ATE169059T1 - Verfahren zur beeinflussung der produktion von beta-lactam antibiotika und zur isolierung grosser mengen von acv-synthetase - Google Patents

Verfahren zur beeinflussung der produktion von beta-lactam antibiotika und zur isolierung grosser mengen von acv-synthetase

Info

Publication number: ATE169059T1
Authority: AT; Austria
Prior art keywords: production; beta; lactam antibiotics; influencing; large quantities
Prior art date: 1990-02-28

Application number

AT91200423T

Other languages

English (en)

Inventor

Annemarie Eveline Veenstra

Juan Francisco Martin

Bruno Diez Garcia

Santiago Guttierez

Jose Luis Barredo

Prieto Eduardo Montenegro

Doehren Hans Von

Harriet Palissa

Liempt Henk Van

Original Assignee

Gist Brocades Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-28

Filing date

1991-02-27

Publication date

1998-08-15

1991-02-27 Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv

1998-08-15 Application granted granted Critical

1998-08-15 Publication of ATE169059T1 publication Critical patent/ATE169059T1/de

Links

238000000034 method Methods 0.000 title abstract 5
108010049411 alpha-aminoadipyl-cysteinyl-valine synthetase Proteins 0.000 title abstract 3
239000003782 beta lactam antibiotic agent Substances 0.000 title abstract 2
239000002132 β-lactam antibiotic Substances 0.000 title abstract 2
229940124586 β-lactam antibiotics Drugs 0.000 title abstract 2
241000228431 Acremonium chrysogenum Species 0.000 abstract 1
229930182555 Penicillin Natural products 0.000 abstract 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
241000228150 Penicillium chrysogenum Species 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229940049954 penicillin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT91200423T 1990-02-28 1991-02-27 Verfahren zur beeinflussung der produktion von beta-lactam antibiotika und zur isolierung grosser mengen von acv-synthetase ATE169059T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP90200475		1990-02-28
EP90200488		1990-02-28
EP90201768		1990-07-02
EP90202628		1990-10-03

Publications (1)

Publication Number	Publication Date
ATE169059T1 true ATE169059T1 (de)	1998-08-15

Family

ID=27441987

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91200423T ATE169059T1 (de)	1990-02-28	1991-02-27	Verfahren zur beeinflussung der produktion von beta-lactam antibiotika und zur isolierung grosser mengen von acv-synthetase

Country Status (7)

Country	Link
EP (2)	EP0444758A1 (de)
JP (1)	JPH06105682A (de)
AT (1)	ATE169059T1 (de)
DE (1)	DE69129869T2 (de)
ES (1)	ES2121764T3 (de)
IE (1)	IE910660A1 (de)
PT (1)	PT96912B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002539830A (ja) *	1999-03-26	2002-11-26	ヒューマンジノームサイエンシーズ，インコーポレイテッド	５０個のヒト分泌タンパク質
EP2589663A1 (de) *	2011-11-04	2013-05-08	LEK Pharmaceuticals d.d.	Verfahren zur Herstellung von Clavulansäure
EP3430153A1 (de) *	2016-04-14	2019-01-23	DSM Sinochem Pharmaceuticals Netherlands B.V.	Mbth-ähnliche proteine in eukaryotischen nrps-katalysierten verfahren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0280051A1 (de) *	1987-02-17	1988-08-31	Queen's University At Kingston	ACV-Synthetase
GB8728811D0 (en) *	1987-12-09	1988-01-27	Beecham Group Plc	Novel substance
FI104264B1 (fi) *	1988-08-11	1999-12-15	Dsm Nv	Menetelmä sekundääristen metaboliittien tuoton parantamiseksi käyttämällä rykelmöityjä biosynteettisiä geenejä

1991
- 1991-02-27 ES ES91200423T patent/ES2121764T3/es not_active Expired - Lifetime
- 1991-02-27 EP EP91200422A patent/EP0444758A1/de not_active Ceased
- 1991-02-27 IE IE066091A patent/IE910660A1/en unknown
- 1991-02-27 EP EP91200423A patent/EP0445868B1/de not_active Expired - Lifetime
- 1991-02-27 AT AT91200423T patent/ATE169059T1/de not_active IP Right Cessation
- 1991-02-27 DE DE69129869T patent/DE69129869T2/de not_active Expired - Fee Related
- 1991-02-28 JP JP3119620A patent/JPH06105682A/ja active Pending
- 1991-02-28 PT PT96912A patent/PT96912B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69129869D1 (de)	1998-09-03
JPH06105682A (ja)	1994-04-19
EP0445868A1 (de)	1991-09-11
ES2121764T3 (es)	1998-12-16
DE69129869T2 (de)	1999-01-14
PT96912A (pt)	1991-10-31
EP0444758A1 (de)	1991-09-04
EP0445868B1 (de)	1998-07-29
IE910660A1 (en)	1991-08-28
PT96912B (pt)	1998-07-31

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Legal Events

Date	Code	Title	Description
1999-02-15	UEP	Publication of translation of european patent specification
2002-11-15	REN	Ceased due to non-payment of the annual fee