DK0608111T3 - Isolering og struktur af spongistatin 1 og anvendelse deraf som anti-tumormiddel - Google Patents

Isolering og struktur af spongistatin 1 og anvendelse deraf som anti-tumormiddel

Info

Publication number: DK0608111T3
Authority: DK; Denmark
Prior art keywords: spongistatin; found; isolation; tumor agent; tci50
Prior art date: 1993-01-19

Application number

DK94300362T

Other languages

English (en)

Inventor

George R Pettit

Cherry L Herald

Zbigniew A Cichacz

Original Assignee

Univ Arizona

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-19

Filing date

1994-01-19

Publication date

1999-01-18

1994-01-19 Application filed by Univ Arizona filed Critical Univ Arizona

1999-01-18 Application granted granted Critical

1999-01-18 Publication of DK0608111T3 publication Critical patent/DK0608111T3/da

Links

ICXJVZHDZFXYQC-UHFFFAOYSA-N spongistatin 1 Natural products OC1C(O2)(O)CC(O)C(C)C2CCCC=CC(O2)CC(O)CC2(O2)CC(OC)CC2CC(=O)C(C)C(OC(C)=O)C(C)C(=C)CC(O2)CC(C)(O)CC2(O2)CC(OC(C)=O)CC2CC(=O)OC2C(O)C(CC(=C)CC(O)C=CC(Cl)=C)OC1C2C ICXJVZHDZFXYQC-UHFFFAOYSA-N 0.000 title abstract 2
HAOCRCFHEPRQOY-JKTUOYIXSA-N spongistatin-1 Chemical compound C([C@@H]1C[C@@H](C[C@@]2(C[C@@H](O)C[C@@H](C2)\C=C/CCC[C@@H]2[C@H](C)[C@@H](O)C[C@](O2)(O)[C@H]2O)O1)OC)C(=O)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)C(=C)C[C@H](O1)C[C@](C)(O)C[C@@]1(O1)C[C@@H](OC(C)=O)C[C@@H]1CC(=O)O[C@H]1[C@H](O)[C@@H](CC(=C)C(C)[C@H](O)\C=C\C(Cl)=C)O[C@@H]2[C@@H]1C HAOCRCFHEPRQOY-JKTUOYIXSA-N 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 title 1
238000002955 isolation Methods 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 1
241000243142 Porifera Species 0.000 abstract 1
241000520664 Spongia Species 0.000 abstract 1
DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000002596 lactones Chemical class 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK94300362T 1993-01-19 1994-01-19 Isolering og struktur af spongistatin 1 og anvendelse deraf som anti-tumormiddel DK0608111T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/006,270 US5436400A (en)	1993-01-19	1993-01-19	Isolation and structure of spongistatin 1

Publications (1)

Publication Number	Publication Date
DK0608111T3 true DK0608111T3 (da)	1999-01-18

Family

ID=21720096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94300362T DK0608111T3 (da)	1993-01-19	1994-01-19	Isolering og struktur af spongistatin 1 og anvendelse deraf som anti-tumormiddel

Country Status (8)

Country	Link
US (1)	US5436400A (da)
EP (1)	EP0608111B1 (da)
JP (1)	JPH072866A (da)
AT (1)	ATE166652T1 (da)
CA (1)	CA2113656C (da)
DE (1)	DE69410492T2 (da)
DK (1)	DK0608111T3 (da)
ES (1)	ES2119077T3 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5393897A (en) *	1993-07-02	1995-02-28	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Isolation and structure of spongistatins 5,7,8 and 9
WO1997048278A1 (en) *	1996-06-18	1997-12-24	Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of The Arizona State University	Antifungal activity of the spongistatins
US5883120A (en) *	1997-06-16	1999-03-16	Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University	Antifungal activity of the spongistatins
US5952376A (en) *	1997-11-07	1999-09-14	The Trustees Of The University Of Pennsylvania	Trienyl compounds
US6521661B1 (en)	2000-07-20	2003-02-18	Harbor Branch Oceanographic Institution, Inc.	Cyclic peroxides as novel antifungal agents
US20180030095A1 (en)	2015-02-13	2018-02-01	George Robert Pettit	Silstatin compounds
WO2019094709A1 (en)	2017-11-09	2019-05-16	Pettit George R	Betulastatin compounds
CN114605430B (zh) *	2022-03-18	2023-09-05	中国科学院海洋研究所	一种大环双内酯类化合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4833257A (en) *	1986-07-28	1989-05-23	Arizona Board Of Regents	Compositions of matter and methods of using same
US5196447A (en) *	1991-08-08	1993-03-23	Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting On Behalf Of Arizona State University	Neristatin 1

1993
- 1993-01-19 US US08/006,270 patent/US5436400A/en not_active Expired - Fee Related
1994
- 1994-01-17 JP JP6030762A patent/JPH072866A/ja active Pending
- 1994-01-18 CA CA002113656A patent/CA2113656C/en not_active Expired - Fee Related
- 1994-01-19 DK DK94300362T patent/DK0608111T3/da active
- 1994-01-19 DE DE69410492T patent/DE69410492T2/de not_active Expired - Fee Related
- 1994-01-19 ES ES94300362T patent/ES2119077T3/es not_active Expired - Lifetime
- 1994-01-19 EP EP94300362A patent/EP0608111B1/en not_active Expired - Lifetime
- 1994-01-19 AT AT94300362T patent/ATE166652T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2119077T3 (es)	1998-10-01
DE69410492D1 (de)	1998-07-02
DE69410492T2 (de)	1998-11-05
JPH072866A (ja)	1995-01-06
EP0608111B1 (en)	1998-05-27
ATE166652T1 (de)	1998-06-15
EP0608111A1 (en)	1994-07-27
CA2113656C (en)	2000-07-18
CA2113656A1 (en)	1994-07-20
US5436400A (en)	1995-07-25

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