ATE172459T1 - Durch 2- und 5- alkyl und phenyl substituierte 4- (1-hydroxy, 1-acyloxy oder 1-carbamoyloxy)-5- hydroxy-2(5h)-furanone als antiinflammatorische mittel - Google Patents

Durch 2- und 5- alkyl und phenyl substituierte 4- (1-hydroxy, 1-acyloxy oder 1-carbamoyloxy)-5- hydroxy-2(5h)-furanone als antiinflammatorische mittel

Info

Publication number
ATE172459T1
ATE172459T1 AT92911576T AT92911576T ATE172459T1 AT E172459 T1 ATE172459 T1 AT E172459T1 AT 92911576 T AT92911576 T AT 92911576T AT 92911576 T AT92911576 T AT 92911576T AT E172459 T1 ATE172459 T1 AT E172459T1
Authority
AT
Austria
Prior art keywords
alkyl
phenyl
hydroxy
substituted phenyl
carbons
Prior art date
Application number
AT92911576T
Other languages
English (en)
Inventor
Gary C M Lee
Michael E Garst
George Sachs
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ATE172459T1 publication Critical patent/ATE172459T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
AT92911576T 1991-04-30 1992-04-29 Durch 2- und 5- alkyl und phenyl substituierte 4- (1-hydroxy, 1-acyloxy oder 1-carbamoyloxy)-5- hydroxy-2(5h)-furanone als antiinflammatorische mittel ATE172459T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/693,204 US5183906A (en) 1991-04-30 1991-04-30 2- and 5-alkyl and phenyl substituted 4-(1-hydroxy, 1-acyloxy or 1-carbamoyloxy)-5-hydroxy-2 (5h)-furanones as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
ATE172459T1 true ATE172459T1 (de) 1998-11-15

Family

ID=24783742

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92911576T ATE172459T1 (de) 1991-04-30 1992-04-29 Durch 2- und 5- alkyl und phenyl substituierte 4- (1-hydroxy, 1-acyloxy oder 1-carbamoyloxy)-5- hydroxy-2(5h)-furanone als antiinflammatorische mittel

Country Status (10)

Country Link
US (1) US5183906A (de)
EP (1) EP0579769B1 (de)
JP (1) JP3181054B2 (de)
AT (1) ATE172459T1 (de)
AU (1) AU1923892A (de)
CA (1) CA2109064A1 (de)
DE (1) DE69227366T2 (de)
ES (1) ES2124261T3 (de)
NO (1) NO933918L (de)
WO (1) WO1992019610A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268387A (en) * 1992-04-24 1993-12-07 Allergan, Inc. Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss
WO1994026279A1 (en) * 1993-05-18 1994-11-24 The Upjohn Company Bisphosphonate esters for treating gastric disorders
SK20396A3 (en) * 1993-08-19 1997-03-05 Warner Lambert Co Substituted 2(5h)furanone, 2(5h)thiophenone or 2(5h)pyrrolone derivatives and pharmaceutical compositions on their base
US5464865A (en) * 1993-12-22 1995-11-07 Ortho Pharmaceutical Corporation 4-aryl- and 4-arylthio-5-hydroxy-2(5H)-furanones as inhibitors of phospholipase A2
US5451686A (en) * 1994-04-15 1995-09-19 Allergan, Inc. 3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5H)-furanones as anti-inflammatory agents
US5639468A (en) * 1995-06-07 1997-06-17 University Of Southern California Method for reducing or preventing post-surgical adhesion formation using manoalide and analogs thereof
US5922759A (en) * 1996-06-21 1999-07-13 Warner-Lambert Company Butenolide endothelin antagonists
US5998468A (en) * 1995-08-24 1999-12-07 Warner-Lambert Company Furanone endothelin antagonists
US5891892A (en) * 1996-10-29 1999-04-06 Warner-Lambert Company Small molecule biaryl compounds as inhibitors of endothelin converting enzyme
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP2063905B1 (de) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
FR2978963A1 (fr) 2011-08-11 2013-02-15 Ascorbix Nouveaux derives des furanones et composition pharmaceutique les contenant

