ATE171209T1 - Verfahren zur stabilisierung von biologischen macromolekularen substanzen und anderen organischen produkten - Google Patents

Verfahren zur stabilisierung von biologischen macromolekularen substanzen und anderen organischen produkten

Info

Publication number: ATE171209T1
Authority: AT; Austria
Prior art keywords: organic products; macromolecular substances; sugar; biological macromolecular; stabilizing biological
Prior art date: 1990-05-14

Application number

AT91909487T

Other languages

English (en)

Inventor

Bruce Joseph The Old Vic Roser

Camilo Colaco

Original Assignee

Quadrant Holdings Cambridge

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-14

Filing date

1991-05-14

Publication date

1998-10-15

1991-05-14 Application filed by Quadrant Holdings Cambridge filed Critical Quadrant Holdings Cambridge

1998-10-15 Application granted granted Critical

1998-10-15 Publication of ATE171209T1 publication Critical patent/ATE171209T1/de

Links

229920002521 macromolecule Polymers 0.000 title 1
230000000087 stabilizing effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
239000000126 substance Substances 0.000 abstract 2
150000005846 sugar alcohols Chemical class 0.000 abstract 2
QWIZNVHXZXRPDR-UHFFFAOYSA-N D-melezitose Natural products O1C(CO)C(O)C(O)C(O)C1OC1C(O)C(CO)OC1(CO)OC1OC(CO)C(O)C(O)C1O QWIZNVHXZXRPDR-UHFFFAOYSA-N 0.000 abstract 1
MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 abstract 1
UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 abstract 1
MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 abstract 1
229930182470 glycoside Natural products 0.000 abstract 1
150000002338 glycosides Chemical class 0.000 abstract 1
QWIZNVHXZXRPDR-WSCXOGSTSA-N melezitose Chemical compound O([C@@]1(O[C@@H]([C@H]([C@@H]1O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)CO)CO)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QWIZNVHXZXRPDR-WSCXOGSTSA-N 0.000 abstract 1
229920001542 oligosaccharide Polymers 0.000 abstract 1
150000002482 oligosaccharides Chemical class 0.000 abstract 1
150000002894 organic compounds Chemical class 0.000 abstract 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 abstract 1
UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Veterinary Medicine (AREA)
Analytical Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
General Engineering & Computer Science (AREA)
Saccharide Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

AT91909487T 1990-05-14 1991-05-14 Verfahren zur stabilisierung von biologischen macromolekularen substanzen und anderen organischen produkten ATE171209T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909010742A GB9010742D0 (en)	1990-05-14	1990-05-14	Stabilization of biological macromolecular substances

Publications (1)

Publication Number	Publication Date
ATE171209T1 true ATE171209T1 (de)	1998-10-15

Family

ID=10675945

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91909487T ATE171209T1 (de)	1990-05-14	1991-05-14	Verfahren zur stabilisierung von biologischen macromolekularen substanzen und anderen organischen produkten

Country Status (9)

Country	Link
EP (1)	EP0541556B1 (de)
JP (1)	JP3101320B2 (de)
AT (1)	ATE171209T1 (de)
AU (1)	AU7872591A (de)
DE (1)	DE69130223T2 (de)
DK (1)	DK0541556T3 (de)
ES (1)	ES2125237T3 (de)
GB (1)	GB9010742D0 (de)
WO (1)	WO1991018091A1 (de)

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ATE268605T1 (de) *	1994-03-04	2004-06-15	Genentech Inc	Pharmazeutische akzeptabel dnase zusammensetzung
ATE416755T1 (de)	1994-03-07	2008-12-15	Nektar Therapeutics	Verfahren und zusammensetzung für die pulmonale darreichung von insulin
US5955448A (en)	1994-08-19	1999-09-21	Quadrant Holdings Cambridge Limited	Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
DE69523163T2 (de) *	1994-07-20	2002-03-07	Kyowa Hakko Kogyo Co., Ltd.	Verfahren zur herstellung von stabilisierter getrockeneter carboxyesterase
US6586006B2 (en)	1994-08-04	2003-07-01	Elan Drug Delivery Limited	Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
ATE252373T1 (de) *	1994-08-04	2003-11-15	Elan Drug Delivery Ltd	Feste verabreichungssysteme zur gesteuerten freisetzung von darin eingebauten molekülen sowie verfahren zu deren herstellung
US6290991B1 (en)	1994-12-02	2001-09-18	Quandrant Holdings Cambridge Limited	Solid dose delivery vehicle and methods of making same
EE9700138A (et)	1994-12-22	1997-12-15	Astra Aktiebolag	Aerosoolravimvormid
SE9404468D0 (sv) *	1994-12-22	1994-12-22	Astra Ab	Powder formulations
US6524557B1 (en)	1994-12-22	2003-02-25	Astrazeneca Ab	Aerosol formulations of peptides and proteins
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US6964771B1 (en)	1995-06-07	2005-11-15	Elan Drug Delivery Limited	Method for stably incorporating substances within dry, foamed glass matrices
DE69628007T2 (de) *	1995-06-07	2003-11-27	Elan Drug Delivery Ltd., Ruddington	Verfahren zur stabilen einarbeitung von substanzen in trockene geschäumte glasmatrizen und auf diese weise hergestellte zusammensetzungen
IT1276684B1 (it) *	1995-06-08	1997-11-03	Bioextech Inc	Formulazioni idrosolubili di collagenasi stabilizzata e procedimento per la loro preparazione
GB9616536D0 (en) *	1996-08-06	1996-09-25	Quadrant Holdings Cambridge	Co-amoxiclav dosage form
ID21635A (id) *	1996-12-20	1999-07-08	Astra Pharma Prod	Komposisi farmasi untuk pengeringan beku
US6565885B1 (en)	1997-09-29	2003-05-20	Inhale Therapeutic Systems, Inc.	Methods of spray drying pharmaceutical compositions
US20060165606A1 (en)	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6309623B1 (en)	1997-09-29	2001-10-30	Inhale Therapeutic Systems, Inc.	Stabilized preparations for use in metered dose inhalers
EP0913177A1 (de)	1997-11-03	1999-05-06	Roche Diagnostics GmbH	Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung
DE19818842C1 (de) *	1998-04-28	2000-01-05	Suedzucker Ag	Erkältungsmittel
US6225289B1 (en)	1998-12-10	2001-05-01	Genvec, Inc.	Methods and compositions for preserving adenoviral vectors
US6190701B1 (en)	1999-03-17	2001-02-20	Peter M. Ronai	Composition and method for stable injectable liquids
IL149778A0 (en) *	1999-11-22	2002-11-10	Universal Preservation Technologies Inc	Preservation of sensitive biological material
US7871598B1 (en)	2000-05-10	2011-01-18	Novartis Ag	Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
EP1449523A1 (de) *	2000-10-13	2004-08-25	Cambridge Biostability Ltd	Zusammensetzung und Verfahren für injizierbare Flüssigkeiten
US6872357B1 (en)	2000-11-22	2005-03-29	Quadrant Drug Delivery Limited	Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying
ES2180416B1 (es)	2001-03-12	2004-06-01	BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A.	Procedimiento para la preparacion de mezclas de reaccion estabilizadas, total o parcialmente desecadas, que comprenden, al menos, una enzima, mezclas de reaccion y kits que las contienen.
PT1458360E (pt)	2001-12-19	2011-07-13	Novartis Ag	Derivados de indole como agonistas do recetor s1p1
PL209134B1 (pl) *	2002-04-03	2011-07-29	Solvay Pharm Bv	Sposób wytwarzania kompozycji farmaceutycznej zawierającej naturalny związek kanabinoidowy i kompozycja farmaceutyczna otrzymywana tym sposobem
ES2214144B1 (es) *	2003-02-26	2005-09-01	BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A.	Composicion estabilizada para ensayos fluorimetricos, colorimetricos o quimio-luminiscentes, kits que la contienen y procedimiento para su obtencion.
MX2011001624A (es)	2008-08-21	2011-03-28	Octapharma Ag	Factor viii y ix humano producido en forma recombinante.
WO2010144683A2 (en)	2009-06-12	2010-12-16	Micronics, Inc.	Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices
JP5721704B2 (ja)	2009-06-12	2015-05-20	マイクロニクス，インコーポレイテッド	マイクロ流体デバイス内のｔａｑポリメラーゼを乾燥保存するための再水和可能なマトリックス
BR112012009023A2 (pt)	2009-10-22	2019-09-24	Biotools Biotechnologial & Medical Laboratories S A	método pra detecção. diferenciação e identificação de eubactérias específica de táxons em uma amostra biológica por meio de técnicas de análise de sequenciamento e kit
AU2015202570B2 (en) *	2010-04-20	2017-04-06	Octapharma Ag	New stabilizing agent for pharmaceutical proteins
CA2796729C (en) *	2010-04-20	2020-06-23	Octapharma Ag	Melezitose for stabilizing human blood plasma proteins
JP2019043961A (ja) *	2010-04-20	2019-03-22	オクタファルマ・アーゲー	医薬タンパク質の新規な安定化剤
DE112011102286B4 (de) *	2010-07-07	2018-11-15	Thermo Fisher Scientific Gmbh	Massenspektrometrische Quantifizierung von Analyten unter Verwendung eines Universalreporters
US9480966B2 (en)	2012-04-30	2016-11-01	General Electric Company	Substrates and methods for collection, stabilization and elution of biomolecules
GB201301457D0 (en)	2013-01-28	2013-03-13	Fluorogenics Ltd	Freeze-dried composition
US9534214B2 (en) *	2013-10-31	2017-01-03	General Electric Company	Substrates and associated methods for elution of nucleic acids
EP3134441B1 (de) *	2014-04-25	2019-12-18	General Electric Company	Substrate und verfahren zur ansammlung, stabilisierung und eluierung von biomolekülen
FR3034418B1 (fr) *	2015-04-03	2018-09-28	Roquette Freres	Utilisation de combinaisons particulieres de carbohydrates pour stabiliser des proteines, et compositions proteiques contenant de telles combinaisons
ES2818569T3 (es)	2015-09-09	2021-04-13	Drawbridge Health Inc	Métodos para la recopilación, estabilización y conservación de muestras
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GB8903593D0 (en) *	1989-02-16	1989-04-05	Pafra Ltd	Storage of materials

1990
- 1990-05-14 GB GB909010742A patent/GB9010742D0/en active Pending
1991
- 1991-05-14 JP JP03509304A patent/JP3101320B2/ja not_active Expired - Fee Related
- 1991-05-14 DK DK91909487T patent/DK0541556T3/da active
- 1991-05-14 AU AU78725/91A patent/AU7872591A/en not_active Abandoned
- 1991-05-14 EP EP91909487A patent/EP0541556B1/de not_active Expired - Lifetime
- 1991-05-14 WO PCT/GB1991/000759 patent/WO1991018091A1/en not_active Ceased
- 1991-05-14 AT AT91909487T patent/ATE171209T1/de not_active IP Right Cessation
- 1991-05-14 ES ES91909487T patent/ES2125237T3/es not_active Expired - Lifetime
- 1991-05-14 DE DE69130223T patent/DE69130223T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69130223T2 (de)	1999-08-26
WO1991018091A1 (en)	1991-11-28
EP0541556A1 (de)	1993-05-19
JP3101320B2 (ja)	2000-10-23
ES2125237T3 (es)	1999-03-01
DE69130223D1 (de)	1998-10-22
JPH05508315A (ja)	1993-11-25
GB9010742D0 (en)	1990-07-04
EP0541556B1 (de)	1998-09-16
AU7872591A (en)	1991-12-10
DK0541556T3 (da)	1999-06-14

Legal Events

Date	Code	Title	Description
1999-05-15	UEP	Publication of translation of european patent specification
2006-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE171209T1 (de)	1998-10-15	Verfahren zur stabilisierung von biologischen macromolekularen substanzen und anderen organischen produkten
WO1987005300A3 (en)	1987-10-22	Protein preservation
DE3875796D1 (de)	1992-12-17	Kombiniertes verfahren zur thermischen und chemischen behandlung von lignocellulosehaltiger biomasse und zur gewinnung von furfural.
DK384280A (da)	1981-03-12	Fremgangsmaade til fremstilling af substituerede 4-thiazolyl-3-hydroxy-3-pyrrolin-2,5-dioner
ATE147700T1 (de)	1997-02-15	Vorrichtung zur behandlung von festen stoffen
MX9102430A (es)	1992-07-01	Metodo para la elaboracion de articulos moldeados de celulosa.
DE3874019D1 (de)	1992-10-01	Verfahren zur konservierung von transplantierbaren, in vitro kultivierten epithelgeweben.
DE3863893D1 (de)	1991-08-29	Verfahren zur sterilisation von temperaturbelastbaren behaeltern unter reinraumbedingungen.
NL162364C (nl)	1980-05-16	Werkwijze voor het bereiden van preparaten voor het beinvloeden van de plantengroei op basis van n-alkoxyalkyl-2,6-dialkylchlooraceetaniliden, werkwijze voor de selectieve bestrijding van ongewenste planten- groei in culturen van gekweekte planten en werkwijze voor het bereiden van n-alkoxyalkyl-2,6-dialkyl- chlooraceetaniliden.
DE68919942D1 (de)	1995-01-26	Verfahren zum Trocknen von biologischen Produkten.
NO891743L (no)	1989-10-27	Fremgangsmaate til behandling av celluloseholdige materialer.
ATE141509T1 (de)	1996-09-15	Verfahren zum lagern von erythrozyten
DK0391644T3 (da)	1996-07-15	Arylsubstituerede rhodaninderivater
IT1230484B (it)	1991-10-24	Procedimento per il candeggio di materie tessili
NO950227D0 (no)	1995-01-20	Fremgangsmåte for preservering av oftalmologiske saltvannsopplösninger og sammensetninger for formålet
DE69013423D1 (de)	1994-11-24	Verfahren zur Konservierung pflanzlicher Embryonen.
DE59005066D1 (de)	1994-04-28	Verfahren und Vorrichtung zum Keimfreimachen, Desinfizieren und/oder Trocknen.
DK0440537T3 (da)	1995-05-29	Fremgangsmåde til raffinering af blandinger fremkommet ved behandling af fedtholdige medier ved hjælp af cyclodextrin og indeholdende komplekser af cyclodextrin med lipofile forbindelser af fedtsyretypen
NO892089D0 (no)	1989-05-24	Fremgangsmaate og anordning for konservering av planter, plantestoffer, plantekjoett eller andre organiske stoffer.
ATE56149T1 (de)	1990-09-15	Verfahren zum pasteurisieren von fibronectin.
DE58904294D1 (de)	1993-06-09	Beheizte foerdervorrichtung und verfahren zum desinfizieren von kontaminiertem, zerkleinertem krankenhausmuell.
DK0551326T3 (da)	1995-07-03	Fremgangsmåde og indretning til fjernelse af skindet fra levnedsmiddelprodukter såsom fisk, fugt eller grøntsager
DE68902668D1 (de)	1992-10-08	Verfahren zur thermischen behandlung von galliumarsenid-einkristallen.
DE69112592D1 (de)	1995-10-05	Trockenätzprozess für Galliumarsenid.
DE69000618D1 (de)	1993-02-04	Stabilisierungs- und konservierungsverfahren fuer biologische produkte und so behandelte produkte.