ATE170186T1 - 2-(indol-2-yl-carbonylamino)-thiazolderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen - Google Patents

2-(indol-2-yl-carbonylamino)-thiazolderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen

Info

Publication number: ATE170186T1
Authority: AT; Austria
Prior art keywords: group; alkyl; optionally substituted; image; optionally
Prior art date: 1991-06-05

Application number

AT92401518T

Other languages

English (en)

Inventor

Robert Boigegrain

Roger Brodin

Danielle Gully

Jean-Charles Molimard

Dominique Olliero

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-05

Filing date

1992-06-03

Publication date

1998-09-15

1992-06-03 Application filed by Sanofi Sa filed Critical Sanofi Sa

1998-09-15 Application granted granted Critical

1998-09-15 Publication of ATE170186T1 publication Critical patent/ATE170186T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
LAYGQJJPLOWSRJ-UHFFFAOYSA-N n-(1,3-thiazol-2-yl)-1h-indole-2-carboxamide Chemical class C=1C2=CC=CC=C2NC=1C(=O)NC1=NC=CS1 LAYGQJJPLOWSRJ-UHFFFAOYSA-N 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
125000005242 carbamoyl alkyl group Chemical group 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
125000002843 carboxylic acid group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
KGFYHTZWPPHNLQ-AWEZNQCLSA-N rivaroxaban Chemical compound S1C(Cl)=CC=C1C(=O)NC[C@@H]1OC(=O)N(C=2C=CC(=CC=2)N2C(COCC2)=O)C1 KGFYHTZWPPHNLQ-AWEZNQCLSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT92401518T 1991-06-05 1992-06-03 2-(indol-2-yl-carbonylamino)-thiazolderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen ATE170186T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9106814A FR2677356B1 (fr)	1991-06-05	1991-06-05	Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.

Publications (1)

Publication Number	Publication Date
ATE170186T1 true ATE170186T1 (de)	1998-09-15

Family

ID=9413505

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92401518T ATE170186T1 (de)	1991-06-05	1992-06-03	2-(indol-2-yl-carbonylamino)-thiazolderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen

Country Status (23)

Country	Link
US (2)	US5314889A (de)
EP (1)	EP0518731B1 (de)
JP (1)	JP3199451B2 (de)
KR (1)	KR100222309B1 (de)
AT (1)	ATE170186T1 (de)
AU (1)	AU650754B2 (de)
BR (2)	BR9202156A (de)
CA (1)	CA2070526A1 (de)
CZ (1)	CZ289003B6 (de)
DE (1)	DE69226729T2 (de)
ES (1)	ES2121575T3 (de)
FI (1)	FI922589A7 (de)
FR (1)	FR2677356B1 (de)
HU (1)	HU221312B1 (de)
IE (1)	IE921814A1 (de)
IL (1)	IL102004A (de)
MX (1)	MX9202662A (de)
NO (1)	NO300135B1 (de)
NZ (1)	NZ243009A (de)
RU (1)	RU2059637C1 (de)
TW (1)	TW202448B (de)
UA (1)	UA26899C2 (de)
ZA (1)	ZA923981B (de)

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US6187536B1 (en)	1997-02-18	2001-02-13	Thomas Jefferson University	Methods of identifying and detecting pancreatic cancer
CO4970713A1 (es) *	1997-09-19	2000-11-07	Sanofi Synthelabo	Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen
FR2768737B1 (fr) *	1997-09-19	2000-05-19	Sanofi Sa	Derives de carboxamidothiazoles, leur preparation, les compositions pharmaceutiques en contenant
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US20040077697A1 (en) *	2001-02-02	2004-04-22	Hiroyuki Koshio	2-Acylaminothiazole derivative or its salt
US7638536B2 (en) *	2002-01-18	2009-12-29	Astellas Pharma Inc.	2-Acylaminothiazole derivative or salt thereof
US20030225054A1 (en) *	2002-06-03	2003-12-04	Jingwu Duan	Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents
FR2854158B1 (fr) *	2003-04-25	2006-11-17	Sanofi Synthelabo	Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
EP1647553A4 (de) *	2003-07-17	2008-12-31	Astellas Pharma Inc	2-acylaminothiazolderivat oder salz davon
SA04250288B1 (ar) *	2003-09-19	2008-07-19	سولفاي فارماسوتيكالز بي . في	مشتقات ثيازول thiazole كمعدلات لمستقبل المكونات الكيميائية للقنب cannabinoid
CN100509808C (zh) *	2003-12-08	2009-07-08	霍夫曼-拉罗奇有限公司	新型噻唑衍生物
JP4638355B2 (ja) *	2003-12-26	2011-02-23	協和発酵キリン株式会社	チアゾール誘導体
GB0401336D0 (en) *	2004-01-21	2004-02-25	Novartis Ag	Organic compounds
AU2005247943A1 (en)	2004-05-23	2005-12-08	Gerard M. Housey	Theramutein modulators
FR2872813B1 (fr) *	2004-07-09	2007-01-19	Sanofi Synthelabo	Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
RU2007109073A (ru) *	2004-08-13	2008-09-20	Дженентек, Инк. (Us)	Ингибиторы для атф-зависимого фермента на основе тиазола
FR2876692B1 (fr) *	2004-10-19	2007-02-23	Sanofi Aventis Sa	Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
JP4774995B2 (ja) *	2005-01-12	2011-09-21	アステラス製薬株式会社	アシルアミノチアゾール誘導体を有効成分とする医薬組成物
BRPI0611187A2 (pt) *	2005-06-03	2010-08-24	Xenon Pharmaceuticals Inc	derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
US20100280023A1 (en) *	2005-06-23	2010-11-04	Kyowa Hakko Kogyo Co., Ltd.	Thiazole derivatives
CA2617817C (en)	2005-08-02	2014-05-27	Kyowa Kirin Co., Ltd.	Thiazole derivatives for treating or preventing sleep disorders
JP2009514941A (ja) *	2005-11-08	2009-04-09	アステラス製薬株式会社	血小板減少症を治療する化合物および方法
FR2895989B1 (fr) *	2006-01-06	2010-04-30	Sanofi Aventis	Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
TWI444370B (zh) *	2006-01-25	2014-07-11	Synta Pharmaceuticals Corp	用於發炎及免疫相關用途之噻唑及噻二唑化合物
CN101096363B (zh) *	2006-06-27	2011-05-11	中国人民解放军军事医学科学院毒物药物研究所	2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
WO2008021283A2 (en) *	2006-08-08	2008-02-21	Akarx, Inc.	Compositions and methods for increasing blood platelet levels in humans
EP2240029A4 (de) *	2008-01-07	2012-08-22	Synta Pharmaceuticals Corp	Verbindungen zur verwendung gegen entzündungs- und immunspezifische erkrankungen
RU2506267C2 (ru) *	2008-03-31	2014-02-10	Дженентек, Инк.	Бензопирановые и бензоксепиновые ингибиторы рi3k и их применение
EP2464352A1 (de) *	2009-08-14	2012-06-20	Eisai Inc.	Verwendung von e5501 zur anregung der thrombozytenproduktion
AU2010299820A1 (en) *	2009-09-28	2012-04-19	F. Hoffmann-La Roche Ag	Benzoxepin PI3K inhibitor compounds and methods of use
CA2772691C (en) *	2009-09-28	2017-10-03	F. Hoffmann-La Roche Ag	Benzoxazepin pi3k inhibitor compounds and methods of use
ES2557465T3 (es) *	2010-03-17	2016-01-26	Taivex Therapeutics Inc.	Moduladores de la actividad de HEC 1 y procedimientos para ello
BR112013024122A2 (pt)	2011-03-21	2019-09-24	Hoffmann La Roche	compostos de benzoxazepina seletivos para p110 delta pi3k e métodos de uso
KR20140131359A (ko)	2012-02-17	2014-11-12	에프. 호프만-라 로슈 아게	트라이사이클릭 화합물 및 이의 사용 방법
EP3846793B1 (de)	2018-09-07	2024-01-24	PIC Therapeutics, Inc.	Eif4e-inhibitoren und verwendungen davon
MX2022010944A (es)	2020-03-03	2022-11-09	Pic Therapeutics Inc	Inhibidores del factor de iniciacion de traduccion eucariotica 4e (eif4e) y sus usos.
JP7592158B2 (ja)	2021-05-06	2024-11-29	三菱電機株式会社	ピッキングシステム
TW202315621A (zh)	2021-08-25	2023-04-16	美商皮克醫療公司	Ｅｉｆ４ｅ抑制劑及其用途
JP2024532276A (ja)	2021-08-25	2024-09-05	ピクセラピューティクス，インコーポレイテッド	ｅＩＦ４Ｅ阻害剤及びその使用

