ES2008418A6 - Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo. - Google Patents

Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo.

Info

Publication number
ES2008418A6
ES2008418A6 ES8800226A ES8800226A ES2008418A6 ES 2008418 A6 ES2008418 A6 ES 2008418A6 ES 8800226 A ES8800226 A ES 8800226A ES 8800226 A ES8800226 A ES 8800226A ES 2008418 A6 ES2008418 A6 ES 2008418A6
Authority
ES
Spain
Prior art keywords
potassium clavulanate
novel
rosettes
recrystallisation
crystallisation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8800226A
Other languages
English (en)
Inventor
Dennis Edward Clark
Shaukat Hussain Malik
Paul Gerard Butterly
Clive Elton Badman
Jeffrey David Haseler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES2008418A6 publication Critical patent/ES2008418A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA OBTENCION DE UNA NUEVA FORMA CRISTALINA DEL CLAVULANATO DE POTASIO Y DE COMPOSICIONES DEL MISMO. COMPRENDE HACER QUE PRECIPITE EL CLAVULANATO DE POTASIO (I) DE LA SOLUCION, EN TALES CONDICIONES QUE LA FORMA DE ROSETAS SEA PRECIPITADA ADECUADAMENTE ADICIONANDO UNA SOLUCION DE IONES CLAVULANATO AUN NO-DISOLVENTE PARA EL CLAVULANATO DE POTASIO, EN PRESENCIA DE IONES POTASIO, EN DONDE LA PRECIPITACION SE REALIZA PREFERENTEMENTE A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 15 GC. LAS COMPOSICIONES PUEDEN CONSEGUIRSE OBTENIENDO EL CLAVUNALATO DE POTASIO CRISTALINO EN FORMA DE ROSETAS CRISTALINAS MEZCLADAS O ASOCIADAS CON UN COMPUESTO DE LACTAM ANTIBACTERIANAMENTE ACTIVO. EL PRODUCTO PRESENTA LA UTILIDAD HABITUAL EN EL CAMPO DEL TRATAMIENTO DE LAS INFECCIONES BACTERIANAS EN MAMIFEROS, PRESENTANDO PROPIEDADES MEJORADAS DE ELABORACION, YA QUE EN LA NUEVA CRISTALINA FLUYE CON MAS FACILIDAD Y PUEDE TAMIZARSE MEJOR QUE EL CLAVULANATO DE POTASIO NORMALEN FORMA DE AGUJAS.
ES8800226A 1987-01-29 1988-01-27 Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo. Expired ES2008418A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US878187A 1987-01-29 1987-01-29
US7494487A 1987-07-17 1987-07-17

Publications (1)

Publication Number Publication Date
ES2008418A6 true ES2008418A6 (es) 1989-07-16

Family

ID=26678616

Family Applications (2)

Application Number Title Priority Date Filing Date
ES88300704T Expired - Lifetime ES2074048T3 (es) 1987-01-29 1988-01-27 Procedimiento para la cristalizacion de clavulanato de potasio.
ES8800226A Expired ES2008418A6 (es) 1987-01-29 1988-01-27 Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES88300704T Expired - Lifetime ES2074048T3 (es) 1987-01-29 1988-01-27 Procedimiento para la cristalizacion de clavulanato de potasio.

Country Status (19)

Country Link
EP (1) EP0277008B1 (es)
JP (2) JP2648321B2 (es)
KR (1) KR960004535B1 (es)
AT (1) AT399154B (es)
AU (1) AU620538B2 (es)
BE (1) BE1000734A3 (es)
CA (1) CA1326486C (es)
CH (1) CH677671A5 (es)
DE (1) DE3853962T2 (es)
DK (1) DK175709B1 (es)
ES (2) ES2074048T3 (es)
FR (1) FR2610196B1 (es)
GB (1) GB2200355B (es)
GR (1) GR1000035B (es)
IE (1) IE880217L (es)
IT (1) IT1227072B (es)
LU (1) LU87123A1 (es)
NZ (1) NZ223316A (es)
PT (1) PT86631B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2435859A (en) * 1945-06-06 1948-02-10 John E Whitman Garment hanger
US2494711A (en) * 1946-06-28 1950-01-17 Kusher Hyman Garment hanger
US3474943A (en) * 1967-02-21 1969-10-28 Frank Mcbain Skirt hanger
SE7805391L (sv) * 1978-05-11 1979-11-12 Karner & Co Ab Kledhengare
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SE9401169L (sv) * 1994-04-08 1995-10-09 Corimed Gmbh Förfarande för framställning av ett antibekteriellt aktivt ämne samt användning därav
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
ATE260096T1 (de) * 1999-04-01 2004-03-15 Dsm Ip Assets Bv Agglomerate durch kristallisation
BRPI0110774B8 (pt) 2000-05-13 2021-05-25 Smithkline Beecham Plc processo para purificação de um sal de ácido clavulânico
US20060275219A1 (en) * 2003-06-10 2006-12-07 Taisho Pharmaceutical Co., Ltd. Radial spherical crystallization product, process for producing the same, and dry powder preparation containing the crystallization product
CN100384853C (zh) * 2004-05-10 2008-04-30 河北张药股份有限公司 替卡西林钠的合成方法
KR102459377B1 (ko) * 2022-03-18 2022-10-28 주식회사 에이치투뉴트리션 무알콜 단백질 맥주의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1504425A (en) * 1975-08-20 1978-03-22 Beecham Group Ltd Salts of clavulanic acid
GB2003863B (en) * 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
US4454069A (en) * 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
EP0080862B1 (en) * 1981-12-02 1985-09-25 Beecham Group Plc Pharmaceutical formulation comprising beta-lactam antibiotics
FR2586561B1 (fr) * 1985-09-05 1988-05-20 Rhone Poulenc Sante Procede de preparation d'agglomerats spheriques de paracetamol et produits obtenus

Also Published As

Publication number Publication date
AU1092788A (en) 1988-08-04
BE1000734A3 (fr) 1989-03-21
LU87123A1 (fr) 1988-05-03
AT399154B (de) 1995-03-27
ES2074048T3 (es) 1995-09-01
IT1227072B (it) 1991-03-14
DK40488A (da) 1988-07-30
GB2200355B (en) 1990-08-01
JP2648321B2 (ja) 1997-08-27
GR1000035B (el) 1990-03-12
GB8801765D0 (en) 1988-02-24
GB2200355A (en) 1988-08-03
FR2610196A1 (fr) 1988-08-05
DK40488D0 (da) 1988-01-27
KR890002166A (ko) 1989-04-08
PT86631B (pt) 1992-01-31
DE3853962D1 (de) 1995-07-20
IE880217L (en) 1988-07-29
NZ223316A (en) 1989-10-27
EP0277008B1 (en) 1995-06-14
KR960004535B1 (ko) 1996-04-06
CH677671A5 (es) 1991-06-14
EP0277008A1 (en) 1988-08-03
GR880100031A (en) 1988-12-16
DK175709B1 (da) 2005-01-31
AU620538B2 (en) 1992-02-20
JP2716966B2 (ja) 1998-02-18
DE3853962T2 (de) 1996-02-08
JPS63270687A (ja) 1988-11-08
ATA16388A (de) 1994-08-15
PT86631A (pt) 1988-02-01
JPH09169771A (ja) 1997-06-30
CA1326486C (en) 1994-01-25
IT8847572A0 (it) 1988-06-27
FR2610196B1 (fr) 1991-06-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20080128