ATE172247T1 - Car-rezeptoren und verwandte moleküle und entsprechende methoden - Google Patents

Car-rezeptoren und verwandte moleküle und entsprechende methoden

Info

Publication number
ATE172247T1
ATE172247T1 AT93906143T AT93906143T ATE172247T1 AT E172247 T1 ATE172247 T1 AT E172247T1 AT 93906143 T AT93906143 T AT 93906143T AT 93906143 T AT93906143 T AT 93906143T AT E172247 T1 ATE172247 T1 AT E172247T1
Authority
AT
Austria
Prior art keywords
car
related molecules
corresponding methods
disclosed
receptor
Prior art date
Application number
AT93906143T
Other languages
English (en)
Inventor
David D Moore
Myriam I Baes
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of ATE172247T1 publication Critical patent/ATE172247T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT93906143T 1992-02-26 1993-02-22 Car-rezeptoren und verwandte moleküle und entsprechende methoden ATE172247T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/843,350 US5756448A (en) 1992-02-26 1992-02-26 Constitute activator of retinoid (CAR) receptor polypeptides

Publications (1)

Publication Number Publication Date
ATE172247T1 true ATE172247T1 (de) 1998-10-15

Family

ID=25289720

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93906143T ATE172247T1 (de) 1992-02-26 1993-02-22 Car-rezeptoren und verwandte moleküle und entsprechende methoden

Country Status (9)

Country Link
US (3) US5756448A (de)
EP (1) EP0628054B1 (de)
JP (1) JPH07504416A (de)
KR (1) KR950700328A (de)
AT (1) ATE172247T1 (de)
AU (1) AU684458B2 (de)
CA (1) CA2117491A1 (de)
DE (1) DE69321580T2 (de)
WO (1) WO1993017041A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989242B1 (en) * 1992-02-26 2006-01-24 The General Hospital Coporation Car receptors and related molecules and methods
DE69535829D1 (de) * 1994-08-20 2008-10-16 Gendaq Ltd Verbesserung in bezug auf bindungsproteine bei der erkennung von dna
AU4344197A (en) * 1996-09-13 1998-04-02 Albert Einstein College Of Medicine Of Yeshiva University Car, a novel coxsackievirus and adenovirus receptor
EP1017716A4 (de) * 1997-09-19 2001-01-03 Gen Hospital Corp Car-rezeptoren, verwandte moleküle und methoden
US7118885B2 (en) 1997-10-14 2006-10-10 Pfizer Inc. Nucleic acid encoding vitamin D receptor related polypeptide
SE9801148D0 (sv) * 1997-10-14 1998-03-31 Pharmacia & Upjohn Ab New receptors
AU3742100A (en) * 1999-03-16 2000-10-04 Glaxo Group Limited Nuclear receptor arylating compounds
US6287813B1 (en) 1999-04-23 2001-09-11 Cistronics Cell Technology Gmbh Antibiotic-based gene regulation system
NZ520095A (en) 2000-01-13 2004-05-28 Genentech Inc Novel Stra6 polypeptides, nucleic acids, antibodies, compositions and methods of treatments for inhibiting tumor cell growth
AU2000253227A1 (en) * 2000-05-01 2001-11-12 The Brigham And Women's Hospital, Inc. The car receptor as a mediator of migratory cell chemotaxis and/or chemokinesis
US7176243B2 (en) * 2000-06-02 2007-02-13 The General Hospital Corporation CaR receptor as a mediator of migratory cell chemotaxis and/or chemokinesis
US20040006775A1 (en) * 2001-09-21 2004-01-08 Moore David D. Screening systems and methods for identifying modulators of xenobiotic matabolism
EP1330645A4 (de) * 2000-09-21 2005-04-27 Baylor College Medicine Sichtungssysteme und -verfahren zum identifizieren von modulatoren eines xenobiotischen metabolismus
US7186879B2 (en) * 2000-09-21 2007-03-06 Baylor College Of Medicine Screening systems and methods for identifying modulators of xenobiotic metabolism
AU2003213164A1 (en) * 2002-02-19 2003-09-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Mutated constitutively active nuclear orphan receptor
US7301014B2 (en) * 2002-02-28 2007-11-27 Wyeth Nucleic acid molecule encoding a novel estrogen receptor beta variant
EP1531666B1 (de) * 2002-05-29 2013-10-23 Regeneron Pharmaceuticals, Inc. Induzierbares eukaryonten-expressionssystem
US8673589B2 (en) 2002-05-29 2014-03-18 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
EP1371661A1 (de) * 2002-06-13 2003-12-17 LION Bioscience AG CAR-Rezeptorvarianten in der Ligand-Bindungs Domäne
WO2004029218A2 (en) * 2002-09-27 2004-04-08 Incyte Corporation Receptors and membrane-associated proteins
CA2503787A1 (en) * 2002-11-05 2004-05-27 Regeneron Pharmaceuticals, Inc. Methods of isolation of active compounds and activated targets
JP2007526776A (ja) * 2004-03-04 2007-09-20 ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ 生物活性ｄｎａ結合部位及び関連する方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870009A (en) * 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5077211A (en) * 1988-07-06 1991-12-31 Applied Genetics, Inc. Purification and administration of dna repair enzymes
US5217867A (en) * 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
AU633045B2 (en) * 1988-12-23 1993-01-21 Salk Institute For Biological Studies, The Receptor transcription-repression activity compositions and methods
AU655912B2 (en) * 1989-03-17 1995-01-19 Salk Institute For Biological Studies, The Hormone response element compositions and assay
CA2057049A1 (en) * 1989-05-26 1990-11-27 Ronald M. Evans Dominant negative members of the steroid/thyroid superfamily of receptors
US5260432A (en) * 1989-06-22 1993-11-09 Sloan-Kettering Institute For Cancer Research Human gamma retinoic acid receptor DNA
US5091518A (en) * 1989-11-16 1992-02-25 The Salk Institute For Biological Studies Beta retinoic acid response elements compositions and assays
EP0514488B1 (de) * 1990-02-09 2000-09-13 The Salk Institute For Biological Studies Retinoid-rezeptor-zusammensetzungen und verfahren
WO1991014695A1 (en) * 1990-03-22 1991-10-03 The Salk Institute For Biological Studies Insect retinoid receptor compositions and methods
US5183736A (en) * 1990-03-30 1993-02-02 La Jolla Cancer Research Foundation Methods using estrogen receptor as a constitutive transcriptional activator and a repressor
WO1993001559A1 (en) * 1991-07-12 1993-01-21 Omron Corporation Apparatus and method for determining or setting adequate illuminating and photographing condition, etc., in picture processing system; and apparatus and method for aiding the determination or setting
EP0609240B1 (de) * 1991-09-17 2002-04-03 The Salk Institute For Biological Studies Rezeptoren der steroid/thyroid superfamilie von rezeptoren

Also Published As

Publication number Publication date
AU3728393A (en) 1993-09-13
US5756448A (en) 1998-05-26
EP0628054B1 (de) 1998-10-14
EP0628054A1 (de) 1994-12-14
DE69321580D1 (de) 1998-11-19
JPH07504416A (ja) 1995-05-18
US5710017A (en) 1998-01-20
US5686574A (en) 1997-11-11
AU684458B2 (en) 1997-12-18
DE69321580T2 (de) 1999-06-17
CA2117491A1 (en) 1993-09-02
EP0628054A4 (de) 1997-03-19
KR950700328A (ko) 1995-01-16
WO1993017041A1 (en) 1993-09-02

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