ATE172458T1 - 1,5-benzodiazepin-derivate verwendbar als cck oder gastrin antagonisten - Google Patents

1,5-benzodiazepin-derivate verwendbar als cck oder gastrin antagonisten

Info

Publication number: ATE172458T1
Authority: AT; Austria
Prior art keywords: substituted; hydroxy; 4alkyl; group; pct
Prior art date: 1993-07-20

Application number

AT94924256T

Other languages

English (en)

Inventor

Giovanni Curotto

Mario Pellegatti

Stefano Polinelli

Original Assignee

Glaxo Wellcome Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-20

Filing date

1994-07-18

Publication date

1998-11-15

1994-07-18 Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa

1998-11-15 Application granted granted Critical

1998-11-15 Publication of ATE172458T1 publication Critical patent/ATE172458T1/de

Links

102100021022 Gastrin Human genes 0.000 title abstract 2
108010052343 Gastrins Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 title abstract 2
ZVAPWJGRRUHKGP-UHFFFAOYSA-N 1h-1,5-benzodiazepine Chemical class N1C=CC=NC2=CC=CC=C12 ZVAPWJGRRUHKGP-UHFFFAOYSA-N 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
229910052757 nitrogen Inorganic materials 0.000 abstract 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
-1 hydroxy, phenyl Chemical group 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
239000005864 Sulphur Chemical group 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
125000004185 ester group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT94924256T 1993-07-20 1994-07-18 1,5-benzodiazepin-derivate verwendbar als cck oder gastrin antagonisten ATE172458T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939315018A GB9315018D0 (en)	1993-07-20	1993-07-20	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE172458T1 true ATE172458T1 (de)	1998-11-15

Family

ID=10739123

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94924256T ATE172458T1 (de)	1993-07-20	1994-07-18	1,5-benzodiazepin-derivate verwendbar als cck oder gastrin antagonisten

Country Status (8)

Country	Link
US (1)	US5733867A (de)
EP (1)	EP0710229B1 (de)
JP (1)	JPH09501417A (de)
AT (1)	ATE172458T1 (de)
AU (1)	AU7458894A (de)
DE (1)	DE69414117D1 (de)
GB (1)	GB9315018D0 (de)
WO (1)	WO1995003284A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5739129A (en) *	1994-04-14	1998-04-14	Glaxo Wellcome Inc.	CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
PE27497A1 (es) *	1994-04-15	1997-08-07	Glaxo Inc	Derivados de 1,5 benzodiazepina
CN104817489B (zh) *	2015-03-11	2017-06-27	西安交通大学	一种具有抗肿瘤活性的杂环联苯芳基脲类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL48613A0 (en) *	1975-12-08	1976-02-29	Iscar Ltd	Cutting tool providing mounting for interchangeable cutting inserts
FR2443318A1 (fr) *	1978-12-08	1980-07-04	Caumette Georges	Outil a rainer le bois a plaquettes reversibles jetables
FR2641280B1 (fr) *	1988-12-29	1994-01-21	Roussel Uclaf	Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
GB9201181D0 (en) *	1992-01-21	1992-03-11	Glaxo Spa	Chemical compounds
GB9201180D0 (en) *	1992-01-21	1992-03-11	Glaxo Group Ltd	Chemical compounds
US5552319A (en) *	1993-07-20	1996-09-03	Biochem Technology, Inc.	Apparatus and method for monitoring and controlling biological activity in wastewater and controlling the treatment thereof

1993
- 1993-07-20 GB GB939315018A patent/GB9315018D0/en active Pending
1994
- 1994-07-18 AT AT94924256T patent/ATE172458T1/de not_active IP Right Cessation
- 1994-07-18 US US08/578,534 patent/US5733867A/en not_active Expired - Fee Related
- 1994-07-18 DE DE69414117T patent/DE69414117D1/de not_active Expired - Lifetime
- 1994-07-18 WO PCT/EP1994/002352 patent/WO1995003284A1/en not_active Ceased
- 1994-07-18 EP EP94924256A patent/EP0710229B1/de not_active Expired - Lifetime
- 1994-07-18 AU AU74588/94A patent/AU7458894A/en not_active Abandoned
- 1994-07-18 JP JP7504925A patent/JPH09501417A/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
GB9315018D0 (en)	1993-09-01
US5733867A (en)	1998-03-31
AU7458894A (en)	1995-02-20
EP0710229A1 (de)	1996-05-08
DE69414117D1 (de)	1998-11-26
EP0710229B1 (de)	1998-10-21
JPH09501417A (ja)	1997-02-10
WO1995003284A1 (en)	1995-02-02

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Legal Events

Date	Code	Title	Description
1999-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties