ATE172247T1 - Car-rezeptoren und verwandte moleküle und entsprechende methoden - Google Patents

Car-rezeptoren und verwandte moleküle und entsprechende methoden

Info

Publication number
ATE172247T1
ATE172247T1 AT93906143T AT93906143T ATE172247T1 AT E172247 T1 ATE172247 T1 AT E172247T1 AT 93906143 T AT93906143 T AT 93906143T AT 93906143 T AT93906143 T AT 93906143T AT E172247 T1 ATE172247 T1 AT E172247T1
Authority
AT
Austria
Prior art keywords
car
related molecules
corresponding methods
disclosed
receptor
Prior art date
Application number
AT93906143T
Other languages
English (en)
Inventor
David D Moore
Myriam I Baes
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of ATE172247T1 publication Critical patent/ATE172247T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT93906143T 1992-02-26 1993-02-22 Car-rezeptoren und verwandte moleküle und entsprechende methoden ATE172247T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/843,350 US5756448A (en) 1992-02-26 1992-02-26 Constitute activator of retinoid (CAR) receptor polypeptides

Publications (1)

Publication Number Publication Date
ATE172247T1 true ATE172247T1 (de) 1998-10-15

Family

ID=25289720

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93906143T ATE172247T1 (de) 1992-02-26 1993-02-22 Car-rezeptoren und verwandte moleküle und entsprechende methoden

Country Status (9)

Country Link
US (3) US5756448A (de)
EP (1) EP0628054B1 (de)
JP (1) JPH07504416A (de)
KR (1) KR950700328A (de)
AT (1) ATE172247T1 (de)
AU (1) AU684458B2 (de)
CA (1) CA2117491A1 (de)
DE (1) DE69321580T2 (de)
WO (1) WO1993017041A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989242B1 (en) * 1992-02-26 2006-01-24 The General Hospital Coporation Car receptors and related molecules and methods
USRE39229E1 (en) * 1994-08-20 2006-08-08 Gendaq Limited Binding proteins for recognition of DNA
WO1998011221A2 (en) * 1996-09-13 1998-03-19 Dana-Farber Cancer Institute Car, a novel coxsackievirus and adenovirus receptor
WO1999015555A1 (en) * 1997-09-19 1999-04-01 The General Hospital Corporation Car receptors and related molecules and methods
SE9801148D0 (sv) * 1997-10-14 1998-03-31 Pharmacia & Upjohn Ab New receptors
US7118885B2 (en) 1997-10-14 2006-10-10 Pfizer Inc. Nucleic acid encoding vitamin D receptor related polypeptide
JP2002539185A (ja) * 1999-03-16 2002-11-19 グラクソ グループ リミテッド 核内受容体アリール化化合物
US6287813B1 (en) 1999-04-23 2001-09-11 Cistronics Cell Technology Gmbh Antibiotic-based gene regulation system
CA2397207C (en) 2000-01-13 2013-12-03 Genentech, Inc. Novel stra6 polypeptides
WO2001083546A1 (en) * 2000-05-01 2001-11-08 The General Hospital Corporation THE CaR RECEPTOR AS A MEDIATOR OF MIGRATORY CELL CHEMOTAXIS AND/OR CHEMOKINESIS
US7176243B2 (en) * 2000-06-02 2007-02-13 The General Hospital Corporation CaR receptor as a mediator of migratory cell chemotaxis and/or chemokinesis
US7186879B2 (en) * 2000-09-21 2007-03-06 Baylor College Of Medicine Screening systems and methods for identifying modulators of xenobiotic metabolism
US20040006775A1 (en) * 2001-09-21 2004-01-08 Moore David D. Screening systems and methods for identifying modulators of xenobiotic matabolism
AU9119201A (en) * 2000-09-21 2002-04-02 Baylor College Medicine Screening systems and methods for identifying modulators of xenobiotic metabolism
AU2003213164A1 (en) * 2002-02-19 2003-09-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Mutated constitutively active nuclear orphan receptor
US7301014B2 (en) * 2002-02-28 2007-11-27 Wyeth Nucleic acid molecule encoding a novel estrogen receptor beta variant
ES2439874T3 (es) * 2002-05-29 2014-01-27 Regeneron Pharmaceuticals, Inc. Sistema de expresión en eucariotas inducible
US8673589B2 (en) 2002-05-29 2014-03-18 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
EP1371661A1 (de) * 2002-06-13 2003-12-17 LION Bioscience AG CAR-Rezeptorvarianten in der Ligand-Bindungs Domäne
AU2003272799A1 (en) * 2002-09-27 2004-04-19 Incyte Corporation Receptors and membrane-associated proteins
WO2004043563A2 (en) * 2002-11-05 2004-05-27 Regeneron Pharmaceuticals, Inc. Methods of isolation of active compounds and activated targets
WO2005088306A2 (en) * 2004-03-04 2005-09-22 Whitehead Institute For Biomedical Research Biologically-active dna-binding sites and related methods

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870009A (en) * 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5077211A (en) * 1988-07-06 1991-12-31 Applied Genetics, Inc. Purification and administration of dna repair enzymes
US5217867A (en) * 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
WO1990007517A1 (en) * 1988-12-23 1990-07-12 The Salk Institute For Biological Studies Receptor transcription-repression activity compositions and methods
ATE166360T1 (de) * 1989-03-17 1998-06-15 Salk Inst For Biological Studi Zusammensetzung und testverfahren eines elementes als antwort auf ein hormon
EP0473716A4 (en) * 1989-05-26 1992-09-09 The Salk Institute For Biological Studies Dominant negative members of the steroid/thyroid superfamily of receptors
US5260432A (en) * 1989-06-22 1993-11-09 Sloan-Kettering Institute For Cancer Research Human gamma retinoic acid receptor DNA
US5091518A (en) * 1989-11-16 1992-02-25 The Salk Institute For Biological Studies Beta retinoic acid response elements compositions and assays
ES2152920T3 (es) * 1990-02-09 2001-02-16 Salk Inst For Biological Studi Composiciones receptoras de retinoides y metodos.
JPH11508121A (ja) * 1990-03-22 1999-07-21 ザ ソーク インスティテュート フォア バイオロジカル スタディーズ 昆虫レチノイドレセプター組成物および方法
US5183736A (en) * 1990-03-30 1993-02-02 La Jolla Cancer Research Foundation Methods using estrogen receptor as a constitutive transcriptional activator and a repressor
KR970003328B1 (ko) * 1991-07-12 1997-03-17 오므론 가부시끼가이샤 화상 처리 시스템에 있어서, 알맞은 조명조건, 촬영조건등을 결정 및 설정하기 위한 또는 결정 및 설정을 지원하기 위한 장치 및 방법
CA2115452A1 (en) * 1991-09-17 1993-04-01 Ronald M. Evans Receptor of the thyroid/steroid hormone receptor superfamily

Also Published As

Publication number Publication date
EP0628054A4 (de) 1997-03-19
EP0628054A1 (de) 1994-12-14
US5710017A (en) 1998-01-20
WO1993017041A1 (en) 1993-09-02
JPH07504416A (ja) 1995-05-18
CA2117491A1 (en) 1993-09-02
AU684458B2 (en) 1997-12-18
AU3728393A (en) 1993-09-13
DE69321580D1 (de) 1998-11-19
KR950700328A (ko) 1995-01-16
DE69321580T2 (de) 1999-06-17
EP0628054B1 (de) 1998-10-14
US5756448A (en) 1998-05-26
US5686574A (en) 1997-11-11

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