UA26899C2 - Гетероциклічhі похідhі заміщеhих 2-ациламіhо-5-тіазолів, способи їх одержаhhя, похідhе заміщеhого 2-аміhотіазолу, похідhе 2-аміhо-4-феhілтіазолу - Google Patents

Гетероциклічhі похідhі заміщеhих 2-ациламіhо-5-тіазолів, способи їх одержаhhя, похідhе заміщеhого 2-аміhотіазолу, похідhе 2-аміhо-4-феhілтіазолу

Info

Publication number: UA26899C2
Authority: UA; Ukraine
Prior art keywords: group; alkyl; optionally substituted; image; optionally
Prior art date: 1991-06-05

Application number

UA93002939A

Other languages

English (en)

Inventor

Робер БУАЖЕГРЕH

Роже БРОДЕH

Данієль ГЮЛЛІ

Жан-Шарль Молімар

Домінік ОЛЛІЄРО

Original Assignee

Саhофі

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-05

Filing date

1993-06-15

Publication date

1999-12-29

1993-06-15 Application filed by Саhофі filed Critical Саhофі

1999-12-29 Publication of UA26899C2 publication Critical patent/UA26899C2/uk

Links

125000000217 alkyl group Chemical group 0.000 abstract 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
125000005242 carbamoyl alkyl group Chemical group 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
125000002843 carboxylic acid group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
KGFYHTZWPPHNLQ-AWEZNQCLSA-N rivaroxaban Chemical compound S1C(Cl)=CC=C1C(=O)NC[C@@H]1OC(=O)N(C=2C=CC(=CC=2)N2C(COCC2)=O)C1 KGFYHTZWPPHNLQ-AWEZNQCLSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

UA93002939A 1991-06-05 1993-06-15 Гетероциклічhі похідhі заміщеhих 2-ациламіhо-5-тіазолів, способи їх одержаhhя, похідhе заміщеhого 2-аміhотіазолу, похідhе 2-аміhо-4-феhілтіазолу UA26899C2 (uk)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9106814A FR2677356B1 (fr)	1991-06-05	1991-06-05	Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.

Publications (1)

Publication Number	Publication Date
UA26899C2 true UA26899C2 (uk)	1999-12-29

Family

ID=9413505

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA93002939A UA26899C2 (uk)	1991-06-05	1993-06-15	Гетероциклічhі похідhі заміщеhих 2-ациламіhо-5-тіазолів, способи їх одержаhhя, похідhе заміщеhого 2-аміhотіазолу, похідhе 2-аміhо-4-феhілтіазолу

Country Status (23)

Country	Link
US (2)	US5314889A (uk)
EP (1)	EP0518731B1 (uk)
JP (1)	JP3199451B2 (uk)
KR (1)	KR100222309B1 (uk)
AT (1)	ATE170186T1 (uk)
AU (1)	AU650754B2 (uk)
BR (2)	BR9202156A (uk)
CA (1)	CA2070526A1 (uk)
CZ (1)	CZ289003B6 (uk)
DE (1)	DE69226729T2 (uk)
ES (1)	ES2121575T3 (uk)
FI (1)	FI922589A7 (uk)
FR (1)	FR2677356B1 (uk)
HU (1)	HU221312B1 (uk)
IE (1)	IE921814A1 (uk)
IL (1)	IL102004A (uk)
MX (1)	MX9202662A (uk)
NO (1)	NO300135B1 (uk)
NZ (1)	NZ243009A (uk)
RU (1)	RU2059637C1 (uk)
TW (1)	TW202448B (uk)
UA (1)	UA26899C2 (uk)
ZA (1)	ZA923981B (uk)

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FR2703995B1 (fr) *	1993-04-16	1995-07-21	Sanofi Elf	5-acylamino 1,2,4-thiadiazoles, leur preparation et compositions pharmaceutiques en contenant.
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WO1998035707A1 (en)	1997-02-18	1998-08-20	Thomas Jefferson University	Compositions that bind to pancreatic cancer cells and methods of using the same
CO4970713A1 (es)	1997-09-19	2000-11-07	Sanofi Synthelabo	Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen
FR2768737B1 (fr) *	1997-09-19	2000-05-19	Sanofi Sa	Derives de carboxamidothiazoles, leur preparation, les compositions pharmaceutiques en contenant
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PT1466912E (pt) *	2002-01-18	2013-06-28	Astellas Pharma Inc	Derivado de 2-aciloaminotiazol ou seu sal
US20030225054A1 (en) *	2002-06-03	2003-12-04	Jingwu Duan	Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents
FR2854158B1 (fr) *	2003-04-25	2006-11-17	Sanofi Synthelabo	Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
JP4324791B2 (ja) *	2003-07-17	2009-09-02	アステラス製薬株式会社	２−アシルアミノチアゾール誘導体又はその塩
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FR2872813B1 (fr) *	2004-07-09	2007-01-19	Sanofi Synthelabo	Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
BRPI0515012A (pt) *	2004-08-13	2008-07-01	Genentech Inc	substáncia quìmica, composição e formulação farmacêutica, método de tratamento, método de inibição de pelo menos uma enzima que utiliza atp e uso
FR2876692B1 (fr) *	2004-10-19	2007-02-23	Sanofi Aventis Sa	Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
JP4774995B2 (ja) *	2005-01-12	2011-09-21	アステラス製薬株式会社	アシルアミノチアゾール誘導体を有効成分とする医薬組成物
EP2029138A1 (en) *	2005-06-03	2009-03-04	Xenon Pharmaceuticals Inc.	Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
EP1894930A4 (en)	2005-06-23	2010-06-23	Kyowa Hakko Kirin Co Ltd	THIAZOLE DERIVATIVE
DK1921077T3 (en)	2005-08-02	2017-10-23	Kyowa Hakko Kirin Co Ltd	Means for treating and / or preventing sleep disorders
WO2007054783A2 (en) *	2005-11-08	2007-05-18	Astellas Pharma Inc.	Compositions and methods for treating thrombocytopenia
FR2895989B1 (fr) *	2006-01-06	2010-04-30	Sanofi Aventis	Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
JP2009524677A (ja) *	2006-01-25	2009-07-02	シンタファーマシューティカルズコーポレーション	炎症および免疫関連使用用のチアゾールおよびチアジアゾール化合物
CN101096363B (zh) *	2006-06-27	2011-05-11	中国人民解放军军事医学科学院毒物药物研究所	2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
ES2452032T3 (es) *	2006-08-08	2014-03-31	Akarx, Inc.	Composiciones y métodos para aumentar los niveles de plaquetas de la sangre en humanos
US20110052643A1 (en) *	2008-01-07	2011-03-03	Synta Pharmaceuticals Corp.	Compounds for inflammation and immune-related uses
ES2480994T3 (es)	2008-03-31	2014-07-29	Genentech, Inc.	Compuestos de tipo benzopirano y benzoxepina inhibidores de PI3K y métodos de uso
WO2011019990A1 (en) *	2009-08-14	2011-02-17	Eisai, Inc.	Use of e5501 for stimulating platelet production
TWI423980B (zh)	2009-09-28	2014-01-21	Hoffmann La Roche	苯并氧氮呯ｐｉ３ｋ抑制劑化合物及使用方法
US8263633B2 (en) *	2009-09-28	2012-09-11	F. Hoffman-La Roche Ag	Benzoxepin PI3K inhibitor compounds and methods of use
CN103038231B (zh) *	2010-03-17	2016-04-20	泰纬生命科技股份有限公司	Hec1活性调节剂及其方法
KR20140032383A (ko)	2011-03-21	2014-03-14	에프. 호프만-라 로슈 아게	Pi3k p110 델타에 대하여 선택적인 벤즈옥사제핀 화합물 및 이의 사용 방법
AR089999A1 (es)	2012-02-17	2014-10-01	Hoffmann La Roche	Compuestos triciclicos y metodos para el uso de los mismos
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AR121506A1 (es)	2020-03-03	2022-06-08	Pic Therapeutics Inc	Inhibidores del eif4e y sus usos
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1991
- 1991-06-05 FR FR9106814A patent/FR2677356B1/fr not_active Expired - Fee Related
1992
- 1992-05-26 IL IL102004A patent/IL102004A/xx not_active IP Right Cessation
- 1992-05-28 AU AU17279/92A patent/AU650754B2/en not_active Ceased
- 1992-05-29 US US07/889,910 patent/US5314889A/en not_active Expired - Fee Related
- 1992-06-01 ZA ZA923981A patent/ZA923981B/xx unknown
- 1992-06-01 TW TW081104270A patent/TW202448B/zh active
- 1992-06-03 DE DE69226729T patent/DE69226729T2/de not_active Expired - Fee Related
- 1992-06-03 AT AT92401518T patent/ATE170186T1/de not_active IP Right Cessation
- 1992-06-03 EP EP92401518A patent/EP0518731B1/fr not_active Expired - Lifetime
- 1992-06-03 ES ES92401518T patent/ES2121575T3/es not_active Expired - Lifetime
- 1992-06-03 NZ NZ243009A patent/NZ243009A/en unknown
- 1992-06-04 CA CA002070526A patent/CA2070526A1/en not_active Abandoned
- 1992-06-04 CZ CS19921693A patent/CZ289003B6/cs not_active IP Right Cessation
- 1992-06-04 NO NO922215A patent/NO300135B1/no not_active IP Right Cessation
- 1992-06-04 MX MX9202662A patent/MX9202662A/es not_active IP Right Cessation
- 1992-06-04 JP JP14415092A patent/JP3199451B2/ja not_active Expired - Fee Related
- 1992-06-04 HU HU9201870A patent/HU221312B1/hu not_active IP Right Cessation
- 1992-06-04 RU SU5011874/04A patent/RU2059637C1/ru not_active IP Right Cessation
- 1992-06-04 FI FI922589A patent/FI922589A7/fi not_active Application Discontinuation
- 1992-06-05 BR BR929202156A patent/BR9202156A/pt not_active Application Discontinuation
- 1992-06-05 KR KR1019920009859A patent/KR100222309B1/ko not_active Expired - Fee Related
- 1992-07-01 IE IE181492A patent/IE921814A1/en not_active IP Right Cessation
1993
- 1993-06-15 UA UA93002939A patent/UA26899C2/uk unknown
1994
- 1994-03-03 US US08/205,408 patent/US5380736A/en not_active Expired - Fee Related
1997
- 1997-05-12 BR BR1100786-9A patent/BR1100786A/pt active IP Right Grant

Also Published As

Publication number	Publication date
NZ243009A (en)	1995-05-26
US5314889A (en)	1994-05-24
IL102004A (en)	1997-04-15
EP0518731B1 (fr)	1998-08-26
AU1727992A (en)	1992-12-10
RU2059637C1 (ru)	1996-05-10
HUT75870A (en)	1997-05-28
BR1100786A (pt)	2000-03-14
JPH05155871A (ja)	1993-06-22
CS169392A3 (en)	1992-12-16
BR9202156A (pt)	1993-02-02
IL102004A0 (en)	1992-12-30
ES2121575T3 (es)	1998-12-01
DE69226729T2 (de)	1999-05-06
NO300135B1 (no)	1997-04-14
ZA923981B (en)	1993-12-01
KR930000492A (ko)	1993-01-15
MX9202662A (es)	1992-12-31
KR100222309B1 (ko)	1999-10-01
TW202448B (uk)	1993-03-21
IE921814A1 (en)	1992-12-16
HU221312B1 (en)	2002-09-28
NO922215D0 (no)	1992-06-04
CZ289003B6 (cs)	2001-10-17
HK1012397A1 (en)	1999-07-30
DE69226729D1 (de)	1998-10-01
HU9201870D0 (en)	1992-08-28
ATE170186T1 (de)	1998-09-15
US5380736A (en)	1995-01-10
FR2677356B1 (fr)	1995-03-17
EP0518731A1 (fr)	1992-12-16
FI922589A7 (fi)	1992-12-06
JP3199451B2 (ja)	2001-08-20
FR2677356A1 (fr)	1992-12-11
CA2070526A1 (en)	1992-12-06
NO922215L (no)	1992-12-07
FI922589A0 (fi)	1992-06-04
AU650754B2 (en)	1994-06-30

Publication	Publication Date	Title
AU650754B2 (en)	1994-06-30	Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaceutical compositions containing them
SE8406585D0 (sv)	1984-12-21	Benzoic acid derivatives
FI863564A0 (fi)	1986-09-04	Foerfarande foer framstaellning av heterocykliskt substituerade indoler.
MX9202947A (es)	1992-07-01	Compuesto antibacteriano de quinolina.
JPS568361A (en)	1981-01-28	Pyroglutamic acid derivative and analogue
NO892579L (no)	1989-06-21	Heterocykliske forbindelser.
BG60699B2 (bg)	1995-12-29	Антибактериални цефалоспоринови съединения
CA1272482C (en)	1990-08-07	QUINOLINECARBOXYLIC ACID DERIVATIVES
FI834451A0 (fi)	1983-12-05	Foerfarande foer framstaellning av nya substituerade 1,4-dihydropyridiner
ATE182889T1 (de)	1999-08-15	Bicyclische amidinderivate als no-synthetase inhibitoren
DE3474022D1 (de)	1988-10-20	Quinazoline and isoquinoline derivatives
ATE143949T1 (de)	1996-10-15	Buten- oder propensäure-derivate
ATE33133T1 (de)	1988-04-15	Alpha-alkyl-polyencarbonsaeuren, ihre derivate und ihre verwendung in der behandlung von psoriasis.
DE60037766D1 (de)	2008-02-21	Verfahren zur Herstellung von 2-Alkyl-3-aminothiophen Derivate und 3-Aminothiophen Derivate
DK384485A (da)	1986-02-26	1,6-naphthyridinderivater med kardilaterende virkning
ATE5397T1 (de)	1983-12-15	Cinnamoyl-zimtsaeure-derivat, seine herstellung und seine therapeutische anwendung.
ES523890A0 (es)	1985-04-01	Un procedimiento para preparar derivados de penem.
ATE149494T1 (de)	1997-03-15	Benzopyranderivate und verfahren zu deren herstellung
MX9102514A (es)	1992-09-01	Novedosos derivados de aminoalquilcetona, su procenovedosos derivados de aminoalquilcetona, su procenovedosos derivados de amino alquil cetona, su procedimiento de preparacion y sus aplicaciones terapdimiento de preparacion y sus aplicaciones terapeudimiento de preparacion y sus aplicaciones terapeuticas. ticas. euticas.
YU128291A (sh)	1994-09-09	Postpak za dobijanje 6-(3-substituisanih aminopropionil) 7-deacetilforskolinskih derivata
ATE86620T1 (de)	1993-03-15	7-(1-imidazolyl)-1,4-dihydro-4-oxo-6,8-difluoro 1-cyclopropylchinolincarbonsaeure-derivate, ihre herstellung und ihre verwendung als arzneimittel.
GB2004294A (en)	1979-03-28	Process for the manufacture of phthalides