ATE170846T1 - Antivirale nukleosidanaloge - Google Patents

Antivirale nukleosidanaloge

Info

Publication number
ATE170846T1
ATE170846T1 AT93905536T AT93905536T ATE170846T1 AT E170846 T1 ATE170846 T1 AT E170846T1 AT 93905536 T AT93905536 T AT 93905536T AT 93905536 T AT93905536 T AT 93905536T AT E170846 T1 ATE170846 T1 AT E170846T1
Authority
AT
Austria
Prior art keywords
nucleoside analogues
antiviral nucleoside
substituted
benzimidazole base
hepatitis
Prior art date
Application number
AT93905536T
Other languages
English (en)
Inventor
Leroy B Townsend
John Charles Drach
Steven Spencer Good
Susan Mary Daluge
Michael Tolar Martin
Original Assignee
Wellcome Found
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found, Univ Michigan filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE170846T1 publication Critical patent/ATE170846T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT93905536T 1992-03-09 1993-03-08 Antivirale nukleosidanaloge ATE170846T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929205071A GB9205071D0 (en) 1992-03-09 1992-03-09 Therapeutic nucleosides

Publications (1)

Publication Number Publication Date
ATE170846T1 true ATE170846T1 (de) 1998-09-15

Family

ID=10711750

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93905536T ATE170846T1 (de) 1992-03-09 1993-03-08 Antivirale nukleosidanaloge

Country Status (20)

Country Link
US (1) US5534535A (de)
EP (1) EP0630368B1 (de)
JP (1) JP3450854B2 (de)
KR (2) KR950700887A (de)
AT (1) ATE170846T1 (de)
AU (1) AU672597B2 (de)
CA (1) CA2131693A1 (de)
CZ (1) CZ209494A3 (de)
DE (1) DE69320945T2 (de)
DK (1) DK0630368T3 (de)
ES (1) ES2123048T3 (de)
FI (1) FI944134L (de)
GB (1) GB9205071D0 (de)
HU (1) HUT68445A (de)
IL (1) IL104976A (de)
NZ (1) NZ249554A (de)
RU (1) RU2141952C1 (de)
TW (1) TW366339B (de)
WO (1) WO1993018009A1 (de)
ZA (1) ZA931647B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
GB9413724D0 (en) 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
HUT77440A (hu) * 1994-09-09 1998-04-28 The Regents Of The University Of Michigan Karbociklusos gyűrűhöz kapcsoló benzimidazolokat tartalmazó vírus-ellenes nukleozid analógok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
US5811073A (en) * 1995-06-19 1998-09-22 President And Fellows Of Harvard College Method for radioisotopic detection and localization of inflammation in a host
US5912356A (en) * 1995-09-11 1999-06-15 Glaxo Wellcome Inc. Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
CA2280761A1 (en) 1997-02-13 1998-08-20 Stanley Dawes Chamberlain Benzimidazole derivatives
SK285228B6 (sk) * 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén
BR9810745A (pt) 1997-06-10 2001-03-13 Glaxo Group Ltd Derivados de benzimidazol
NZ502882A (en) 1997-07-30 2002-02-01 Glaxo Group Ltd Lyxofuranosyl benzimidazoles as antiviral agents
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
EP1964569A3 (de) 2000-04-13 2009-07-22 Pharmasset, Inc. 3'- oder 2'-Hydroxymethyl-substituierte Nukleosidderivate zur Behandlung von Virusinfektionen
RU2293763C2 (ru) * 2005-05-18 2007-02-20 Государственное учреждение Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова Российской академии медицинских наук (ГУ НИИВС им. И.И. Мечникова РАМН) Способ получения акарицидно-моющего средства для борьбы с клещами
RU2294959C2 (ru) * 2005-05-18 2007-03-10 Общество с ограниченной ответственностью "Карат" (ООО "Карат") Способ получения акарицидно-моющего средства для борьбы с клещами
TW200831081A (en) 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
WO2009042013A1 (en) 2007-08-02 2009-04-02 Millennium Pharmaceuticals, Inc. Process for the synthesis of e1 activating enzyme inhibitors
KR101608259B1 (ko) 2008-04-28 2016-04-01 교린 세이야꾸 가부시키 가이샤 시클로펜틸아크릴산아미드 유도체
US11499722B2 (en) * 2020-04-30 2022-11-15 Bsh Home Appliances Corporation Household cooking appliance having an oven door with an interior camera

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2405070A1 (de) * 1973-02-20 1974-08-22 United States Borax Chem Substituierte benzimidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
DE2432269A1 (de) * 1974-07-05 1976-01-22 Boehringer Mannheim Gmbh Basisch substituierte derivate des 4-hydroxybenzimidazols und verfahren zu ihrer herstellung
US4410385A (en) * 1981-01-28 1983-10-18 General Electric Company Method of making a composite article
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles
US4677210A (en) * 1985-06-19 1987-06-30 Rorer Pharmaceutical Corporation 1-arylalkoxy- and 1-arylalkylthioaryl-2-pyrazolines as anti-inflammatory or anti-allergic agents
ES2008418A6 (es) * 1987-01-29 1989-07-16 Beecham Group Plc Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo.
US4996308A (en) * 1988-03-25 1991-02-26 Merrell Dow Pharmaceuticals Inc. Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives
GB8826205D0 (en) 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
GB8926417D0 (en) * 1989-11-22 1990-01-10 Wellcome Found Heterocyclic compounds
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides

Also Published As

Publication number Publication date
HU9402582D0 (en) 1994-11-28
KR950700887A (ko) 1995-02-20
FI944134A7 (fi) 1994-11-07
EP0630368A1 (de) 1994-12-28
ZA931647B (en) 1994-09-08
FI944134L (fi) 1994-11-07
IL104976A0 (en) 1993-07-08
NZ249554A (en) 1996-05-28
CZ209494A3 (en) 1995-11-15
DK0630368T3 (da) 1999-06-07
EP0630368B1 (de) 1998-09-09
HUT68445A (en) 1995-06-28
RU94043771A (ru) 1996-08-10
DE69320945T2 (de) 1999-02-04
FI944134A0 (fi) 1994-09-08
CA2131693A1 (en) 1993-09-16
TW366339B (en) 1999-08-11
DE69320945D1 (de) 1998-10-15
JP3450854B2 (ja) 2003-09-29
ES2123048T3 (es) 1999-01-01
AU3643293A (en) 1993-10-05
JPH07506816A (ja) 1995-07-27
IL104976A (en) 1998-10-30
AU672597B2 (en) 1996-10-10
KR970705547A (ko) 1997-10-09
RU2141952C1 (ru) 1999-11-27
US5534535A (en) 1996-07-09
GB9205071D0 (en) 1992-04-22
WO1993018009A1 (en) 1993-09-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee