatives used as mitochondrially targeted antioxidants

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4725010A (en) *	1986-07-18	1988-02-16	Essex Group, Inc.	Control apparatus and method
JPS5522636A (en) *	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
JPS6051189A (ja) *	1983-08-30	1985-03-22	Sankyo Co Ltd	チアゾリジン誘導体およびその製造法
US5130379A (en) *	1988-03-08	1992-07-14	Pfizer Inc.	Hypoglycemic thiazolidinedione derivatives
US5120754A (en) *	1988-03-08	1992-06-09	Pfizer Inc.	Thiazolidinedione hypoglycemic agents
GB8910639D0 (en) *	1989-05-09	1989-06-21	Beecham Group Plc	Novel compounds
GB8919434D0 (en) *	1989-08-25	1989-10-11	Beecham Group Plc	Novel compounds
US5143930A (en) *	1990-02-07	1992-09-01	Sankyo Company, Limited	Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
NO302471B1 (no) *	1991-12-26	1998-03-09	Sankyo Co	Tiazolidinforbindelser og farmasöytisk preparat

1992
- 1992-12-22 NO NO924988A patent/NO302519B1/no not_active IP Right Cessation
- 1992-12-23 CA CA002086179A patent/CA2086179C/en not_active Expired - Fee Related
- 1992-12-23 ZA ZA9210020A patent/ZA9210020B/xx unknown
- 1992-12-23 FI FI925848A patent/FI925848A7/fi unknown
- 1992-12-23 HU HUP9204121A patent/HU215448B/hu not_active IP Right Cessation
- 1992-12-23 NZ NZ245611A patent/NZ245611A/en unknown
- 1992-12-24 AT AT92311814T patent/ATE165092T1/de not_active IP Right Cessation
- 1992-12-24 AU AU30429/92A patent/AU654222B2/en not_active Ceased
- 1992-12-24 EP EP92311814A patent/EP0549366B1/de not_active Expired - Lifetime
- 1992-12-24 DE DE69225123T patent/DE69225123T2/de not_active Expired - Fee Related
- 1992-12-24 DK DK92311814T patent/DK0549366T3/da active
- 1992-12-24 TW TW081110380A patent/TW211008B/zh active
- 1992-12-24 KR KR1019920025528A patent/KR100198183B1/ko not_active Expired - Fee Related
- 1992-12-24 ES ES92311814T patent/ES2115650T3/es not_active Expired - Lifetime
- 1992-12-25 RU RU92016230A patent/RU2103265C1/ru active
- 1992-12-25 JP JP4346121A patent/JP2833948B2/ja not_active Expired - Fee Related
- 1992-12-25 IL IL10423792A patent/IL104237A/en not_active IP Right Cessation
- 1992-12-26 CN CN92113835A patent/CN1033639C/zh not_active Expired - Fee Related
- 1992-12-28 MX MX9207594A patent/MX9207594A/es not_active IP Right Cessation
- 1992-12-28 US US07/997,210 patent/US5338855A/en not_active Expired - Fee Related
- 1992-12-28 CZ CS923896A patent/CZ279917B6/cs not_active IP Right Cessation
1998
- 1998-04-15 GR GR980400859T patent/GR3026656T3/el unknown
- 1998-06-23 HK HK98106107A patent/HK1007050A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK0549366T3 (da)	1999-03-08
AU3042992A (en)	1993-07-01
DE69225123T2 (de)	1998-12-24
DE69225123D1 (de)	1998-05-20
NO302519B1 (no)	1998-03-16
RU2103265C1 (ru)	1998-01-27
KR100198183B1 (ko)	1999-06-15
CZ389692A3 (en)	1994-01-19
HU9204121D0 (en)	1993-04-28
EP0549366B1 (de)	1998-04-15
NO924988L (no)	1993-06-28
NO924988D0 (no)	1992-12-22
HUT67704A (en)	1995-04-28
EP0549366A1 (de)	1993-06-30
FI925848A7 (fi)	1993-06-27
JPH05255288A (ja)	1993-10-05
MX9207594A (es)	1994-06-30
FI925848A0 (fi)	1992-12-23
CA2086179A1 (en)	1993-06-27
ZA9210020B (en)	1993-07-02
TW211008B (de)	1993-08-11
NZ245611A (en)	1994-06-27
CN1074679A (zh)	1993-07-28
JP2833948B2 (ja)	1998-12-09
ES2115650T3 (es)	1998-07-01
AU654222B2 (en)	1994-10-27
CN1033639C (zh)	1996-12-25
CA2086179C (en)	2000-10-17
HK1007050A1 (en)	1999-03-26
GR3026656T3 (en)	1998-07-31
HU215448B (hu)	1999-04-28
IL104237A (en)	1996-10-16
US5338855A (en)	1994-08-16
CZ279917B6 (cs)	1995-08-16

Legal Events

Date	Code	Title	Description
1998-11-15	UEP	Publication of translation of european patent specification
2002-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69225123D1 (de)	1998-05-20	Thiazolidinederivate, die eine Quinone-Gruppe enthalten, ihre Herstellung und therapeutische Anwendung
DE69204041D1 (de)	1995-09-14	Thiazolidinverbindeungen, deren Herstellung und therapeutische Verwendung.
DE69004815D1 (de)	1994-01-13	1,8-Benzonaphthyridinderivate, ihre Herstellung und diese enthaltende Zusammensetzungen.
ES551274A0 (es)	1988-04-01	Un procedimiento para la sintesis de derivados de imidazol.
DE69222459D1 (de)	1997-11-06	Thiazolidindionderivate, ihre Herstellung und Anwendung
RU92016230A (ru)	1995-06-19	Тиазолидиновые соединения, фармацевтическая композиция, способ лечения и способы получения соединений
NZ246598A (en)	1997-08-22	Trazodone derivatives; compounds and preparation, pharmaceutical compositions; intermediate compounds
ATE98960T1 (de)	1994-01-15	1,8-benzonaphthyridinderivate, ihre herstellung und diese enthaltende zusammensetzungen.
ATE52504T1 (de)	1990-05-15	Aroylsubstituierte dihydro-1,4-thiazine.
ES2044883T3 (es)	1994-01-16	Procedimiento para preparar quinoxalinas sustituidas.
IL79280A (en)	1990-07-12	4-(6-oxo-dihydro or tetrahydropyridazin-3-yl)benzene derivatives,their preparation and pharmaceutical compositions containing them
ATE126504T1 (de)	1995-09-15	1-phenoxycarbonyl-2-pyrrolidon-derivate und nootrope wirkstoffe.