ATE170857T1 - Chinuclidine derivate als squalen synthase inhibitore - Google Patents

Chinuclidine derivate als squalen synthase inhibitore

Info

Publication number: ATE170857T1
Authority: AT; Austria
Prior art keywords: alkylcarbamoyl; alkylamino; hydroxy; hydrogen; squalene synthase
Prior art date: 1992-04-10

Application number

AT93908010T

Other languages

English (en)

Inventor

George Robert Brown

Keith Blakeney Mallion

Peter John Harrison

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-10

Filing date

1993-04-08

Publication date

1998-09-15

1993-04-08 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1998-09-15 Application granted granted Critical

1998-09-15 Publication of ATE170857T1 publication Critical patent/ATE170857T1/de

Links

108010022535 Farnesyl-Diphosphate Farnesyltransferase Proteins 0.000 title abstract 2
102100037997 Squalene synthase Human genes 0.000 title abstract 2
SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical class C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 title 1
-1 hydroxy, amino Chemical group 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
125000005118 N-alkylcarbamoyl group Chemical group 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Urology & Nephrology (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT93908010T 1992-04-10 1993-04-08 Chinuclidine derivate als squalen synthase inhibitore ATE170857T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929207961A GB9207961D0 (en)	1992-04-10	1992-04-10	Heterocyclic derivatives

Publications (1)

Publication Number	Publication Date
ATE170857T1 true ATE170857T1 (de)	1998-09-15

Family

ID=10713853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93908010T ATE170857T1 (de)	1992-04-10	1993-04-08	Chinuclidine derivate als squalen synthase inhibitore

Country Status (8)

Country	Link
EP (1)	EP0596057B1 (de)
JP (1)	JPH06511015A (de)
AT (1)	ATE170857T1 (de)
AU (1)	AU3900693A (de)
CA (1)	CA2093782A1 (de)
DE (1)	DE69320911T2 (de)
GB (1)	GB9207961D0 (de)
WO (1)	WO1993021183A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9226577D0 (en) *	1992-12-21	1993-02-17	Ici Plc	Heterocyclic derivatives
US5556990A (en) *	1994-12-16	1996-09-17	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
RU2266905C2 (ru)	1999-09-28	2005-12-27	Эйсай Ко., Лтд.	Хинуклидиновые соединения, содержащие их лекарственные средства и способы получения хинуклидиновых соединений
US6401329B1 (en)	1999-12-21	2002-06-11	Vishay Dale Electronics, Inc.	Method for making overlay surface mount resistor
US7112593B2 (en) *	2001-03-27	2006-09-26	Eisai Co., Ltd.	N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient
US8226675B2 (en)	2007-03-22	2012-07-24	Ethicon Endo-Surgery, Inc.	Surgical instruments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1752792A (en) *	1991-03-08	1992-10-06	Rhone-Poulenc Rorer International (Holdings) Inc.	Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors

1992
- 1992-04-10 GB GB929207961A patent/GB9207961D0/en active Pending
1993
- 1993-04-08 EP EP93908010A patent/EP0596057B1/de not_active Expired - Lifetime
- 1993-04-08 AT AT93908010T patent/ATE170857T1/de not_active IP Right Cessation
- 1993-04-08 AU AU39006/93A patent/AU3900693A/en not_active Abandoned
- 1993-04-08 JP JP5518099A patent/JPH06511015A/ja active Pending
- 1993-04-08 WO PCT/GB1993/000743 patent/WO1993021183A1/en not_active Ceased
- 1993-04-08 DE DE69320911T patent/DE69320911T2/de not_active Expired - Fee Related
- 1993-04-08 CA CA002093782A patent/CA2093782A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0596057A1 (de)	1994-05-11
AU3900693A (en)	1993-11-18
CA2093782A1 (en)	1993-10-11
EP0596057B1 (de)	1998-09-09
WO1993021183A1 (en)	1993-10-28
DE69320911D1 (de)	1998-10-15
DE69320911T2 (de)	1999-04-15
JPH06511015A (ja)	1994-12-08
GB9207961D0 (en)	1992-05-27

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Legal Events

Date	Code	Title	Description
1999-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties