ATE165T1 - Fluoren- und fluoranthenderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. - Google Patents

Fluoren- und fluoranthenderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Info

Publication number: ATE165T1
Authority: AT; Austria
Prior art keywords: alkyl; radical; hydrogen atom; fluorene; processes
Prior art date: 1978-07-28

Application number

AT79400459T

Other languages

German (de)

English (en)

Inventor

Regis Dupont

Patrick Andre Louis Lardenois

Claude Constant Henri Morel

Jonathan Reid Frost

Gabor Itsvan Koletar

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-07-28

Filing date

1979-07-05

Publication date

1981-09-15

1978-07-28 Priority claimed from FR7822352A external-priority patent/FR2432025A1/fr

1978-07-28 Priority claimed from FR7822353A external-priority patent/FR2432026A1/fr

1979-07-05 Application filed by Synthelabo filed Critical Synthelabo

1981-09-15 Application granted granted Critical

1981-09-15 Publication of ATE165T1 publication Critical patent/ATE165T1/de

Links

NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 title 2
GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthene Chemical class C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000002252 acyl group Chemical group 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
206010002660 Anoxia Diseases 0.000 abstract 1
206010021143 Hypoxia Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000006307 alkoxy benzyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000006177 alkyl benzyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002219 fluoranthenes Chemical class 0.000 abstract 1
150000002220 fluorenes Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
-1 halogenobenzyl Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000004089 psychotropic agent Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT79400459T 1978-07-28 1979-07-05 Fluoren- und fluoranthenderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. ATE165T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR7822352A FR2432025A1 (fr)	1978-07-28	1978-07-28	Derives d'imidazo et de pyrimido-pyrido-indoles, leur preparation et leur application en therapeutique
FR7822353A FR2432026A1 (fr)	1978-07-28	1978-07-28	Derives de fluorenes et de fluoranthenes et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
ATE165T1 true ATE165T1 (de)	1981-09-15

Family

ID=26220699

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT79400459T ATE165T1 (de)	1978-07-28	1979-07-05	Fluoren- und fluoranthenderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Country Status (13)

Country	Link
US (1)	US4277476A (fr)
EP (1)	EP0008249B1 (fr)
AT (1)	ATE165T1 (fr)
AU (1)	AU524307B2 (fr)
CA (1)	CA1107729A (fr)
DE (1)	DE2960689D1 (fr)
DK (1)	DK316279A (fr)
ES (1)	ES482889A1 (fr)
FI (1)	FI65250C (fr)
GR (1)	GR75070B (fr)
NO (1)	NO792476L (fr)
NZ (1)	NZ191141A (fr)
PT (1)	PT69988A (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2455044A1 (fr) *	1979-04-26	1980-11-21	Synthelabo	Pyrido-indoles et leur application en therapeutique
US4367230A (en) *	1980-01-04	1983-01-04	Tanabe Seiyaku Co., Ltd.	Novel triazafluoranthene compound and processes for preparing the same
US4428880A (en)	1981-05-04	1984-01-31	S.A. Omnichem	Azepino[4,5-d]indole derivatives and preparation thereof
GB2184685B (en) *	1985-12-19	1989-10-11	Braas & Co Gmbh	Plastically deformable sheet material
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
US7767689B2 (en)	2004-03-15	2010-08-03	Ptc Therapeutics, Inc.	Carboline derivatives useful in the treatment of cancer
EA201200555A1 (ru)	2004-03-15	2013-01-30	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Производные карболина, полезные в ингибировании ангиогенеза
US8076353B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
US8076352B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
KR20090071598A (ko)	2006-09-18	2009-07-01	랩터 파마슈티컬 인코포레이티드	수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
EP2398500B1 (fr)	2009-02-20	2019-03-13	2-BBB Medicines B.V.	Sustème d'administration de médicament à base de glutathionne
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2556574A (en) *	1949-06-24	1951-06-12	Allen & Hanburys Ltd	Indolopteridines and process for preparing same
US3108108A (en) *	1959-09-25	1963-10-22	Bayer Ag	Aza analogues of polynuclear o-quinones
US3122544A (en) *	1962-11-13	1964-02-25	American Home Prod	4-amino-2-aryl-6h-indeno(2, 3-g)-pteridin-6-ones
US3470181A (en) *	1967-10-23	1969-09-30	American Home Prod	Fused 2-pyrimidinepropionic acid compounds,related compounds,and the process for their preparation
US3631046A (en) *	1969-05-28	1971-12-28	Sandoz Ag	Tetracyclic quinazolin-ones
BE759337A (fr) *	1969-11-24	1971-05-24	Lilly Co Eli	Benzimidazol (2,1-b)-quinazolin (6h) ones qui sont des immuno-depresseurs, et nouvelles benzimidazo (2,1-b) quinazolin-12-(6h) ones
US3963720A (en) *	1972-10-27	1976-06-15	Sandoz, Inc.	Tetracyclic imidazo [2,1-b] quinazolinone derivatives
CH601299A5 (en) *	1973-11-07	1978-07-14	Vni Khim Farmatsevtichesky I I	Pyrazino(1,2,3-ab)beta carbolines and homologues

