ATE171448T1 - Thiazolidin-2,4-dione, salze hiervon sowie verfahren zur herstellung - Google Patents

Thiazolidin-2,4-dione, salze hiervon sowie verfahren zur herstellung

Info

Publication number: ATE171448T1
Authority: AT; Austria
Prior art keywords: same; thiazolidine; dione; lower alkyl; salts
Prior art date: 1991-02-25

Application number

AT92905305T

Other languages

English (en)

Inventor

Michiro Tomonuma Nogi-M Ohnota

Kyuya - Nisshincho -Ch Okamura

Yoshihiro - Bessho-Mach Hirata

Koji Tomonuma Murakami

Mitsuo - Suna Ohashi

Original Assignee

Kyorin Seiyaku Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-25

Filing date

1992-02-24

Publication date

1998-10-15

1992-02-24 Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk

1998-10-15 Application granted granted Critical

1998-10-15 Publication of ATE171448T1 publication Critical patent/ATE171448T1/de

Links

150000003839 salts Chemical class 0.000 title abstract 2
ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 title 1
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
150000001473 2,4-thiazolidinediones Chemical class 0.000 abstract 1
102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
108010053754 Aldehyde reductase Proteins 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000002218 hypoglycaemic effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
-1 phenyl naphthyl Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT92905305T 1991-02-25 1992-02-24 Thiazolidin-2,4-dione, salze hiervon sowie verfahren zur herstellung ATE171448T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP5327591		1991-02-25
JP4072496A JP3053490B2 (ja)	1991-02-25	1992-02-21	チアゾリジン−２，４−ジオン誘導体とその塩及び製造法

Publications (1)

Publication Number	Publication Date
ATE171448T1 true ATE171448T1 (de)	1998-10-15

Family

ID=26393992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92905305T ATE171448T1 (de)	1991-02-25	1992-02-24	Thiazolidin-2,4-dione, salze hiervon sowie verfahren zur herstellung

Country Status (12)

Country	Link
US (1)	US5342850A (de)
EP (1)	EP0526658B1 (de)
JP (1)	JP3053490B2 (de)
KR (1)	KR960012206B1 (de)
AT (1)	ATE171448T1 (de)
AU (1)	AU645886B2 (de)
CA (1)	CA2081113C (de)
DE (1)	DE69227080T2 (de)
DK (1)	DK0526658T3 (de)
ES (1)	ES2122991T3 (de)
HU (1)	HU217116B (de)
WO (1)	WO1992014719A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2145257A1 (en) *	1994-03-23	1995-09-24	Takashi Fujita	Thiazolidine and oxazolidine derivatives, their preparation and their medical use
FR2733685B1 (fr) *	1995-05-05	1997-05-30	Adir	Utilisation des derives du benzopyrane pour l'obtention de compositions pharmaceutiques destinees au traitement des pathologies liees a l'echangeur c1-/hc03-, na+ independant
JP3906935B2 (ja) *	1995-12-18	2007-04-18	杏林製薬株式会社	Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法
EA200000687A1 (ru) *	1997-12-19	2000-12-25	Мерк Энд Ко., Инк.	Производные арилтиазолидиндиона
US6008237A (en) *	1997-12-19	1999-12-28	Merck & Co., Inc.	Arylthiazolidinedione derivatives
US6756360B1 (en) *	1998-12-24	2004-06-29	Metabasis Therapeutics, Inc.	Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
CA2377246A1 (en)	1999-06-18	2000-12-28	Ranjit C. Desai	Arylthiazolidinedione and aryloxazolidinedione derivatives
ATE333448T1 (de) *	1999-06-18	2006-08-15	Merck & Co Inc	Arylthiazolidinedione und aryloxa zolidinedion- derivate
MXPA02006156A (es) *	1999-12-22	2003-09-22	Metabasis Therapeutics Inc	Nuevos profarmacos de bisamidato fosfonato.
ATE340168T1 (de) *	2000-02-01	2006-10-15	Kyorin Seiyaku Kk	Alkalimetallsalz von thiazolidin-2,4-dion- derivaten
CN1426402A (zh)	2000-04-25	2003-06-25	杏林制药株式会社	噻唑烷二酮衍生物的新颖的稳定晶体及其制法
US7563774B2 (en) *	2000-06-29	2009-07-21	Metabasis Therapeutics, Inc.	Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
ITRM20020016A1 (it) *	2002-01-15	2003-07-15	Sigma Tau Ind Farmaceuti	Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza
JP2008510018A (ja) *	2004-08-18	2008-04-03	メタバシス・セラピューティクス・インコーポレイテッド	フルクトース−１，６−ビスホスファターゼの新規チアゾール阻害物質
US8686048B2 (en) *	2010-05-06	2014-04-01	Rhizen Pharmaceuticals Sa	Immunomodulator and anti-inflammatory compounds
KR102384153B1 (ko)	2018-01-09	2022-04-06	주식회사 엘지에너지솔루션	이형지 커버를 포함하는 전지팩

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5522636A (en) *	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
JPS5728073A (en) *	1980-07-29	1982-02-15	Takeda Chem Ind Ltd	Inhibitor for aldose reducing enzyme
DE3479419D1 (en) *	1983-01-17	1989-09-21	Pfizer	Aldose reductase inhibiting 5-(2-alkoxyphenyl)thiazolidinediones
EP0842925A1 (de) *	1987-09-04	1998-05-20	Beecham Group Plc	Substituierte Thiazolidindionderivate

1992
- 1992-02-21 JP JP4072496A patent/JP3053490B2/ja not_active Expired - Fee Related
- 1992-02-24 KR KR1019920702622A patent/KR960012206B1/ko not_active Expired - Fee Related
- 1992-02-24 ES ES92905305T patent/ES2122991T3/es not_active Expired - Lifetime
- 1992-02-24 EP EP92905305A patent/EP0526658B1/de not_active Expired - Lifetime
- 1992-02-24 DK DK92905305T patent/DK0526658T3/da active
- 1992-02-24 HU HU9203284A patent/HU217116B/hu not_active IP Right Cessation
- 1992-02-24 WO PCT/JP1992/000189 patent/WO1992014719A1/ja not_active Ceased
- 1992-02-24 AT AT92905305T patent/ATE171448T1/de not_active IP Right Cessation
- 1992-02-24 US US07/934,519 patent/US5342850A/en not_active Expired - Fee Related
- 1992-02-24 CA CA002081113A patent/CA2081113C/en not_active Expired - Fee Related
- 1992-02-24 AU AU12059/92A patent/AU645886B2/en not_active Ceased
- 1992-02-24 DE DE69227080T patent/DE69227080T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR960012206B1 (ko)	1996-09-16
CA2081113A1 (en)	1992-08-26
DE69227080D1 (de)	1998-10-29
HU9203284D0 (en)	1992-12-28
ES2122991T3 (es)	1999-01-01
JPH0592960A (ja)	1993-04-16
EP0526658A4 (en)	1993-04-21
WO1992014719A1 (fr)	1992-09-03
EP0526658B1 (de)	1998-09-23
AU1205992A (en)	1992-09-15
DE69227080T2 (de)	1999-05-20
HUT66972A (en)	1995-01-30
HU217116B (hu)	1999-11-29
AU645886B2 (en)	1994-01-27
JP3053490B2 (ja)	2000-06-19
CA2081113C (en)	2001-03-06
KR937000469A (ko)	1993-03-15
US5342850A (en)	1994-08-30
EP0526658A1 (de)	1993-02-10
DK0526658T3 (da)	1999-06-14

Legal Events

Date	Code	Title	Description
1999-08-15	UEP	Publication of translation of european patent specification
2004-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE171448T1 (de)	1998-10-15	Thiazolidin-2,4-dione, salze hiervon sowie verfahren zur herstellung
DE69006984D1 (de)	1994-04-07	Thiazolidinedionederivate.
IE44707L (en)	1977-08-13	Proline derivatives
DK444685D0 (da)	1985-10-01	Tiazolidindionderivater, farmaceutiske praeparater indeholdende dem ogfremgangsmaader til fremstilling deraf
YU47066B (sh)	1994-12-28	Postupak za dobijanje derivata tiazolidin-2,4-diona
DK0615549T3 (da)	1999-11-15	Fremgangsmåde til fremstilling af farmaceutisk aktive thiazolidin- eller oxazolidinforbindelser med en gærreduktase
KR880002829A (ko)	1988-05-11	디하이드로피리딘 항알러지제 및 소염제
KR920007987A (ko)	1992-05-27	니트로구아니딘 유도체의 제조 방법
EP1055683A4 (de)	2007-07-25	Neuartiges acetamid-derivat und verwendung desselben
DE3864707D1 (de)	1991-10-17	Benzoxazin-derivate und verfahren zu ihrer herstellung.
ATE171450T1 (de)	1998-10-15	Thiazolidin-2,4-dion-derivate, salze hiervon sowie verfahren zur herstellung
DE69427978D1 (de)	2001-09-20	Zwischenprodukt zur verwendung in der synthese und verfahren zur herstellung eines aminopiperazinderivates
ATE307807T1 (de)	2005-11-15	Herstellung von thiazolen
ATE67194T1 (de)	1991-09-15	Thiadiazolylacetamid-derivate, verfahren zu ihrer herstellung und ihre verwendung.
JPS6438090A (en)	1989-02-08	Thiazolidine compound
HUT49845A (en)	1989-11-28	Process for producing optically active n-substituted alanine derivatives with herbicidal effect
JPS54157590A (en)	1979-12-12	Perhydroimidazothiazole derivative and agricultural horticultural fungicides comprising it
DE69000335D1 (de)	1992-10-29	Butalactin, verfahren zu seiner herstellung und seine verwendung als arzneimittel.