BRPI9913138B8 - derivado de quinolin-2-ona substituído com alquinila e composição farmacêutica contendo o mesmo - Google Patents

derivado de quinolin-2-ona substituído com alquinila e composição farmacêutica contendo o mesmo

Info

Publication number
BRPI9913138B8
BRPI9913138B8 BRPI9913138A BR9913138A BRPI9913138B8 BR PI9913138 B8 BRPI9913138 B8 BR PI9913138B8 BR PI9913138 A BRPI9913138 A BR PI9913138A BR 9913138 A BR9913138 A BR 9913138A BR PI9913138 B8 BRPI9913138 B8 BR PI9913138B8
Authority
BR
Brazil
Prior art keywords
formula
alkynyl
mammals
derivative
pharmaceutical composition
Prior art date
Application number
BRPI9913138A
Other languages
English (en)
Other versions
BR9913138A (pt
BR9913138B1 (pt
Inventor
Joseph Peter Lyssikatos
Susan Deborah La Greca
Original Assignee
Osi Pharm Inc
Pfizer
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharm Inc, Pfizer, Pfizer Prod Inc filed Critical Osi Pharm Inc
Publication of BR9913138A publication Critical patent/BR9913138A/pt
Publication of BR9913138B1 publication Critical patent/BR9913138B1/pt
Publication of BRPI9913138B8 publication Critical patent/BRPI9913138B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

patente de invenção: <b>"derivados de quinolin-2-ona substituídos com alquinila úteis como agentes contra o câncer"<d>. a presente invenção refere-se a composto da fórmula 1 e a seus sais, pró-drogas e solvatos farmaceuticamente aceitáveis, em que r¹, r², r^ 4^, r^ 5^, r^ 6^, r^ 7^, r^ 8^, r^ 9^, r^ 10^ e r^ 11^ são tais como aqui se definem. os composto acima da fórmula 1 são úteis no tratamento de distúrbios hiperproliferativos, tais como câncer, em mamíferos. a invenção também refere-se a composições farmacêuticas que contêm compostos da fórmula 1 e a métodos para a inibição do crescimento anormal das células, incluindo o câncer, em mamíferos, pela administração de compostos da fórmula 1, a mamíferos que tenham necessidade de tal tratamento.
BRPI9913138A 1998-08-27 1999-08-06 derivado de quinolin-2-ona substituído com alquinila e composição farmacêutica contendo o mesmo BRPI9913138B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9814598P 1998-08-27 1998-08-27
PCT/IB1999/001398 WO2000012499A1 (en) 1998-08-27 1999-08-06 Alkynyl-substituted quinolin-2-one derivatives useful as anticancer agents

Publications (3)

Publication Number Publication Date
BR9913138A BR9913138A (pt) 2001-05-08
BR9913138B1 BR9913138B1 (pt) 2013-11-05
BRPI9913138B8 true BRPI9913138B8 (pt) 2016-05-17

Family

ID=22267481

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9913138A BRPI9913138B8 (pt) 1998-08-27 1999-08-06 derivado de quinolin-2-ona substituído com alquinila e composição farmacêutica contendo o mesmo

Country Status (40)

Country Link
US (3) US6150377A (pt)
EP (1) EP1107963B1 (pt)
JP (1) JP3495706B2 (pt)
KR (1) KR20010072991A (pt)
CN (1) CN1314904A (pt)
AP (1) AP2001002079A0 (pt)
AT (1) ATE321037T1 (pt)
AU (1) AU4925499A (pt)
BG (1) BG105365A (pt)
BR (1) BRPI9913138B8 (pt)
CA (2) CA2341690C (pt)
CO (1) CO5130017A1 (pt)
CZ (1) CZ2001660A3 (pt)
DE (1) DE69930518T2 (pt)
DZ (1) DZ2880A1 (pt)
EA (1) EA200100135A1 (pt)
EE (1) EE200100118A (pt)
ES (1) ES2259237T3 (pt)
GE (1) GEP20033001B (pt)
GT (1) GT199900140A (pt)
HK (1) HK1039123A1 (pt)
HR (1) HRP20010142A2 (pt)
HU (1) HUP0103228A3 (pt)
ID (1) ID27562A (pt)
IL (1) IL141239A0 (pt)
IS (1) IS5818A (pt)
MA (1) MA26680A1 (pt)
NO (1) NO20010964L (pt)
NZ (1) NZ509372A (pt)
OA (1) OA11645A (pt)
PA (1) PA8480101A1 (pt)
PE (1) PE20000986A1 (pt)
PL (1) PL346426A1 (pt)
SK (1) SK2442001A3 (pt)
SV (1) SV1999000141A (pt)
TN (1) TNSN99162A1 (pt)
TR (1) TR200101343T2 (pt)
UY (1) UY25682A1 (pt)
WO (1) WO2000012499A1 (pt)
ZA (1) ZA200101173B (pt)

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Also Published As

Publication number Publication date
HK1039123A1 (zh) 2002-04-12
AP2001002079A0 (en) 2001-03-31
UY25682A1 (es) 2000-03-31
TNSN99162A1 (fr) 2005-11-10
NZ509372A (en) 2003-08-29
DE69930518T2 (de) 2006-09-21
IL141239A0 (en) 2002-03-10
EP1107963A1 (en) 2001-06-20
GT199900140A (es) 2001-02-14
US6579887B2 (en) 2003-06-17
HUP0103228A2 (hu) 2002-02-28
ES2259237T3 (es) 2006-09-16
JP3495706B2 (ja) 2004-02-09
SV1999000141A (es) 2000-07-06
CZ2001660A3 (cs) 2002-05-15
DZ2880A1 (fr) 2003-12-15
HRP20010142A2 (en) 2002-02-28
CA2578326C (en) 2009-11-24
PL346426A1 (en) 2002-02-11
KR20010072991A (ko) 2001-07-31
CO5130017A1 (es) 2002-02-27
EA200100135A1 (ru) 2001-08-27
CA2578326A1 (en) 2000-03-09
WO2000012499A1 (en) 2000-03-09
CA2341690C (en) 2007-04-17
MA26680A1 (fr) 2004-12-20
EE200100118A (et) 2002-06-17
PE20000986A1 (es) 2000-09-30
BR9913138A (pt) 2001-05-08
CN1314904A (zh) 2001-09-26
SK2442001A3 (en) 2002-10-08
JP2002523504A (ja) 2002-07-30
US20020128287A1 (en) 2002-09-12
ZA200101173B (en) 2002-04-12
PA8480101A1 (es) 2003-06-30
HUP0103228A3 (en) 2003-01-28
DE69930518D1 (de) 2006-05-11
OA11645A (en) 2004-11-16
TR200101343T2 (tr) 2001-09-21
ID27562A (id) 2001-04-12
EP1107963B1 (en) 2006-03-22
BR9913138B1 (pt) 2013-11-05
ATE321037T1 (de) 2006-04-15
AU4925499A (en) 2000-03-21
NO20010964L (no) 2001-04-26
BG105365A (en) 2001-11-30
IS5818A (is) 2001-01-19
US6150377A (en) 2000-11-21
GEP20033001B (en) 2003-06-25
CA2341690A1 (en) 2000-03-09
US6294552B1 (en) 2001-09-25
NO20010964D0 (no) 2001-02-26

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