ATE168887T1 - Hemmung von dysfunctionalen uterusblutungen - Google Patents

Hemmung von dysfunctionalen uterusblutungen

Info

Publication number: ATE168887T1
Authority: AT; Austria
Prior art keywords: bleeding; uternal; dysfunctional; inhibition; chem
Prior art date: 1993-12-21

Application number

AT94309475T

Other languages

English (en)

Inventor

Patrick Peter Keohane

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-21

Filing date

1994-12-19

Publication date

1998-08-15

1994-12-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1998-08-15 Application granted granted Critical

1998-08-15 Publication of ATE168887T1 publication Critical patent/ATE168887T1/de

Links

230000000740 bleeding effect Effects 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
206010013908 Dysfunctional uterine bleeding Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010027514 Metrorrhagia Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT94309475T 1993-12-21 1994-12-19 Hemmung von dysfunctionalen uterusblutungen ATE168887T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/171,391 US5446053A (en)	1993-12-21	1993-12-21	Methods of inhibiting dysfunctional uterine bleeding

Publications (1)

Publication Number	Publication Date
ATE168887T1 true ATE168887T1 (de)	1998-08-15

Family

ID=22623570

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94309475T ATE168887T1 (de)	1993-12-21	1994-12-19	Hemmung von dysfunctionalen uterusblutungen

Country Status (20)

Country	Link
US (2)	US5446053A (de)
EP (1)	EP0659417B1 (de)
JP (1)	JPH07215858A (de)
KR (1)	KR950016726A (de)
CN (1)	CN1109752A (de)
AT (1)	ATE168887T1 (de)
AU (1)	AU692490B2 (de)
CA (1)	CA2138510A1 (de)
CZ (1)	CZ321094A3 (de)
DE (1)	DE69412049T2 (de)
DK (1)	DK0659417T3 (de)
ES (1)	ES2119094T3 (de)
GR (1)	GR3027706T3 (de)
HU (1)	HUT71469A (de)
IL (1)	IL112037A (de)
NO (1)	NO944930L (de)
NZ (1)	NZ270167A (de)
PH (1)	PH31099A (de)
RU (1)	RU94044456A (de)
ZA (1)	ZA9410080B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5811447A (en)	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en)	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en)	1993-05-13	2001-06-26	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US5770609A (en)	1993-01-28	1998-06-23	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US5595722A (en)	1993-01-28	1997-01-21	Neorx Corporation	Method for identifying an agent which increases TGF-beta levels
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
WO1994026303A1 (en)	1993-05-13	1994-11-24	Neorx Corporation	Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US5856340A (en) *	1995-02-28	1999-01-05	Eli Lilly And Company	Method of treating estrogen dependent cancers
JPH11510479A (ja)	1995-06-07	1999-09-14	ネオルックスコーポレイション	タモキシフェン類似体による心臓血管疾病の予防及び治療
IL120266A (en) *	1996-02-28	2005-05-17	Pfizer	Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
TW442286B (en) *	1996-02-28	2001-06-23	Pfizer	New therapeutic uses of estrogen agonists
WO1998046588A2 (en) *	1997-04-11	1998-10-22	Neorx Corporation	Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6054446A (en)	1997-12-24	2000-04-25	Sri International	Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
KR20010080254A (ko) *	1998-11-26	2001-08-22	야마구찌 다까시	주기 투여용 의약조성물
CZ20013912A3 (cs)	1999-05-04	2002-05-15	Strakan Limited	Androgen glykosid, sloučenina, testosteron-ß-D-glukosid, 5 alfa-Dihydrotestosteron- 17ß-D-glukosid, farmaceutický prostředek a pouľití sloučeniny
IN191020B (de)	2000-03-28	2003-09-13	Dabur Res Foundation
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
WO2002094788A1 (en) *	2001-05-22	2002-11-28	Eli Lilly And Company	2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
EP1401446B1 (de) *	2001-05-22	2005-02-09	Eli Lilly And Company	Tetrahydrochinolin-derivate zur behandlung von krankheiten ausgelöst durch zu hohem oder zu niedrigem oestrogenspiegel
TW200407124A (en) *	2002-06-25	2004-05-16	Wyeth Corp	Use of thio-oxindole derivatives in treatment of hormone-related conditions
KR102295878B1 (ko)	2021-06-16	2021-08-31	최경선	셀프용 등 지압기

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) *	1981-04-03	1983-04-19	Eli Lilly And Company	Synthesis of acylated benzothiophenes
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
US4859585A (en) *	1986-04-17	1989-08-22	Trustees Of Tufts College	In-vitro methods for identifying compositions which are agonists and antagonists of estrogens
US5075321A (en) *	1987-03-24	1991-12-24	University Of Pennsylvania	Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes
US5395842A (en) *	1988-10-31	1995-03-07	Endorecherche Inc.	Anti-estrogenic compounds and compositions
JP3157882B2 (ja) *	1991-11-15	2001-04-16	帝国臓器製薬株式会社	新規なベンゾチオフエン誘導体

1993
- 1993-12-21 US US08/171,391 patent/US5446053A/en not_active Expired - Lifetime
1994
- 1994-12-19 RU RU94044456/14A patent/RU94044456A/ru unknown
- 1994-12-19 NO NO944930A patent/NO944930L/no unknown
- 1994-12-19 KR KR1019940034917A patent/KR950016726A/ko not_active Withdrawn
- 1994-12-19 AU AU81561/94A patent/AU692490B2/en not_active Ceased
- 1994-12-19 ES ES94309475T patent/ES2119094T3/es not_active Expired - Lifetime
- 1994-12-19 HU HU9403663A patent/HUT71469A/hu unknown
- 1994-12-19 EP EP94309475A patent/EP0659417B1/de not_active Expired - Lifetime
- 1994-12-19 DE DE69412049T patent/DE69412049T2/de not_active Expired - Fee Related
- 1994-12-19 CZ CZ943210A patent/CZ321094A3/cs unknown
- 1994-12-19 IL IL11203794A patent/IL112037A/en not_active IP Right Cessation
- 1994-12-19 ZA ZA9410080A patent/ZA9410080B/xx unknown
- 1994-12-19 CN CN94119734A patent/CN1109752A/zh active Pending
- 1994-12-19 NZ NZ270167A patent/NZ270167A/xx unknown
- 1994-12-19 PH PH49597A patent/PH31099A/en unknown
- 1994-12-19 DK DK94309475T patent/DK0659417T3/da active
- 1994-12-19 CA CA002138510A patent/CA2138510A1/en not_active Abandoned
- 1994-12-19 AT AT94309475T patent/ATE168887T1/de not_active IP Right Cessation
- 1994-12-19 JP JP6314590A patent/JPH07215858A/ja active Pending
1995
- 1995-04-14 US US08/422,388 patent/US5552416A/en not_active Expired - Lifetime
1998
- 1998-08-20 GR GR980401883T patent/GR3027706T3/el unknown

Also Published As

Publication number	Publication date
DE69412049T2 (de)	1999-01-14
PH31099A (en)	1998-02-05
DE69412049D1 (de)	1998-09-03
AU692490B2 (en)	1998-06-11
JPH07215858A (ja)	1995-08-15
EP0659417A3 (de)	1995-09-06
ZA9410080B (en)	1996-06-19
HU9403663D0 (en)	1995-02-28
DK0659417T3 (da)	1998-12-07
HUT71469A (en)	1995-11-28
NZ270167A (en)	1997-08-22
IL112037A0 (en)	1995-03-15
US5552416A (en)	1996-09-03
CA2138510A1 (en)	1995-06-22
NO944930L (no)	1995-06-22
ES2119094T3 (es)	1998-10-01
NO944930D0 (no)	1994-12-19
CN1109752A (zh)	1995-10-11
US5446053A (en)	1995-08-29
CZ321094A3 (en)	1995-08-16
AU8156194A (en)	1995-06-29
IL112037A (en)	1999-03-12
EP0659417A2 (de)	1995-06-28
KR950016726A (ko)	1995-07-20
RU94044456A (ru)	1996-10-10
EP0659417B1 (de)	1998-07-29
GR3027706T3 (en)	1998-11-30

Legal Events

Date	Code	Title	Description
2005-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ES2157957T3 (es)	2001-09-01	Procedimientos para inhibir la endometriosis.
DE69412049D1 (de)	1998-09-03	Hemmung von dysfunctionalen Uterusblutungen
DE69402173D1 (de)	1997-04-24	Hemmung von Thrombin
ES2172525T3 (es)	2002-10-01	Inhibicion de la fibrosis uterina.
DE69402165D1 (de)	1997-04-24	Hemmung von Seborrhoe und Akne
NO943873D0 (no)	1994-10-13	Hemming av bruskdegradering
NO944917D0 (no)	1994-12-19	Anvendelse av 2-fenyl-3-aroyltiofener for inhibering av eggstokkdysgenese, forsinket pubertet eller seksuell infantilisme
DK0659414T3 (da)	2001-09-24	Inhibering af hirutisme og alopeci hos kvinder
FI970716A0 (fi)	1997-02-20	Menetelmiä primaarisen kohdun limakalvon liikakasvun estämiseksi