ATE171708T1 - Flüssigphasensynthese von peptiden und peptidderivaten - Google Patents

Flüssigphasensynthese von peptiden und peptidderivaten

Info

Publication number: ATE171708T1
Authority: AT; Austria
Prior art keywords: peptides; liquid phase; peptide derivatives; phase synthesis; protecting group
Prior art date: 1992-06-16

Application number

AT93916581T

Other languages

English (en)

Inventor

Gary A Siwruck

John S Eynon

Original Assignee

Kinerton Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-16

Filing date

1993-06-16

Publication date

1998-10-15

1993-06-16 Application filed by Kinerton Ltd filed Critical Kinerton Ltd

1998-10-15 Application granted granted Critical

1998-10-15 Publication of ATE171708T1 publication Critical patent/ATE171708T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
230000015572 biosynthetic process Effects 0.000 title abstract 2
239000007791 liquid phase Substances 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 abstract 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
229910021529 ammonia Inorganic materials 0.000 abstract 1
150000001718 carbodiimides Chemical class 0.000 abstract 1
239000007822 coupling agent Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
238000010189 synthetic method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT93916581T 1992-06-16 1993-06-16 Flüssigphasensynthese von peptiden und peptidderivaten ATE171708T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IE194292A IE921942A1 (en)	1992-06-16	1992-06-16	Liquid phase synthesis of peptides and peptide derivatives

Publications (1)

Publication Number	Publication Date
ATE171708T1 true ATE171708T1 (de)	1998-10-15

Family

ID=11039683

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93916581T ATE171708T1 (de)	1992-06-16	1993-06-16	Flüssigphasensynthese von peptiden und peptidderivaten

Country Status (11)

Country	Link
EP (1)	EP0598899B1 (de)
JP (1)	JPH06509821A (de)
AT (1)	ATE171708T1 (de)
AU (1)	AU671660B2 (de)
CA (1)	CA2115668A1 (de)
DE (1)	DE69321324T2 (de)
DK (1)	DK0598899T3 (de)
ES (1)	ES2123059T3 (de)
IE (1)	IE921942A1 (de)
NZ (1)	NZ254389A (de)
WO (1)	WO1993025571A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE37160E1 (en) *	1990-06-12	2001-05-01	Rutgers, The State University	Synthesis of tyrosine derived diphenol monomers
US5587507A (en) *	1995-03-31	1996-12-24	Rutgers, The State University	Synthesis of tyrosine derived diphenol monomers
US5874532A (en) *	1997-01-08	1999-02-23	Nexstar Pharmaceuticals, Inc.	Method for solution phase synthesis of oligonucleotides and peptides
ATE376556T1 (de)	2003-12-31	2007-11-15	Hoffmann La Roche	Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel
EP1701976A2 (de) *	2003-12-31	2006-09-20	F.Hoffmann-La Roche Ag	Peptidsynthese und entschützung mit cosolvenz
ES2729197T3 (es) *	2006-03-01	2019-10-30	Kaneka Corp	Método de producción de péptidos
JP5212371B2 (ja) *	2007-07-25	2013-06-19	味の素株式会社	ペプチドの製造方法
US10450343B2 (en)	2013-03-21	2019-10-22	Sanofi-Aventis Deutschland Gmbh	Synthesis of cyclic imide containing peptide products
CA2907454C (en)	2013-03-21	2021-05-04	Sanofi-Aventis Deutschland Gmbh	Synthesis of hydantoin containing peptide products
CN107406480B (zh) *	2015-03-04	2022-06-24	Jitsubo株式会社	肽合成方法
CN108697770B (zh)	2015-12-21	2023-08-01	得克萨斯技术大学联合体	用于溶液相gap肽合成的系统和方法
KR101791526B1 (ko) *	2016-02-18	2017-11-01	(주)케어젠	발모 촉진 활성을 나타내는 펩타이드 및 이의 용도
US12024537B2 (en)	2018-05-31	2024-07-02	Sederma	Compositions and methods for chemical synthesis
EP3802554B1 (de) *	2018-05-31	2023-12-13	Sederma	Verfahren für peptidsynthese in der lösungsphase und schutzstrategien dafür
WO2020159837A1 (en) *	2019-02-01	2020-08-06	Gap Peptides Llc	Synthesis strategy for gap protecting group

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3121707A (en) *	1960-11-23	1964-02-18	American Cyanamid Co	Peptide synthesis using n-n' carbonyldiimidazole activator
US3769271A (en) *	1971-04-15	1973-10-30	Lilly Co Eli	N-protected amino acids and peptides
US4581168A (en) *	1983-02-21	1986-04-08	Sanofi	Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides
US4859736A (en) *	1987-03-30	1989-08-22	Ciba-Geigy Corporation	Synthetic polystyrene resin and its use in solid phase peptide synthesis

1992
- 1992-06-16 IE IE194292A patent/IE921942A1/en not_active Application Discontinuation
1993
- 1993-06-16 NZ NZ254389A patent/NZ254389A/en unknown
- 1993-06-16 EP EP93916581A patent/EP0598899B1/de not_active Expired - Lifetime
- 1993-06-16 JP JP6501810A patent/JPH06509821A/ja active Pending
- 1993-06-16 CA CA002115668A patent/CA2115668A1/en not_active Abandoned
- 1993-06-16 WO PCT/US1993/005783 patent/WO1993025571A1/en not_active Ceased
- 1993-06-16 DE DE69321324T patent/DE69321324T2/de not_active Expired - Fee Related
- 1993-06-16 ES ES93916581T patent/ES2123059T3/es not_active Expired - Lifetime
- 1993-06-16 DK DK93916581T patent/DK0598899T3/da active
- 1993-06-16 AT AT93916581T patent/ATE171708T1/de not_active IP Right Cessation
- 1993-06-16 AU AU46381/93A patent/AU671660B2/en not_active Ceased

Also Published As

Publication number	Publication date
DK0598899T3 (da)	1999-02-08
IE921942A1 (en)	1993-12-29
JPH06509821A (ja)	1994-11-02
NZ254389A (en)	1996-03-26
EP0598899A4 (en)	1995-08-16
AU671660B2 (en)	1996-09-05
EP0598899A1 (de)	1994-06-01
DE69321324T2 (de)	1999-03-11
WO1993025571A1 (en)	1993-12-23
EP0598899B1 (de)	1998-09-30
ES2123059T3 (es)	1999-01-01
DE69321324D1 (de)	1998-11-05
AU4638193A (en)	1994-01-04
CA2115668A1 (en)	1993-12-23

Legal Events

Date	Code	Title	Description
1999-05-15	UEP	Publication of translation of european patent specification
2001-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE171708T1 (de)	1998-10-15	Flüssigphasensynthese von peptiden und peptidderivaten
PT89961A (pt)	1989-11-10	Processo para a preparacao de n-carboxianidridos de aminoacidos protegidos por uretano
MX9301457A (es)	1994-02-28	Agentes antifungicos de peptidos ciclicos y proceso para su preparacion.
BR9408087A (pt)	1998-07-14	Recuperação de um aminoácido
NO940299D0 (no)	1994-01-28	peptid med organbestkyttende aktivitet
DK0437563T3 (da)	1995-05-29	Bioligiske aktive lægemiddelpolymerderivater
PT83535B (pt)	1989-05-31	Processo para a preparacao de composicoes farmaceuticas contendo derivados de aminoacidos
IT8319160A0 (it)	1983-01-18	Procedimento di sintesi di peptidi e agenti di bloccaggio di amminoacidi.
ES2171018T3 (es)	2002-08-16	Uso de agentes inmunomoduladores.
DK0752425T3 (da)	2000-04-10	Peptidligander for den konstante region på immunoglobuliner
NO983691L (no)	1998-08-12	Forbindelser tilh°rende amidiniumfamilien, farmas°ytiske preparater inneholdende disse samt anvendelse derav
ATE201693T1 (de)	2001-06-15	Hämoregulierende peptide
DE69002881D1 (de)	1993-09-30	Peptide und deren Benutzung.
DE69830866D1 (de)	2005-08-25	Verfahren zur Herstellung von Nitroguanidin-Derivaten ausgehend von 2-Nitroimino-hexahydro-1,3,5-triazinen in Anwesenheit von Ammoniak, primärem oder sekundärem Amin
ATE30919T1 (de)	1987-12-15	Magensekretion hemmende peptidderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel.
DE69315730D1 (de)	1998-01-29	Verfahren zur Herstellung von Peptiden und neue Zwischenverbindungen dazu
NZ511747A (en)	2004-03-26	Regulatory/unfolding peptides of ezrin
BR9815448A (pt)	2001-10-16	Derivados de imino-aza-antraciclinona para o tratamento de amiloidose
CA1264899C (en)	1990-01-23	SYNTHESIS OF PEPTIDES USING THIOXANTHYLMETHYLOXYCARBONYL DIOXIDES
AU639751B2 (en)	1993-08-05	Temporary minimal protection synthesis of lh-rh analogs
SE9402253D0 (sv)	1994-06-27	Process
DK0661328T3 (da)	2000-07-03	Hidtil ukendte epoxid-amin-addukter som hærdere til vandige epoxidsystemer
ATE283276T1 (de)	2004-12-15	Deoxyhypusin reagenz und peptide
HU9401818D0 (en)	1994-09-28	Process for the preparation of an alpha-amino acid amide
이진식 et al.	1995	The Influence of Protecting Groups on the β-Sheet Structure Stability of Protected Peptides