ATE166652T1 - Isolierung und struktur von spongistatin 1 und dessen verwendung als antitumor-mittel - Google Patents

Isolierung und struktur von spongistatin 1 und dessen verwendung als antitumor-mittel

Info

Publication number: ATE166652T1
Authority: AT; Austria
Prior art keywords: spongistatin; found; isolation; antitumor agent; tci50
Prior art date: 1993-01-19

Application number

AT94300362T

Other languages

English (en)

Inventor

George R Pettit

Cherry L Herald

Zbigniew A Cichacz

Original Assignee

Univ Arizona

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-19

Filing date

1994-01-19

Publication date

1998-06-15

1994-01-19 Application filed by Univ Arizona filed Critical Univ Arizona

1998-06-15 Application granted granted Critical

1998-06-15 Publication of ATE166652T1 publication Critical patent/ATE166652T1/de

Links

ICXJVZHDZFXYQC-UHFFFAOYSA-N spongistatin 1 Natural products OC1C(O2)(O)CC(O)C(C)C2CCCC=CC(O2)CC(O)CC2(O2)CC(OC)CC2CC(=O)C(C)C(OC(C)=O)C(C)C(=C)CC(O2)CC(C)(O)CC2(O2)CC(OC(C)=O)CC2CC(=O)OC2C(O)C(CC(=C)CC(O)C=CC(Cl)=C)OC1C2C ICXJVZHDZFXYQC-UHFFFAOYSA-N 0.000 title abstract 2
HAOCRCFHEPRQOY-JKTUOYIXSA-N spongistatin-1 Chemical compound C([C@@H]1C[C@@H](C[C@@]2(C[C@@H](O)C[C@@H](C2)\C=C/CCC[C@@H]2[C@H](C)[C@@H](O)C[C@](O2)(O)[C@H]2O)O1)OC)C(=O)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)C(=C)C[C@H](O1)C[C@](C)(O)C[C@@]1(O1)C[C@@H](OC(C)=O)C[C@@H]1CC(=O)O[C@H]1[C@H](O)[C@@H](CC(=C)C(C)[C@H](O)\C=C\C(Cl)=C)O[C@@H]2[C@@H]1C HAOCRCFHEPRQOY-JKTUOYIXSA-N 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 title 1
238000002955 isolation Methods 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 1
241000243142 Porifera Species 0.000 abstract 1
241000520664 Spongia Species 0.000 abstract 1
DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000002596 lactones Chemical class 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT94300362T 1993-01-19 1994-01-19 Isolierung und struktur von spongistatin 1 und dessen verwendung als antitumor-mittel ATE166652T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/006,270 US5436400A (en)	1993-01-19	1993-01-19	Isolation and structure of spongistatin 1

Publications (1)

Publication Number	Publication Date
ATE166652T1 true ATE166652T1 (de)	1998-06-15

Family

ID=21720096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94300362T ATE166652T1 (de)	1993-01-19	1994-01-19	Isolierung und struktur von spongistatin 1 und dessen verwendung als antitumor-mittel

Country Status (8)

Country	Link
US (1)	US5436400A (de)
EP (1)	EP0608111B1 (de)
JP (1)	JPH072866A (de)
AT (1)	ATE166652T1 (de)
CA (1)	CA2113656C (de)
DE (1)	DE69410492T2 (de)
DK (1)	DK0608111T3 (de)
ES (1)	ES2119077T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5393897A (en) *	1993-07-02	1995-02-28	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Isolation and structure of spongistatins 5,7,8 and 9
WO1997048278A1 (en) *	1996-06-18	1997-12-24	Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of The Arizona State University	Antifungal activity of the spongistatins
US5883120A (en) *	1997-06-16	1999-03-16	Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University	Antifungal activity of the spongistatins
US5952376A (en) *	1997-11-07	1999-09-14	The Trustees Of The University Of Pennsylvania	Trienyl compounds
US6521661B1 (en)	2000-07-20	2003-02-18	Harbor Branch Oceanographic Institution, Inc.	Cyclic peroxides as novel antifungal agents
WO2016130969A1 (en)	2015-02-13	2016-08-18	George Robert Pettit	Silstatin compounds
WO2019094709A1 (en)	2017-11-09	2019-05-16	Pettit George R	Betulastatin compounds
CN114605430B (zh) *	2022-03-18	2023-09-05	中国科学院海洋研究所	一种大环双内酯类化合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4833257A (en) *	1986-07-28	1989-05-23	Arizona Board Of Regents	Compositions of matter and methods of using same
US5196447A (en) *	1991-08-08	1993-03-23	Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting On Behalf Of Arizona State University	Neristatin 1

1993
- 1993-01-19 US US08/006,270 patent/US5436400A/en not_active Expired - Fee Related
1994
- 1994-01-17 JP JP6030762A patent/JPH072866A/ja active Pending
- 1994-01-18 CA CA002113656A patent/CA2113656C/en not_active Expired - Fee Related
- 1994-01-19 DK DK94300362T patent/DK0608111T3/da active
- 1994-01-19 AT AT94300362T patent/ATE166652T1/de not_active IP Right Cessation
- 1994-01-19 ES ES94300362T patent/ES2119077T3/es not_active Expired - Lifetime
- 1994-01-19 EP EP94300362A patent/EP0608111B1/de not_active Expired - Lifetime
- 1994-01-19 DE DE69410492T patent/DE69410492T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69410492D1 (de)	1998-07-02
DE69410492T2 (de)	1998-11-05
EP0608111B1 (de)	1998-05-27
EP0608111A1 (de)	1994-07-27
JPH072866A (ja)	1995-01-06
CA2113656A1 (en)	1994-07-20
US5436400A (en)	1995-07-25
CA2113656C (en)	2000-07-18
ES2119077T3 (es)	1998-10-01
DK0608111T3 (da)	1999-01-18

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Legal Events

Date	Code	Title	Description
1998-11-15	UEP	Publication of translation of european patent specification
2005-10-15	REN	Ceased due to non-payment of the annual fee