MX9207594A - Compuestos de tiazolidina que contienen un grupo de quinona, su preparacion y sus usos terapeuticos. - Google Patents

Compuestos de tiazolidina que contienen un grupo de quinona, su preparacion y sus usos terapeuticos.

Info

Publication number
MX9207594A
MX9207594A MX9207594A MX9207594A MX9207594A MX 9207594 A MX9207594 A MX 9207594A MX 9207594 A MX9207594 A MX 9207594A MX 9207594 A MX9207594 A MX 9207594A MX 9207594 A MX9207594 A MX 9207594A
Authority
MX
Mexico
Prior art keywords
quinone
preparation
group
compounds containing
therapeutic uses
Prior art date
Application number
MX9207594A
Other languages
English (en)
Inventor
Yuichi Aizawa
Kunio Wada
Takashi Fujita
Hiroyoshi Horikoshi
Takao Yoshioka
Takahide Nishi
Tsutomu Kanat
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of MX9207594A publication Critical patent/MX9207594A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Los compuestos de la fórmula (I) en la que R2 y R3 son cada uno alquilo o alcoxi, o R2 y R3 juntos forman un anillo de benceno opcionalmente substituido y cuando R2 y R3 juntos forman dicho anillo de benceno, R1 es hidrógeno, halógeno o alquilo; R4 y R5 ambos representan hidrógeno, o juntos representan una ligadura sencilla carbono-carbono; W es una ligadura sencilla o alquileno; y Z es un átomo de hidrógeno o un catión tienen actividades terapéuticas y profilácticas valiosas, incluyendo actividades antidiabéticas.
MX9207594A 1991-12-26 1992-12-28 Compuestos de tiazolidina que contienen un grupo de quinona, su preparacion y sus usos terapeuticos. MX9207594A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34457091 1991-12-26

Publications (1)

Publication Number Publication Date
MX9207594A true MX9207594A (es) 1994-06-30

Family

ID=18370296

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9207594A MX9207594A (es) 1991-12-26 1992-12-28 Compuestos de tiazolidina que contienen un grupo de quinona, su preparacion y sus usos terapeuticos.

Country Status (23)

Country Link
US (1) US5338855A (es)
EP (1) EP0549366B1 (es)
JP (1) JP2833948B2 (es)
KR (1) KR100198183B1 (es)
CN (1) CN1033639C (es)
AT (1) ATE165092T1 (es)
AU (1) AU654222B2 (es)
CA (1) CA2086179C (es)
CZ (1) CZ279917B6 (es)
DE (1) DE69225123T2 (es)
DK (1) DK0549366T3 (es)
ES (1) ES2115650T3 (es)
FI (1) FI925848A7 (es)
GR (1) GR3026656T3 (es)
HK (1) HK1007050A1 (es)
HU (1) HU215448B (es)
IL (1) IL104237A (es)
MX (1) MX9207594A (es)
NO (1) NO302519B1 (es)
NZ (1) NZ245611A (es)
RU (1) RU2103265C1 (es)
TW (1) TW211008B (es)
ZA (1) ZA9210020B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO302471B1 (no) * 1991-12-26 1998-03-09 Sankyo Co Tiazolidinforbindelser og farmasöytisk preparat
NO305987B1 (no) * 1994-04-11 1999-08-30 Sankyo Co Heterosykliske forbindelser med antidiabetisk aktivitet, deres anvendelse og farmasoeytisk preparat inneholdende disse
CZ293016B6 (cs) * 1995-06-01 2004-01-14 Sankyo Company Limited Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem
US6147101A (en) * 1995-06-02 2000-11-14 Kyorin Pharmaceutical Co., Ltd. N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same
JP3144624B2 (ja) * 1995-06-02 2001-03-12 杏林製薬株式会社 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
US6001862A (en) * 1995-06-02 1999-12-14 Kyorin Pharameuticals Co., Ltd. N-benzyldioxothiazolidylbenzamide derivatives and processes for preparing the same
EP0783888A1 (en) * 1995-12-26 1997-07-16 Sankyo Company Limited Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis
JPH10338679A (ja) * 1997-04-08 1998-12-22 Mitsubishi Rayon Co Ltd チアゾリジン誘導体の製造方法
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
US6077849A (en) * 1998-04-02 2000-06-20 Merck & Co., Inc. Antidiabetic agents
US6028088A (en) * 1998-10-30 2000-02-22 The University Of Mississippi Flavonoid derivatives
US6127394A (en) * 1999-03-08 2000-10-03 The University Of Mississippi 1,2-Dithiolane derivatives
US6204288B1 (en) 1999-03-08 2001-03-20 The University Of Mississippi 1,2-dithiolane derivatives
AU2001228854A1 (en) * 2000-02-01 2001-08-14 Kyorin Pharmaceutical Co. Ltd. Alkali metal salt of thiazolidine-2,4-dione derivative
US7888334B2 (en) 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
KR101003960B1 (ko) 2003-08-22 2010-12-30 안티포딘 파마슈티칼스, 인코포레이티드 미토콘드리아 표적화 산화방지제로서 사용되는 미토퀴논 유도체를 포함하는 약제학적 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725010A (en) * 1986-07-18 1988-02-16 Essex Group, Inc. Control apparatus and method
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
US5130379A (en) * 1988-03-08 1992-07-14 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US5120754A (en) * 1988-03-08 1992-06-09 Pfizer Inc. Thiazolidinedione hypoglycemic agents
GB8910639D0 (en) * 1989-05-09 1989-06-21 Beecham Group Plc Novel compounds
GB8919434D0 (en) * 1989-08-25 1989-10-11 Beecham Group Plc Novel compounds
US5143930A (en) * 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
NO302471B1 (no) * 1991-12-26 1998-03-09 Sankyo Co Tiazolidinforbindelser og farmasöytisk preparat

Also Published As

Publication number Publication date
NO924988L (no) 1993-06-28
CZ389692A3 (en) 1994-01-19
ES2115650T3 (es) 1998-07-01
DE69225123T2 (de) 1998-12-24
FI925848A0 (fi) 1992-12-23
JP2833948B2 (ja) 1998-12-09
HUT67704A (en) 1995-04-28
IL104237A (en) 1996-10-16
GR3026656T3 (en) 1998-07-31
CZ279917B6 (cs) 1995-08-16
ZA9210020B (en) 1993-07-02
HU215448B (hu) 1999-04-28
DE69225123D1 (de) 1998-05-20
FI925848A7 (fi) 1993-06-27
CA2086179C (en) 2000-10-17
RU2103265C1 (ru) 1998-01-27
CN1033639C (zh) 1996-12-25
NO924988D0 (no) 1992-12-22
AU654222B2 (en) 1994-10-27
KR100198183B1 (ko) 1999-06-15
CA2086179A1 (en) 1993-06-27
EP0549366A1 (en) 1993-06-30
DK0549366T3 (da) 1999-03-08
HK1007050A1 (en) 1999-03-26
HU9204121D0 (en) 1993-04-28
JPH05255288A (ja) 1993-10-05
US5338855A (en) 1994-08-16
EP0549366B1 (en) 1998-04-15
NO302519B1 (no) 1998-03-16
TW211008B (es) 1993-08-11
AU3042992A (en) 1993-07-01
ATE165092T1 (de) 1998-05-15
NZ245611A (en) 1994-06-27
CN1074679A (zh) 1993-07-28

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees