ATE169638T1 - Analoge des menschlichen interleukin-8. - Google Patents

Analoge des menschlichen interleukin-8.

Info

Publication number: ATE169638T1
Authority: AT; Austria
Prior art keywords: pct; analogs; leu5; human interleukin; arg6
Prior art date: 1991-12-04

Application number

AT92924514T

Other languages

English (en)

Inventor

Ian Clark-Lewis

Bernhard Moser

Original Assignee

Biomedical Res Centre Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-04

Filing date

1992-12-03

Publication date

1998-08-15

1992-12-03 Application filed by Biomedical Res Centre Ltd filed Critical Biomedical Res Centre Ltd

1998-08-15 Application granted granted Critical

1998-08-15 Publication of ATE169638T1 publication Critical patent/ATE169638T1/de

Links

101001055222 Homo sapiens Interleukin-8 Proteins 0.000 title abstract 3
102000052624 human CXCL8 Human genes 0.000 title abstract 3
XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical class C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 9
102000004890 Interleukin-8 Human genes 0.000 abstract 5
108090001007 Interleukin-8 Proteins 0.000 abstract 5
229940096397 interleukin-8 Drugs 0.000 abstract 5
102100038796 E3 ubiquitin-protein ligase TRIM13 Human genes 0.000 abstract 3
101000664589 Homo sapiens E3 ubiquitin-protein ligase TRIM13 Proteins 0.000 abstract 3
101100491597 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) arg-6 gene Proteins 0.000 abstract 2
239000005557 antagonist Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000000440 neutrophil Anatomy 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5421—IL-8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/141—Interleukin

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT92924514T 1991-12-04 1992-12-03 Analoge des menschlichen interleukin-8. ATE169638T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US80157891A	1991-12-04	1991-12-04

Publications (1)

Publication Number	Publication Date
ATE169638T1 true ATE169638T1 (de)	1998-08-15

Family

ID=25181500

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92924514T ATE169638T1 (de)	1991-12-04	1992-12-03	Analoge des menschlichen interleukin-8.

Country Status (7)

Country	Link
US (1)	US5665346A (de)
EP (1)	EP0616615B1 (de)
AT (1)	ATE169638T1 (de)
AU (1)	AU3078892A (de)
CA (1)	CA2124461A1 (de)
DE (1)	DE69226649D1 (de)
WO (1)	WO1993011159A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6258550B1 (en)	1993-04-23	2001-07-10	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
ATE344324T1 (de) *	1993-09-14	2006-11-15	Imp Innovations Ltd	Eotaxin = eosinophil chemotaktisches cytokin
AU3460295A (en) *	1994-06-20	1996-01-15	Chiron Corporation	Polypeptides with interleukin 8 receptor 1 (il8r1) binding domains
US5912232A (en) *	1994-09-23	1999-06-15	Board Of Regents Of The University Of Nebraska	Anti-inflammatory polypeptide antagonists of human I1-8
WO1996009062A1 (en) *	1994-09-23	1996-03-28	University Of Nebraska Board Of Regents	Polypeptide agonists and antagonists of human interleukin-8
US5627156A (en) *	1994-09-23	1997-05-06	University Of Nebraska Board Of Regents	Polypeptide agonists for human interleukin-8
US5656724A (en) *	1994-10-26	1997-08-12	Repligen Corporation	Chemokine-like proteins and methods of use
US5789539A (en) *	1994-10-26	1998-08-04	Repligen Corporation	Chemokine-like proteins and methods of use
AU6283996A (en) *	1995-06-20	1997-01-22	Chiron Corporation	Polypeptides with interleukin-8 receptor binding
US7067117B1 (en)	1997-09-11	2006-06-27	Cambridge University Technical Services, Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US6989435B2 (en)	1997-09-11	2006-01-24	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US7238711B1 (en)	1999-03-17	2007-07-03	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US20070116669A1 (en) *	2002-09-13	2007-05-24	Chemokine Therapeutics Corporation	Interferon-inducible protein-10 (IP-10 or CXCL10) chemokine analogs for the treatment of human diseases
US7091310B2 (en) *	2002-09-13	2006-08-15	Chemokine Therapeutics Corporation	Chemokine analogs for the treatment of human disease
US20060233748A1 (en) *	2002-09-13	2006-10-19	Ahmed Merzouk	Mimetics of interleukin-8 and methods of using them in the prevention, treatment, diagnosis, and ameliorization of symptoms of a disease
WO2002070565A2 (en) *	2001-03-01	2002-09-12	University Of Saskatchewan Technologies Inc.	High-affinity antagonists of elr-cxc chemokines
US20090022657A1 (en) *	2003-10-22	2009-01-22	Applied Research Systems Ars Holding N.V.	Novel CXCL8 antagonists
EP1894571A1 (de) *	2006-08-29	2008-03-05	Protaffin Biotechnologie AG	Verwendung von modifizierten IL-8 Proteinen zur Behandlung von Reperfusionsschäden und Transplantatabstossung
WO2011029931A1 (en) *	2009-09-11	2011-03-17	Protaffin Biotechnologie Ag	Composition for treatment of cxcl8-mediated lung inflammation
EP3315510B1 (de) *	2015-06-03	2025-02-19	Rise Biopharmaceuticals, Inc. (Beijing)	Modifiziertes chemokinpeptid
US12226454B2 (en)	2015-06-03	2025-02-18	Rise Biopharmaceuticals Inc.	Pharmaceutical compositions and use thereof for relieving anticancer drug resistance and enhancing sensitivity of anticancer drug
US12329804B2 (en)	2015-06-03	2025-06-17	Rise Biopharmaceuticals Inc.	Modified chemokine peptide and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5093242A (en) *	1986-10-02	1992-03-03	Massachusetts Institute Of Technology	Methods of generating desired amino-terminal residues in proteins
DE3890998B4 (de) *	1987-11-19	2008-01-03	Novartis Ag	Neutrophilenaktivierungsfaktor, Verfahren zu seiner Herstellung und ihn enthaltende pharmazeutische Zusammensetzung
EP0429542B1 (de) *	1988-08-15	1995-12-06	Brigham And Women's Hospital	Leukozyten-adhäsions-inhibitor
WO1991008483A1 (en) *	1989-11-29	1991-06-13	Brigham And Women's Hospital	Endothelial-derived il-8
AU6952391A (en) *	1989-11-29	1991-06-26	Brigham And Women's Hospital	(ala il-8)77 as a leukocyte adhesion inhibitor
US5079228A (en) *	1990-02-05	1992-01-07	Board Of Regents, The University Of Texas System	Peptide inhibitors of neutrophil activating factor induced chemotaxis
IE913192A1 (en) *	1990-09-12	1992-02-25	Scripps Research Inst	Active site of interleukin-8: polypeptide analogs and¹antibodies
WO1993001826A1 (en) *	1991-07-19	1993-02-04	East Carolina University	Method of treating asthma

1992
- 1992-12-03 US US08/244,702 patent/US5665346A/en not_active Expired - Fee Related
- 1992-12-03 WO PCT/CA1992/000528 patent/WO1993011159A1/en not_active Ceased
- 1992-12-03 DE DE69226649T patent/DE69226649D1/de not_active Expired - Lifetime
- 1992-12-03 AU AU30788/92A patent/AU3078892A/en not_active Abandoned
- 1992-12-03 EP EP92924514A patent/EP0616615B1/de not_active Expired - Lifetime
- 1992-12-03 AT AT92924514T patent/ATE169638T1/de not_active IP Right Cessation
- 1992-12-03 CA CA002124461A patent/CA2124461A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2124461A1 (en)	1993-06-10
DE69226649D1 (de)	1998-09-17
AU3078892A (en)	1993-06-28
EP0616615A1 (de)	1994-09-28
EP0616615B1 (de)	1998-08-12
WO1993011159A1 (en)	1993-06-10
US5665346A (en)	1997-09-09

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Legal Events

Date	Code	Title	Description
1999-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties