ATE171454T1 - Verfahren zur herstellung von cefixime trihydrat - Google Patents
Verfahren zur herstellung von cefixime trihydratInfo
- Publication number
- ATE171454T1 ATE171454T1 AT95921739T AT95921739T ATE171454T1 AT E171454 T1 ATE171454 T1 AT E171454T1 AT 95921739 T AT95921739 T AT 95921739T AT 95921739 T AT95921739 T AT 95921739T AT E171454 T1 ATE171454 T1 AT E171454T1
- Authority
- AT
- Austria
- Prior art keywords
- tert
- producing
- cepheme
- butoxycarbonylmethoxyimino
- aminothiazol
- Prior art date
Links
- OKBVVJOGVLARMR-VINNURBNSA-N (6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1C(N)=NC(C(=N/OCC(O)=O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 OKBVVJOGVLARMR-VINNURBNSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- XSQPXYAKVKORFJ-ZSOIEALJSA-N (2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]iminoacetic acid Chemical compound CC(C)(C)OC(=O)CO\N=C(/C(O)=O)C1=CSC(N)=N1 XSQPXYAKVKORFJ-ZSOIEALJSA-N 0.000 abstract 1
- GQLGFBRMCCVQLU-XCGJVMPOSA-N (6r)-7-amino-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(C=C)=C(C(O)=O)N2C(=O)C(N)[C@H]21 GQLGFBRMCCVQLU-XCGJVMPOSA-N 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- OKBVVJOGVLARMR-QSWIMTSFSA-N cefixime Chemical compound S1C(N)=NC(C(=N\OCC(O)=O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 OKBVVJOGVLARMR-QSWIMTSFSA-N 0.000 abstract 1
- 229960002129 cefixime Drugs 0.000 abstract 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH01751/94A CH688319A5 (fr) | 1994-06-03 | 1994-06-03 | Procédé pour la préparation du céfixime trihydraté. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE171454T1 true ATE171454T1 (de) | 1998-10-15 |
Family
ID=4217712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95921739T ATE171454T1 (de) | 1994-06-03 | 1995-05-10 | Verfahren zur herstellung von cefixime trihydrat |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0763043B1 (de) |
| KR (1) | KR100223384B1 (de) |
| AT (1) | ATE171454T1 (de) |
| AU (1) | AU2670295A (de) |
| CH (1) | CH688319A5 (de) |
| DE (1) | DE69504971T2 (de) |
| ES (1) | ES2120911B1 (de) |
| PE (1) | PE13296A1 (de) |
| WO (1) | WO1995033753A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| AT404251B (de) * | 1996-08-14 | 1998-10-27 | Biochemie Gmbh | Neues kristallines salz von cefixim |
| PT102061B (pt) * | 1997-10-08 | 2000-06-30 | J K Ind Ltd | Processo de preparacao de um antibiotico cefalosporina geralmente activo-cefixime |
| US20040166434A1 (en) | 2003-02-21 | 2004-08-26 | Dammel Ralph R. | Photoresist composition for deep ultraviolet lithography |
| US8008478B2 (en) | 2004-12-21 | 2011-08-30 | Lupin Limited | Process for the preparation of cefixime |
| PL1863822T3 (pl) | 2005-03-29 | 2010-03-31 | Hetero Drugs Ltd | Ulepszony sposób wytwarzania cefiksymu |
| CN1312158C (zh) * | 2005-05-20 | 2007-04-25 | 天津市医药集团技术发展有限公司 | 一种头孢克肟的制备方法 |
| WO2016142902A1 (en) * | 2015-03-11 | 2016-09-15 | Lupin Limited | Cefixime with reduced surface area and high stability |
| CN108546270B (zh) * | 2017-05-31 | 2019-11-08 | 郑州大学第一附属医院 | 制备头孢地尼的方法 |
| JP7649455B2 (ja) | 2021-07-12 | 2025-03-21 | ウシオ電機株式会社 | 光源装置、誘電体バリア放電ランプの点灯回路、誘電体バリア放電ランプの点灯方法 |
| CN113968874B (zh) * | 2021-10-29 | 2023-01-31 | 国药集团威奇达药业有限公司 | 头孢克肟的精制方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
-
1994
- 1994-06-03 CH CH01751/94A patent/CH688319A5/fr not_active IP Right Cessation
-
1995
- 1995-05-10 KR KR1019960706881A patent/KR100223384B1/ko not_active Expired - Fee Related
- 1995-05-10 EP EP95921739A patent/EP0763043B1/de not_active Expired - Lifetime
- 1995-05-10 AT AT95921739T patent/ATE171454T1/de not_active IP Right Cessation
- 1995-05-10 WO PCT/EP1995/001759 patent/WO1995033753A1/fr not_active Ceased
- 1995-05-10 DE DE69504971T patent/DE69504971T2/de not_active Expired - Fee Related
- 1995-05-10 AU AU26702/95A patent/AU2670295A/en not_active Abandoned
- 1995-06-02 PE PE1995270369A patent/PE13296A1/es not_active Application Discontinuation
-
1996
- 1996-02-02 ES ES09650004A patent/ES2120911B1/es not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995033753A1 (fr) | 1995-12-14 |
| DE69504971D1 (de) | 1998-10-29 |
| EP0763043B1 (de) | 1998-09-23 |
| ES2120911A1 (es) | 1998-11-01 |
| AU2670295A (en) | 1996-01-04 |
| ES2120911B1 (es) | 1999-07-01 |
| CH688319A5 (fr) | 1997-07-31 |
| EP0763043A1 (de) | 1997-03-19 |
| PE13296A1 (es) | 1996-05-10 |
| KR970703348A (ko) | 1997-07-03 |
| DE69504971T2 (de) | 1999-05-20 |
| KR100223384B1 (ko) | 1999-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |