ATE171458T1 - Verfahren zur herstellung glycin-konjugierter gallensäure - Google Patents

Verfahren zur herstellung glycin-konjugierter gallensäure

Info

Publication number: ATE171458T1
Authority: AT; Austria
Prior art keywords: alpha; acids; bale; conjugate; acid
Prior art date: 1992-08-04

Application number

AT93109377T

Other languages

English (en)

Inventor

Antonio Bonaldi

Egidio Molinari

Aldo Roda

Original Assignee

Erregierre Ind Chim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-04

Filing date

1993-06-11

Publication date

1998-10-15

1993-06-11 Application filed by Erregierre Ind Chim filed Critical Erregierre Ind Chim

1998-10-15 Application granted granted Critical

1998-10-15 Publication of ATE171458T1 publication Critical patent/ATE171458T1/de

Links

239000002253 acid Substances 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
208000000857 Hepatic Insufficiency Diseases 0.000 abstract 1
206010019663 Hepatic failure Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003613 bile acid Substances 0.000 abstract 1
239000003858 bile acid conjugate Substances 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT93109377T 1992-08-04 1993-06-11 Verfahren zur herstellung glycin-konjugierter gallensäure ATE171458T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI921924A IT1255485B (it)	1992-08-04	1992-08-04	Processo per preparare gli acidi biliari coniugati con la glicina e relative composizioni terapeutiche per il trattamento dell'insufficienza epatica

Publications (1)

Publication Number	Publication Date
ATE171458T1 true ATE171458T1 (de)	1998-10-15

Family

ID=11363833

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93109377T ATE171458T1 (de)	1992-08-04	1993-06-11	Verfahren zur herstellung glycin-konjugierter gallensäure

Country Status (6)

Country	Link
EP (1)	EP0583566B1 (de)
JP (1)	JPH0687883A (de)
AT (1)	ATE171458T1 (de)
CA (1)	CA2092218A1 (de)
DE (1)	DE69321177D1 (de)
IT (1)	IT1255485B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2016073767A1 (en)	2014-11-06	2016-05-12	Enanta Pharmaceuticals, Inc.	Bile acid analogs an fxr/tgr5 agonists and methods of use thereof
US11578097B2 (en)	2014-11-26	2023-02-14	Enanta Pharmaceuticals, Inc.	Tetrazole derivatives of bile acids as FXR/TGR5 agonists and methods of use thereof
JP2017535570A (ja)	2014-11-26	2017-11-30	エナンタファーマシューティカルズインコーポレイテッド	Ｆｘｒ／ｔｇｒ５アゴニストとしての胆汁酸類似体およびその使用方法
US10208081B2 (en)	2014-11-26	2019-02-19	Enanta Pharmaceuticals, Inc.	Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
MX2017010376A (es)	2015-02-11	2017-12-20	Enanta Pharm Inc	Análogos de ácido biliar como agonistas de fxr/tgr5 y métodos para el uso de los mismos.
CA2981503C (en)	2015-03-31	2023-09-19	Enanta Pharmaceuticals, Inc.	Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
WO2017147159A1 (en)	2016-02-23	2017-08-31	Enanta Pharmaceuticals, Inc.	Deuterated bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
WO2017147174A1 (en)	2016-02-23	2017-08-31	Enanta Pharmaceuticals, Inc.	Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof
US10323060B2 (en) *	2016-02-23	2019-06-18	Enanta Pharmaceuticals, Inc.	Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof
CA3045023A1 (en)	2016-11-29	2018-06-07	Enanta Pharmaceuticals, Inc.	Process for preparation of sulfonylurea bile acid derivatives
US10472386B2 (en)	2017-02-14	2019-11-12	Enanta Pharmaceuticals, Inc.	Bile acid derivatives as FXR agonists and methods of use thereof
CA3058754A1 (en)	2017-04-07	2018-10-11	Enanta Pharmaceuticals, Inc.	Process for preparation of sulfonyl carbamate bile acid derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5826360B2 (ja) *	1974-08-23	1983-06-02	エ−ザイカブシキガイシヤ	グリコケノデオキシコ−ルサンノセイホウ
CA1173823A (en) *	1980-08-26	1984-09-04	Leonard M. Hjelmeland	Nondenaturing zwitterionic detergent for membrane biochemistry
JPS5826360A (ja) *	1981-08-11	1983-02-16	Sony Corp	カセツトロ−デイング機構
IT1152801B (it) *	1982-08-17	1987-01-14	Proter Spa	Composti steroidei ad attivita' coleretica, processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo
IT1230796B (it) *	1989-05-30	1991-10-29	Prodotti Chimici Alimentari	Procedimento per la preparazione di acido tauroursodesossicolico biidrato.

1992
- 1992-08-04 IT ITMI921924A patent/IT1255485B/it active IP Right Grant
1993
- 1993-03-23 CA CA002092218A patent/CA2092218A1/en not_active Abandoned
- 1993-03-26 JP JP5067941A patent/JPH0687883A/ja active Pending
- 1993-06-11 AT AT93109377T patent/ATE171458T1/de not_active IP Right Cessation
- 1993-06-11 DE DE69321177T patent/DE69321177D1/de not_active Expired - Lifetime
- 1993-06-11 EP EP93109377A patent/EP0583566B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH0687883A (ja)	1994-03-29
EP0583566B1 (de)	1998-09-23
CA2092218A1 (en)	1994-02-05
DE69321177D1 (de)	1998-10-29
EP0583566A2 (de)	1994-02-23
ITMI921924A0 (it)	1992-08-04
IT1255485B (it)	1995-11-06
EP0583566A3 (en)	1995-12-27
ITMI921924A1 (it)	1994-02-04

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Legal Events

Date	Code	Title	Description
1999-03-15	REN	Ceased due to non-payment of the annual fee