1979
- 1979-07-05 EP EP79400459A patent/EP0008249B1/fr not_active Expired
- 1979-07-05 AT AT79400459T patent/ATE165T1/de not_active IP Right Cessation
- 1979-07-05 DE DE7979400459T patent/DE2960689D1/de not_active Expired
- 1979-07-26 NO NO792476A patent/NO792476L/no unknown
- 1979-07-26 AU AU49278/79A patent/AU524307B2/en not_active Ceased
- 1979-07-26 PT PT69988A patent/PT69988A/fr unknown
- 1979-07-26 CA CA332,589A patent/CA1107729A/fr not_active Expired
- 1979-07-26 US US06/060,857 patent/US4277476A/en not_active Expired - Lifetime
- 1979-07-26 DK DK316279A patent/DK316279A/da not_active Application Discontinuation
- 1979-07-27 ES ES482889A patent/ES482889A1/es not_active Expired
- 1979-07-27 NZ NZ191141A patent/NZ191141A/xx unknown
- 1979-07-27 FI FI792366A patent/FI65250C/fi not_active IP Right Cessation
1981
- 1981-01-05 GR GR59709A patent/GR75070B/el unknown

Also Published As

Publication number	Publication date
NZ191141A (en)	1983-02-15
GR75070B (fr)	1984-07-13
PT69988A (fr)	1979-08-01
FI792366A7 (fi)	1980-01-29
FI65250C (fi)	1984-04-10
CA1107729A (fr)	1981-08-25
EP0008249A3 (en)	1980-05-14
ES482889A1 (es)	1980-04-16
EP0008249A2 (fr)	1980-02-20
FI65250B (fi)	1983-12-30
EP0008249B1 (fr)	1981-08-26
DE2960689D1 (en)	1981-11-19
AU4927879A (en)	1980-01-31
DK316279A (da)	1980-01-29
NO792476L (no)	1980-01-29
US4277476A (en)	1981-07-07
AU524307B2 (en)	1982-09-09

Similar Documents

Publication	Publication Date	Title
DE2960689D1 (en)	1981-11-19	Fluorene and fluoranthene derivatives, process for their preparation and their therapeutic application
FI930602A0 (fi)	1993-02-11	Ortosubstituerade bensoylguanidiner, foerfarande foer framstaellning av dessa, anvaendning av dessa som laekemedel eller diagnostiska aemnen samt laekemedel innehaollande desamma
ATE57699T1 (de)	1990-11-15	Pyridoncarbonsauere-derivate und verfahren zu ihrer herstellung.
ATE74352T1 (de)	1992-04-15	Dekahydrochinolinderivate, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zubereitungen.
GR3002415T3 (en)	1992-12-30	Esters of cyclopropanecarboxylic acids related to pyrethric acid, process for their preparation and their use as parasiticides
ZA816259B (en)	1983-04-27	2-(1,4-benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
ATE27806T1 (de)	1987-07-15	Norbornan- und norbornencarbonsaeureamide und verfahren zu deren herstellung.
DE3870167D1 (de)	1992-05-21	N-(vinblastinoyl-23)-derivate von 1-aminomethylposphonsaeure, verfahren zu ihrer herstellung und sie enthaltende arzneimittel.
NO161620C (no)	1989-09-06	Analogifremgangsm te for fremstilling av terapeutisk aktive 8-alkyltio-2-piperazino-pyrimido(5,4-d)pyrimidin-derivater.
ATE14424T1 (de)	1985-08-15	Imidazolidin-derivate, verfahren zu deren herstellung und therapeutische anwendung.
ES470916A1 (es)	1979-10-01	un procedimiento para la preparacion de derivados de acidos4-hidroxi-2-quinolinon-3-carboxilicos
FI823194L (fi)	1983-03-17	Foerfarande foer framstaellning av 2-amino-1,2,3,4-tetrohydronaftalenderivat
ATE46156T1 (de)	1989-09-15	1,3-benzoxathiol-derivate, deren verwendung und deren herstellung.
ES8504180A1 (es)	1985-04-01	Procedimiento para preparar nuevos derivados de piperidina
ATE70838T1 (de)	1992-01-15	Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung.
ATE10370T1 (de)	1984-12-15	Benzothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung.
SE8204791D0 (sv)	1982-08-20	Process for preparing alkoxy-vincaminic acid esters and alkoxy-apovincaminic acid esters
ES8702909A1 (es)	1987-01-16	Un procedimiento para la prepparacion de un derivado de tetrahidro-b-carbolina.
SE7901707L (sv)	1979-08-28	2-betoxibensamider
DE3776171D1 (de)	1992-03-05	1-styrensulfonyl-2-oxo-5-hydroxy-pyrrolidine, ihre vorprodukte und verfahren zur herstellung, sie enthaltende zusammensetzungen und ihre anwendung als heilmittel.
HUT42459A (en)	1987-07-28	Process for production of optically active derivatives of asole
ATE2222T1 (de)	1983-01-15	Digoxin-derivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
SE7905025L (sv)	1979-12-10	Tereftalsyramonoamidderivat, forfarande for framstellning derav och antiallergiskt medel
ATE292T1 (de)	1981-10-15	Spiro-derivate von 3-(3,5 -dihalogenphenyl)-oxazolidin-2-thion-4-onen, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide.
FI951834L (fi)	1995-04-18	19,11 -sillan käsittäviä steroideja

Legal Events

Date	Code	Title
1982-05-15	UEP	Publication of translation of european patent specification
1985-04-15	REN	Ceased due to non-payment of the annual fee
1985-05-15	REN	Ceased due to non-payment of the annual fee