ATE168985T1 - Neue antivirale mittel - Google Patents

Neue antivirale mittel

Info

Publication number: ATE168985T1
Authority: AT; Austria
Prior art keywords: hypericin; ethyl; compounds; antiviral agents; new antiviral
Prior art date: 1993-05-27

Application number

AT94921214T

Other languages

English (en)

Inventor

Yehuda Mazur

Gad Lavie

Daniel Meruelo

David Lavie

Original Assignee

Yeda Res & Dev

Univ New York School Medicine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-27

Filing date

1994-05-27

Publication date

1998-08-15

1994-05-27 Application filed by Yeda Res & Dev, Univ New York School Medicine filed Critical Yeda Res & Dev

1998-08-15 Application granted granted Critical

1998-08-15 Publication of ATE168985T1 publication Critical patent/ATE168985T1/de

Links

239000003443 antiviral agent Substances 0.000 title 1
BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 abstract 3
229940005608 hypericin Drugs 0.000 abstract 3
PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 abstract 3
SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
-1 2-(2-methoxyethoxy)ethyl Chemical group 0.000 abstract 1
125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000000798 anti-retroviral effect Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000003262 carboxylic acid ester group Chemical group [H]C([H])([*:2])OC(=O)C([H])([H])[*:1] 0.000 abstract 1
150000001990 dicarboxylic acid derivatives Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
150000002762 monocarboxylic acid derivatives Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Orthopedics, Nursing, And Contraception (AREA)

AT94921214T 1993-05-27 1994-05-27 Neue antivirale mittel ATE168985T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/068,379 US6576784B1 (en)	1993-05-27	1993-05-27	Antiviral agents

Publications (1)

Publication Number	Publication Date
ATE168985T1 true ATE168985T1 (de)	1998-08-15

Family

ID=22082194

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94921214T ATE168985T1 (de)	1993-05-27	1994-05-27	Neue antivirale mittel

Country Status (12)

Country	Link
US (1)	US6576784B1 (de)
EP (1)	EP0702669B1 (de)
JP (1)	JPH08510753A (de)
AT (1)	ATE168985T1 (de)
AU (1)	AU689120B2 (de)
CA (1)	CA2163793C (de)
DE (1)	DE69412095T2 (de)
DK (1)	DK0702669T3 (de)
ES (1)	ES2122303T3 (de)
GR (1)	GR3027710T3 (de)
IL (1)	IL109807A (de)
WO (1)	WO1994027952A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL121440A0 (en)	1997-07-31	1998-01-04	Yeda Res & Dev	The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
EP1094712A4 (de) *	1998-07-09	2004-09-08	Cv Technologies Inc	Hypericin unr hypericum-extrakt: spezifische t-typ calciumkanalblocker, und ihre verwendung als t-typ calciumkanalgerichtete therapeutika
DK175561B1 (da) *	1999-01-11	2004-12-06	Lego As	Legetöjsbyggesæt med system til overföring af energi mellem byggeelementer
EP1040825A1 (de) *	1999-03-11	2000-10-04	K.U. Leuven Research & Development	Mittel zur Diagnostik von Harnblasenkarzinom
US7195783B2 (en)	1999-07-09	2007-03-27	Fx Life Sciences International Gmbh	Hypericin and hypericum extract: specific T-type calcium channel blocker, and their use as T-type calcium channel targeted therapeutics
US7037534B2 (en) *	2001-10-24	2006-05-02	Aphios Corporation	Inactivation of viral infections agents by chemiluminescence activated light-sensitive compounds
US20080199458A1 (en) *	2007-01-19	2008-08-21	Jian-Er Lin	Influenza prevention and treatment composition
RU2719582C1 (ru) *	2016-03-01	2020-04-21	Солидженикс, Инк.	Системы и способы для получения синтетического гиперицина

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL93682A (en) *	1989-03-16	1996-06-18	Yeda Res & Dev	Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them
AU3056492A (en)	1991-11-01	1993-06-07	New York University	Hypericin compositions for treating t-cell mediated diseases

