IT1254996B - Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione - Google Patents

Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione

Info

Publication number
IT1254996B
IT1254996B ITMI921559A ITMI921559A IT1254996B IT 1254996 B IT1254996 B IT 1254996B IT MI921559 A ITMI921559 A IT MI921559A IT MI921559 A ITMI921559 A IT MI921559A IT 1254996 B IT1254996 B IT 1254996B
Authority
IT
Italy
Prior art keywords
eseroline
esters
anticolinesterasics
alkylcarbammic
amino
Prior art date
Application number
ITMI921559A
Other languages
English (en)
Inventor
Mario Brufani
Sperandina Lappa
Pier Giuseppe Pagella
Stefano Maiorana
Donata Marchesini
Original Assignee
Mediolanum Farmaceutici Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Farmaceutici Srl filed Critical Mediolanum Farmaceutici Srl
Publication of ITMI921559A0 publication Critical patent/ITMI921559A0/it
Priority to ITMI921559A priority Critical patent/IT1254996B/it
Priority to EP93109932A priority patent/EP0575954B1/en
Priority to DE69320705T priority patent/DE69320705D1/de
Priority to AT93109932T priority patent/ATE170522T1/de
Priority to US08/079,921 priority patent/US5302593A/en
Priority to KR1019930011626A priority patent/KR940005627A/ko
Priority to CA002099648A priority patent/CA2099648A1/en
Priority to JP5175912A priority patent/JPH06206882A/ja
Publication of ITMI921559A1 publication Critical patent/ITMI921559A1/it
Priority to US08/177,325 priority patent/US5424451A/en
Application granted granted Critical
Publication of IT1254996B publication Critical patent/IT1254996B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici, avente formula generale (I) (FORMULA I) R è un'ammina scelta nel gruppo costituito da (FORMULA II) ed n, R1, R2, R3 ed R4 hanno il significato definito nel testo.
ITMI921559A 1992-06-25 1992-06-25 Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione IT1254996B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ITMI921559A IT1254996B (it) 1992-06-25 1992-06-25 Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione
EP93109932A EP0575954B1 (en) 1992-06-25 1993-06-22 Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase acitivity inhibitors and relative preparation process
DE69320705T DE69320705D1 (de) 1992-06-25 1993-06-22 Aminoalkylcarbamatester von Eserolin verwendbar als Inhibitoren von Cholinesteraseaktivität und Verfahren zu deren Herstellung
AT93109932T ATE170522T1 (de) 1992-06-25 1993-06-22 Aminoalkylcarbamatester von eserolin verwendbar als inhibitoren von cholinesteraseaktivität und verfahren zu deren herstellung
US08/079,921 US5302593A (en) 1992-06-25 1993-06-23 Aminoalkylcarbamic esters of eseroline suitable for use as chlorinesterase activity inhibitors
KR1019930011626A KR940005627A (ko) 1992-06-25 1993-06-24 콜린에스테라제 활성 저해제로서 적합한 에제롤린의 아미노알킬카르밤산 에스테르 및 이의 제조방법
CA002099648A CA2099648A1 (en) 1992-06-25 1993-06-24 Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase activity inhibitors and relative preparation process
JP5175912A JPH06206882A (ja) 1992-06-25 1993-06-24 コリンエステラーゼ活性インヒビターとしての使用に適したエセロリンのアミノアルキルカルバミンエステル及びその調製法
US08/177,325 US5424451A (en) 1992-06-25 1994-01-04 Process for preparing aminoalkylcarbamic esters of eseroline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI921559A IT1254996B (it) 1992-06-25 1992-06-25 Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione

Publications (3)

Publication Number Publication Date
ITMI921559A0 ITMI921559A0 (it) 1992-06-25
ITMI921559A1 ITMI921559A1 (it) 1993-12-25
IT1254996B true IT1254996B (it) 1995-10-11

Family

ID=11363576

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI921559A IT1254996B (it) 1992-06-25 1992-06-25 Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione

Country Status (8)

Country Link
US (2) US5302593A (it)
EP (1) EP0575954B1 (it)
JP (1) JPH06206882A (it)
KR (1) KR940005627A (it)
AT (1) ATE170522T1 (it)
CA (1) CA2099648A1 (it)
DE (1) DE69320705D1 (it)
IT (1) IT1254996B (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133444A (en) 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
IT1271679B (it) * 1994-07-18 1997-06-04 Mediolanum Farmaceutici Srl Derivati del fenilcarbammato atti all'impiego come anticolinesterasici
WO1996040709A1 (en) * 1995-06-07 1996-12-19 Perseptive Biosystems, Inc. Pna-dna chimeras and pna synthons for their preparation
US5952506A (en) * 1997-04-24 1999-09-14 American Home Products Corporation Process for the synthesis of 4- 6- (hexylcarbamoyloxy) hexylcarbamoyloxy!-piperidine-1-carboxylic acid 4-phenoxyphenyl ester
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
US20110212928A1 (en) 2010-02-09 2011-09-01 The Johns Hopkins University Methods and compositions for improving cognitive function
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
NZ738682A (en) 2015-05-22 2022-01-28 Agenebio Inc Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
EP0513703A3 (en) * 1991-05-13 1993-01-13 Magis Farmaceutici S.P.A. Carbamate esters of eseroline having anticholinesterase activity, a process for their preparation and relative pharmaceutical compositions containing them as the active principle

Also Published As

Publication number Publication date
EP0575954A1 (en) 1993-12-29
ITMI921559A0 (it) 1992-06-25
US5424451A (en) 1995-06-13
CA2099648A1 (en) 1993-12-26
US5302593A (en) 1994-04-12
ITMI921559A1 (it) 1993-12-25
DE69320705D1 (de) 1998-10-08
KR940005627A (ko) 1994-03-22
ATE170522T1 (de) 1998-09-15
EP0575954B1 (en) 1998-09-02
JPH06206882A (ja) 1994-07-26

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970627