ATE171449T1 - Oxadolderivate - Google Patents

Oxadolderivate

Info

Publication number
ATE171449T1
ATE171449T1 AT91912700T AT91912700T ATE171449T1 AT E171449 T1 ATE171449 T1 AT E171449T1 AT 91912700 T AT91912700 T AT 91912700T AT 91912700 T AT91912700 T AT 91912700T AT E171449 T1 ATE171449 T1 AT E171449T1
Authority
AT
Austria
Prior art keywords
oxadol
derivatives
oxadol derivatives
Prior art date
Application number
AT91912700T
Other languages
English (en)
Inventor
Frans Eduard Janssens
Francois Maria Sommen
Ann Christina Joannes Dierckx
Ludwig Paul Cooymans
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE171449T1 publication Critical patent/ATE171449T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT91912700T 1990-07-19 1991-07-09 Oxadolderivate ATE171449T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55432690A 1990-07-19 1990-07-19

Publications (1)

Publication Number Publication Date
ATE171449T1 true ATE171449T1 (de) 1998-10-15

Family

ID=24212929

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91912700T ATE171449T1 (de) 1990-07-19 1991-07-09 Oxadolderivate

Country Status (31)

Country Link
EP (1) EP0539421B1 (de)
JP (1) JP3070951B2 (de)
KR (1) KR100190299B1 (de)
CN (1) CN1043640C (de)
AP (1) AP267A (de)
AT (1) ATE171449T1 (de)
AU (1) AU644202B2 (de)
BG (1) BG61342B1 (de)
CA (1) CA2086545A1 (de)
CZ (1) CZ279344B6 (de)
DE (1) DE69130255T2 (de)
ES (1) ES2121784T3 (de)
FI (1) FI930198A0 (de)
HU (1) HUT64340A (de)
IE (1) IE912532A1 (de)
IL (1) IL98864A (de)
MA (1) MA22226A1 (de)
MX (1) MX9100312A (de)
MY (1) MY107973A (de)
NO (1) NO300459B1 (de)
NZ (1) NZ238864A (de)
PL (1) PL169361B1 (de)
PT (1) PT98365B (de)
RO (1) RO111768B1 (de)
RU (1) RU2059636C1 (de)
SK (1) SK278133B6 (de)
TN (1) TNSN91062A1 (de)
TW (1) TW235964B (de)
WO (1) WO1992001687A1 (de)
YU (1) YU126391A (de)
ZA (1) ZA915653B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3258293A (en) * 1992-01-09 1993-08-03 Janssen Pharmaceutica N.V. Antihistaminic piperazinyl derivatives
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
EP1418175A1 (de) 1999-06-28 2004-05-12 Janssen Pharmaceutica N.V. Replikationsinhibitoren des respiratorischen Synzytialvirus
ATE258928T1 (de) 1999-06-28 2004-02-15 Janssen Pharmaceutica Nv Respiratorisches syncytialvirus replikation inhibitoren
EP1400519B1 (de) 1999-06-28 2007-03-07 Janssen Pharmaceutica N.V. Hemmer des Respiratorischen Syncytial Virus
EP1479676A1 (de) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Benzimidazolderivate als Faktor Xa-Inhibitoren
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
MY142783A (en) 2003-12-18 2010-12-31 Tibotec Pharm Ltd 5-or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
TWI356055B (en) 2003-12-18 2012-01-11 Tibotec Pharm Ltd Aminobenzimidazoles and benzimidazoles as inhibito
CN103450159A (zh) 2003-12-18 2013-12-18 泰博特克药品有限公司 作为呼吸道合胞病毒复制的抑制剂的哌啶-氨基-苯并咪唑类衍生物
US7855194B2 (en) * 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives
TWI377511B (en) 2008-12-05 2012-11-21 Ind Tech Res Inst Flame detecting method and system
RU2417995C1 (ru) * 2009-09-21 2011-05-10 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУ ВПО "КубГТУ") Способ получения 3-(2-замещенных-1,3-оксазол-4-ил)пиридин-2(1н)-онов
CN104098609B (zh) * 2014-07-28 2016-08-17 陕西科技大学 含二茂铁的咪唑并[2,1-b]-1,3,4-噻二唑、制备方法及其应用
EP3233077B1 (de) 2014-12-19 2026-05-06 The Broad Institute, Inc. Dopamin-d2-rezeptor-liganden
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
US4835161A (en) * 1986-02-03 1989-05-30 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
US4897401A (en) * 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines

Also Published As

Publication number Publication date
BG61342B1 (en) 1997-06-30
ES2121784T3 (es) 1998-12-16
BG97314A (bg) 1994-01-24
PL297611A1 (de) 1992-07-13
NZ238864A (en) 1993-08-26
ZA915653B (en) 1993-03-31
YU126391A (sh) 1994-06-10
NO930156L (no) 1993-01-18
TW235964B (de) 1994-12-11
HUT64340A (en) 1993-12-28
NO930156D0 (no) 1993-01-18
CN1058215A (zh) 1992-01-29
JPH05508839A (ja) 1993-12-09
CN1043640C (zh) 1999-06-16
MX9100312A (es) 1992-02-28
CA2086545A1 (en) 1992-01-20
MA22226A1 (fr) 1992-04-01
IL98864A (en) 1995-12-08
CS224091A3 (en) 1992-02-19
PT98365B (pt) 1999-01-29
JP3070951B2 (ja) 2000-07-31
WO1992001687A1 (en) 1992-02-06
MY107973A (en) 1996-07-15
IL98864A0 (en) 1992-07-15
DE69130255T2 (de) 1999-04-08
CZ279344B6 (cs) 1995-04-12
EP0539421B1 (de) 1998-09-23
SK278133B6 (en) 1996-02-07
AU644202B2 (en) 1993-12-02
PL169361B1 (pl) 1996-07-31
AP9100298A0 (en) 1991-07-31
RO111768B1 (ro) 1997-01-30
HU9300097D0 (en) 1993-04-28
AP267A (en) 1993-06-16
NO300459B1 (no) 1997-06-02
FI930198A7 (fi) 1993-01-18
TNSN91062A1 (fr) 1992-10-25
RU2059636C1 (ru) 1996-05-10
IE912532A1 (en) 1992-01-29
PT98365A (pt) 1992-05-29
KR100190299B1 (ko) 1999-06-01
EP0539421A1 (de) 1993-05-05
FI930198A0 (fi) 1993-01-18
DE69130255D1 (de) 1998-10-29
AU8214191A (en) 1992-02-18

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee