ATE169816T1 - Verwendung von melatonin in niedrigen oralen dosen zum herbeiführen von schlaf - Google Patents

Verwendung von melatonin in niedrigen oralen dosen zum herbeiführen von schlaf

Info

Publication number: ATE169816T1
Authority: AT; Austria
Prior art keywords: melatonin; oral doses; low oral; induce sleep; sleep
Prior art date: 1992-10-01

Application number

AT93923164T

Other languages

English (en)

Inventor

Richard J Wurtman

Original Assignee

Massachusetts Inst Technology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-01

Filing date

1993-09-29

Publication date

1998-09-15

1993-09-29 Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology

1998-09-15 Application granted granted Critical

1998-09-15 Publication of ATE169816T1 publication Critical patent/ATE169816T1/de

Links

YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 title abstract 2
DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title abstract 2
229960003987 melatonin Drugs 0.000 title abstract 2
208000032140 Sleepiness Diseases 0.000 abstract 2
206010041349 Somnolence Diseases 0.000 abstract 2
230000037321 sleepiness Effects 0.000 abstract 2
230000001939 inductive effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Anesthesiology (AREA)
Indole Compounds (AREA)

AT93923164T 1992-10-01 1993-09-29 Verwendung von melatonin in niedrigen oralen dosen zum herbeiführen von schlaf ATE169816T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US95530492A	1992-10-01	1992-10-01
US08/093,317 US5449683A (en)	1992-10-01	1993-07-16	Methods of inducing sleep using melatonin

Publications (1)

Publication Number	Publication Date
ATE169816T1 true ATE169816T1 (de)	1998-09-15

Family

ID=26787395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93923164T ATE169816T1 (de)	1992-10-01	1993-09-29	Verwendung von melatonin in niedrigen oralen dosen zum herbeiführen von schlaf

Country Status (9)

Country	Link
US (2)	US5449683A (de)
EP (1)	EP0663825B1 (de)
JP (1)	JP3133760B2 (de)
AT (1)	ATE169816T1 (de)
CA (1)	CA2146151C (de)
DE (1)	DE69320485T2 (de)
DK (1)	DK0663825T3 (de)
ES (1)	ES2123064T3 (de)
WO (1)	WO1994007487A1 (de)

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US5753709A (en) *	1995-06-07	1998-05-19	Bristol-Myers Squibb Company	N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
AU6241796A (en) *	1995-06-27	1997-01-30	Takeda Chemical Industries Ltd.	4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists
CA2186412A1 (en) *	1995-10-31	1997-05-01	Katherine S. Takaki	Ethylamino carbazole melatonergic agents
DE19713141A1 (de) *	1996-03-29	1997-10-30	Labtec Gmbh	Transdermales System mit Melatonin
US5808151A (en) *	1996-04-17	1998-09-15	Bristol-Myers Squibb Company	Biphenylamido derivatives as melatonergic agents
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US5948817A (en) *	1997-03-05	1999-09-07	Bristol-Myers Squibb Company	Polycyclic ethyl alkylamide melatonergic agents
EP0867181A1 (de) *	1997-03-26	1998-09-30	Franciscus Wilhelmus Henricus Maria Merkus	Melatoninhaltiges Nasalpräparat
NZ501321A (en) *	1997-03-26	2001-04-27	Franciscus W	Nasal Melatonin composition
FR2762993B1 (fr) *	1997-05-06	1999-08-13	Inst Rech Biolog Sa	Nouvelle utilisation de phospholipides d'origine animale en therapeutique et/ou dietetique
US6028112A (en) *	1997-05-23	2000-02-22	Bristol-Myers Squibb Company	Spirocyclopropyl fluorenes as melatonergic agents
AU2333099A (en) *	1998-03-20	1999-10-18	Bristol-Myers Squibb Company	Aryloxyanilides and related compounds
EP1082115A4 (de)	1998-06-05	2002-10-24	Bristol Myers Squibb Co	Heterocyclische cis cyclopropanderivate als melatoninergische mittel
ES2213022T3 (es)	1999-06-30	2004-08-16	Bristol-Myers Squibb Company	Derivados de aminopirrolidina heterociclicos utiles como agentes melatonergicos.
CA2357114C (en) *	2001-03-22	2010-06-29	Pooger Properties Ltd.	Use of melatonin in the manufacture of a medicament for treating attention deficit hyperactive disorder
IL144900A (en)	2001-08-14	2013-12-31	Neurim Pharma 1991	Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
US6569894B1 (en)	2001-10-04	2003-05-27	Bristol-Myers Squibb Company	Arylalkylbenzofuran derivatives as melatonergic agents
US6737431B2 (en)	2002-03-12	2004-05-18	Bristol-Myers Squibb Company	Benzoxazole derivatives as novel melatonergic agents
DE60313785T2 (de) *	2002-09-26	2008-01-24	Pooger Properties Ltd., St. Helier, Jersey	Kombinierte verwendung von melatonin und methylphenidat zur behandlung von aufmerksamkeits-/hyperaktivitätsstörungen.
US6703412B1 (en)	2002-09-27	2004-03-09	Holly A. Rosenthal	Method of treating sleeplessness with melatonin on an acute basis
US9119846B2 (en)	2003-04-29	2015-09-01	Neurim Pharmaceuticals (1991) Ltd.	Method and composition for enhancing cognition in alzheimer's patients
IL155666A (en) *	2003-04-29	2013-12-31	Neurim Pharma 1991	Insomnia treatment
JP4891069B2 (ja) *	2004-03-31	2012-03-07	カルピス株式会社	内因性メラトニン分泌リズムの位相調整又は振幅増強剤、及び概日リズム改善剤
WO2005097101A1 (ja) *	2004-04-06	2005-10-20	Taiyokagaku Co., Ltd.	睡眠改善用組成物
WO2005109080A2 (en)	2004-04-23	2005-11-17	Physician Engineered Products Inc.	Head mounted photoeffective device
US7546165B2 (en) *	2005-12-19	2009-06-09	Cardiac Pacemakers, Inc.	Interconnections of implantable lead conductors and electrodes and reinforcement therefor
WO2007095716A1 (en)	2006-02-23	2007-08-30	Iomedix Sleep International Srl	Compositions and methods for the induction and maintenance of quality sleep
US20080171085A1 (en) *	2007-01-11	2008-07-17	Natrol, Inc.	Novel biphasic delivery system for a pharmaceutical or nutraceutical composition and method of administration
US20080248106A1 (en)	2007-04-05	2008-10-09	Marvin Heuer	Melatonin-based composition for improved sleep
WO2008122102A1 (en) *	2007-04-05	2008-10-16	Iomedix Development International Srl	Melatonin-based composition for improved sleep
US20100256215A1 (en) *	2009-04-02	2010-10-07	Silver Eagle Labs Nv, Llc	Menthol-Melatonin Dissolving Film
US20100256197A1 (en) *	2009-04-02	2010-10-07	Silver Eagle Labs Nv, Llc	Nicotine Dissolving Film With Or Without Menthol
US9532952B2 (en)	2011-01-28	2017-01-03	Physician's Seal, LLC	Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
WO2012103411A2 (en)	2011-01-28	2012-08-02	Zx Pharma, Llc	Controlled-release melatonin composition and related methods
US10369310B2 (en) *	2014-03-05	2019-08-06	ResMed Pty Ltd	Method and apparatus for treatment of respiratory disorders
US10849856B2 (en)	2016-10-31	2020-12-01	Neurim Pharmaceuticals Ltd.	Melatonin mini-tablets and method of manufacturing the same
MX386987B (es)	2016-10-31	2025-03-19	Neurim Pharma 1991	Mini-tabletas de melatonina y métodos de fabricación de las mismas.
IT201900002913A1 (it)	2019-03-01	2020-09-01	Nicola Pescosolido	Composto utile per il trattamento del glaucoma
JP2024526109A (ja)	2021-07-05	2024-07-17	セレスタカンパニーエルエルシー	安眠を促進するための組成物ならびにその製造方法および使用方法
US11833182B2 (en)	2021-08-10	2023-12-05	Shaklee Corporation	Sleep product

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JPS5557563A (en) *	1978-10-21	1980-04-28	Hoechst Ag	Melatonine nasal application composition
JPS6045513A (ja) *	1983-05-18	1985-03-12	モナシユ　ユニバ−シテイ	身体行動および機能の日周期の不調を軽減する薬剤
DE3466215D1 (en) *	1983-05-18	1987-10-22	Univ Monash	The use of melatonin for the manufacture of a medicament
US4600723A (en) *	1983-05-18	1986-07-15	Monash University	Method for minimizing disturbances in circadian rhythms of bodily performance and function
US4687763A (en) *	1985-02-25	1987-08-18	Massachusetts Institute Of Technology	Composition and method for increasing levels or release of brain serotonin
JPH0418034A (ja) *	1990-05-11	1992-01-22	Kanegafuchi Chem Ind Co Ltd	点眼組成物
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IT1243193B (it) *	1990-08-10	1994-05-24	Medea Res Srl	Composizioni farmaceutiche orali a base di melatonina
US5242941A (en) *	1990-12-04	1993-09-07	State Of Oregon	Methods of treating circadian rhythm disorders
IT1251544B (it) *	1991-05-13	1995-05-17	Gabriele Biella	Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico
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IT1254995B (it) *	1992-06-24	1995-10-11		Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
US5449683A (en) *	1992-10-01	1995-09-12	Massachussetts Institute Of Technology	Methods of inducing sleep using melatonin

1993
- 1993-07-16 US US08/093,317 patent/US5449683A/en not_active Expired - Lifetime
- 1993-09-29 AT AT93923164T patent/ATE169816T1/de not_active IP Right Cessation
- 1993-09-29 JP JP06509286A patent/JP3133760B2/ja not_active Expired - Fee Related
- 1993-09-29 DK DK93923164T patent/DK0663825T3/da active
- 1993-09-29 WO PCT/US1993/009273 patent/WO1994007487A1/en not_active Ceased
- 1993-09-29 CA CA002146151A patent/CA2146151C/en not_active Expired - Fee Related
- 1993-09-29 EP EP93923164A patent/EP0663825B1/de not_active Expired - Lifetime
- 1993-09-29 ES ES93923164T patent/ES2123064T3/es not_active Expired - Lifetime
- 1993-09-29 DE DE69320485T patent/DE69320485T2/de not_active Expired - Fee Related
1995
- 1995-06-07 US US08/475,452 patent/US5641801A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP3133760B2 (ja)	2001-02-13
US5449683A (en)	1995-09-12
ES2123064T3 (es)	1999-01-01
DE69320485T2 (de)	1999-04-01
WO1994007487A1 (en)	1994-04-14
EP0663825B1 (de)	1998-08-19
CA2146151C (en)	1997-09-02
US5641801A (en)	1997-06-24
DE69320485D1 (de)	1998-09-24
JPH08502259A (ja)	1996-03-12
DK0663825T3 (da)	1999-05-25
EP0663825A1 (de)	1995-07-26

Legal Events

Date	Code	Title	Description
1999-04-15	UEP	Publication of translation of european patent specification
2004-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69320485D1 (de)	1998-09-24	VERWENDUNG VON MELATONIN in niedrigen oralen Dosen ZUM HERBEIFÜHREN VON SCHLAF
NO952469D0 (no)	1995-06-20	Terapautisk kombinasjon som inneholder interferon
DK162986A (da)	1986-10-13	Terapeutisk middel i enhedsdosisform
DE69735581D1 (de)	2006-05-18	Dosierungsform für eine verzögerte und zunehmende wirkstoffsfreisetzung
DK0562041T3 (da)	2002-10-28	Undermættet transdermal lægemiddeludleveringsanordning, der udviser forøget lægemiddelflux
FI875795A7 (fi)	1988-10-16	Valonsäteilyttämislaite käytettäväksi nenän- ja nielun tiehyeiden lääketieteelliseen hoitoon.
ATE184792T1 (de)	1999-10-15	2-bromomelatonin zur behandlung von schlafstörungen
DE3687099D1 (de)	1992-12-17	Verwendung von einem cartilago-induzierenden faktor (cif) zur herstellung eines arzneimittels zur behandlung von entzuendungen.
DE69034018D1 (de)	2002-12-19	Kombinierte verwendung von hyaluronsäure und therapeutischen wirkstoffen zur verbesserung des therapeutischen effekts
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MX9602442A (es)	1997-02-28	Un tratamiento con fluoroquinolona a dosis unica elevada.
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NO145789C (no)	1982-06-02	Nye piperidinforbindelser med plaquehemmende virkning og for anvendelse i preparater for behandling av munnhule og tannflater
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ATE200617T1 (de)	2001-05-15	Pharmazeutische zusammensetzungen zur transdermalen verabreichung von melatonin und/oder seine analoge
SE7700626L (sv)	1977-07-30	Patientstol for ltandbehandling
ATE229981T1 (de)	2003-01-15	Glykolisierte cytokine
IT8809313A0 (it)	1988-01-22	Macchina per il trattamento terapeutico di lombalgie e lombosciatalgie
ATE78695T1 (de)	1992-08-15	Verwendung und mittel zur verminderung der nebenwirkungen von tnf.
ES2051788T3 (es)	1994-07-01	Un producto farmaceutico.
DE59207468D1 (de)	1996-12-05	Verwendung von interleukin 10 zur herstellung von arzneimitteln mit tumorhemmender wirksamkeit