ATE172112T1 - Verfahren zur herstellung eines retardpräparates, das diltiazem in einer einzigen tagesdosis enthält - Google Patents

Verfahren zur herstellung eines retardpräparates, das diltiazem in einer einzigen tagesdosis enthält

Info

Publication number: ATE172112T1
Authority: AT; Austria
Prior art keywords: sustained; producing; daily dose; preparation containing; release preparation
Prior art date: 1987-02-20

Application number

AT88100839T

Other languages

English (en)

Inventor

Dieter Barth

Original Assignee

Farmarc Nederland Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-20

Filing date

1988-01-21

Publication date

1998-10-15

1988-01-21 Application filed by Farmarc Nederland Bv filed Critical Farmarc Nederland Bv

1998-10-15 Application granted granted Critical

1998-10-15 Publication of ATE172112T1 publication Critical patent/ATE172112T1/de

Links

HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 title abstract 2
229960004166 diltiazem Drugs 0.000 title abstract 2
239000003405 delayed action preparation Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000010521 absorption reaction Methods 0.000 abstract 2
230000036765 blood level Effects 0.000 abstract 2
239000008188 pellet Substances 0.000 abstract 2
239000013543 active substance Substances 0.000 abstract 1
239000007903 gelatin capsule Substances 0.000 abstract 1
239000012729 immediate-release (IR) formulation Substances 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000002035 prolonged effect Effects 0.000 abstract 1
239000007909 solid dosage form Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT88100839T 1987-02-20 1988-01-21 Verfahren zur herstellung eines retardpräparates, das diltiazem in einer einzigen tagesdosis enthält ATE172112T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH63787		1987-02-20

Publications (1)

Publication Number	Publication Date
ATE172112T1 true ATE172112T1 (de)	1998-10-15

Family

ID=4191649

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88100839T ATE172112T1 (de)	1987-02-20	1988-01-21	Verfahren zur herstellung eines retardpräparates, das diltiazem in einer einzigen tagesdosis enthält

Country Status (12)

Country	Link
EP (1)	EP0282698B1 (de)
JP (1)	JP2863528B2 (de)
KR (1)	KR960011232B1 (de)
AT (1)	ATE172112T1 (de)
AU (1)	AU1196988A (de)
BR (1)	BR8800763A (de)
CA (1)	CA1327006C (de)
DE (1)	DE3856258T2 (de)
DK (1)	DK173505B1 (de)
ES (1)	ES2125215T3 (de)
MX (1)	MX10490A (de)
ZA (1)	ZA881181B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3737741A1 (de) *	1987-11-06	1989-05-18	Goedecke Ag	Oral anzuwendende arzneiform zur einmal taeglichen behandlung der hypertonie mit diltiazemhydrochlorid
DE3922167A1 (de) *	1988-04-16	1991-01-17	Sanol Arznei Schwarz Gmbh	Oral zu verabreichende diltiazemhydrochlorid enthaltende pharmazeutische zubereitung zur einmal taeglichen applikation und verfahren zu deren herstellung
US5133974A (en) *	1989-05-05	1992-07-28	Kv Pharmaceutical Company	Extended release pharmaceutical formulations
SE8902699D0 (sv) *	1989-08-09	1989-08-09	Lejus Medical Ab	Diltiazem containing pharmaceutical compositios
ZA923474B (en) *	1991-05-20	1993-01-27	Marion Merrell Dow Inc	Diltiazem formulation
US5286497A (en) *	1991-05-20	1994-02-15	Carderm Capital L.P.	Diltiazem formulation
JP3746315B2 (ja)	1994-07-07	2006-02-15	ダイセル化学工業株式会社	分離剤
US5834024A (en)	1995-01-05	1998-11-10	Fh Faulding & Co. Limited	Controlled absorption diltiazem pharmaceutical formulation
US5567441A (en) *	1995-03-24	1996-10-22	Andrx Pharmaceuticals Inc.	Diltiazem controlled release formulation
FR2742660B1 (fr) *	1995-12-22	1998-04-03	Ethypharm Lab Prod Ethiques	Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif
AU2021997A (en) *	1996-03-08	1997-09-22	Nycomed Danmark A/S	Modified release multiple-units dosage composition
US5830503A (en) *	1996-06-21	1998-11-03	Andrx Pharmaceuticals, Inc.	Enteric coated diltiazem once-a-day formulation
FR2754710B1 (fr) *	1996-10-22	1998-12-31	Prographarm Lab	Procede de preparation d'une forme pharmaceutique multiparticulaire a liberation controlee plurisequentielle
US6162463A (en) *	1997-05-01	2000-12-19	Dov Pharmaceutical Inc	Extended release formulation of diltiazem hydrochloride
US6299773B1 (en)	1998-06-22	2001-10-09	Asahi Kasei Kogyo Kabushiki Kaisha	Porous polyvinylidene fluoride resin film and process for producing the same
US7108866B1 (en) *	1999-12-10	2006-09-19	Biovall Laboratories International Srl	Chronotherapeutic diltiazem formulations and the administration thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4173626A (en) *	1978-12-11	1979-11-06	Merck & Co., Inc.	Sustained release indomethacin
JPS5867616A (ja) *	1981-10-15	1983-04-22	Tanabe Seiyaku Co Ltd	腸溶性マイクロカプセル
JPS604120A (ja) *	1983-06-22	1985-01-10	Shionogi & Co Ltd	作用持続型ピナシジル製剤
FR2554718B1 (fr) *	1983-11-14	1986-04-04	Ethypharm Sa	Nouvelles formes galeniques du sulpiride utilisables par voie orale
IE56999B1 (en) *	1983-12-22	1992-03-11	Elan Corp Plc	Pharmaceutical formulation
IT1178511B (it) *	1984-09-14	1987-09-09	Pharmatec Spa	Procedimento per la preparazione di una forma solida per uso orale a base di nifedipina con rilascio

1988
- 1988-01-13 DK DK198800153A patent/DK173505B1/da not_active IP Right Cessation
- 1988-01-21 AT AT88100839T patent/ATE172112T1/de not_active IP Right Cessation
- 1988-01-21 DE DE3856258T patent/DE3856258T2/de not_active Expired - Fee Related
- 1988-01-21 ES ES88100839T patent/ES2125215T3/es not_active Expired - Lifetime
- 1988-01-21 EP EP88100839A patent/EP0282698B1/de not_active Expired - Lifetime
- 1988-02-15 JP JP63031018A patent/JP2863528B2/ja not_active Expired - Fee Related
- 1988-02-19 BR BR8800763A patent/BR8800763A/pt not_active Application Discontinuation
- 1988-02-19 MX MX1049088A patent/MX10490A/es unknown
- 1988-02-19 AU AU11969/88A patent/AU1196988A/en not_active Abandoned
- 1988-02-19 CA CA000559331A patent/CA1327006C/en not_active Expired - Fee Related
- 1988-02-19 ZA ZA881181A patent/ZA881181B/xx unknown
- 1988-02-20 KR KR1019880001831A patent/KR960011232B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MX10490A (es)	1993-12-01
EP0282698B1 (de)	1998-10-14
DK15388A (da)	1988-08-21
DK173505B1 (da)	2001-01-15
DE3856258T2 (de)	1999-04-29
EP0282698A1 (de)	1988-09-21
JPH01216934A (ja)	1989-08-30
ZA881181B (en)	1988-08-16
KR880009640A (ko)	1988-10-04
DE3856258D1 (de)	1998-11-19
DK15388D0 (da)	1988-01-13
JP2863528B2 (ja)	1999-03-03
BR8800763A (pt)	1988-10-04
ES2125215T3 (es)	1999-03-01
KR960011232B1 (ko)	1996-08-21
CA1327006C (en)	1994-02-15
AU1196988A (en)	1988-08-25

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Legal Events

Date	Code	Title	Description
1999-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties