ATE171474T1 - Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen - Google Patents

Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen

Info

Publication number
ATE171474T1
ATE171474T1 AT92918054T AT92918054T ATE171474T1 AT E171474 T1 ATE171474 T1 AT E171474T1 AT 92918054 T AT92918054 T AT 92918054T AT 92918054 T AT92918054 T AT 92918054T AT E171474 T1 ATE171474 T1 AT E171474T1
Authority
AT
Austria
Prior art keywords
recombinant
yeasts
highly stable
production
proteins
Prior art date
Application number
AT92918054T
Other languages
English (en)
Inventor
Reinhard Fleer
Alain Fournier
Patrice Yeh
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of ATE171474T1 publication Critical patent/ATE171474T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT92918054T 1991-08-02 1992-08-03 Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen ATE171474T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9109854A FR2679920A1 (fr) 1991-08-02 1991-08-02 Levures recombinantes hautement stables pour la production de proteines recombinantes, leur preparation et leur utilisation.

Publications (1)

Publication Number Publication Date
ATE171474T1 true ATE171474T1 (de) 1998-10-15

Family

ID=9415866

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92918054T ATE171474T1 (de) 1991-08-02 1992-08-03 Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen

Country Status (13)

Country Link
US (2) US5593858A (de)
EP (2) EP0531181A1 (de)
JP (1) JPH06509234A (de)
AT (1) ATE171474T1 (de)
AU (1) AU2474892A (de)
CA (1) CA2113551A1 (de)
DE (1) DE69227116T2 (de)
DK (1) DK0597035T3 (de)
ES (1) ES2123006T3 (de)
FR (1) FR2679920A1 (de)
NZ (1) NZ243782A (de)
WO (1) WO1993003159A1 (de)
ZA (1) ZA925735B (de)

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US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
AU3511500A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
AU3731400A (en) * 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Methods and compositions useful in inhibiting apoptosis
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
DE10101962B4 (de) * 2001-01-17 2006-07-27 Tad Pharma Gmbh DNA-Sequenz mit regulatorischen Bereichen zur Expression von Proteinen
US7285269B2 (en) * 2002-12-02 2007-10-23 Amgen Fremont, Inc. Antibodies directed to tumor necrosis factor
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
DE102008057451A1 (de) * 2008-11-14 2010-05-20 Martin-Luther-Universität Halle-Wittenberg Verfahren zur oralen Vakzinierung mittels rekombinanter Hefen
CA2746818A1 (en) 2008-12-24 2010-07-01 C5 Yeast Company B.V. Xylose isomerase genes and their use in fermentation of pentose sugars
UA108853C2 (uk) 2009-07-10 2015-06-25 Спосіб ферментації галактози
AR081827A1 (es) 2010-04-21 2012-10-24 Dsm Ip Assets Bv Proceso para producir celulas capaces de convertir arabinosa
WO2011149353A1 (en) 2010-05-27 2011-12-01 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from acetic acid and glycerol
WO2011150313A1 (en) 2010-05-28 2011-12-01 Codexis, Inc. Pentose fermentation by a recombinant microorganism
CN103154234B (zh) 2010-10-13 2016-08-17 帝斯曼知识产权资产管理有限公司 发酵戊糖和葡萄糖的酵母细胞
WO2012067510A1 (en) 2010-11-18 2012-05-24 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from glycerol
WO2012125027A1 (en) 2011-03-14 2012-09-20 Dsm Ip Assets B.V. Yeast strains that ferment uronic acids
US8663962B2 (en) 2011-03-30 2014-03-04 Codexis, Inc. Pentose fermentation by a recombinant microorganism
EP2699589A2 (de) 2011-04-22 2014-02-26 DSM IP Assets B.V. Hefezelle mit fähigkeit zur umwandlung von zuckern, einschliesslich arabinose und xylose
US8778652B2 (en) 2011-06-30 2014-07-15 Codexis, Inc. Pentose fermentation by a recombinant microorganism
EP2546336A1 (de) 2011-07-11 2013-01-16 DSM IP Assets B.V. Hefestränge, die Uronsäure verbrauchen und Fermentierungsprodukte wie Ethanol herstellen
AR087423A1 (es) 2011-08-04 2014-03-19 Dsm Ip Assets Bv Celula capaz de fermentar azucares pentosas
EP2554668A1 (de) 2011-08-04 2013-02-06 DSM IP Assets B.V. Zelle zur Fermentierung von Pentosezucker
AU2012346662B2 (en) 2011-11-30 2016-07-28 Danisco Us Inc. Yeast strains engineered to produce ethanol from acetic acid and glycerol
JP6468561B2 (ja) 2012-07-19 2019-02-13 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． ＡｇｓＥ欠損株
IN2015DN01042A (de) 2012-08-28 2015-06-26 Dsm Ip Assets Bv
WO2014033018A1 (en) 2012-08-28 2014-03-06 Dsm Ip Assets B.V. Yeast strains engineered to produce ethanol from acetate
US10273507B2 (en) 2012-10-16 2019-04-30 Dsm Ip Assets B.V. Cells with improved pentose conversion
EP2922953A4 (de) 2012-11-20 2016-11-09 Shell Int Research Pentosefermentierung durch einen rekombinanten mikroorganismus
PL3686280T3 (pl) 2013-02-04 2022-09-19 Dsm Ip Assets B.V. Polipeptyd degradujący węglowodany i jego zastosowania
WO2014202624A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202620A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202622A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202621A1 (en) 2013-06-20 2014-12-24 Dsm Ip Assets B.V. Carbohydrate degrading polypeptide and uses thereof
WO2014207113A1 (en) 2013-06-26 2014-12-31 Abengoa Bioenergia Nuevas Tecnologias S.A. Yeasts engineered for the production of valuable chemicals from sugars
US20180030482A1 (en) 2014-04-18 2018-02-01 Moralco B.V. Use of acetaldehyde in the fermentative production of ethanol
DE102014210308A1 (de) 2014-05-30 2015-12-03 Wacker Chemie Ag Hefestamm zur Produktion von Carotinoiden
WO2017050652A1 (en) 2015-09-25 2017-03-30 Dsm Ip Assets B.V. Asparaginase
CN108884480A (zh) 2015-12-30 2018-11-23 帝斯曼知识产权资产管理有限公司 三酰基甘油的部分酶水解
CA3010288A1 (en) 2015-12-30 2017-07-06 Dsm Ip Assets B.V. Partial enzymatic hydrolysis of triacylglycerols
WO2017211930A1 (en) 2016-06-10 2017-12-14 Dsm Ip Assets B.V. Mutant lipase and use thereof
EP3559210A1 (de) 2016-12-21 2019-10-30 Vib Vzw Xyloseisomerasen, die eine effiziente xylosefermentierungsfähigkeit auf hefe übertragen
US12161777B2 (en) 2020-07-02 2024-12-10 Davol Inc. Flowable hemostatic suspension
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
JP2024500994A (ja) 2020-12-28 2024-01-10 デボル，インコーポレイテッド タンパク質及び多官能化変性ポリエチレングリコール系架橋剤を含む反応性乾燥粉末状止血用材料
WO2023064638A2 (en) * 2021-10-15 2023-04-20 The Trustees Of Columbia University In The City Of New York Compositions and methods for treating skin conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857467A (en) * 1986-07-23 1989-08-15 Phillips Petroleum Company Carbon and energy source markers for transformation of strains of the genes Pichia
FR2649991B2 (fr) * 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
FR2635115B1 (fr) * 1988-08-05 1992-04-03 Rhone Poulenc Sante Procede de preparation de la serum albumine humaine a partir d'une levure

Also Published As

Publication number Publication date
DE69227116T2 (de) 1999-03-25
CA2113551A1 (fr) 1993-02-18
JPH06509234A (ja) 1994-10-20
WO1993003159A1 (fr) 1993-02-18
EP0597035A1 (de) 1994-05-18
FR2679920B1 (de) 1994-08-19
USRE37767E1 (en) 2002-06-25
EP0597035B1 (de) 1998-09-23
AU2474892A (en) 1993-03-02
EP0531181A1 (de) 1993-03-10
ZA925735B (en) 1993-04-28
FR2679920A1 (fr) 1993-02-05
ES2123006T3 (es) 1999-01-01
DE69227116D1 (de) 1998-10-29
NZ243782A (en) 1994-07-26
US5593858A (en) 1997-01-14
DK0597035T3 (da) 1999-02-15

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