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1991
- 1991-06-05 FR FR9106814A patent/FR2677356B1/fr not_active Expired - Fee Related
1992
- 1992-05-26 IL IL102004A patent/IL102004A/xx not_active IP Right Cessation
- 1992-05-28 AU AU17279/92A patent/AU650754B2/en not_active Ceased
- 1992-05-29 US US07/889,910 patent/US5314889A/en not_active Expired - Fee Related
- 1992-06-01 TW TW081104270A patent/TW202448B/zh active
- 1992-06-01 ZA ZA923981A patent/ZA923981B/xx unknown
- 1992-06-03 ES ES92401518T patent/ES2121575T3/es not_active Expired - Lifetime
- 1992-06-03 NZ NZ243009A patent/NZ243009A/en unknown
- 1992-06-03 DE DE69226729T patent/DE69226729T2/de not_active Expired - Fee Related
- 1992-06-03 AT AT92401518T patent/ATE170186T1/de not_active IP Right Cessation
- 1992-06-03 EP EP92401518A patent/EP0518731B1/de not_active Expired - Lifetime
- 1992-06-04 HU HU9201870A patent/HU221312B1/hu not_active IP Right Cessation
- 1992-06-04 CA CA002070526A patent/CA2070526A1/en not_active Abandoned
- 1992-06-04 MX MX9202662A patent/MX9202662A/es not_active IP Right Cessation
- 1992-06-04 CZ CS19921693A patent/CZ289003B6/cs not_active IP Right Cessation
- 1992-06-04 FI FI922589A patent/FI922589A7/fi not_active Application Discontinuation
- 1992-06-04 RU SU5011874/04A patent/RU2059637C1/ru not_active IP Right Cessation
- 1992-06-04 JP JP14415092A patent/JP3199451B2/ja not_active Expired - Fee Related
- 1992-06-04 NO NO922215A patent/NO300135B1/no not_active IP Right Cessation
- 1992-06-05 KR KR1019920009859A patent/KR100222309B1/ko not_active Expired - Fee Related
- 1992-06-05 BR BR929202156A patent/BR9202156A/pt not_active Application Discontinuation
- 1992-07-01 IE IE181492A patent/IE921814A1/en not_active IP Right Cessation
1993
- 1993-06-15 UA UA93002939A patent/UA26899C2/uk unknown
1994
- 1994-03-03 US US08/205,408 patent/US5380736A/en not_active Expired - Fee Related
1997
- 1997-05-12 BR BR1100786-9A patent/BR1100786A/pt active IP Right Grant

Also Published As

Publication number	Publication date
AU1727992A (en)	1992-12-10
CZ289003B6 (cs)	2001-10-17
FI922589A7 (fi)	1992-12-06
IE921814A1 (en)	1992-12-16
FR2677356B1 (fr)	1995-03-17
HUT75870A (en)	1997-05-28
IL102004A (en)	1997-04-15
NO922215L (no)	1992-12-07
HK1012397A1 (en)	1999-07-30
CS169392A3 (en)	1992-12-16
NO922215D0 (no)	1992-06-04
DE69226729D1 (de)	1998-10-01
EP0518731B1 (de)	1998-08-26
EP0518731A1 (de)	1992-12-16
JPH05155871A (ja)	1993-06-22
ZA923981B (en)	1993-12-01
BR9202156A (pt)	1993-02-02
JP3199451B2 (ja)	2001-08-20
TW202448B (de)	1993-03-21
IL102004A0 (en)	1992-12-30
RU2059637C1 (ru)	1996-05-10
FR2677356A1 (fr)	1992-12-11
DE69226729T2 (de)	1999-05-06
HU9201870D0 (en)	1992-08-28
NZ243009A (en)	1995-05-26
BR1100786A (pt)	2000-03-14
UA26899C2 (uk)	1999-12-29
US5380736A (en)	1995-01-10
ES2121575T3 (es)	1998-12-01
NO300135B1 (no)	1997-04-14
KR100222309B1 (ko)	1999-10-01
KR930000492A (ko)	1993-01-15
FI922589A0 (fi)	1992-06-04
CA2070526A1 (en)	1992-12-06
HU221312B1 (en)	2002-09-28
MX9202662A (es)	1992-12-31
AU650754B2 (en)	1994-06-30
US5314889A (en)	1994-05-24

Legal Events

Date	Code	Title	Description
1999-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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