ATE169339T1 - Mindestens ein tetrahydropyrimidinderivat (thp(a) oder thp(b)) enthaltende pharmazeutische zusammensetzungen - Google Patents

Mindestens ein tetrahydropyrimidinderivat (thp(a) oder thp(b)) enthaltende pharmazeutische zusammensetzungen

Info

Publication number
ATE169339T1
ATE169339T1 AT93101515T AT93101515T ATE169339T1 AT E169339 T1 ATE169339 T1 AT E169339T1 AT 93101515 T AT93101515 T AT 93101515T AT 93101515 T AT93101515 T AT 93101515T AT E169339 T1 ATE169339 T1 AT E169339T1
Authority
AT
Austria
Prior art keywords
thp
pharmaceutical compositions
tetrahydropyrimidene
derivative
compositions containing
Prior art date
Application number
AT93101515T
Other languages
English (en)
Inventor
Aviva Lapidot
Livia Inbar
Yosef Aloni
Edna Ben-Asher
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE169339T1 publication Critical patent/ATE169339T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT93101515T 1992-01-30 1993-02-01 Mindestens ein tetrahydropyrimidinderivat (thp(a) oder thp(b)) enthaltende pharmazeutische zusammensetzungen ATE169339T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL10081092A IL100810A (en) 1992-01-30 1992-01-30 Pharmaceutical preparations including 2 - methyl - carboxy - 5 - hydroxy - tetrahydropyrimidine and / or 2 - methyl - 4 - carboxy - tetrahydropyrimidine, plywood methods

Publications (1)

Publication Number Publication Date
ATE169339T1 true ATE169339T1 (de) 1998-08-15

Family

ID=11063323

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93101515T ATE169339T1 (de) 1992-01-30 1993-02-01 Mindestens ein tetrahydropyrimidinderivat (thp(a) oder thp(b)) enthaltende pharmazeutische zusammensetzungen

Country Status (12)

Country Link
US (1) US5789414A (de)
EP (2) EP0845539A1 (de)
JP (1) JPH0717864A (de)
CN (1) CN1080172A (de)
AT (1) ATE169339T1 (de)
AU (1) AU3213993A (de)
CA (1) CA2088390A1 (de)
DE (1) DE69320075T2 (de)
HU (1) HUT67711A (de)
IL (1) IL100810A (de)
NZ (1) NZ245797A (de)
ZA (1) ZA93652B (de)

Families Citing this family (44)

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Publication number Priority date Publication date Assignee Title
DE4244580A1 (de) * 1992-12-31 1994-07-07 Galinski Erwin A Verfahren zur in vivo Gewinnung von Inhaltsstoffen aus Zellen
DE4342560A1 (de) 1993-12-14 1995-06-22 Marbert Gmbh Ectoin und Ectoinderivate als Feuchtigkeitsspender in Kosmetikprodukten
DE19711082A1 (de) * 1997-03-18 1998-09-24 Degussa Verfahren zur Abtrennung von Tetrahydropyrimidinen aus wäßrigen Lösungen
IL123256A0 (en) 1998-02-10 1998-09-24 Yeda Res & Dev Methods for dna amplification and sequencing
DE19821378A1 (de) * 1998-05-13 1999-11-18 Degussa Verfahren zur Auftrennung von Tetrahydropyrimidinderivaten
US20030157040A1 (en) * 1998-08-01 2003-08-21 Merck Patent Gmbh Use of ectoine or ectoine derivatives in cosmetic formulations
US20040047828A1 (en) * 1998-08-01 2004-03-11 Merck Patent Gmbh Ectoin or ection derivatives and surfactants
DE19834816A1 (de) * 1998-08-01 2000-02-03 Merck Patent Gmbh Verwendung von Ectoin oder Ectoin-Derivaten in kosmetischen Formulierungen
AU5812800A (en) * 1999-06-12 2001-01-02 Stefan Barth Pharmaceutical preparation
DE19957470A1 (de) 1999-11-24 2001-06-21 Actinodrug Pharmaceuticals Gmb Tetrahydropyrimidin-Dioxygenase-Gen sowie Verfahren zur enzymatischen in vivo und in vitro Produktion von hydroxylierten Tetrahydropyrimidinen
DE10002725A1 (de) * 2000-01-11 2001-07-12 Beiersdorf Ag Wirkstoffe und Zubereitungen für die Hautaufhellung und zur Verhinderung der Hautbräunung (skin whitening)
DE10043456A1 (de) * 2000-09-04 2002-03-14 Merck Patent Gmbh Verwendung von Ectoin oder Ectoin-Derivaten zur Stabilisierung von p53
US7048910B2 (en) * 2000-09-07 2006-05-23 Merck Patent Gmbh Use of ectoine or ectoine derivatives for oral care
DE10047444A1 (de) * 2000-09-21 2002-04-11 Bitop Gmbh Verfahren zur Trennung und hochreinen Isolierung von niedermolekularen, strukturell ähnlichen Verbindungen insbesondere von Tetrahydropyrimidinderivaten wie z.B. 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidincarbonsäuren (Ectoine) und deren Spaltprodukte
DE10214257A1 (de) * 2002-03-28 2003-10-16 Merck Patent Gmbh Verwendung von kompatiblen Soluten zur Inhibierung der Freisetzung von Ceramiden
AU2005245338B2 (en) * 2004-04-08 2011-11-17 Biomatrica, Inc. Integration of sample storage and sample management for life science
US9089568B2 (en) * 2005-03-12 2015-07-28 Bitop Ag Method of using compatible solutes containing ectoine and/or hydroxyectoine
FR2896990B1 (fr) * 2006-02-03 2008-05-02 Lvmh Rech Composition protectrice et regenerante
DE102007052380A1 (de) * 2007-10-31 2009-05-07 Bitop Ag Osmolythaltige Zubereitungen zur Anwendung bei trockenen Schleimhäuten
JP5781928B2 (ja) * 2008-07-16 2015-09-24 ビトップ アーゲーｂｉｔｏｐ ＡＧ 環状アミジンの合成
DE102008039231A1 (de) 2008-08-22 2010-02-25 Bitop Ag Verwendung von Glucosylglycerol
US10463891B2 (en) 2008-09-30 2019-11-05 Symrise Ag Extracts of Isochrysis sp.
EP3348255B1 (de) 2008-12-05 2021-11-10 Symrise AG Extrakte der tetraselmis sp. für kosmetische und therapeutische zwecke
EP2430195B1 (de) * 2009-05-11 2019-01-23 Biomatrica, INC. Zusammensetzungen und verfahren zur lagerung biologischer proben
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
WO2012018639A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
WO2012018638A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
CN102225067B (zh) * 2011-04-29 2012-10-03 济南环肽医药科技有限公司 一种治疗胃癌的药物组合物
CN102258526B (zh) * 2011-04-29 2012-10-31 山东大学 一种抗肿瘤药物组合物
CN102210868A (zh) * 2011-04-29 2011-10-12 济南环肽医药科技有限公司 四氢嘧啶及其衍生物在制备口服吸收促进剂中的应用
CN102240298B (zh) * 2011-04-29 2012-07-04 济南环肽医药科技有限公司 一种抗肿瘤的药物组合物
CN102617707B (zh) * 2011-09-19 2014-01-29 江苏师范大学 放线菌素d新同系物2-甲基-放线菌素d的制备方法
EP3249054A1 (de) 2012-12-20 2017-11-29 Biomatrica, INC. Formulierungen und verfahren zur stabilisierung von pcr-reagenzien
ES2701758T3 (es) 2013-02-27 2019-02-25 Symrise Ag Extracto de jengibre para la protección de citoblastos
EP2862852B1 (de) 2013-10-18 2018-07-04 Symrise AG Harnstoffderivate für den Schutz von Stammzellen
ES2643590T3 (es) 2014-03-18 2017-11-23 Symrise Ag Dióxido de titanio revestido para reducir el efecto de blanqueamiento en la piel
EP2939710B1 (de) 2014-04-29 2020-06-17 Symrise AG Aktive Mischungen
WO2015191632A1 (en) 2014-06-10 2015-12-17 Biomatrica, Inc. Stabilization of thrombocytes at ambient temperatures
EP3045161B1 (de) 2015-01-18 2026-03-25 Symrise AG Verwendung von Wirkstoffgemischen aus 1,2-Hexandiol und 1,2-Octandiol in kosmetischen, pharmazeutischen oder dermatologischen Emulsionen
KR102589056B1 (ko) 2015-12-08 2023-10-12 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
CN105669560B (zh) * 2016-01-12 2019-02-19 天津科技大学 一种从发酵液中分离提取四氢嘧啶的方法
CN106361764A (zh) * 2016-08-29 2017-02-01 沂水县人民医院 一种肝癌手术切口用冲洗液
CN109053587A (zh) * 2018-08-31 2018-12-21 山东福田药业有限公司 一种从嗜盐微生物发酵液中分离提取四氢嘧啶的方法
CN110982843B (zh) * 2019-10-31 2021-12-28 温州大学 四氢嘧啶用于调节dna凝聚强弱的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261995A (en) * 1979-08-31 1981-04-14 Syntex (U.S.A.) Inc. 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives

Also Published As

Publication number Publication date
IL100810A (en) 1996-12-05
EP0553884A1 (de) 1993-08-04
US5789414A (en) 1998-08-04
CA2088390A1 (en) 1993-07-31
AU3213993A (en) 1993-08-05
DE69320075D1 (de) 1998-09-10
CN1080172A (zh) 1994-01-05
HUT67711A (en) 1995-04-28
EP0553884B1 (de) 1998-08-05
DE69320075T2 (de) 1999-04-22
HU9300251D0 (en) 1993-04-28
NZ245797A (en) 1995-07-26
EP0845539A1 (de) 1998-06-03
JPH0717864A (ja) 1995-01-20
ZA93652B (en) 1993-09-02
IL100810A0 (en) 1992-09-06

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Legal Events

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