DK0702669T3 - Hidtil ukendte antivirale midler - Google Patents

Hidtil ukendte antivirale midler

Info

Publication number: DK0702669T3
Authority: DK; Denmark
Prior art keywords: hypericin; ethyl; compounds; antiviral agents; new antiviral
Prior art date: 1993-05-27

Application number

DK94921214T

Other languages

English (en)

Inventor

Yehuda Mazur

Gad Lavie

Daniel Meruelo

David Lavie

Original Assignee

Yeda Res & Dev

Univ New York School Medicine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-27

Filing date

1994-05-27

Publication date

1998-11-09

1994-05-27 Application filed by Yeda Res & Dev, Univ New York School Medicine filed Critical Yeda Res & Dev

1998-11-09 Application granted granted Critical

1998-11-09 Publication of DK0702669T3 publication Critical patent/DK0702669T3/da

Links

239000003443 antiviral agent Substances 0.000 title 1
BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 abstract 3
229940005608 hypericin Drugs 0.000 abstract 3
PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 abstract 3
SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
-1 2-(2-methoxyethoxy)ethyl Chemical group 0.000 abstract 1
125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000000798 anti-retroviral effect Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000003262 carboxylic acid ester group Chemical group [H]C([H])([*:2])OC(=O)C([H])([H])[*:1] 0.000 abstract 1
150000001990 dicarboxylic acid derivatives Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
150000002762 monocarboxylic acid derivatives Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Orthopedics, Nursing, And Contraception (AREA)

DK94921214T 1993-05-27 1994-05-27 Hidtil ukendte antivirale midler DK0702669T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/068,379 US6576784B1 (en)	1993-05-27	1993-05-27	Antiviral agents
PCT/US1994/005975 WO1994027952A1 (en)	1993-05-27	1994-05-27	Novel antiviral agents

Publications (1)

Publication Number	Publication Date
DK0702669T3 true DK0702669T3 (da)	1998-11-09

Family

ID=22082194

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94921214T DK0702669T3 (da)	1993-05-27	1994-05-27	Hidtil ukendte antivirale midler

Country Status (12)

Country	Link
US (1)	US6576784B1 (da)
EP (1)	EP0702669B1 (da)
JP (1)	JPH08510753A (da)
AT (1)	ATE168985T1 (da)
AU (1)	AU689120B2 (da)
CA (1)	CA2163793C (da)
DE (1)	DE69412095T2 (da)
DK (1)	DK0702669T3 (da)
ES (1)	ES2122303T3 (da)
GR (1)	GR3027710T3 (da)
IL (1)	IL109807A (da)
WO (1)	WO1994027952A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL121440A0 (en)	1997-07-31	1998-01-04	Yeda Res & Dev	The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
JP2002520260A (ja) *	1998-07-09	2002-07-09	シーヴイテクノロジーズインコーポレイテッド	ヒペリシンおよびヒペリスム抽出物：特定のｔ型カルシウムチャネル遮断剤、およびそれらのｔ型カルシウムチャネルを標的にした治療法としての使用
DK175561B1 (da) *	1999-01-11	2004-12-06	Lego As	Legetöjsbyggesæt med system til overföring af energi mellem byggeelementer
EP1040825A1 (en) *	1999-03-11	2000-10-04	K.U. Leuven Research & Development	Means for diagnosing bladder carcinoma
US7195783B2 (en)	1999-07-09	2007-03-27	Fx Life Sciences International Gmbh	Hypericin and hypericum extract: specific T-type calcium channel blocker, and their use as T-type calcium channel targeted therapeutics
US7037534B2 (en) *	2001-10-24	2006-05-02	Aphios Corporation	Inactivation of viral infections agents by chemiluminescence activated light-sensitive compounds
US20080199458A1 (en) *	2007-01-19	2008-08-21	Jian-Er Lin	Influenza prevention and treatment composition
EP4414354A3 (en) *	2016-03-01	2024-10-30	Soligenix, Inc.	Systems and methods for producing synthetic hypericin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL93682A (en) *	1989-03-16	1996-06-18	Yeda Res & Dev	Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them
WO1993008797A1 (en)	1991-11-01	1993-05-13	New York University	Hypericin compositions for treating t-cell mediated diseases

1993
- 1993-05-27 US US08/068,379 patent/US6576784B1/en not_active Expired - Lifetime
1994
- 1994-05-27 DE DE69412095T patent/DE69412095T2/de not_active Expired - Fee Related
- 1994-05-27 CA CA002163793A patent/CA2163793C/en not_active Expired - Fee Related
- 1994-05-27 DK DK94921214T patent/DK0702669T3/da active
- 1994-05-27 WO PCT/US1994/005975 patent/WO1994027952A1/en not_active Ceased
- 1994-05-27 AT AT94921214T patent/ATE168985T1/de not_active IP Right Cessation
- 1994-05-27 ES ES94921214T patent/ES2122303T3/es not_active Expired - Lifetime
- 1994-05-27 IL IL10980794A patent/IL109807A/en not_active IP Right Cessation
- 1994-05-27 EP EP94921214A patent/EP0702669B1/en not_active Expired - Lifetime
- 1994-05-27 JP JP7500974A patent/JPH08510753A/ja active Pending
- 1994-05-27 AU AU72023/94A patent/AU689120B2/en not_active Ceased
1998
- 1998-08-20 GR GR980401887T patent/GR3027710T3/el unknown

Also Published As

Publication number	Publication date
EP0702669A4 (en)	1996-01-29
IL109807A0 (en)	1994-08-26
GR3027710T3 (en)	1998-11-30
AU7202394A (en)	1994-12-20
US6576784B1 (en)	2003-06-10
DE69412095D1 (de)	1998-09-03
ATE168985T1 (de)	1998-08-15
CA2163793A1 (en)	1994-12-08
JPH08510753A (ja)	1996-11-12
CA2163793C (en)	2007-04-17
WO1994027952A1 (en)	1994-12-08
ES2122303T3 (es)	1998-12-16
EP0702669A1 (en)	1996-03-27
IL109807A (en)	1998-12-06
AU689120B2 (en)	1998-03-26
EP0702669B1 (en)	1998-07-29
DE69412095T2 (de)	1998-12-03

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