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2359208A (en) * 1941-03-21 1944-09-26 Lilly Co Eli beta-substituted-delta alpha,beta-gamma-butyrolactones and beta-substituted-beta-hydroxy-gamma-butyrolactones and the methods of preparing them
US2359096A (en) * 1941-03-21 1944-09-26 Lilly Co Eli beta-substituted-delta alpha, beta-gamma-butyrolactones and beta-substituted - beta - hydroxy-gamma-butyrolactones and methods of preparing them
DE3472958D1 (en) * 1983-08-03 1988-09-01 Univ California Synthetic analgesic and/or anti-inflammatory derivatives of manoalide
US4447445A (en) * 1983-08-03 1984-05-08 The Regents Of The University Of Calif. Manoalide, an anti-inflammatory analgesic marine natural product
US4789749A (en) * 1984-06-18 1988-12-06 The Regents Of The University Of California Manoalide analogs
US4874782A (en) * 1985-07-01 1989-10-17 Eli Lilly And Company Furanone derivatives
ZA864674B (en) * 1985-07-01 1988-02-24 Lilly Co Eli Furanone derivatives
US4786651A (en) * 1986-02-03 1988-11-22 Allergan, Inc. Treatment of cutaneous hyperproliferative dermatoses with manoalide
DE3615157A1 (de) * 1986-05-05 1987-11-12 Schwabe Willmar Gmbh & Co 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe
US5089485A (en) * 1988-11-18 1992-02-18 Allergan, Inc. Anti-inflammatory furanones
US5043457A (en) * 1990-04-17 1991-08-27 Allergan, Inc. 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents
CA1329390C (en) * 1987-06-08 1994-05-10 John N. Bonfiglio Anti-inflammatory furanones
US5037811A (en) * 1990-04-17 1991-08-06 Allergan, Inc. 4-(oxygen, sulfur or nitrogen substituted)-methyl 5-hydroxy-2(5H)-furanones as anti-inflammatory agents
US5059611A (en) * 1988-11-18 1991-10-22 Allergan, Inc. Anti-inflammatory 5-hydroxy-2-furanones
US4916241A (en) * 1988-06-06 1990-04-10 American Home Products Corporation Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones
JPH0222271A (ja) * 1988-07-11 1990-01-25 Kuraray Co Ltd 共役γ−オキシブテノライド化合物およびこれを有効成分とする抗潰瘍剤
US4935530A (en) * 1988-10-18 1990-06-19 Allergan, Inc. Process for preparing 5-substituted-3-furaldehydes
EP0369813A3 (de) * 1988-11-18 1991-02-27 Allergan, Inc Entzündungshemmende Furanone
US5045564A (en) * 1988-12-07 1991-09-03 Allergan, Inc. Anti-inflammatory 2-furanones
EP0372941A3 (de) * 1988-12-07 1991-02-06 Allergan, Inc Entzündungshemmende 5-Hydroxy-2-furanone
US5013850A (en) * 1990-03-30 1991-05-07 Allergan, Inc. 4-ethyl and 4-ethenyl-5-hydroxy-2(5H)-furanones substituted on alpha carbon of the ethyl or ethenyl side chain with a long chain alkyl group and on the beta carbon with a polar group, as anti-inflammatory agents

Also Published As

Publication number Publication date
WO1992019610A1 (en) 1992-11-12
NO933918L (no) 1993-12-28
JP3181054B2 (ja) 2001-07-03
EP0579769B1 (de) 1998-10-21
US5183906A (en) 1993-02-02
JPH06507171A (ja) 1994-08-11
ES2124261T3 (es) 1999-02-01
EP0579769A1 (de) 1994-01-26
DE69227366D1 (de) 1998-11-26
CA2109064A1 (en) 1992-10-31
NO933918D0 (no) 1993-10-29
AU1923892A (en) 1992-12-21
DE69227366T2 (de) 1999-06-10

Similar Documents

Publication Publication Date Title
ATE172459T1 (de) Durch 2- und 5- alkyl und phenyl substituierte 4- (1-hydroxy, 1-acyloxy oder 1-carbamoyloxy)-5- hydroxy-2(5h)-furanone als antiinflammatorische mittel
AU653057B2 (en) Cosmetic composition
BR8707408A (pt) Novos 5-alcoxi-2,4-diamino-alquibenzenos e composicoes de tingimento de cabelo com 5-alcoxi-2,4-diamino-alquil-benzenos
NZ238647A (en) Benz-oxazole, -thiazole, -oxazine and -thiazine derivatives and pharmaceutical compositions; intermediate compounds
DK0855401T3 (da) Kontrastsammensætninger til kernemagnetisk resonans
ATE165972T1 (de) 2(5h)- in position 3-substituierte furanone als ca 2+ antagonisten und entzündungshemmende mittel
SE7602122L (sv) Nya piperazinyliminorifamyciner och sett att framstella desamma
DE68906422D1 (de) Fluessigkristall-verbindung.
DK0460488T3 (da) Svovlholdige heterocykliske forbindelser
AU2321688A (en) Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloalkanes
ATE125278T1 (de) Biologisch abbaubarer copolyester von 4- hydroxyprolin und diesen enthaltende pharmazeutische zusammensetzung.
ES2061487T3 (es) Compuestos macrolidos.
KR920007947A (ko) 살균성 바이오세라믹 조성물
ATE69605T1 (de) Azolylpropenyl- und azolylmethyloxiran-derivate und diese enthaltende fungizide.
IE830469L (en) Fungicidal cyanopropenoates
DE68911237D1 (de) Nichtionische Trijodbenzin-Verbindungen und diese enthaltende Kontrastmittel.
EP0285980A3 (de) Riechstoffe und diese enthaltende Riechstoffkompositionen
DE3172309D1 (en) Substituted 3,5-diamino-1,2,4-oxadiazoles and 3,5-diamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them
ATE8059T1 (de) Verwendung einer gruppe von dioxa-alkyltricyclododecenen als riechstoffe; diese enthaltende riechstoffkompositionen; neue dioxa- alkyl-tricyclododecene dieser gruppe.
ES467861A1 (es) Procedimiento de preparacion de espiro-oxazolidinas esteroi-des y sus esteroisomeros.
GB2020656A (en) Tricyclo- alpha , beta -unsaturated ketones
FI812777L (fi) Foerfarande foer framstaellning av nya cardenolid-bis-digitoxosider
ATE233748T1 (de) Benzo(b)pyranderivate verwendbar als äusserlich anzuwendende hautbehandlungsmittel
SE8004622L (sv) Acylaminobensoesyraderivat
ATE214687T1 (de) Cycloalkylether und sie enthaltende riechstoffzusammensetzungen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties