PT89961A - Processo para a preparacao de n-carboxianidridos de aminoacidos protegidos por uretano - Google Patents
Processo para a preparacao de n-carboxianidridos de aminoacidos protegidos por uretanoInfo
- Publication number
- PT89961A PT89961A PT89961A PT8996189A PT89961A PT 89961 A PT89961 A PT 89961A PT 89961 A PT89961 A PT 89961A PT 8996189 A PT8996189 A PT 8996189A PT 89961 A PT89961 A PT 89961A
- Authority
- PT
- Portugal
- Prior art keywords
- urethane
- preparation
- carboxyanidrides
- protein aminoacid
- protein
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 title 1
- 235000001014 amino acid Nutrition 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 title 1
- 235000018102 proteins Nutrition 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000001243 protein synthesis Methods 0.000 abstract 1
- 230000014616 translation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Polyethers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/168,087 US4946942A (en) | 1988-03-11 | 1988-03-11 | Urethane-protected amino acid-N-carboxyanhydrides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT89961A true PT89961A (pt) | 1989-11-10 |
| PT89961B PT89961B (pt) | 1994-04-29 |
Family
ID=22610066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT89961A PT89961B (pt) | 1988-03-11 | 1989-03-09 | Processo para a preparacao de n-carboxianidridos de aminoacidos protegidos por uretano |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4946942A (pt) |
| EP (1) | EP0357750B1 (pt) |
| JP (1) | JP2875834B2 (pt) |
| KR (1) | KR970002229B1 (pt) |
| CN (1) | CN1022412C (pt) |
| AT (1) | ATE108438T1 (pt) |
| AU (1) | AU616054B2 (pt) |
| CA (1) | CA1321280C (pt) |
| CZ (1) | CZ148989A3 (pt) |
| DD (1) | DD280322A5 (pt) |
| DE (1) | DE68916722T2 (pt) |
| FI (1) | FI102379B1 (pt) |
| HU (1) | HU205091B (pt) |
| IE (1) | IE65149B1 (pt) |
| IL (1) | IL89541A0 (pt) |
| NO (1) | NO306304B1 (pt) |
| NZ (1) | NZ228282A (pt) |
| PT (1) | PT89961B (pt) |
| RU (1) | RU2007396C1 (pt) |
| WO (1) | WO1989008643A1 (pt) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5006661A (en) * | 1987-06-16 | 1991-04-09 | University Of Cincinnati | Selective stereospecific biologically active beta-lactams |
| DE3839379A1 (de) * | 1988-11-22 | 1990-05-23 | Hoechst Ag | Verfahren zur herstellung von tripeptiden |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5547839A (en) * | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US6919211B1 (en) | 1989-06-07 | 2005-07-19 | Affymetrix, Inc. | Polypeptide arrays |
| US6406844B1 (en) | 1989-06-07 | 2002-06-18 | Affymetrix, Inc. | Very large scale immobilized polymer synthesis |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US6416952B1 (en) | 1989-06-07 | 2002-07-09 | Affymetrix, Inc. | Photolithographic and other means for manufacturing arrays |
| US6346413B1 (en) | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
| US6309822B1 (en) | 1989-06-07 | 2001-10-30 | Affymetrix, Inc. | Method for comparing copy number of nucleic acid sequences |
| US6551784B2 (en) | 1989-06-07 | 2003-04-22 | Affymetrix Inc | Method of comparing nucleic acid sequences |
| US6955915B2 (en) | 1989-06-07 | 2005-10-18 | Affymetrix, Inc. | Apparatus comprising polymers |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US6506558B1 (en) | 1990-03-07 | 2003-01-14 | Affymetrix Inc. | Very large scale immobilized polymer synthesis |
| WO1992010588A1 (en) | 1990-12-06 | 1992-06-25 | Affymax Technologies N.V. | Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides |
| US6468740B1 (en) | 1992-11-05 | 2002-10-22 | Affymetrix, Inc. | Cyclic and substituted immobilized molecular synthesis |
| TW306932B (pt) * | 1993-08-27 | 1997-06-01 | Holland Sweetener Co | |
| US7323298B1 (en) * | 1994-06-17 | 2008-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Microarray for determining the relative abundances of polynuceotide sequences |
| US7625697B2 (en) * | 1994-06-17 | 2009-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for constructing subarrays and subarrays made thereby |
| US7378236B1 (en) | 1994-06-17 | 2008-05-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method for analyzing gene expression patterns |
| IN184759B (pt) * | 1997-07-22 | 2000-09-23 | Kaneka Corp | |
| WO2000005247A1 (en) * | 1998-07-21 | 2000-02-03 | Kaneka Corporation | Method for crystallizing maleic acid salt of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-l-proline |
| US6545264B1 (en) | 1998-10-30 | 2003-04-08 | Affymetrix, Inc. | Systems and methods for high performance scanning |
| SE0000382D0 (sv) | 2000-02-07 | 2000-02-07 | Astrazeneca Ab | New process |
| CN1388804A (zh) * | 2000-07-04 | 2003-01-01 | 三井化学株式会社 | 在氮原子上具有取代基的氨基酸－n－羧基酸酐 |
| DE10333368B4 (de) * | 2003-07-23 | 2008-08-28 | Universität Leipzig | Oberflächenfunktionalisiertes Trägermaterial, Verfahren zu dessen Herstellung und dessen Verwendungen |
| FR2858976B1 (fr) * | 2003-08-22 | 2006-02-10 | Isochem Sa | Procede d'obtention de n-carboxyanhydrides d'alpha-aminoacides a protection urethane |
| CN100575348C (zh) * | 2004-10-26 | 2009-12-30 | 西格玛-奥尔德利希公司 | 氨基酸n-羧酸酐的合成 |
| US8067402B2 (en) | 2005-12-12 | 2011-11-29 | Allaccem, Inc. | Methods and systems for coating an oral surface |
| EP2125026B1 (en) | 2007-02-21 | 2014-09-24 | AllAccem, Inc. | Bridged polycyclic compound based compositions for the inhibition and amelioration of disease |
| US20090035816A1 (en) * | 2007-08-02 | 2009-02-05 | Scinopharm Taiwan Ltd. | Process for the preparation of a polypeptide |
| US8153618B2 (en) * | 2007-08-10 | 2012-04-10 | Allaccem, Inc. | Bridged polycyclic compound based compositions for topical applications for pets |
| US8188068B2 (en) * | 2007-08-10 | 2012-05-29 | Allaccem, Inc. | Bridged polycyclic compound based compositions for coating oral surfaces in pets |
| US8153617B2 (en) * | 2007-08-10 | 2012-04-10 | Allaccem, Inc. | Bridged polycyclic compound based compositions for coating oral surfaces in humans |
| US20090074833A1 (en) * | 2007-08-17 | 2009-03-19 | Whiteford Jeffery A | Bridged polycyclic compound based compositions for controlling bone resorption |
| FR2928372B1 (fr) * | 2008-03-10 | 2010-12-31 | Solvay | Procede de synthese peptidique |
| US20100004218A1 (en) * | 2008-06-20 | 2010-01-07 | Whiteford Jeffery A | Bridged polycyclic compound based compositions for renal therapy |
| US20100016270A1 (en) * | 2008-06-20 | 2010-01-21 | Whiteford Jeffery A | Bridged polycyclic compound based compositions for controlling cholesterol levels |
| KR101559217B1 (ko) * | 2011-03-25 | 2015-10-12 | 닛뽕소다 가부시키가이샤 | 글루타민산벤질에스테르 n-무수카르복실산 |
| MX376146B (es) | 2015-03-17 | 2025-03-07 | Regeneron Pharma | Reactivos de acilacion de aminoacidos y metodos para usar los mismos. |
| JP6766432B2 (ja) * | 2016-04-28 | 2020-10-14 | Jsr株式会社 | ポリアミノ酸の製造方法 |
| JP7067798B2 (ja) * | 2017-03-02 | 2022-05-16 | 株式会社糖鎖工学研究所 | アミノ酸ポリマーの製造方法 |
| CN112778236A (zh) * | 2019-11-08 | 2021-05-11 | 华东理工大学 | β、γ-氨基酸N-羧基硫代羰基环内酸酐单体的合成、聚合反应、聚合物制备及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1173562A (en) * | 1966-04-25 | 1969-12-10 | Pierrel Spa | Chloramphenicol Ester Salts, the Preparation therof and Compositions Containing them |
| US4267344A (en) * | 1972-09-22 | 1981-05-12 | Proteinkemisk Institut. Tilknyttet Akademiet For De Tekniske Videnskaber | N-Substituted N-carboxyanhydrides of α-amino acids and their application in the preparation of peptides |
| US4038411A (en) * | 1973-09-25 | 1977-07-26 | Merck & Co., Inc. | Antihypertensive amino acid esters |
| US4038282A (en) * | 1975-11-26 | 1977-07-26 | Merck & Co., Inc. | Pyridyl-4-methyl-succinimidocarbonate and process for its preparation |
| US4367234A (en) * | 1980-07-28 | 1983-01-04 | Pfizer Inc. | Hypoglycemic 5-substituted oxazolidine-2,4-diones |
-
1988
- 1988-03-11 US US07/168,087 patent/US4946942A/en not_active Expired - Lifetime
-
1989
- 1989-03-03 KR KR1019890702114A patent/KR970002229B1/ko not_active Expired - Fee Related
- 1989-03-03 WO PCT/US1989/000875 patent/WO1989008643A1/en not_active Ceased
- 1989-03-03 AU AU41887/89A patent/AU616054B2/en not_active Ceased
- 1989-03-03 DE DE68916722T patent/DE68916722T2/de not_active Expired - Fee Related
- 1989-03-03 JP JP1503158A patent/JP2875834B2/ja not_active Expired - Fee Related
- 1989-03-03 AT AT89903412T patent/ATE108438T1/de not_active IP Right Cessation
- 1989-03-03 EP EP89903412A patent/EP0357750B1/en not_active Expired - Lifetime
- 1989-03-03 HU HU891841A patent/HU205091B/hu not_active IP Right Cessation
- 1989-03-06 CA CA000592823A patent/CA1321280C/en not_active Expired - Fee Related
- 1989-03-08 IL IL89541A patent/IL89541A0/xx unknown
- 1989-03-09 PT PT89961A patent/PT89961B/pt not_active IP Right Cessation
- 1989-03-09 NZ NZ228282A patent/NZ228282A/xx unknown
- 1989-03-10 IE IE77889A patent/IE65149B1/en not_active IP Right Cessation
- 1989-03-10 CN CN89101333A patent/CN1022412C/zh not_active Expired - Fee Related
- 1989-03-10 DD DD89326451A patent/DD280322A5/de unknown
- 1989-03-10 CZ CS891489A patent/CZ148989A3/cs unknown
- 1989-11-10 FI FI895382A patent/FI102379B1/fi active IP Right Grant
- 1989-11-10 NO NO894503A patent/NO306304B1/no not_active IP Right Cessation
- 1989-11-10 RU SU894742483A patent/RU2007396C1/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO894503D0 (no) | 1989-11-10 |
| AU4188789A (en) | 1989-10-05 |
| KR900700469A (ko) | 1990-08-13 |
| DD280322A5 (de) | 1990-07-04 |
| JP2875834B2 (ja) | 1999-03-31 |
| CA1321280C (en) | 1993-08-10 |
| AU616054B2 (en) | 1991-10-17 |
| DE68916722T2 (de) | 1994-11-03 |
| IE890778L (en) | 1989-09-11 |
| HUT52488A (en) | 1990-07-28 |
| KR970002229B1 (ko) | 1997-02-26 |
| PT89961B (pt) | 1994-04-29 |
| JPH02503923A (ja) | 1990-11-15 |
| HK1007744A1 (en) | 1999-04-23 |
| HU891841D0 (en) | 1990-04-28 |
| NO306304B1 (no) | 1999-10-18 |
| FI895382A0 (fi) | 1989-11-10 |
| HU205091B (en) | 1992-03-30 |
| EP0357750A1 (en) | 1990-03-14 |
| FI102379B (fi) | 1998-11-30 |
| CN1040793A (zh) | 1990-03-28 |
| WO1989008643A1 (en) | 1989-09-21 |
| EP0357750B1 (en) | 1994-07-13 |
| EP0357750A4 (en) | 1991-01-30 |
| IE65149B1 (en) | 1995-10-04 |
| IL89541A0 (en) | 1989-09-10 |
| FI102379B1 (fi) | 1998-11-30 |
| US4946942A (en) | 1990-08-07 |
| CZ148989A3 (en) | 1997-11-12 |
| CN1022412C (zh) | 1993-10-13 |
| NO894503L (no) | 1989-11-10 |
| DE68916722D1 (de) | 1994-08-18 |
| RU2007396C1 (ru) | 1994-02-15 |
| NZ228282A (en) | 1990-10-26 |
| ATE108438T1 (de) | 1994-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19931018 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20090309 |