1993
- 1993-05-27 US US08/068,379 patent/US6576784B1/en not_active Expired - Lifetime
1994
- 1994-05-27 DE DE69412095T patent/DE69412095T2/de not_active Expired - Fee Related
- 1994-05-27 CA CA002163793A patent/CA2163793C/en not_active Expired - Fee Related
- 1994-05-27 IL IL10980794A patent/IL109807A/en not_active IP Right Cessation
- 1994-05-27 AT AT94921214T patent/ATE168985T1/de not_active IP Right Cessation
- 1994-05-27 EP EP94921214A patent/EP0702669B1/de not_active Expired - Lifetime
- 1994-05-27 DK DK94921214T patent/DK0702669T3/da active
- 1994-05-27 JP JP7500974A patent/JPH08510753A/ja active Pending
- 1994-05-27 WO PCT/US1994/005975 patent/WO1994027952A1/en not_active Ceased
- 1994-05-27 ES ES94921214T patent/ES2122303T3/es not_active Expired - Lifetime
- 1994-05-27 AU AU72023/94A patent/AU689120B2/en not_active Ceased
1998
- 1998-08-20 GR GR980401887T patent/GR3027710T3/el unknown

Also Published As

Publication number	Publication date
DK0702669T3 (da)	1998-11-09
DE69412095T2 (de)	1998-12-03
US6576784B1 (en)	2003-06-10
GR3027710T3 (en)	1998-11-30
DE69412095D1 (de)	1998-09-03
IL109807A (en)	1998-12-06
ES2122303T3 (es)	1998-12-16
CA2163793A1 (en)	1994-12-08
AU689120B2 (en)	1998-03-26
EP0702669A4 (de)	1996-01-29
CA2163793C (en)	2007-04-17
IL109807A0 (en)	1994-08-26
EP0702669B1 (de)	1998-07-29
JPH08510753A (ja)	1996-11-12
EP0702669A1 (de)	1996-03-27
WO1994027952A1 (en)	1994-12-08
AU7202394A (en)	1994-12-20

Similar Documents

Publication	Publication Date	Title
NL300175I2 (nl)	2005-05-02	Methylsulfonylfenyl-2-(5H)-furanonen als remmers van COX-2.
EE200100513A (et)	2002-12-16	Rakkude adhesiooni inhibeerivad põletikuvastased ja immunosupressiivsed ühendid
DE69912581D1 (de)	2003-12-11	Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
ATE377010T1 (de)	2007-11-15	Caspase-inhibitoren und ihre verwendungen
SE7902910L (sv)	1979-10-09	4-tiazolidinkarboxylsyror
DE69212925D1 (de)	1996-09-26	Polymerisationsinhibitoren für Acrylsäure und Ester
CH692199A8 (fr)	2002-06-14	Composes pyridiques et compositions pharmaceutique
ES2066140T3 (es)	1995-03-01	Derivados de acidos 7-ceto- y 7-hidroxi-androsta-3,5-dieno-3-carboxilicos.
FI920732A0 (fi)	1992-02-20	2-substituerade kinoliner, foerfarande foer framstaellning av dessa och anvaendning av dessa i laekemedel.
DE69720996D1 (de)	2003-05-22	Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer
ATE168985T1 (de)	1998-08-15	Neue antivirale mittel
FI935777A0 (fi)	1993-12-21	Inhibitorer foer HIV-proteas anvaendbara vid behandling av AIDS
TR199902350T2 (xx)	2000-04-21	Yeni piridin t�revleri ve onlardan olu�an farmakotik bile�imler.
FI955498A0 (fi)	1995-11-15	Nipekotiinihappojohdannaisia hyytymistä estävinä aineina
ATE223376T1 (de)	2002-09-15	Bisarylcyclobutenderivate als cyclooxygenasehemmer
ATE240299T1 (de)	2003-05-15	Diester prodrugs von decahydroischinoline-3- carbonsäure
DE69702182D1 (de)	2000-07-06	Alkylierte styrole als prodrugs zu cox-2-inhibitoren
ES2196197T3 (es)	2003-12-16	Derivados de benzamida con propiedades inhibidoras de trombina.
ATE244232T1 (de)	2003-07-15	(methylsulfonyl)phenyl-2-(5h)-furanone mit sauerstoff-bindung als cox-2-hemmer
DE60041001D1 (de)	2009-01-15	Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
ES2104174T3 (es)	1997-10-01	Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.
ATE209205T1 (de)	2001-12-15	Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren
RU1833365C (ru)	1993-08-07	Cпocoб пoлучehия tpииoдбehзoльhыx coeдиhehий
ES2139890T3 (es)	2000-02-16	Alquil esteres de dl- di- o tri-hidroxifenilglicina para el tratamiento de estados inflamatorios y alergicos.
ATE294790T1 (de)	2005-05-15	Chlormethylierung von thiophene

Legal Events

Date	Code	Title	Description
2004-02-15	REN	Ceased due to non-payment of the annual fee