ATE373666T1 - Verfahren zur reinigung eines cephalosporin- derivats - Google Patents

Verfahren zur reinigung eines cephalosporin- derivats

Info

Publication number: ATE373666T1
Authority: AT; Austria
Prior art keywords: purifying; cephalosporin derivative; cefixime; ceph; vwhich
Prior art date: 1998-04-02

Application number

AT99917938T

Other languages

English (en)

Inventor

Martin Decristoforo

Johannes Ludescher

Hubert Sturm

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-02

Filing date

1999-03-31

Publication date

2007-10-15

1999-03-31 Application filed by Sandoz Ag filed Critical Sandoz Ag

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE373666T1 publication Critical patent/ATE373666T1/de

Links

238000000034 method Methods 0.000 title abstract 2
229930186147 Cephalosporin Natural products 0.000 title 1
229940124587 cephalosporin Drugs 0.000 title 1
150000001780 cephalosporins Chemical class 0.000 title 1
OKBVVJOGVLARMR-QSWIMTSFSA-N cefixime Chemical compound S1C(N)=NC(C(=N\OCC(O)=O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 OKBVVJOGVLARMR-QSWIMTSFSA-N 0.000 abstract 2
229960002129 cefixime Drugs 0.000 abstract 2
GQLGFBRMCCVQLU-XCGJVMPOSA-N (6r)-7-amino-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(C=C)=C(C(O)=O)N2C(=O)C(N)[C@H]21 GQLGFBRMCCVQLU-XCGJVMPOSA-N 0.000 abstract 1
QIJIUJYANDSEKG-UHFFFAOYSA-N 2,4,4-trimethylpentan-2-amine Chemical class CC(C)(C)CC(C)(C)N QIJIUJYANDSEKG-UHFFFAOYSA-N 0.000 abstract 1
238000005580 one pot reaction Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Peptides Or Proteins (AREA)

AT99917938T 1998-04-02 1999-03-31 Verfahren zur reinigung eines cephalosporin- derivats ATE373666T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT0057598A AT406773B (de)	1998-04-02	1998-04-02	Neues salz von 7-(2-(aminothiazol-4yl)-2-
PCT/EP1999/002222 WO1999051607A2 (en)	1998-04-02	1999-03-31	Process for purification of a cephalosporin derivative

Publications (1)

Publication Number	Publication Date
ATE373666T1 true ATE373666T1 (de)	2007-10-15

Family

ID=3494225

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT0057598A AT406773B (de)	1998-04-02	1998-04-02	Neues salz von 7-(2-(aminothiazol-4yl)-2-
AT99917938T ATE373666T1 (de)	1998-04-02	1999-03-31	Verfahren zur reinigung eines cephalosporin- derivats

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT0057598A AT406773B (de)	1998-04-02	1998-04-02	Neues salz von 7-(2-(aminothiazol-4yl)-2-

Country Status (15)

Country	Link
US (1)	US6825345B2 (de)
EP (1)	EP1068211B1 (de)
JP (1)	JP2002510694A (de)
KR (1)	KR20010034671A (de)
CN (1)	CN1134447C (de)
AT (2)	AT406773B (de)
AU (1)	AU3603599A (de)
BR (1)	BR9909898A (de)
CA (1)	CA2326441C (de)
DE (1)	DE69937143T2 (de)
ES (1)	ES2293720T3 (de)
ID (1)	ID26210A (de)
TR (1)	TR200002838T2 (de)
WO (1)	WO1999051607A2 (de)
ZA (1)	ZA200004899B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT404727B (de) *	1997-01-16	1999-02-25	Biochemie Gmbh	Kristallines salz von cefixim und verfahren zu dessen herstellung
ITMI20012364A1 (it) *	2001-11-09	2003-05-09	Antibioticos Spa	Processo di sintesi della cefixima via alchil-o arilsolfonati
US7244842B2 (en) *	2002-11-15	2007-07-17	Orchid Chemicals & Pharmaceuticals Ltd.	Amorphous hydrate of a cephalosporin antibiotic
AU2003294161A1 (en) *	2003-03-20	2004-10-11	Orchid Chemicals And Pharmaceuticals Ltd	An improved process for the preparation of cefoxitin
MX2007007476A (es) *	2004-12-21	2007-08-15	Lupin Ltd	Proceso para la preparacion de cefixima.
WO2006103686A1 (en) *	2005-03-29	2006-10-05	Hetero Drugs Limited	An improved process for the preparation of cefixime
CN1312158C (zh) *	2005-05-20	2007-04-25	天津市医药集团技术发展有限公司	一种头孢克肟的制备方法
CN101812075B (zh) *	2010-05-07	2012-06-13	郝志艳	一种头孢克肟化合物及其新制法
CN103265562A (zh) *	2013-05-29	2013-08-28	四川方向药业有限责任公司	头孢克肟的制备方法
CN103965216A (zh) *	2014-05-21	2014-08-06	广州白云山制药股份有限公司广州白云山化学制药厂	7-（噻唑羧甲氧亚氨基)- 3-三嗪环头孢化合物的制造方法
CN103965217A (zh) *	2014-05-21	2014-08-06	广州白云山制药股份有限公司广州白云山化学制药厂	3-三嗪环-7-（噻唑羧甲氧亚氨基）头孢烷酸的制备方法
WO2016142902A1 (en) *	2015-03-11	2016-09-15	Lupin Limited	Cefixime with reduced surface area and high stability

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA806977B (en) *	1979-11-19	1981-10-28	Fujisawa Pharmaceutical Co	7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
JPS58986A (ja) *	1981-05-07	1983-01-06	Fujisawa Pharmaceut Co Ltd	セフェム化合物
JPS57192392A (en) *	1981-05-19	1982-11-26	Sankyo Co Ltd	Production of 3-alkoxymethylcephalosporin
AU564150B2 (en) *	1982-04-30	1987-08-06	Takeda Chemical Industries Ltd.	1-sulfo-2-azetidinone derivatives
EP0096297B1 (de) *	1982-06-03	1988-06-15	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Verfahren zur Herstellung von 1-Sulfo-2-oxoazetidinderivaten
EP0096296B1 (de)	1982-06-03	1987-07-29	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	1-Sulfo-2-oxoazetidinderivate
JPS59163387A (ja) *	1983-03-07	1984-09-14	Sankyo Co Ltd	３−アルコキシメチルセフアロスポリンの製造方法
JPH0692416B2 (ja) *	1985-03-13	1994-11-16	三共株式会社	セフアロスポラン酸誘導体
ES2042507T3 (es) *	1986-02-07	1993-12-16	Hoffmann La Roche	Procedimiento para la obtencion de carboxiamidas.
US5359057A (en)	1986-02-07	1994-10-25	Hoffmann-La Roche Inc.	Acylation of amines
JPH01242589A (ja) *	1988-03-22	1989-09-27	Fujisawa Pharmaceut Co Ltd	セフエム化合物
DK0630380T3 (da) *	1992-02-05	2001-12-10	Biochemie Gmbh	Fremgangsmåde til rensning af et 3-cephem-4-carboxylsyrederivat
PT658558E (pt) *	1993-11-17	2001-06-29	Biochemie Gmbh	Separacao de isomeros da cefalosporina
AT403049B (de) *	1995-08-14	1997-10-27	Biochemie Gmbh	Abreicherung von 7-adca in 3-vinyl-aca
AT404251B (de) *	1996-08-14	1998-10-27	Biochemie Gmbh	Neues kristallines salz von cefixim
EP0831093A1 (de) *	1996-09-23	1998-03-25	F. Hoffmann-La Roche Ag	1-Carba-(desthia)-cephalosporinderivate
TW538045B (en) *	1997-01-16	2003-06-21	Biochemie Gmbh	Process for purifying cefixime

1998
- 1998-04-02 AT AT0057598A patent/AT406773B/de not_active IP Right Cessation
1999
- 1999-03-31 CA CA002326441A patent/CA2326441C/en not_active Expired - Fee Related
- 1999-03-31 AT AT99917938T patent/ATE373666T1/de not_active IP Right Cessation
- 1999-03-31 DE DE69937143T patent/DE69937143T2/de not_active Expired - Lifetime
- 1999-03-31 AU AU36035/99A patent/AU3603599A/en not_active Abandoned
- 1999-03-31 WO PCT/EP1999/002222 patent/WO1999051607A2/en not_active Ceased
- 1999-03-31 ID IDW20001932A patent/ID26210A/id unknown
- 1999-03-31 KR KR1020007010634A patent/KR20010034671A/ko not_active Ceased
- 1999-03-31 EP EP99917938A patent/EP1068211B1/de not_active Expired - Lifetime
- 1999-03-31 BR BR9909898-9A patent/BR9909898A/pt not_active Application Discontinuation
- 1999-03-31 TR TR2000/02838T patent/TR200002838T2/xx unknown
- 1999-03-31 CN CNB998046205A patent/CN1134447C/zh not_active Expired - Fee Related
- 1999-03-31 JP JP2000542328A patent/JP2002510694A/ja active Pending
- 1999-03-31 ES ES99917938T patent/ES2293720T3/es not_active Expired - Lifetime
2000
- 2000-09-14 ZA ZA200004899A patent/ZA200004899B/xx unknown
2002
- 2002-09-30 US US10/261,748 patent/US6825345B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6825345B2 (en)	2004-11-30
BR9909898A (pt)	2000-12-26
CA2326441A1 (en)	1999-10-14
AU3603599A (en)	1999-10-25
DE69937143T2 (de)	2008-06-12
CA2326441C (en)	2008-03-18
KR20010034671A (ko)	2001-04-25
WO1999051607A3 (en)	2000-01-27
HK1034078A1 (en)	2001-10-12
ATA57598A (de)	2000-01-15
ID26210A (id)	2000-12-07
US20030208065A1 (en)	2003-11-06
ZA200004899B (en)	2001-12-24
CN1295576A (zh)	2001-05-16
AT406773B (de)	2000-08-25
TR200002838T2 (tr)	2001-02-21
CN1134447C (zh)	2004-01-14
JP2002510694A (ja)	2002-04-09
EP1068211A2 (de)	2001-01-17
WO1999051607A2 (en)	1999-10-14
ES2293720T3 (es)	2008-03-16
DE69937143D1 (de)	2007-10-31
EP1068211B1 (de)	2007-09-19

Legal Events

Date

Code

Title

Description

2008-03-15

UEP

Publication of translation of european patent specification

Ref document number: 1068211

Country of ref document: EP

2011-12-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATA57097A (de)	1998-11-15	Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
ATE373666T1 (de)	2007-10-15	Verfahren zur reinigung eines cephalosporin- derivats
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