ATE170522T1 - Aminoalkylcarbamatester von eserolin verwendbar als inhibitoren von cholinesteraseaktivität und verfahren zu deren herstellung - Google Patents

Aminoalkylcarbamatester von eserolin verwendbar als inhibitoren von cholinesteraseaktivität und verfahren zu deren herstellung

Info

Publication number
ATE170522T1
ATE170522T1 AT93109932T AT93109932T ATE170522T1 AT E170522 T1 ATE170522 T1 AT E170522T1 AT 93109932 T AT93109932 T AT 93109932T AT 93109932 T AT93109932 T AT 93109932T AT E170522 T1 ATE170522 T1 AT E170522T1
Authority
AT
Austria
Prior art keywords
eseroline
esters
inhibitors
aminoalkylcarbamate
usable
Prior art date
Application number
AT93109932T
Other languages
English (en)
Inventor
Maria Alessandra Alisi
Mario E Brufani
Maria Candida Cesta
Luigi Filocamo
Gianluca Gostoli
Sperandina Lappa
Pier Giuseppe Pagella
Enrico Ferrari
Stefano Maiorana
Donata Marchesini
Original Assignee
Mediolanum Farmaceutici Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Farmaceutici Srl filed Critical Mediolanum Farmaceutici Srl
Application granted granted Critical
Publication of ATE170522T1 publication Critical patent/ATE170522T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT93109932T 1992-06-25 1993-06-22 Aminoalkylcarbamatester von eserolin verwendbar als inhibitoren von cholinesteraseaktivität und verfahren zu deren herstellung ATE170522T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI921559A IT1254996B (it) 1992-06-25 1992-06-25 Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione

Publications (1)

Publication Number Publication Date
ATE170522T1 true ATE170522T1 (de) 1998-09-15

Family

ID=11363576

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93109932T ATE170522T1 (de) 1992-06-25 1993-06-22 Aminoalkylcarbamatester von eserolin verwendbar als inhibitoren von cholinesteraseaktivität und verfahren zu deren herstellung

Country Status (8)

Country Link
US (2) US5302593A (de)
EP (1) EP0575954B1 (de)
JP (1) JPH06206882A (de)
KR (1) KR940005627A (de)
AT (1) ATE170522T1 (de)
CA (1) CA2099648A1 (de)
DE (1) DE69320705D1 (de)
IT (1) IT1254996B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133444A (en) 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
IT1271679B (it) * 1994-07-18 1997-06-04 Mediolanum Farmaceutici Srl Derivati del fenilcarbammato atti all'impiego come anticolinesterasici
WO1996040709A1 (en) * 1995-06-07 1996-12-19 Perseptive Biosystems, Inc. Pna-dna chimeras and pna synthons for their preparation
US5952506A (en) * 1997-04-24 1999-09-14 American Home Products Corporation Process for the synthesis of 4- 6- (hexylcarbamoyloxy) hexylcarbamoyloxy!-piperidine-1-carboxylic acid 4-phenoxyphenyl ester
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
US20110212928A1 (en) 2010-02-09 2011-09-01 The Johns Hopkins University Methods and compositions for improving cognitive function
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
EP2968220B1 (de) 2013-03-15 2021-05-05 Agenebio, Inc. Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
NZ738682A (en) 2015-05-22 2022-01-28 Agenebio Inc Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
EP0513703A3 (en) * 1991-05-13 1993-01-13 Magis Farmaceutici S.P.A. Carbamate esters of eseroline having anticholinesterase activity, a process for their preparation and relative pharmaceutical compositions containing them as the active principle

Also Published As

Publication number Publication date
EP0575954A1 (de) 1993-12-29
ITMI921559A0 (it) 1992-06-25
IT1254996B (it) 1995-10-11
US5424451A (en) 1995-06-13
CA2099648A1 (en) 1993-12-26
US5302593A (en) 1994-04-12
ITMI921559A1 (it) 1993-12-25
DE69320705D1 (de) 1998-10-08
KR940005627A (ko) 1994-03-22
EP0575954B1 (de) 1998-09-02
JPH06206882A (ja) 1994-07-26

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Legal Events

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